产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
产品信息
| 别名 | Brain-Derived Neurotrophic Factor; BDNF; Abrineurin |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Ala19-Arg247(R125A,R127A,R128A) |
| 检索号 | P23560 |
| 分子量 | 25.6 kDa |
| 表观分子量 | 28 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C,stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 运输 | The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 100mM NaCl, 0.02% Tween 80, pH 6.0. |
背景介绍
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin Receptor p75 (p75NTR) and vps10p domain-containing Receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase Receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
FAQs
Q：{{item.question}}
A：
暂无数据
产品资料
注：百度浏览器无法支持扫一扫功能，请输入识别码，获取相应产品资料
识别码示意图
