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产品概述
产品信息
| 别名 | Epidermal Growth Factor Receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine- Protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Leu25-Ser645 |
| 检索号 | P00533 |
| 分子量 | 95.7 kDa |
| 表观分子量 | 120-160 kDa |
| 标签 | C-Fc |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
EGFR is a transmembrane glyco Protein that is a member of the Protein kinase superfamily. This Protein is a Receptor for members of the Epidermal Growth Factor family. EGFR is a cell surface Protein that binds to Epidermal Growth Factor. Binding of the Protein to a Ligand induces Receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other Proteins like RGS16, activating its GTPase activity and probably coupling the EGF Receptor signaling to the G Protein-coupled Receptor signaling.
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