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产品概述
产品信息
| 别名 | Fms-related Tyrosine Kinase 3 Ligand; Flt3 Ligand; Flt3L; SL Cytokine; FLT3LG |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Thr27-Pro184 |
| 检索号 | P49771 |
| 分子量 | 19 kDa |
| 表观分子量 | 24-32 kDa |
| 标签 | C-6His |
| 生物活性 | Immobilized Human FLT3LG (C-6His) 5 μg/ml (100 μl/well) can bind Human FLT3 (C-Fc). The EC50 of Human FLT3 (C-Fc) is not higher than 10 ng/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Fms-Related Tyrosine Kinase 3 Ligand (FLT3LG) is a hematopoietic four helical bundle Cytokine. Mature human Flt-3 Ligand consists of a extracellular domain (ECD) with a Cytokine-like domain and a juxtamembrane tether region, a transmembrane segment, and a cytoplasmic tail. Human and mouse Flt-3 Ligand show cross-species activity. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts.It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other Growth Factors, Flt3 Ligand stimulates the proliferation and differentiation of various blood cell progenitors by activiation of Flt 3 Receptor.
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