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产品概述
产品信息
| 别名 | Interleukin-21 Receptor; IL-21 Receptor; IL-21R; CD360. |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Cys20-Pro236 |
| 检索号 | Q9HBE5 |
| 分子量 | 26.0 kDa |
| 表观分子量 | 40-55kDa |
| 标签 | C-6His |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4. |
| 复融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin-21 Receptor is also known as IL-21 Receptor, IL-21R, CD360. In humans, it is encoded by the IL21R gene. It belongs to the type I Cytokine Receptor family. Type 4 subfamily contains 2 fibronectin type-III domains. Interleukin-21 Receptor is selectively expressed in lymphoid tissues and highly expressed in thymus and spleen. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells. It also promotes the anti-tumor activity of CD8+ T-cells and NK cells.
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