产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factorReceptor 2; TNF-R2; TNF-RII; Tumor necrosis factor Receptor type II; p75; p80 TNF-alphaReceptor; CD120b |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Pro24-Thr206 |
| 检索号 | P20333 |
| 分子量 | 46.5 kDa |
| 表观分子量 | 60 kDa |
| 生物活性 | Immobilized Recombinant Human TNF RII-mFc at 1μg/ml (100 μl/well) can bind Recombinant Human TNF alpha-His. The ED50 of Recombinant Human TNF alpha-His is 1.97 ng/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
| 复融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Tumor necrosis factor Receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosisfactor Receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58%and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressedpredominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as onendothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, andmesenchymal stem cells.TNF RII binds to the membranebound forms of TNFα and Lymphotoxinα/ TNFβ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNFbiological activity by binding TNF thereby preventing it from activating membrane TNF Receptors.
FAQs
Q：{{item.question}}
A：
暂无数据
产品资料
注：百度浏览器无法支持扫一扫功能，请输入识别码，获取相应产品资料
识别码示意图
