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产品概述
产品信息
| 别名 | Interleukin-2 Receptor subunit beta; IL2RB; IL-2 Receptor subunit beta; IL-2R subunit beta; High affinity IL-2 Receptor subunit beta; CD122 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala27-Asp239 |
| 检索号 | P14784 |
| 分子量 | 25.6 kDa |
| 表观分子量 | 35-40 kDa |
| 标签 | C-6His |
| 生物活性 | Loaded Human IL-2RB-His on HIS1K Biosensor, can bind Human IL-2 with an affinity constant of 0.27 uM as determined in BLI assay. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Human IL-2RB, also known asInterleukin-2 Receptor subunit beta,is the Receptor for Interleukin-2. IL2 Receptor complex is involved in Receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 Receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane Protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for Receptor-mediated signaling via physically or functionally coupling to other signaling molecules, such as the Jak-STAT and Src-family Protein tyrosine kinase although it lacks apparent catalytic Motifs.
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