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产品概述
产品信息
| 别名 | Interferon lambda-1; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29; IL-29; IFNL1; IL29; ZCYTO21 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Gly20-Thr200 |
| 检索号 | Q8IU54 |
| 分子量 | 21.4 kDa |
| 表观分子量 | 28-35 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Interleukin-29 (IL-29) is a secreted Protein which belongs to the IL-28/ IL-29 family. IL-29 is a Cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II Cytokine Receptor that consisted of IL-10 Receptor beta (IL-10R beta) and an orphan class II Receptor chain, designated IL-28R alpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II Cytokine Receptor composed of IL10RB and IL28RA. The Ligand/ Receptor complex seems to signal through the Jak-STAT pathway.
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