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产品概述
产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 1B; Tumor necrosis factor Receptor 2; Tumor necrosis factor Receptor type II; p75; p80 TNF-alpha Receptor; TBP-2; TBPII; TNFRSF1B; TNFBR; TNFR2 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Leu23-Asp257 |
| 检索号 | P20333 |
| 分子量 | 26.2 kDa |
| 表观分子量 | 40 kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Tumor necrosis factor Receptor superfamily member 1B is a 461 amino acids Protein that belongs to the TNFR (tumor necrosis factor Receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This Receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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