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人牙周膜干细胞
Human Periodontal Ligament Stem Cells
货号：CP-H234
规格：5×10⁵Cells/T25培养瓶
价格： ￥8880
培养基货号： CM-H234
产品概述
人牙周膜干细胞
Cat NO.: CP-H234
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产品名称：人牙周膜干细胞
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英文简称：PDLSCs
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组织来源：牙周膜组织
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
人牙周膜干细胞分离自牙周膜组织；牙周膜(牙周韧带、牙周间隙)是由致密结缔组织所构成。多数纤维排列成束，纤维的一端埋于牙骨质内，另一端则埋于牙槽窝骨壁里，使牙齿固位于牙槽窝内；牙周膜内有神经、血管、淋巴和上皮细胞等。成纤维细胞(Fibroblast)是疏松结缔组织的主要细胞成分，由胚胎时期的间充质细胞分化而来。间充质干细胞(mesenchymal stem cells，MSCs)来源于胚胎时期的中胚层组织，具有很强的自我复制和多向分化潜能，具有向脂肪细胞、成骨细胞、软骨细胞及肌细胞等多种终末细胞定向分化的能力，运用 MSCs来修复软骨损伤具有很好的应用前景，目前已能够从骨髓、脂肪、滑膜、骨骼、肌肉等组织以及羊水、脐带、脐带血中分离和制备间充质干细胞。牙周膜干细胞参与了牙周组织的病变、修复及再生过程。现在，利用牙周膜干细胞建立体外模型，已经成为有关员研究牙周组织疾病的重要手段。
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方法简介：
普诺赛实验室分离的人牙周膜干细胞采用胶原酶消化结合差速贴壁法制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的人牙周膜干细胞经CD44免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-H234 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 成纤维细胞样 传代特性 可传3-5代左右 消化液 0.25%胰蛋白酶 人牙周膜干细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages (2023-04-10)
作者：Yuran Su:1.Department of Prosthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China. ; Sifan Ai:1.Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Collaborative Innovation Center of Chemical Science and Engineering, and National Institute of Functional Materials, Nankai University, Tianjin 300071, China. ; Youqing Shen:1.Department of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China. ; Wen Cheng:1.Department of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China. ; Chenyu Xu:1.Department of Orthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China. ; Lei Sui:1.Department of Prosthodontics, School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China. ; Yanhong Zhao:1.Department of Orth
期刊：Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages
影响因子 ：5.6
引用产品： 人牙周膜干细胞 , RAW 264.7 细胞
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CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF (2023-09-22)
作者：Yao Duan:1.Second Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, PR China. ; Chanyuan Jin:1.Second Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, PR China. ; Yuwei Wu:1.Second Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, PR China. ; Yan Chen:1.Second Clinical Division, Peking University School and Hospital
期刊：CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
DOI：10.1016/j.tice.2023.102223
影响因子 ：2.6
引用产品： 人牙周膜干细胞
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Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway. (2022-12-15)
作者：Xincong Li:1.Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Yue Zhao:1.Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Haoran Peng:1.Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Deao Gu:1.Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Chao Liu:1.Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Shuangshuang Ren:1.Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. ; Leiying Miao:1.Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of N
期刊：Robust intervention for oxidative stress-induced injury in periodontitis via controllably released nanoparticles that regulate the ROS-PINK1-Parkin pathway.
DOI：10.3389/fbioe.2022.1081977
影响因子 ：6.1
引用产品： 人牙周膜干细胞
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