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  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞

人骨髓间充质干细胞
Human Bone Marrow Mesenchymal Stem Cells

货号:CP-H166

规格:5×10⁵Cells/T25培养瓶

价格: ¥7380

培养基货号: CM-H166

数量: - +
  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞
  • 人骨髓间充质干细胞
产品概述

人骨髓间充质干细胞

Cat NO.: CP-H166

  1. 产品名称:人骨髓间充质干细胞

  2. 英文简称:BMSCs,MSCs

  3. 组织来源:骨髓

  4. 产品规格:5×105cells/T25细胞培养瓶

  5. 细胞简介:

    人骨髓间充质干细胞(BMSC)分离自骨髓;骨髓是机体的造血组织,位于身体的许多骨骼内。成年动物的骨髓分两种:红骨髓和黄骨髓。红骨髓能制造红细胞、血小板和各种白细胞。血小板有止血作用,白细胞能杀灭与抑制各种病原体,包括细菌、病毒等;某些淋巴细胞能制造抗体。因此,骨髓不但是造血器官,它还是重要的免疫器官。骨髓是存在于长骨(如肱骨、股骨)的骨髓腔和扁平骨(如髂骨)的稀松骨质间的网眼中,是一种海绵状的组织,能产生血细胞的骨髓略呈红色,称为红骨髓。出生时,红骨髓充满全身骨髓腔,随着年龄增大,脂肪细胞增多,相当部分红骨髓被黄骨髓取代,最后几乎只有扁平骨骨髓腔中有红骨髓。骨髓基质系统内存在的骨髓间充质干细胞是一种除造血干细胞以外的、具有高度自我更新能力和多向分化潜能的干细胞,可以向骨、软骨、肌组织、皮肤、脂肪、神经等多种组织分化,因此可以作为组织工程中的种子细胞。在骨髓中,BMSC占骨髓有核细胞总数的0.001%-0.1%,含量极低。骨髓间充质干细胞的体外培养条件要求较高,在培养过程中,受贴壁时间、种植密度、血清含量、培养温度和培养基pH值等条件的影响。

  6. 方法简介:

    普诺赛实验室分离的人骨髓间充质干细胞采用冲洗骨髓、密度梯度离心、差速贴壁法结合培养基筛选制备而来,细胞总量约为5×10⁵cells/瓶。

  7. 质量检测:

    普诺赛实验室分离的人骨髓间充质干细胞经CD29或CD90免疫荧光鉴定,纯度可达90%以上,且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。

  8. 培养信息:

    包被条件
    培养基含FBS、生长添加剂、Penicillin、Streptomycin等
    产品货号CM-H166
    换液频率每2-3天换液一次
    生长特性贴壁
    细胞形态成纤维细胞样
    传代特性可传3-5代左右;3代以内状态最佳
    消化液0.25%胰蛋白酶
    培养条件气相:空气,95%;CO2,5%

    人骨髓间充质干细胞体外培养周期有限;建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养,以此保证该细胞的最佳培养状态。

参考文献
文献列表
  • Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects(2022/11/09)

    作者:Shuaijie Li, Liyan Zhang, Chunyu Liu

    期刊:Bioactive Materials

    DOI:10.1016/j.bioactmat.2022.10.021

    影响因子 :16.874

    引用产品:CP-H166

  • An injectable self-adaptive polymer as a drug carrier for the treatment of nontraumatic early-stage osteonecrosis of the femoral head(2022/03/12)

    作者:Ning Kong, Hang Yang, Run Tian

    期刊:Bone Research

    DOI:10.1038/s41413-022-00196-y

    影响因子 :12.700

    引用产品:CL-0378 CP-H166

  • Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration(2024/04/09)

    作者:Dandan Wang, Yaru Guo, Xuehui Zhang

    期刊:Bone Research

    DOI:10.1038/s41413-024-00325-9

    影响因子 :12.700

    引用产品:CP-H166

  • pH-triggered chitosan-sodium caseinate nanocarriers with charge-switching property: Characterization and applications in dental care(2024/02/23)

    作者:Mingxia Wang, Yaqian Li, Yuxuan Zhao

    期刊:FOOD HYDROCOLLOIDS

    DOI:10.1016/j.foodhyd.2024.109919

    影响因子 :10.700

    引用产品:CP-H166

  • HWJMSC-EVs promote cartilage regeneration and repair via the ITGB1/TGF-β/Smad2/3 axis mediated by microfractures(2024/04/12)

    作者:Zhian Chen, Tianhua Zhou, Huan Luo

    期刊:JOURNAL OF NANOBIOTECHNOLOGY

    DOI:10.1186/s12951-024-02451-2

    影响因子 :10.200

    引用产品:CP-H166

  • Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells(2023/09/30)

    作者:Wenkai Chen, Zongguang Li, Naichun Yu

    期刊:JOURNAL OF NANOBIOTECHNOLOGY

    DOI:10.1186/s12951-023-02129-1

    影响因子 :10.200

    引用产品:CL-0157 CL-0202 CL-0236 CP-H166

  • Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect(2022/11/17)

    作者:Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu, Guangrong Ji

    期刊:International Journal of Nanomedicine

    DOI:10.2147/IJN.S379917

    影响因子 :8.000

    引用产品:CL-0157 CP-H166

  • Bioinformatic analysis of related immune cell infiltration and key genes in the progression of osteonecrosis of the femoral head(2024/01/11)

    作者:Xudong Duan, Fangze Xing, Jiewen Zhang

    期刊:Frontiers in Immunology

    DOI:10.3389/fimmu.2023.1340446

    影响因子 :7.300

    引用产品:CP-H166

  • Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK(2023/01/14)

    作者:Zhijuan Xie, Jun Tang, Zhong Chen

    期刊:Inflammation Research

    DOI:10.1007/s00011-022-01653-4

    影响因子 :6.700

    引用产品:CL-0109 CP-H166

  • CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway(2022/11/18)

    作者:Liu Ansong, Chen Yong, Zhong Da, Wang Chenggong, Yu Mi, Liu Chao, Yang Zhijun, Chen Wenkang, Yin Ke

    期刊:MOLECULAR MEDICINE

    DOI:10.1186/s10020-022-00557-7

    影响因子 :5.700

    引用产品:CP-H166

  • Osteogenesis-Related Long Noncoding RNA GAS5 as a Novel Biomarker for Osteonecrosis of Femoral Head.(2022/03/22)

    作者:Guanzhi Liu, Sen Luo, Yutian Lei

    期刊:Frontiers in Cell and Developmental Biology

    DOI:10.3389/fcell.2022.857612

    影响因子 :5.500

    引用产品:CP-H166

  • Inhibitory role of bone marrow mesenchymal stem cells-derived exosome in non-small-cell lung cancer: microRNA-30b-5p, EZH2 and PI3K/AKT pathway(2023/09/12)

    作者:Tong Wu, Qi Tian, Ruiji Liu

    期刊:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

    DOI:10.1111/jcmm.17933

    影响因子 :5.300

    引用产品:164210 CL-0005 CL-0016 CL-0165 CM-H166 CP-H166 PB180120 PM150210 PM150910

  • Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells(2024/02/13)

    作者:Wenhui Shen, Xianhui Zeng, Xiangchen Zeng

    期刊:CHEMICO-BIOLOGICAL INTERACTIONS

    DOI:10.1016/j.cbi.2024.110904

    影响因子 :5.100

    引用产品:CP-H166

  • Injectable EC-BMSC hydrogel with prolonged VEGF action for enhanced angiogenesis(2023/06/21)

    作者:Shuqin Chen, Bing Han, Yanran Zhao

    期刊:POLYMER TESTING

    DOI:10.1016/j.polymertesting.2023.108109

    影响因子 :5.100

    引用产品:CP-H166

  • Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4(2022/02/24)

    作者:Chao Sun, Cuicui Shi, Xiaoyan Duan

    期刊:Bioengineered

    DOI:10.1080/21655979.2021.2023799

    影响因子 :4.900

    引用产品:CL-0560 CP-H166

  • MSC-Derived Exosomes Ameliorate Intervertebral Disc Degeneration By Regulating the Keap1/Nrf2 Axis(2023/08/01)

    作者:Guangyu Xu, Xiao Lu, Siyang Liu

    期刊:Stem Cell Reviews and Reports

    DOI:10.1007/s12015-023-10570-w

    影响因子 :4.800

    引用产品:CP-H166

  • Conductive material Gel@Ti3C2/MT regulates the PI3K/AKT/HIF-1α/TIMP1 pathway affecting MT1 for inhibiting osteosarcoma(2024/04/16)

    作者:Weilin Zhang, Jinguo Liang, Dingbin Li

    期刊:CHEMICAL ENGINEERING SCIENCE

    DOI:10.1016/j.ces.2024.120129

    影响因子 :4.700

    引用产品:CP-H166

  • Incorporating GSE4 peptide in PEG/hyaluronic acid hydrogels to promote the alveolar epithelial differentiation of mesenchymal stem cells(2023/03/09)

    作者:Xiaoqiong Wang, Leisha Cui, Jing Hong

    期刊:POLYMER

    DOI:10.1016/j.polymer.2023.125861

    影响因子 :4.600

    引用产品:CM-H010 CP-H166 PB180120

  • Mesenchymal stem cell-derived exosomal miR-548x-3p inhibits pyroptosis of vascular endothelial cells through HMGB1 in heat stroke(2023/09/25)

    作者:Yanfang Pei, Wenfeng Ma, Huifang Wang

    期刊:GENOMICS

    DOI:10.1016/j.ygeno.2023.110719

    影响因子 :4.400

    引用产品:CM-H166 CP-H166

  • Extracellular vesicles derived from hypoxia-preconditioned bone marrow mesenchymal stem cells ameliorate lower limb ischemia by delivering miR-34c(2023/02/02)

    作者:Xitao Peng, Junhua Liu, Lijun Ren

    期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY

    DOI:10.1007/s11010-023-04666-7

    影响因子 :4.300

    引用产品:CL-0233 CL-0675 CM-0675 CP-H166

  • Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis(2021/2/24)

    作者:Wei Weng, Shengdi Di, Shitong Xing

    期刊:Molecular And Cellular Biochemistry

    DOI:10.1007/s11010-021-04074-9

    影响因子 :4.300

    引用产品:CP-H166

  • Analysis of the potential biological mechanisms of Danyu Gukang Pill against osteonecrosis of the femoral head based on network pharmacology(2023/01/31)

    作者:Yongchang Guo, Wenxi Li, Yuju Cao

    期刊:BMC Complementary Medicine and Therapies

    DOI:10.1186/s12906-023-03843-x

    影响因子 :3.900

    引用产品:CP-H166

  • Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing(2020/08/12)

    作者:Lan Jiang, Yanguo Zhang, Tao Liu

    期刊:Biochimie

    DOI:10.1016/j.biochi.2020.08.003

    影响因子 :3.900

    引用产品:CP-H166

  • GelMA/κ-carrageenan double-network hydrogels with superior mechanics and biocompatibility(2023/01/06)

    作者:Xueqi Gan, Chen Li, Jiyu Sun

    期刊:RSC Advances

    DOI:10.1039/D2RA06101E

    影响因子 :3.900

    引用产品:CP-H166

  • Mesenchymal stem cell exosomes inhibit nucleus pulposus cell apoptosis via the miR-125b-5p/TRAF6/NF-κB pathway axis: Exosomes attenuate disc degeneration through the miR-125b/TRAF6/NF-κB axis(2023/11/15)

    作者:Yang Duan, Cheng Yu, Wenhao Kuang

    期刊:ACTA BIOCHIMICA ET BIOPHYSICA SINICA

    DOI:10.3724/abbs.2023241

    影响因子 :3.700

    引用产品:CP-H166

  • Hypoxia pretreatment improves the therapeutic potential of bone marrow mesenchymal stem cells in hindlimb ischemia via upregulation of NRG-1(2022/01/29)

    作者:Xitao Peng, Bing Liang, Haisheng Wang

    期刊:Cell And Tissue Research

    DOI:10.1007/s00441-021-03562-0

    影响因子 :3.600

    引用产品:CP-H166

  • Mesenchymal stromal cells can repair radiation-induced pulmonary fibrosis via a DKK-1-mediated Wnt/β-catenin pathway(2021/01/26)

    作者:Lihong Shao, Yuyu Zhang

    期刊:Cell And Tissue Research

    DOI:10.1007/s00441-020-03325-3

    影响因子 :3.600

    引用产品:CP-H166

  • Mesenchymal stem cell exosomal tsRNA-21109 alleviate systemic lupus erythematosus by inhibiting macrophage M1 polarization(2021/08/28)

    作者:Rui Dou, Xiulei Zhang, Xiangdong Xu

    期刊:Molecular Immunology

    DOI:10.1016/j.molimm.2021.08.015

    影响因子 :3.600

    引用产品:CL-0233 CP-H166

  • Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway(2023/12/31)

    作者:Hongyan Sun, Shitao Lu, Gaowei Qu

    期刊:AUTOIMMUNITY

    DOI:10.1080/08916934.2023.2290357

    影响因子 :3.500

    引用产品:CP-H166

  • MEG3 shuttled by exosomes released from human bone marrow mesenchymal stem cells promotes TP53 stability to regulate MCM5 transcription in keloid fibroblasts(2024/04/30)

    作者:Feibin Zhu, Yuanjian Ye, Ying Shao

    期刊:JOURNAL OF GENE MEDICINE

    DOI:10.1002/jgm.3688

    影响因子 :3.500

    引用产品:CP-H166

  • Omaveloxolone ameliorates glucocorticoid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis(2024/05/31)

    作者:Changtao Wan, Chuancai Liang, Hao Peng

    期刊:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

    DOI:10.1016/j.bbrc.2024.150188

    影响因子 :3.100

    引用产品:CP-H166

  • High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy(2023/11/17)

    作者:Jinjin Lu, Lixin Zhang, Ningxin Zhu

    期刊:ARCHIVES OF ORAL BIOLOGY

    DOI:10.1016/j.archoralbio.2023.105851

    影响因子 :3.000

    引用产品:CP-H166

  • Notoginsenoside R1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERα/GSK-3β/β-catenin signalling pathway(2023/10/30)

    作者:Wei Lu, Yuanxin Shi, Minglei Qian

    期刊:INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

    DOI:10.1111/iep.12494

    影响因子 :3.000

    引用产品:CP-H166

  • Human bone marrow mesenchymal stem cells-derived exosomes protect against nerve injury via regulating immune microenvironment in neonatal hypoxic-ischemic brain damage model(2022/01/10)

    作者:Jiaping Shu, Li Jiang, Meiqiu Wang

    期刊:Immunobiology

    DOI:10.1016/j.imbio.2022.152178

    影响因子 :2.800

    引用产品:CP-H166

  • Cimigenol depresses acute myeloid leukemia cells protected by breaking bone marrow stromal cells via CXCR4/SDF‑1α(2022/12/30)

    作者:Bangyun Ma, Huibo Dai, Xingbin Dai

    期刊:Experimental and Therapeutic Medicine

    DOI:10.3892/etm.2022.11779

    影响因子 :2.700

    引用产品:CP-H166

  • Long non-coding RNA taurine upregulated gene 1 is downregulated in osteoporosis and influences the osteogenic differentiation of bone marrow mesenchymal stem cells(2021/4/20)

    作者:Zhaowei Teng, Yun Zhu, Qinggang Hao

    期刊:PeerJ

    DOI:10.7717/peerj.11251

    影响因子 :2.700

    引用产品:CM-H166 CP-H166

  • LINC01234 Sponging of the miR-513a-5p/AOX1 Axis is Upregulated in Osteoporosis and Regulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells(2023/03/24)

    作者:Zhiyuan Yan, Qiansong He

    期刊:MOLECULAR BIOTECHNOLOGY

    DOI:10.1007/s12033-023-00712-3

    影响因子 :2.600

    引用产品:CM-H166 CP-H166

  • MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis(2022/11/26)

    作者:Xu Pengfei, Chang Jun, Ma Guangwen, Liao Faxue, Xu Tangbing, Wu Yunfeng, Yin Zongsheng

    期刊:BMC MUSCULOSKELETAL DISORDERS

    DOI:10.1186/s12891-022-05928-z

    影响因子 :2.300

    引用产品:CP-H166

  • YTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs(2024/05/06)

    作者:Tianyi Yuan, Hongjiang Liu, Abudoukadier Maimaitiyibubaji

    期刊:BMC MUSCULOSKELETAL DISORDERS

    DOI:10.1186/s12891-024-07481-3

    影响因子 :2.300

    引用产品:CP-H166

  • Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs(2023/10/02)

    作者:Jimei Zhang, Ling Zhu, Jianping Zhou

    期刊:IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

    DOI:10.1007/s11626-023-00811-0

    影响因子 :2.100

    引用产品:CP-H166

  • LncRNA TUG regulates osteogenic differentiation of bone marrow mesenchymal stem cells via miRNA-204/SIRT 1(2022/09/01)

    作者:Xiao Ouyang, Yunzhi Ding, Li Yu

    期刊:JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS

    DOI:PMID:36046997

    影响因子 :1.900

    引用产品:CM-H166 CP-H166

  • MicroRNA-4461 derived from bone marrow mesenchymal stem cell exosomes inhibits tumorigenesis by downregulating COPB2 expression in colorectal cancer(2019/10/21)

    作者:Huili Chen, Jiujiang Li, Fei Jiang

    期刊:Bioscience Biotechnology And Biochemistry

    DOI:10.1080/09168451.2019.1677452

    影响因子 :1.600

    引用产品:CP-H166

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