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产品概述
大鼠海马神经元细胞
Cat NO.: CP-R107
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产品名称：大鼠海马神经元细胞
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组织来源：脑海马体
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
大鼠海马神经元细胞分离自海马体；海马体(Hippocampus)，又名海马回、海马区、大脑海马，海马体主要负责记忆和学习。海马神经元细胞是海马区的主要细胞组成，主要功能是参与近期记忆、情绪及内脏功能调节、是老年性痴呆、癫痫等疾病的主要病灶之一。海马属于大脑的边缘系统，在学习、记忆、情绪反应及神经系统疾病的病理生理变化等方面有重要作用，而且海马组织是中枢神经系统内主要的神经干细胞聚集区，具有高度序化板层结构和神经元相对独立分布的特点，境界相对清晰，便于取材，因此，海马神经元体外培养模型被广大基础医学和临床医学研究者当做理想的实验模型。海马神经元细胞培养是研究神经细胞生物学特性和外源干扰因素作用(细胞因子)的有效细胞模型，其在神经生物学，发育生物学体外实验研究中已被广泛应用。
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方法简介：
普诺赛实验室分离的大鼠海马神经元细胞采用胰蛋白酶消化法、神经元专用培养基培养筛选结合化学试剂抑制法制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的大鼠海马神经元细胞经β-Tubulin-Ⅲ免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 PLL（0.1mg/ml） 培养基 含B-27 Supplement、Penicillin、Streptomycin等 产品货号 CM-R107 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 神经元细胞样 传代特性 属于终末分化细胞；属于不增殖细胞群 消化液 0.125%胰蛋白酶 大鼠海马神经元细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling (2023-09-06)
作者：Lin Wang:1.Department of Emergency, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Boxin Ye:1.The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Yongrui Liu:1.The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Jun Li:1.The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Chunhe Li:1.Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Minyong Wen:1.Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China. ; Hongbo Li:1.Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Gu
期刊：Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling
影响因子 ：4.1
引用产品： 大鼠海马神经元细胞
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GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization (2023-12-26)
作者：Huimei Huang:1.The Department of Blood Purification, The First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, Shaanxi, China. ; 2.Department of Nephrology, Xi'an Children's Hospital (The Affiliated Children's Hospital of Xi'an Jiaotong University), 710003 Xi'an, Shaanxi, China. ; Hongli Jiang:1.The Department of Blood Purification, The First Affiliated Hospital of Xi'an Jiaotong University, 710061 Xi'an, Shaanxi, China. ; Hongli Sun:1.Shaanxi Institute for Pediatric Diseases, Xi'an Key Laboratory of Children's Health and Diseases, Xi'an Children's Hospital (The Affiliated Children's Hospital of Xi'an Jiaotong University), 710003 Xi'an, Shaanxi, China. ;
期刊：GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization
影响因子 ：3.1
引用产品： 大鼠海马神经元细胞
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Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors (2023-05-04)
作者：Xuezhu Huang:1.Mental Health Center, West China Hospital, Sichuan University, Chengdu 610000, Sichuan, China; Mental Medicine College, The Medical University of Wenzhou, Wenzhou 325000 Zhejiang, China; Clinical Psychology Department, Nanchong Centre Hospital Affiliated to the Medical College of North Sichuan, Nanchong 637000, Sichuan, China. Electronic address: Huangxuezhu8855@163.com. ; Chuang Yang:1.Department of Psychiatry, the No. 1 Hospital Affiliated to The Medical University of Wenzhou, Wenzhou 325000 Zhejiang, China. ; Min Huang:1.Clinical Psychology Department, Nanchong Centre Hospital Affiliated to The Medical College of North Sichuan, Nanchong 637000, Sichuan, China. ;
期刊：Protective mechanism of the EZH2/microRNA-15a-5p/CXCL10 axis in rats with depressive-like behaviors
DOI：10.1016/j.jchemneu.2023.102283
影响因子 ：2.8
引用产品： 大鼠海马神经元细胞
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Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress (2022-10-07)
作者：Zilong Xu:1.Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; Yanqiu You:1.Department of Laboratory Medicine, The Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. ; Qiuqin Tang:1.Department of Anesthesiology, The Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. ; Hui Zeng:1.Department of Anesthesiology, The Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. ; Tianshou Zhao:1.Department of Anesthesiology, The Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. ; Juan Wang:1.Department of Anesthesiology, The Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. ; Fujun Li:1.Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; 2.Department of Anesthesiology, The Ruikang Hospital Affiliated to Guan
期刊：Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress
DOI：10.1080/13880209.2022.2123941
影响因子 ：3.9
引用产品： 大鼠海马神经元细胞
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Functional mechanism of EGR3 in cerebral ischemia/reperfusion injury in rats by modulating transcription of pri-miR-146a/146b to miR-146 and suppressing SORT1 expression (2022-09-20)
作者：Bin Han:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Jing Wang:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Fengyun Hu:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Yi Liu:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Yaxuan Sun:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Kun Meng:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Pengyu Lu:1.Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi Province, China. ; Haifeng Tang:1.Department of Emergency, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China. Electronic address: HaifengTang0917@163.com. ;
期刊：Functional mechanism of EGR3 in cerebral ischemia/reperfusion injury in rats by modulating transcription of pri-miR-146a/146b to miR-146 and suppressing SORT1 expression
DOI：10.1016/j.brainres.2022.148096
影响因子 ：3.6
引用产品： 大鼠海马神经元细胞 , DMEM/F12完全培养基 (含10%FBS）
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The antidepressant-like effects of Danggui Buxue Decoction in GK rats by activating CREB/BDNF/TrkB signaling pathway (2005-01-20)
作者：Wen-Kai Wang:1.College of Traditional Chinese Medicine•College of Intergrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. ; Yuan Zhou:1.School of Medicine•Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 138 Xianlin Rd, Nanjing, China. ; Lu Fan:1.School of Medicine•Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 138 Xianlin Rd, Nanjing, China. ; Yue Sun:1.College of Traditional Chinese Medicine•College of Intergrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. ; Fan Ge:1.College of Traditional Chinese Medicine•College of Intergrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China. ; Mei Xue:1.College of Traditional Chinese Medicine•College of Intergrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China
期刊：The antidepressant-like effects of Danggui Buxue Decoction in GK rats by activating CREB/BDNF/TrkB signaling pathway
DOI：10.1016/j.phymed.2021.153600
影响因子 ：7.9
引用产品： 大鼠海马神经元细胞
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Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signaling pathway (2001-01-20)
作者：Zhongfan Ruan:1.Department of Neurology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. ; Yan Li:1.Department of Anesthesiology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan, China. ; Rongzhang He:1.Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou, Hunan, China. ; Xuewei Li:1.Department of Neurology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. ;
期刊：Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signaling pathway
DOI：10.1080/1061186X.2020.1864739
影响因子 ：4.5
引用产品： 大鼠海马神经元细胞
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Proteomics and functional study reveal kallikrein-6 enhances communicating hydrocephalus (2012-01-20)
作者：Lei Yuan:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. ; Dongdong Zou:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. ; Xia Yang:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. ; Xin Chen:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. masterchx@hotmail.com. ; Youming Lu:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. ; Aijun Zhang:1.Department of Neurosurgery, The Affiliated Sixth People's Hospital, Shanghai Jiaotong University, NO. 600 Yishan Road, Shanghai, 200233, China. ; Pengqi Zhang:1.Depar
期刊：Proteomics and functional study reveal kallikrein-6 enhances communicating hydrocephalus
DOI：10.1186/s12014-021-09335-9
影响因子 ：3.8
引用产品： 大鼠海马神经元细胞 , 大鼠海马神经元细胞完全培养基
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Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration (2012-08-20)
作者：Chunmao Chen: 1.Department of Orthopaedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 P. R. China; Jincheng Tang: 1.Department of Orthopaedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 P. R. China; Yong Gu: 1.Department of Orthopaedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 P. R. China; Lili Liu: 1.Department of Orthopaedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 P. R. China; Xingzhi Liu: 1.Department of Orthopaedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006 P. R. China; Lianfu Deng: 1.Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong Universit
期刊：Bioinspired Hydrogel Electrospun Fibers for Spinal Cord Regeneration
影响因子 ：19.0
引用产品： 大鼠海马神经元细胞
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