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人脐带血间充质干细胞
Human Umbilical Cord Blood Mesenchymal Stem Cells
货号：CP-H165
规格：5×10⁵Cells/T25培养瓶
价格： ￥7880
培养基货号： CM-H165
产品概述
人脐带血间充质干细胞
Cat NO.: CP-H165
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产品名称：人脐带血间充质干细胞
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英文简称：UCBMSCs,UCB-MSCs
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组织来源：脐带血
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
人脐带血间充质干细胞分离自脐带血；脐带血是胎儿娩出、脐带结扎并离断后残留在胎盘和脐带中的血液。近十几年的研究发现，脐带血中含有可以重建造血和免疫系统的造血干细胞，可用于造血干细胞移植；因此，脐带血已成为造血干细胞的重要来源。脐带血中含有大量的干细胞，干细胞是生命的种子，它会分化成机体的各种细胞，结出各种不同的果实——血液细胞、神经细胞、骨骼细胞等。干细胞是具有自我更新、高度增殖和多项分化潜能的细胞群体；这些细胞可以通过分裂维持自身细胞的特性和数量，又可进一步分化为各种组织细胞，从而在组织修复等方面发挥积极作用。间充质干细胞(MSC)是一种具有高度自我更新和多向分化潜能的干细胞。在不同的诱导条件下，可分化为多种造血细胞以外的组织细胞，并具有造血支持、免疫调节、组织修复等作用；目前，多用于风湿免疫疾病的治疗。间充质干细胞(MSCs)是一种具有自我更新和多向分化潜能的成体干细胞，存在于骨髓、脂肪组织、脐血及多种胎儿组织。它可分泌多种细胞因子及生长因子，促进造血干细胞(HSC)的增殖与分化。MSCs还具有免疫调节、抗炎和组织修复作用，可减轻移植物抗宿主病(GVHD)及其他移植相关并发症。
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方法简介：
普诺赛实验室分离的人脐带血间充质干细胞采用密度梯度离心法、差速贴壁法结合培养基筛选制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的人脐带血间充质干细胞经CD29或CD90免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-H165 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 成纤维细胞样 传代特性 可传3-5代左右；3代以内状态最佳 消化液 0.25%胰蛋白酶 人脐带血间充质干细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury (2024-03-16)
作者：Zhiwei Luan:1.Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; 2.The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. ; Jingsong Liu:1.Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; Mi Li:1.Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; Yangyang Wang:1.Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. ; Yansong Wang:1.Department of Orthopedic surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China. wyshmu1975@163.com. ; 2.NHC Key Laboratory of Cell Transplantation, Harbin Medical University, Harbin, China. wyshmu1975@163.com. ; 3.Heilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, Harbin Medical University, Harbin, China. wyshmu1975@163.com. ;
期刊：Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury
DOI：10.1186/s13018-024-04651-w
影响因子 ：2.6
引用产品： BV2 细胞 , 人脐带血间充质干细胞
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DZIP1 expressed in fibroblasts and tumor cells may affect immunosuppression and metastatic potential in gastric cancer (2023-02-17)
作者：Yi Yin:1.Affiliated Hospital of Nanjing the University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. ; Yuanjie Liu:1.Affiliated Hospital of Nanjing the University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. ; Yunya Wang:1.Affiliated Hospital of Nanjing the University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. ; Jiepin Li:1.Affiliated Hospital of Nanjing the University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210023, Jiangsu P
期刊：DZIP1 expressed in fibroblasts and tumor cells may affect immunosuppression and metastatic potential in gastric cancer
DOI：10.1016/j.intimp.2023.109886
影响因子 ：5.6
引用产品： 人脐带血间充质干细胞
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Effects of stem cell-derived exosomes on neuronal apoptosis and inflammatory cytokines in rats with cerebral ischemia-reperfusion injury via PI3K/AKT pathway-mediated mitochondrial apoptosis (2009-01-20)
作者：Ying Zhang:1.Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ; Jun Yu:1.Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ; Jing Liu:1.Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ; Hongbiao Liu:1.Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ; Jing Li:1.Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ;
期刊：Effects of stem cell-derived exosomes on neuronal apoptosis and inflammatory cytokines in rats with cerebral ischemia-reperfusion injury via PI3K/AKT pathway-mediated mitochondrial apoptosis
DOI：10.1080/08923973.2021.1976794
影响因子 ：3.7
引用产品： 人脐带血间充质干细胞
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