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产品概述
| 名称 | Beta-TC-6 (小鼠胰岛素瘤胰岛β细胞) (STR鉴定正确) |
| 别称 | beta-TC6; beta-TC-6; BetaTC6; betaTC6 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Beta-TC-6细胞来源于转基因小鼠中生长的一个胰肿瘤(胰岛素瘤)，这种小鼠携带了大鼠胰岛素Ⅱ基因启动子调控的SV40早期基因的假基因结构。Beta-TC-6细胞包含大量的胰岛素和小量的胰高血糖素及生长抑素；Beta-TC-6细胞能响应葡萄糖而分泌胰岛素。 |
| 年龄（性别） | 不详 |
| 组织来源 | 胰；胰岛素瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-2 [Cells contain SV40 viral DNA Sequences] |
| 基因表达情况 | insulin, glucagon, and somatostatin |
| 保藏机构 | ATCC; CRL-11506 |
STR鉴定
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STR位点信息
18-3 16 6-7 12,17 5-5 17 X-1 28 1-2 17,19 7-1 26.2,27 8-1 16 1-1 17 19-2 12,13 15-3 21.3,22.3 12-1 17 6-4 18 4-2 20.3 3-2 14 2-1 16 13-1 17.1
11-2 16,17 17-2 15 -
STR鉴定图
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参考文献
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Transepithelial Transport of the Bifunctional Peptide IPYWTY Indirectly Induced Insulin Release Mediated by Active GLP-1 (2023-08-17)
作者：Mingkai Zhang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Ling Zhu:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Hui Zhang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Xingguo Wang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800
期刊：Transepithelial Transport of the Bifunctional Peptide IPYWTY Indirectly Induced Insulin Release Mediated by Active GLP-1
影响因子 ：6.1
引用产品： Beta-TC-6 细胞 , NCI-H716 [H716] 细胞
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Evaluating the In Situ Insulinotropic Effects of Pea Protein Hydrolysates Mediated by Active GLP-1 via a 2D and Dual-Layered Coculture Cell Model (2023-09-18)
作者：Mingkai Zhang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Ling Zhu:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Hui Zhang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. ; Xingguo Wang:1.National Engineering Research Center for Functional Food, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, 1800
期刊：Evaluating the In Situ Insulinotropic Effects of Pea Protein Hydrolysates Mediated by Active GLP-1 via a 2D and Dual-Layered Coculture Cell Model
影响因子 ：6.1
引用产品： Beta-TC-6 细胞 , NCI-H716 [H716] 细胞
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RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway (2023-03-31)
作者：Yurong Zhu:1.Department of Endocrinology and Metabolism, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China. ; Jun Li:1.Department of Endocrinology and Metabolism, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China. ; Tao Ba:1.Department of Endocrinology and Metabolism, Shihezi University School of Medicine, Shihezi, Xinjiang, China. ; Yuan Sun:1.Department of Endocrinology and Metabolism, Shihezi University School of Medicine, Shihezi, Xinjiang, China. ; Xiangyun Chang:1.Department of Endocrinology and Metabolism, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China. ;
期刊：RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway
DOI：10.1080/08916934.2023.2194584
影响因子 ：3.5
引用产品： Beta-TC-6 细胞 , NIT-1 细胞 , HIT-T15 细胞
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A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway (2023-01-03)
作者：Xiaoming Mao:1.Department of Geriatrics, Henan Key Laboratory for Geriatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan, 450003, China. ; Jinliang Zhou:1.Department of Hip Surgery, Luoyang Orthopedic Hospital of Henan Province, Luoyang, Henan, 471000, China. ; Limin Kong:1.Xinxiang Medical University, Xinxiang, Henan, 453003, China; The Sixth People's Hospital of Zhengzhou, Zhengzhou, Henan, 450000, China. ; Li Zhu:1.Department of Thoracic Surgery, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China. ; Desheng Yang:1.Department of Geriatrics, Henan Key Laboratory for Geriatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan, 450003, China. Electronic address: zzdxyds@126.com. ; Zhiyu Zhang:1.Department of Geriatrics, Henan Key Labo
期刊：A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway
DOI：10.1016/j.bbrc.2023.01.004
影响因子 ：3.1
引用产品： Beta-TC-6 细胞 , 293T [HEK-293T] 细胞
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Silencing of DIRAS3 improves the proliferation and insulin secretion of palmitic acid-treated pancreatic β‑cells through regulating PI3K/AKT signaling (2023-09-04)
作者：Ying Li: 1.Department of Endocrine, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, 266042, Shandong, China; Shan Gao: 1.Department of Endocrine, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, 266042, Shandong, China; Ying Yang: 1.Department of Endocrine, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, 266042, Shandong, China; Gang Yin: 1.Department of Cardiology, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, 266042, Shandong, China;
期刊：Silencing of DIRAS3 improves the proliferation and insulin secretion of palmitic acid-treated pancreatic β‑cells through regulating PI3K/AKT signaling
DOI：10.1007/s13410-023-01240-1
影响因子 ：0.9
引用产品： Beta-TC-6 细胞 , INS-1 细胞 , RIN-m5F 细胞 , MIN6 细胞
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