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产品概述
小鼠主动脉内皮细胞
Cat NO.: CP-M075
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产品名称：小鼠主动脉内皮细胞
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组织来源：主动脉组织
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
小鼠主动脉内皮细胞分离自主动脉组织；主动脉是体循环的动脉主干。其运行路径为：升主动脉起于左心室，至右侧第2胸肋关节高度移行为主动脉弓，弓行向左后至第4胸椎体下缘移行为降主动脉；在第12胸椎体高度穿膈的主动脉裂孔移行为腹主动脉，以上为胸主动脉，至第4腰椎体下缘分为左、右髂总动脉；髂总动脉在骶髂关节高度分为髂内、外动脉。主动脉内皮细胞是覆盖在主动脉内面的单层细胞，可分泌一系列血管活性物质而保持血管稳态，当其受到炎症或其它因素刺激后稳态被破坏而导致一些心血管疾病的发生。因此，主动脉内皮细胞已成为研究心血管疾病发病机制及治疗药物不可缺少的工具。内皮细胞或血管内皮是一薄层的专门上皮细胞，由一层扁平细胞所组成。它形成血管的内壁，是血管管腔内血液及其他血管壁(单层鳞状上皮)的接口。内皮细胞是沿着整个循环系统，由心脏直至最小的微血管。
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方法简介：
普诺赛实验室分离的小鼠主动脉内皮细胞采用胰蛋白酶-胶原酶联合消化法结合差速贴壁法、并通过内皮细胞专用培养基培养筛选制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的小鼠主动脉内皮细胞经CD31免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 PLL（0.1mg/ml）或明胶（0.1%） 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-M075 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 内皮细胞样 传代特性 可传2-3代 消化液 0.25%胰蛋白酶 小鼠主动脉内皮细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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Early Detection of Cardiac Fibrosis in Diabetic Mice by Targeting Myocardiopathy and matrix metalloproteinase 2 (2024-01-18)
作者：Hanrui Liu:1.Key Laboratory of Obstet & Gynecol & Pediat Dis, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ; Weifeng Yan:1.Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ; Chengyong Ma:1.Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ; Kun Zhang:1.Key Laboratory of Obstet & Gynecol & Pediat Dis, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ; Kuan Li:1.Key Laboratory of Obstet & Gynecol & Pediat Dis, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ; Rongrong Jin:1.National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China. ; Huayan Xu:1.Key Laboratory of Obstet & Gynecol & Pediat Dis, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 6100
期刊：Early Detection of Cardiac Fibrosis in Diabetic Mice by Targeting Myocardiopathy and matrix metalloproteinase 2
DOI：10.1016/j.actbio.2024.01.017
影响因子 ：9.7
引用产品： 小鼠主动脉平滑肌细胞 , 小鼠主动脉内皮细胞
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MicroRNA-31 regulates TNF-α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6 (2023-05-03)
作者：Zilong Fang:1.Medical School, Kunming University of Science and Technology, Kunming, 650500, PR China; The Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. ; Xinran Tong:1.The Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. ; Guangzheng Shi:1.The Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. ; Wendong Chen:1.The Department of Cardiovascular Medicine, State Key Laboratory of Medi
期刊：MicroRNA-31 regulates TNF-α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6
DOI：10.1016/j.bbrc.2023.05.012
影响因子 ：3.1
引用产品： 小鼠主动脉内皮细胞
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Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis (2009-01-20)
作者：Jingjing Wang:1.Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China (J.W., H.P., Y. Yao, Y. Yu, X.J., J.C., C.X., Q.W.). ; 2.Institute of Genetics and Development, Chinese Academy of Sciences, Beijing, China (J.W.). ; Huixin Peng:1.Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China (J.W., H.P., Y. Yao, Y. Yu, X.J., J.C., C.X., Q.W.). ; Ayse Anil Timur:1.Robert J. Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic, OH (A.A.T.). ; 2.Departments of Molecular Cardiology and Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, OH (A.A.T., V.P., S.-A.Y., C.F., Q.C., Q.W.). ; Vinay Pasupuleti:1.Departments of Mol
期刊：Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis
DOI：10.1161/ATVBAHA.121.316867
影响因子 ：10.5
引用产品： 小鼠主动脉内皮细胞
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Ex vivo to in vivo extrapolation of syringic acid and ferulic acid as grape juice proxies for endothelium-dependent vasodilation: Redefining vasoprotective resveratrol of the French paradox (2006-01-20)
作者：Yunke Huang:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China; Women's Hospital School of Medicine Zhejiang University, Hangzhou 310006, China. ; Min Xu:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Junfeng Li:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Ken Chen:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Liang Xia:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Wei Wang:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Ping Ren:1.Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China; Affiliated Hospital Nanjing University of Chinses Medicin
期刊：Ex vivo to in vivo extrapolation of syringic acid and ferulic acid as grape juice proxies for endothelium-dependent vasodilation: Redefining vasoprotective resveratrol of the French paradox
DOI：10.1016/j.foodchem.2021.130323
影响因子 ：8.8
引用产品： 小鼠主动脉内皮细胞
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The Chemical Composition of Brazilian Green Propolis and Its Protective Effects on Mouse Aortic Endothelial Cells against Inflammatory Injury (2010-00-20)
作者：Xiaolan Xu:1.College of Animal Science (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China. ; Bo Yang:1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. ; 2.Bee Product Processing and Application Research Center of the Ministry of Education, Fuzhou 350002, China. ; Danfeng Wang:1.College of Plant Protection, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou 350002, China. ; Yuxuan Zhu:1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. ; 2.Bee Product Processing and Application Research Center of the Ministry of Education, Fuzhou 350002, China. ; Xiaoqing Miao:1.Bee Product Processing and Application Research Center of the Ministry of Education, Fuzhou 350002, China. ; Wenchao Yang:1.College of Animal Science (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China. ; 2.Bee Product Processing and
期刊：The Chemical Composition of Brazilian Green Propolis and Its Protective Effects on Mouse Aortic Endothelial Cells against Inflammatory Injury
影响因子 ：4.6
引用产品： 小鼠主动脉内皮细胞
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