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小鼠骨髓来源巨噬细胞
Mouse Bone Marrow-Derived Macrophage Cells
货号：CP-M141
规格：5×10⁵Cells/T25培养瓶
价格： ￥3880
培养基货号： CM-M141
产品概述
小鼠骨髓来源巨噬细胞
Cat NO.: CP-M141
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产品名称：小鼠骨髓来源巨噬细胞
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英文简称：BMDM
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组织来源：骨髓
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
小鼠骨髓来源巨噬细胞分离自骨髓；骨髓是机体的造血组织，位于身体的许多骨骼内。成年动物的骨髓分两种：红骨髓和黄骨髓。红骨髓能制造红细胞、血小板和各种白细胞。血小板有止血作用，白细胞能杀灭与抑制各种病原体，包括细菌、病毒等；某些淋巴细胞能制造抗体。因此，骨髓不但是造血器官，它还是重要的免疫器官。骨髓是存在于长骨(如肱骨、股骨)的骨髓腔和扁平骨(如髂骨)的稀松骨质间的网眼中，是一种海绵状的组织，能产生血细胞的骨髓略呈红色，称为红骨髓。出生时，红骨髓充满全身骨髓腔，随着年龄增大，脂肪细胞增多，相当部分红骨髓被黄骨髓取代，最后几乎只有扁平骨骨髓腔中有红骨髓。巨噬细胞属免疫细胞，有多种功能，是研究细胞吞噬、细胞免疫和分子免疫学的重要对象。巨噬细胞较易获得，便于培养，并可进行纯化。巨噬细胞属不繁殖细胞群，在条件适宜下可生活2-3周，多用做原代培养，难以长期生存。巨噬细胞(Macrophages)是一种位于组织内的白血球，源自单核细胞，而单核细胞又来源于骨髓中的前体细胞。巨噬细胞和单核细胞皆为吞噬细胞，在脊椎动物体内参与非特异性防卫(先天性免疫)和特异性防卫(细胞免疫)。它们的主要功能是以固定细胞或游离细胞的形式对细胞残片及病原体进行噬菌作用(即吞噬以及消化)，并激活淋巴球或其他免疫细胞，令其对病原体作出反应。
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方法简介：
普诺赛实验室分离的小鼠骨髓来源巨噬细胞采用分离骨髓单个核细胞经细胞因子诱导分化法制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的小鼠骨髓来源巨噬细胞经CD68免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-M141 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 巨噬细胞样 传代特性 属于终末分化细胞；属于不增殖细胞群 消化液 利多卡因(12mM) 小鼠骨髓来源巨噬细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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A genetically engineered “reinforced concrete” scaffold regulates the N2 neutrophil innate immune cascade to repair bone defects (2024-02-27)
作者：Wenxiao Shi:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Yu Feng:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Jincheng Tang:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Yichang Xu:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Wei Wang:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Lichen Zhang:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, Jiangsu, 215006, P. R. China. ; Xinzhao Jiang:1.Department of Orthopedics, the First Affiliated Hospital of Soochow University, 188
期刊：A genetically engineered “reinforced concrete” scaffold regulates the N2 neutrophil innate immune cascade to repair bone defects
影响因子 ：10.0
引用产品： 小鼠骨髓来源巨噬细胞
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Mesenchymal stem cells overexpressing XIST induce macrophage M2 polarization and improve neural stem cell homeostatic microenvironment, alleviating spinal cord injury (2024-01-10)
作者：Dan Zhu:1.Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Tie Peng:1.Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Zhenwang Zhang:1.Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Shuang Guo:1.Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Ying Su:1.Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Kangwei Zhang:1.Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Jiawei Wang:1.Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, P.R. China. ; Chao Liu:1.Hubei Key Laboratory of Diabetes and
期刊：Mesenchymal stem cells overexpressing XIST induce macrophage M2 polarization and improve neural stem cell homeostatic microenvironment, alleviating spinal cord injury
影响因子 ：8.2
引用产品： 小鼠骨髓来源巨噬细胞 , 小鼠骨髓间充质干细胞 , 小鼠骨髓间充质干细胞成骨诱导分化培养基 , 小鼠骨髓间充质干细胞成脂诱导分化培养基 , 小鼠骨髓间充质干细胞成软骨诱导分化培养基
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Engineering tunable dual peptide hybrid coatings promote osseointegration of implants (2023-12-16)
作者：Zeyu Shou:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. ; 2.Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, People's Republic of China. ; Zhibiao Bai:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. ; Han Zhou:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. ; Yizhe Shen:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. ; Xiaojing Huang:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. ; Hongming Meng:1.Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of
期刊：Engineering tunable dual peptide hybrid coatings promote osseointegration of implants
DOI：10.1016/j.mtbio.2023.100921
影响因子 ：8.2
引用产品： 小鼠骨髓来源巨噬细胞
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Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis (2023-02-08)
作者：Dongcai Liu:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Qingquan Tian:1.General Surgery Department FIVE, People's Hospital of Xiangxi Tujia and Miao Autonomous Prefecture, Jishou, Hunan 416000, China. ; Kuijie Liu:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Feng Ren:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Ganglei Liu:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Jingyu Zhou:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Lianwen Yuan:1.General Surgery Department, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. ; Zhixue Fang:1.Hunan Provincial People's Hospital, The First Affiliate
期刊：Ginsenoside Rg3 Ameliorates DSS-Induced Colitis by Inhibiting NLRP3 Inflammasome Activation and Regulating Microbial Homeostasis
影响因子 ：6.1
引用产品： 小鼠骨髓来源巨噬细胞 , 小鼠结肠黏膜上皮细胞
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Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells (2022-12-23)
作者：Chen Yang: 1.School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191 China;2.Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China; Xiaochen Wang: 1.Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China;2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000 China; Ruipei Xie: 1.Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China; Yiyu Zhang: 1.Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China; Tie Xia: 1.Institute for Immunology, School of Medicine, Tsinghua University, Beijing, 100084 China; Ying Lu: 1.Beijing National Laboratory f
期刊：Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells
影响因子 ：19.9
引用产品： 4T1 细胞 , 小鼠骨髓来源巨噬细胞
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LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS (2001-02-20)
作者：Da-Wei Zhang:1.Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai, 519000, Guangdong Province, China. ; Hong-Gang Wang:1.Department of Orthopaedic and Microsurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, Guangdong Province, China. ; Kui-Bo Zhang:1.Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai, 519000, Guangdong Province, China. ; Yuan-Qing Guo:1.Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai, 519000, Guangdong Province, China. ; Lian-Jun Yang:1.Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai, 519000, Guangdong Province, China. ; Hai Lv:1.Department of Spinal Surgery, The Fifth Affili
期刊：LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS
DOI：10.1007/s00774-021-01294-3
影响因子 ：3.3
引用产品： RAW 264.7 细胞 , 小鼠骨髓来源巨噬细胞
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Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis (2009-01-20)
作者：Zhenyu Zhong:1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China. ; 2.Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. ; Xiaodan Wu:1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China. ; 2.Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. ; Yifan Wang:1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China. ; 2.Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. ; Mengdie Li:1.Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China. ; 2.Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. ; Ya
期刊：Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis
DOI：10.1016/j.bioactmat.2021.09.013
影响因子 ：18.9
引用产品： 小鼠骨髓来源巨噬细胞
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Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors (2003-00-20)
作者：Chenyang Han:1.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing, 210093, China; Department of pharmacy, The Second Affiliated Hospital of Jiaxing University, Zhejiang 314001, China. Electronic address: 691513770@qq.com. ; Yi Yang:1.Department of pharmacy, The Second Affiliated Hospital of Jiaxing University, Zhejiang 314001, China. Electronic address: wasd911@126.com. ; Anqi Yu:1.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China. Electronic address: 1144900357@qq.com. ; Li Guo:1.Department of Center Laboratory, The Second Affiliated Hospital of Jiaxing University, Zhejiang 314001, China. Electronic address: taishanlg@126.com. ; Qiaobing Guan:1.Department of neurology, The Second Affiliated Hospital of Jiaxing University, Zhejiang 314001, China. Electronic address: guanqb@126.com. ; Heping Shen:1.Department of neurology, The Second Affiliated Hospital of Ji
期刊：Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors
DOI：10.1016/j.ejps.2020.105303
影响因子 ：4.6
引用产品： 小鼠骨髓来源巨噬细胞 , BV2 细胞
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