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  • Procell-TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant
  • Procell-TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant
  • Procell-TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant
  • Procell-TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant

TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant

货号:PCK091

价格:¥118034801468023880

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB
物种 Human
表达宿主 CHO Stable Cells
序列信息 Ala279-Ser390
检索号 P01137
分子量 12.8 kDa
表观分子量 13 kDa
生物活性 Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 <1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mMNacl, pH2.5.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
参考文献
文献列表
  • DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-β1-induced ovarian cancer by methylating the TET3 promoter (2022-10-12)

    作者:Zhongxue Ye:1.Department of Gynecology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. ; Yafen Jiang:1.Department of Gynecology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. ; Junlong Wu:1.Department of Orthopedics, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. Electronic address: wujunlo_wjl@163.com. ;

    期刊:DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-β1-induced ovarian cancer by methylating the TET3 promoter

    DOI:10.1016/j.repbio.2022.100701

    影响因子 :2.1

    引用产品: TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant

  • SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis (2007-01-20)

    作者:Wang Yao:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Siqi Wang:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Xing Du:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Chenggang Lin:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Jinbi Zhang:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Zengxiang Pan:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. ; Qifa Li:1.College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. liqifa@njau.edu.cn. ;

    期刊:SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis

    DOI:10.1007/s43032-021-00690-4

    影响因子 :2.9

    引用产品: TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant

  • miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury (2007-09-20)

    作者:Zilun Wei:1.Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing 210008, China. ; Shuaihua Qiao:1.Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ; Jinxuan Zhao:1.Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ; Yihai Liu:1.Department of Cardiology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing 210008, China. ; Qiaoling Li:1.Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ; Zhonghai Wei:1.Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ; Qing Dai:1.Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ; Lina Kang:1.Department of Cardiology, Nanjing Drum Tower Hospital,

    期刊:miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

    DOI:10.1016/j.lfs.2019.116632

    影响因子 :6.1

    引用产品: TGFB1/ TGFβ1/ TGF-β1, Human, Recombinant

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