产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
产品信息
| 别名 | Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB |
| 物种 | Human |
| 表达宿主 | CHO Stable Cells |
| 序列信息 | Ala279-Ser390 |
| 检索号 | P01137 |
| 分子量 | 12.8 kDa |
| 表观分子量 | 13 kDa |
| 生物活性 | Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | <1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mMNacl, pH2.5. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
参考文献
文献列表
-
DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-β1-induced ovarian cancer by methylating the TET3 promoter (2022-10-12)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100701
影响因子 ：2.1
-
SMAD4 Inhibits Granulosa Cell Apoptosis via the miR-183-96-182 Cluster and FoxO1 Axis (2007-01-20)
期刊：Reproductive Sciences
DOI：10.1007/s43032-021-00690-4
影响因子 ：2.9
-
miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury (2007-09-20)
期刊：Life Sciences
影响因子 ：6.1
点击展开收起列表
FAQs
Q：{{item.question}}
A：
暂无数据
产品资料
注：百度浏览器无法支持扫一扫功能，请输入识别码，获取相应产品资料
识别码示意图
