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产品概述
| 名称 | THLE-2 (人肝永生化细胞) (STR鉴定正确) |
| 别称 | THLE2; Transformed Human Liver Epithelial-2 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55%DM/F12+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | THLE-2 is an epithelial cell that was isolated from the left lobe of a donor.THLE-2 and THLE-3 cells express phenotypic characteristics of normal adult liver epithelial cells. They are nontumorigenic when injected into athymic nude mice, have near-diploid karyotypes, and do not express alpha-fetoprotein. [RF84750] THLE-2 and THLE-3 cells metabolize benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 to their ultimate carcinogenic metabolites that adduct DNA, which indicates functional cytochrome P450 pathways. |
| 年龄（性别） | 男性 |
| 组织来源 | 肝脏；左叶 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-2 |
| 致瘤性 | No; No, nude mice |
| 保藏机构 | ATCC; CRL-2706 |
STR鉴定
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STR位点信息
Amelogenin X, Y CSF1PO 11,13 D2S1338 17,23 D3S1358 14,15 D5S818 11,13 D7S820 10,12 D8S1179 13 D13S317 8,12 D16S539 11,13 D18S51 13,16 D19S433 14 D21S11 30,32.2 FGA 22,24 PentaD 10,13 PentaE 12,13 TH01 7,9.3 TPOX 8,11 vWA 16,17 D6S1043 12,18 D12S391 21,23 D2S441 11 -
STR鉴定图
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参考文献
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis (2025-01-27)
期刊：Molecular Cancer
DOI：10.1186/s12943-024-02224-3
影响因子 ：27.7
引用产品： THLE-2 细胞
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Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (2025-01-21)
期刊：Advanced Science
影响因子 ：14.3
引用产品： THLE-2 细胞 , THLE-2细胞专用培养基
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Revealing Molecular Connections between Dissolved Organic Matter in Surface Water Sources and Their Cytotoxicity Influenced by Chlorination Disinfection (2025-01-27)
期刊：ENVIRONMENTAL SCIENCE & TECHNOLOGY
影响因子 ：10.8
引用产品： THLE-2 细胞
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The promoting effect of the POU3F2/METTL16/PFKM cascade on glycolysis and tumorigenesis of hepatocellular carcinoma: Role of the POU3F2/METTL16/PFKM axis in HCC (2025-01-03)
期刊：Annals of Hepatology
DOI：10.1016/j.aohep.2025.101776
影响因子 ：3.7
引用产品： THLE-2 细胞 , THLE-2细胞专用培养基
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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway (2025-01-29)
期刊：PLoS One
DOI：10.1371/journal.pone.0318450
影响因子 ：2.9
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Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway (2024-03-09)
期刊：MedComm
DOI：10.1002/mco2.510
影响因子 ：9.9
引用产品： THLE-2 细胞
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O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export (2024-07-01)
期刊：International Journal of Biological Sciences
影响因子 ：8.2
引用产品： HuH-7 细胞 , THLE-2 细胞 , Hep 3B2.1-7 细胞
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RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling (2024-02-18)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-04964-8
影响因子 ：7.4
引用产品： Hep 3B2.1-7 细胞 , HuH-7 细胞 , PLC/PRF/5 细胞 , Li-7 细胞 , THLE-2 细胞
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Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy (2024-08-03)
期刊：Applied Materials Today
DOI：10.1016/j.apmt.2024.102374
影响因子 ：7.2
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TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population (2024-02-22)
期刊：DIABETES OBESITY & METABOLISM
影响因子 ：5.8
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USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1 (2024-10-08)
期刊：Communications Biology
DOI：10.1038/s42003-024-06999-5
影响因子 ：5.2
引用产品： Hep G2 细胞 , SMMC-7721 细胞 , HuH-7 细胞 , HCCLM3 细胞 , THLE-2 细胞
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The prognostic significance and potential mechanism of PFDN4 in hepatocellular carcinoma (2024-12-06)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113761
影响因子 ：4.8
引用产品： THLE-2 细胞 , MHCC97-L 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , HLF-a 细胞 , SNU-449 细胞
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Schisandra chinensis Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion–Signaling Pathways (2024-07-02)
期刊：Drug Design Development and Therapy
影响因子 ：4.7
引用产品： Hep G2 细胞 , Hep G2细胞专用培养基 , THLE-2 细胞
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HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway (2024-04-05)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23723
影响因子 ：4.6
引用产品： THLE-2 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , THLE-2细胞专用培养基
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Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation (2024-12-10)
期刊：CANCER SCIENCE
影响因子 ：4.5
引用产品： THLE-2 细胞 , THLE-2细胞专用培养基
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LINC02987 suppression hepatocellular carcinoma progression by modulating autophagy via the miR-338-3p/ATG12 axis (2024-12-31)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.114398
影响因子 ：3.3
引用产品： HuH-7 细胞 , Li-7 细胞 , THLE-2 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , Hep G2 细胞
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Cancer-associated fibroblasts-derived exosomal ZNF250 promotes the proliferation, migration, invasion, and immune escape of hepatocellular carcinoma cells by transcriptionally activating PD-L1 (2024-09-09)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.2
引用产品： DMEM高糖 培养基 , 青霉素-链霉素溶液（双抗），100× , Hep 3B2.1-7 细胞 , 特级胎牛血清 , THLE-2 细胞 , RPMI-1640 培养基
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Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma (2024-06-03)
期刊：Annals of Gastroenterological Surgery
影响因子 ：2.9
引用产品： MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , THLE-2 细胞 , BEL-7405 细胞 , SK-Hep-1 细胞
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Overexpression of ZFP69B promotes hepatocellular carcinoma growth by upregulating the expression of TLX1 and TRAPPC9 (2024-09-11)
期刊：Cell Division
DOI：10.1186/s13008-024-00131-z
影响因子 ：2.8
引用产品： THLE-2细胞专用培养基 , THLE-2 细胞
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METTL3-mediated m6A modification of ZNF384 promotes hepatocellular carcinoma progression by transcriptionally activating ACSM1 (2024-09-29)
期刊：Clinical & Translational Oncology
DOI：10.1007/s12094-024-03701-3
影响因子 ：2.8
引用产品： DMEM高糖完全培养基（含10% FBS） , THLE-2 细胞 , DMEM高糖 培养基 , THLE-2细胞专用培养基
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Purpurogallin carboxylic acid exhibits synergistic effects with 5?fluorouracil on liver cancer cells in vitro by targeting ABCG2 (2024-05-08)
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7
引用产品： THLE-2细胞专用培养基 , HuH-7 细胞 , Hep G2 细胞 , THLE-2 细胞
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hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene (2024-09-16)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01330-9
影响因子 ：1.8
引用产品： Hep 3B2.1-7 细胞 , HuH-7 细胞 , THLE-2 细胞
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miR-145-5p regulates hepatocellular carcinoma malignant advancement and immune escape via down-regulation of AcylCoA synthase ACSL4 (2024-12-07)
期刊：Biomolecules and Biomedicine
影响因子 ：0.0
引用产品： THLE-2 细胞
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F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway (2024-09-10)
期刊：Biomolecules and Biomedicine
影响因子 ：
引用产品： THLE-2 细胞
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KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma (2022-12-05)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23492
影响因子 ：5.1
引用产品： HuH-7 细胞 , MHCC-97H 细胞 , Hep G2 细胞 , MHCC97-L 细胞 , THLE-2 细胞
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