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产品概述
| 名称 | THLE-2 (人肝永生化细胞) (STR鉴定正确) |
| 别称 | THLE2; Transformed Human Liver Epithelial-2 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55%DM/F12+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | THLE-2 is an epithelial cell that was isolated from the left lobe of a donor.THLE-2 and THLE-3 cells express phenotypic characteristics of normal adult liver epithelial cells. They are nontumorigenic when injected into athymic nude mice, have near-diploid karyotypes, and do not express alpha-fetoprotein. [RF84750] THLE-2 and THLE-3 cells metabolize benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 to their ultimate carcinogenic metabolites that adduct DNA, which indicates functional cytochrome P450 pathways. |
| 年龄（性别） | 男性 |
| 组织来源 | 肝脏；左叶 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-2 |
| 致瘤性 | No; No, nude mice |
| 保藏机构 | ATCC; CRL-2706 |
STR鉴定
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STR位点信息
Amelogenin X, Y CSF1PO 11,13 D2S1338 17,23 D3S1358 14,15 D5S818 11,13 D7S820 10,12 D8S1179 13 D13S317 8,12 D16S539 11,13 D18S51 13,16 D19S433 14 D21S11 30,32.2 FGA 22,24 PentaD 10,13 PentaE 12,13 TH01 7,9.3 TPOX 8,11 vWA 16,17 D6S1043 12,18 D12S391 21,23 D2S441 11 -
STR鉴定图
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参考文献
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Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway (2024-03-09)
作者：Yufu Peng:1.Division of Liver Surgery Department of General Surgery West China Hospital Sichuan University Chengdu China. ; 2.Laboratory of Integrative Medicine Clinical Research Center for Breast State Key Laboratory of Biotherapy West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China. ; Jing Yu:1.Laboratory of Integrative Medicine Clinical Research Center for Breast State Key Laboratory of Biotherapy West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China. ; Fei Liu:1.Division of Liver Surgery Department of General Surgery West China Hospital Sichuan University Chengdu China. ; Leyi Tang:1.Laboratory of Integrative Medicine Clinical Research Center for Breast State Key Laboratory of Biotherapy West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China. ; Bo Li:1.Division of Liver Surgery Department of General Surgery West China Hospital Sichuan University Chengdu China. ; Wei Zhang:1
期刊：Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway
DOI：10.1002/mco2.510
影响因子 ：9.9
引用产品： THLE-2 细胞
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RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling (2024-02-18)
作者：Yuan Fang:1.Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. ; WeiQiang Tang:1.Institute of Clinical Medicine, Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang, Hunan, People's Republic of China. ; Siming Qu:1.Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. ; ZhiTao Li:1.Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan, China. ; XiaoLi Zhang:1.Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China. ; YingLei Miao:1.Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan, People's Republic of China. ; 2.Yunnan Province Clinical Research Center for
期刊：RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling
DOI：10.1186/s12967-024-04964-8
影响因子 ：7.4
引用产品： Hep 3B2.1-7 细胞 , HuH-7 细胞 , PLC/PRF/5 细胞 , Li-7 细胞 , THLE-2 细胞
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TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population (2024-02-22)
作者：Yingying Wu:1.The Second School of Clinical Medicine of Binzhou Medical University, Yantai, China. ; Chao Zhang:1.Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. ; Shaofei Duan:1.Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China. ; Yushan Li:1.Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China. ; Lu Lu:1.The University of Tennessee Health Science Center, Memphis, Tennessee, USA. ; Akhilesh Bajpai:1.The University of Tennessee Health Science Center, Memphis, Tennessee, USA. ; Chunhua Yang:1.Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China. ; Jia Mi:1.Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University,
期刊：TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population
影响因子 ：5.8
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KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma (2022-12-05)
作者：Zichang Dai:1.Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, P. R. China. ; 2.Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, P. R. China. ; Qiyuan Huang:1.Department of Clinical Biobank Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China. ; Xueran Huang:1.Department of Medical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, P. R. China. ; Chuiyu Zhu:1.Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, P. R. China. ; Kashif Rafiq Zahid:1.Department of Radiation Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. ; Tiancai Liu:1.Key Laboratory of Antibody Engineering of Guangdong Higher
期刊：KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma
DOI：10.1002/mc.23492
影响因子 ：5.1
引用产品： HuH-7 细胞 , MHCC-97H 细胞 , Hep G2 细胞 , MHCC97-L 细胞 , THLE-2 细胞
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