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产品概述
| 名称 | MRC-5 (人胚肺细胞) (STR鉴定正确) |
| 别称 | MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为有限传代细胞系，传代次数过高会导致细胞生长特性发生变化，建议到货3代内完成实验。 |
| 年龄（性别） | 男性；14周龄 |
| 组织来源 | 肺 |
| 细胞类型 | 有限细胞系 |
| 生物安全等级 | BSL-1 |
| 保藏机构 | ATCC; CCL-171 ECACC; 97112601 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11,12 D2S1338 20 D3S1358 15,17 D5S818 11,12 D7S820 10,11 D8S1179 13 D13S317 11,14 D16S539 9,11 D18S51 15,21 D19S433 14,15 D21S11 31.2 FGA 21,23 PentaD 12 PentaE 12,16 TH01 8 TPOX 8 vWA 15 D6S1043 11,19 D12S391 20,22 D2S441 10,11 -
STR鉴定图
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参考文献
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Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy (2024-01-06)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c01889
影响因子 ：7.3
引用产品： A549 [A-549] 细胞 , A549/DDP 细胞 , A549/Tax 细胞 , A-431 细胞 , MRC-5 细胞
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Anti-carbamylated protein antibodies drive AEC II toward a profibrotic phenotype by interacting with carbamylated TLR5 (2024-02-16)
期刊：RHEUMATOLOGY
DOI：10.1093/rheumatology/keae111
影响因子 ：5.5
引用产品： MRC-5 细胞 , IMR-90 细胞 , A549 [A-549] 细胞 , BEAS-2B 细胞
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Cevanine-type alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their antifibrotic activities in vitro (2024-02-10)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2024.114018
影响因子 ：3.8
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Intelligent Dual-Lock Deoxyribonucleic Acid Automatons Boosting Precise Tumor Imaging (2023-01-10)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： A549 [A-549] 细胞 , MRC-5 细胞
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Interleukin-18-primed human umbilical cord-mesenchymal stem cells achieve superior therapeutic efficacy for severe viral pneumonia via enhancing T-cell immunosuppression (2023-01-28)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05597-3
影响因子 ：9.0
引用产品： MRC-5 细胞 , 小鼠Ⅱ型肺泡上皮细胞
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Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma (2023-01-12)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： AML12 细胞 , MRC-5 细胞 , 293T [HEK-293T] 细胞 , RAW 264.7 细胞 , Hep G2 细胞
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Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis (2023-04-14)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1159856
影响因子 ：7.3
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A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis (2023-11-14)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1268141
影响因子 ：7.3
引用产品： MRC-5 细胞
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CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling (2023-03-02)
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.8
引用产品： MRC-5 细胞
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Study of the antiaging effects of bird's nest peptide based on biochemical, cellular, and animal models (2023-03-05)
期刊：Journal of Functional Foods
影响因子 ：5.6
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Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients (2023-06-10)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
引用产品： MRC-5 细胞
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Construction of a TFs-miRNA-mRNA network related to idiopathic pulmonary fibrosis (2023-01-31)
期刊：Annals of Translational Medicine
影响因子 ：3.6
引用产品： MRC-5 细胞
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Integrated bioinformatics analysis for the identification of idiopathic pulmonary fibrosis–related genes and potential therapeutic drugs (2023-10-04)
期刊：BMC Pulmonary Medicine
DOI：10.1186/s12890-023-02678-z
影响因子 ：3.1
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Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p (2023-10-02)
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.9
引用产品： MRC-5 细胞 , MEM 培养基 , 特级胎牛血清 , MEM非必需氨基酸溶液 (NEAA)，100× , 青霉素-链霉素溶液 (双抗)，100×
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Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma (2023-02-24)
期刊：Thoracic Cancer
影响因子 ：2.9
引用产品： MRC-5 细胞 , MRC-5细胞专用培养基 , NCI-H1299 细胞 , NCI-H1975 细胞 , A549 [A-549] 细胞 , NCI-H1650 细胞 , PC-9 细胞
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Krüppel-like factor 15 counteracts endoplasmic reticulum stress and suppresses lung fibroblast proliferation and extracellular matrix accumulation (2023-07-26)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2023.102183
影响因子 ：2.6
引用产品： MRC-5 细胞
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Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3 (2022-11-12)
期刊：CLINICAL AND EXPERIMENTAL IMMUNOLOGY
影响因子 ：5.7
引用产品： MRC-5 细胞 , A549 [A-549] 细胞 , NCI-H358 细胞 , NCI-H1299 细胞 , NCI-H460 [H460] 细胞
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Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14 (2022-08-26)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109146
影响因子 ：5.7
引用产品： WI-38 细胞 , MRC-5 细胞 , WI-38细胞专用培养基 , MRC-5细胞专用培养基
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Circ_0044411 silencing protects infantile pneumonia from lipopolysaccharide-induced cell injury by sponging miR-141-3p to inhibit CCL16 expression (2022-12-19)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109425
影响因子 ：5.7
引用产品： MRC-5 细胞
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Hsa_circ_0092887 targeting miR-490-5p/UBE2T promotes paclitaxel resistance in non-small cell lung cancer (2022-12-22)
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影响因子 ：3.1
引用产品： MRC-5 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , NCI-H1299 细胞 , A549 [A-549] 细胞 , Ham's F-12K 培养基 , RPMI-1640 培养基
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Hsa_circ_0079530/AQP4 Axis Is Related to Non-Small Cell Lung Cancer Development and Radiosensitivity (2022-10-20)
期刊：Annals of Thoracic and Cardiovascular Surgery
影响因子 ：1.9
引用产品： NCI-H2170 细胞 , A549 [A-549] 细胞 , MRC-5 细胞
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1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway (2011-01-20)
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2021.108339
影响因子 ：5.6
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Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis, and inflammatory response by miR-195-5p/TLR4 axis through NF-κB pathway in MRC-5 cells (2003-01-20)
期刊：Bioscience Biotechnology and Biochemistry
影响因子 ：1.6
引用产品： MRC-5 细胞
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