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产品概述
| 名称 | BHT101 (人甲状腺癌细胞(未分化)) (STR鉴定正确) |
| 别称 | BHT-101 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Established from the lymph node metastasis of a 63-year-old woman with anaplastic papillary thyroid carinoma; cells were described in the literature to not produce hormones, but to be partly positive for thyroglobulin- and thyroxine (T4) |
| 年龄（性别） | 女性；63岁 |
| 组织来源 | 甲状腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 甲状腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | 24 hours (PubMed=8099464); ~2-3 days (DSMZ) |
| 保藏机构 | DSMZ; ACC-279 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12,13 D2S1338 20,23 D3S1358 16,17 D5S818 10,11 D7S820 10,11 D8S1179 13,15 D13S317 12 D16S539 9,11 D18S51 12,15 D19S433 13,14,15 D21S11 29,32.2 FGA 18,24 PentaD 9 PentaE 10,17 TH01 9,9.3 TPOX 8 vWA 19 D6S1043 12,14 D12S391 17,22 D2S441 10,11.3 -
STR鉴定图
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参考文献
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DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression (2024-01-17)
作者：Zanbin Li:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Yong Ying:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Xiangtai Zeng:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Jiafeng Liu:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Yang Xie:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Zefu Deng:1.Department of Thyroid a
期刊：DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression
DOI：10.1007/s10142-024-01293-3
影响因子 ：2.9
引用产品： B-CPAP [BC-PAP; BCPAP] 细胞 , 8305C 细胞 , BHT101 细胞 , CAL-62 细胞
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RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex (2023-02-21)
作者：Debin Xu:1.Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Jichun Yu:1.Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Yuting Yang:1.Department of Intensive Care Unit, First Affiliated Hospital of Nanchang University, No. 17, Yongwai Main Street, Nanchang, 330006, China. ; Yunyan Du:1.School of Pharmacy, Nanchang University, No. 471, Bayi Road, Nanchang, 330006, China. ; Hongcheng Lu:1.Department of General Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Shouhua Zhang:1.Department of General Surgery, Affiliated Children's Hospital of Nanchang University, No. 122, Yangming Road, Nanchang, 330006, China. ; Qian Feng:1.Department of General Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Yi Yu:1.Department of Urolo
期刊：RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
DOI：10.1186/s13578-023-00987-8
影响因子 ：7.5
引用产品： TPC-1 细胞 , B-CPAP [BC-PAP; BCPAP] 细胞 , KTC-1 细胞 , C643 细胞 , CAL-62 细胞 , 8305C 细胞 , KMH-2 细胞 , KHM-5M 细胞 , BHT101 细胞
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Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer (2023-06-19)
作者：Qingling Yuan:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. yuanqingling113@163.com. ; Yuxia Fan:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Zheng Liu:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Xiaoming Wang:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Meng Jia:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Yongqiang Dong:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Zushi Geng:1.Department of Thyroid Surgery, The First Affiliated Hospital o
期刊：Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer
DOI：10.1007/s10495-023-01861-1
影响因子 ：7.2
引用产品： TPC-1 细胞 , 8305C 细胞 , BHT101 细胞 , CAL-62 细胞 , HTh-7 细胞
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Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway (2023-07-01)
作者：Chen Peng:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Head and Neck Surgery, Shanxi Province Cancer Hospital, Taiyuan, 030001, China. ; 3.Department of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, 030001, China. ; 4.Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, China. ; Chunming Zhang:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. ; 3.Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. ; Wenjie Yu:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Otolaryngology
期刊：Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway
DOI：10.2174/1568009623666230118111745
影响因子 ：3.0
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FOXA2 suppresses PKM2 transcription and affects the Wnt/β-catenin activity to block aerobic glycolysis in thyroid carcinoma (2023-03-22)
作者：Yawei He:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ; Wanjing Chen:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ; Liang Yu:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ; Yanwei Liu:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ; Yunsheng Cheng:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ; Xianghua Li:1.Department of Molecular Pathology, Hefei Da'an Medical Laboratory Co., Ltd, Hefei, China. ; Gang Yu:1.Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. ;
期刊：FOXA2 suppresses PKM2 transcription and affects the Wnt/β-catenin activity to block aerobic glycolysis in thyroid carcinoma
影响因子 ：2.9
引用产品： B-CPAP [BC-PAP; BCPAP] 细胞 , BHT101 细胞 , 293T [HEK-293T] 细胞
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Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI) (2022-12-28)
作者：Jingtao Luo:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China. ; 2.Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China. ; 3.Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. ; Yun Wang:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China. ; 2.Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China. ; 3.Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. ; Lingkun Zhao:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center
期刊：Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI)
影响因子 ：6.6
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Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways (2004-02-20)
作者：Jingni He:1.Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110022, PR China. ; Ying Zhang:1.Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang, 110022, PR China. ; Baiyu Yao:1.Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110022, PR China. ; Lidong Wang:1.Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110022, PR China. ; Zhong Tian:1.Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110022, PR China. Electronic address: tianzhong@sj-hospital.org. ;
期刊：Tripartite motif containing 63, regulated by E26 transformation specific variant 4, facilitates the thyroid carcinoma progression and the AKT, p38, and ERK signaling pathways
影响因子 ：4.1
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