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产品概述
| 名称 | CAL-62 (人甲状腺癌细胞(未分化)) (STR鉴定正确) |
| 别称 | Cal-62; CAL 62; Cal 62; CAL62; Centre Antoine Lacassagne-62 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Established from the thyroid gland (right lobe) of a 70-year-old woman with thyroid anaplastic carcinoma in 1988; described as being tumorigenic in heterotransplanted nude mice |
| 年龄（性别） | 女性；70岁 |
| 组织来源 | 甲状腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 甲状腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24 hours (DSMZ) |
| 保藏机构 | DSMZ; ACC-448 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 9,12 D2S1338 19,23 D3S1358 16 D5S818 9,12 D7S820 10 D8S1179 13 D13S317 12 D16S539 12,13 D18S51 16 D19S433 14 D21S11 32.2 FGA 19 PentaD 13 PentaE 5,10 TH01 7,9 TPOX 8,9 vWA 16 D6S1043 12 D12S391 22 D2S441 11 -
STR鉴定图
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参考文献
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Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D (2024-01-10)
作者：Chuan Zhou:1.Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; Zisheng Fan:1.Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ; 2.Lingang Laboratory, Shanghai 200031, China. ; 3.Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; Yuejiao Gu:1.Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; 2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. ; Zhiming Ge:1.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. ; 2.School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study,
期刊：Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D
DOI：10.1021/acs.jmedchem.3c01622
影响因子 ：7.3
引用产品： CAL-62 细胞 , HCT 116 细胞 , AGS 细胞 , 重组人胰岛素溶液 (10mg/mL)
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DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression (2024-01-17)
作者：Zanbin Li:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Yong Ying:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Xiangtai Zeng:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Jiafeng Liu:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Yang Xie:1.Department of Thyroid and Hernia Surgery, First Affiliated Hospital of Gannan Medical College, No. 128, Jinling West Road, Ganzhou, 341000, Jiangxi, People's Republic of China. ; Zefu Deng:1.Department of Thyroid a
期刊：DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression
DOI：10.1007/s10142-024-01293-3
影响因子 ：2.9
引用产品： B-CPAP [BC-PAP; BCPAP] 细胞 , 8305C 细胞 , BHT101 细胞 , CAL-62 细胞
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RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex (2023-02-21)
作者：Debin Xu:1.Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Jichun Yu:1.Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Yuting Yang:1.Department of Intensive Care Unit, First Affiliated Hospital of Nanchang University, No. 17, Yongwai Main Street, Nanchang, 330006, China. ; Yunyan Du:1.School of Pharmacy, Nanchang University, No. 471, Bayi Road, Nanchang, 330006, China. ; Hongcheng Lu:1.Department of General Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Shouhua Zhang:1.Department of General Surgery, Affiliated Children's Hospital of Nanchang University, No. 122, Yangming Road, Nanchang, 330006, China. ; Qian Feng:1.Department of General Surgery, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330008, China. ; Yi Yu:1.Department of Urolo
期刊：RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex
DOI：10.1186/s13578-023-00987-8
影响因子 ：7.5
引用产品： TPC-1 细胞 , B-CPAP [BC-PAP; BCPAP] 细胞 , KTC-1 细胞 , C643 细胞 , CAL-62 细胞 , 8305C 细胞 , KMH-2 细胞 , KHM-5M 细胞 , BHT101 细胞
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Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers (2023-03-10)
作者：Zehui Zhou:1.Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; 2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. ; Guizhen Zhou:1.Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; 2.School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. ; Chuan Zhou:1.Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; Zisheng Fan:1.Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. ; Rongrong Cui:1.Drug Discovery and Design Center, State Key Laboratory of Drug Rese
期刊：Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers
DOI：10.1021/acs.jmedchem.3c00075
影响因子 ：7.3
引用产品： Calu-1 细胞 , SW480 [SW-480] 细胞 , CAL-62 细胞 , LoVo 细胞 , HCT 116 细胞 , NCI-H460 [H460] 细胞
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Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer (2023-06-19)
作者：Qingling Yuan:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. yuanqingling113@163.com. ; Yuxia Fan:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Zheng Liu:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Xiaoming Wang:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Meng Jia:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Yongqiang Dong:1.Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, Henan, China. ; Zushi Geng:1.Department of Thyroid Surgery, The First Affiliated Hospital o
期刊：Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer
DOI：10.1007/s10495-023-01861-1
影响因子 ：7.2
引用产品： TPC-1 细胞 , 8305C 细胞 , BHT101 细胞 , CAL-62 细胞 , HTh-7 细胞
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Immunological characteristics of immunogenic cell death genes and malignant progression driving roles of TLR4 in anaplastic thyroid carcinoma (2023-11-21)
作者：Tong Xu:1.Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, 158 Shangtang Road, Xiacheng District, Hangzhou, Zhejiang, 310014, China. ; Chaozhuang Zhu:1.Zhejiang University of Technology, Hangzhou, Zhejiang, China. ; Feifeng Song:1.Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, 158 Shangtang Road, Xiacheng District, Hangzhou, Zhejiang, 310014, China. ; Wanli Zhang:1.Zhejiang University of Technology, Hangzhou, Zhejiang, China. ; Mengnan Yuan:1.Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, 158 Shangtang Road, Xiacheng District, Hangzhou, Zhejiang, 310014, China. ; Zongfu Pan:1.Center for Clinical Pharmacy, Cancer Center, Department of P
期刊：Immunological characteristics of immunogenic cell death genes and malignant progression driving roles of TLR4 in anaplastic thyroid carcinoma
DOI：10.1186/s12885-023-11647-y
影响因子 ：3.8
引用产品： CAL-62 细胞
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Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway (2023-07-01)
作者：Chen Peng:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Head and Neck Surgery, Shanxi Province Cancer Hospital, Taiyuan, 030001, China. ; 3.Department of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, 030001, China. ; 4.Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, China. ; Chunming Zhang:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. ; 3.Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China. ; Wenjie Yu:1.Otolaryngology Head and Neck Surgery Research Institute, Shanxi Medical University, Taiyuan, 030001, China. ; 2.Department of Otolaryngology
期刊：Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway
DOI：10.2174/1568009623666230118111745
影响因子 ：3.0
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Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI) (2022-12-28)
作者：Jingtao Luo:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China. ; 2.Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China. ; 3.Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. ; Yun Wang:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China. ; 2.Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China. ; 3.Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. ; Lingkun Zhao:1.Department of Maxillofacial and Otorhinolaryngology Oncology and Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center
期刊：Anti-Anaplastic Thyroid Cancer (ATC) Effects and Mechanisms of PLX3397 (Pexidartinib), a Multi-Targeted Tyrosine Kinase Inhibitor (TKI)
影响因子 ：6.6
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