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产品概述
人牙髓干细胞
Cat NO.: CP-H231
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产品名称：人牙髓干细胞
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英文简称：DPSC
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组织来源：牙髓组织
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
人牙髓干细胞分离自牙髓组织；牙髓组织位于牙齿内部的牙髓腔内。牙髓腔的外形与牙体形态大致相似，牙冠部髓腔较大，称髓室，牙根部髓腔较细小，称根管，根尖部有小孔，称根尖孔。牙髓组织主要包含神经、血管，淋巴和结缔组织，还有排列在牙髓外周的造牙本质细胞，其作用是造牙本质。牙髓因受到病源刺激物的作用不同以及机体抵抗力的差异，出现不同的病理变化，在临床上会表现为一系列不同的症状和体征。牙髓充血状况持续时间较长后，转化为急性牙髓炎症。间充质干细胞(mesenchymal stem cells，MSCs)来源于胚胎时期的中胚层组织，具有很强的自我复制和多向分化潜能，具有向脂肪细胞、成骨细胞、软骨细胞及肌细胞等多种终末细胞定向分化的能力，运用 MSCs来修复软骨损伤具有很好的应用前景，目前已能够从骨髓、脂肪、滑膜、骨骼、肌肉等组织以及羊水、脐带、脐带血中分离和制备间充质干细胞。
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方法简介：
普诺赛实验室分离的人牙髓干细胞采用胶原酶消化法、低密度稀释克隆制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的人牙髓干细胞经CD90免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-H231 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 成纤维细胞样 传代特性 可传3-5代左右 消化液 0.25%胰蛋白酶 人牙髓干细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration (2024-03-22)
作者：HaoRan Du:1.College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China. ; 2.Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. ; Bang Li:1.College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China. ; Rui Yu:1.College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China. ; Xiaoxuan Lu:1.College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China. ; ChengLin Li:1.College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China. ; HuiHui
期刊：ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration
DOI：10.1016/j.bioactmat.2024.02.014
影响因子 ：18.9
引用产品： 人牙髓干细胞
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Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy (2023-11-17)
作者：Mingxi Yang:1.Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, People's Republic of China. ; 2.Department of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun, 130031, People's Republic of China. ; Haiqiu Li:1.Department of Hand and Podiatric Surgery, Orthopedics Center, The First Hospital of Jilin University, Jilin University, Changchun, 130031, People's Republic of China. ; Xinchen Liu:1.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China. ; Lei Huang:1.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, 130021, People's Republic of China. ; Boya Zhang:1.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatol
期刊：Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
DOI：10.1186/s12951-023-02194-6
影响因子 ：10.2
引用产品： 人牙髓干细胞 , 人牙髓干细胞完全培养基
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Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo (2023-09-21)
作者：Zitian Liang:1.Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, 510182, People's Republic of China. ; Ding Chen:1.Department of Prosthodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, 510182, People's Republic of China. ; Ye Jiang:1.Department of Endodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, 510182, People's Republic of China. ; Zhikang
期刊：Multifunctional Lithium-Doped Mesoporous Nanoparticles for Effective Dentin Regeneration in vivo
影响因子 ：8.0
引用产品： 人牙髓干细胞
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Effects of Sulforaphene on the Cariogenic Properties of Streptococcus Mutans In Vitro and Dental Caries Development In Vivo (2023-08-24)
作者：Yuehong Zhou:1.The College of Renji, Wenzhou Medical University, Wenzhou 325000, China. ; Binhan Zhang:1.State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. ; 2.The College of Life Science, Sichuan University, Chengdu 610041, China. ; Yufei Wang:1.State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. ; Rongdang Hu:1.The College of Renji, Wenzhou Medical University, Wenzhou 325000, China. ;
期刊：Effects of Sulforaphene on the Cariogenic Properties of Streptococcus Mutans In Vitro and Dental Caries Development In Vivo
DOI：10.3390/antibiotics12091359
影响因子 ：4.8
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Enhanced activity and differentiation of periodontal ligament stem cells by chitosan scaffold and its application in periodontal bone regeneration (2023-10-01)
作者：Zhou, Guoqiang: 1.Department of Stomatology, Chaoyang District Civil Aviation General Hospital of Beijing, Beijing, 100123, PR China; Liu, Ye: 1.Department of Stomatology, Chaoyang District Civil Aviation General Hospital of Beijing, Beijing, 100123, PR China; Wang, Ding: 1.Department of Stomatology, Chaoyang District Civil Aviation General Hospital of Beijing, Beijing, 100123, PR China; Zhang, Fengqiu: 1.Department of Periodontal, Beijing Stomatological Hospital, Capital Medical University, No. 4, Tiantan Xili, Dongcheng District, Beijing, 100050, PR China;
期刊：Enhanced activity and differentiation of periodontal ligament stem cells by chitosan scaffold and its application in periodontal bone regeneration
影响因子 ：0.7
引用产品： 人牙髓干细胞 , 人牙髓干细胞完全培养基
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SNHG7 promotes the osteo/dentinogenic differentiation ability of human dental pulp stem cells by interacting with hsa-miR-6512–3p in an inflammatory microenvironment (2010-01-20)
作者：Wenyu Chen:1.Department of Stomatology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, 410000, China. Electronic address: chengwenyu08@126.com. ;
期刊：SNHG7 promotes the osteo/dentinogenic differentiation ability of human dental pulp stem cells by interacting with hsa-miR-6512–3p in an inflammatory microenvironment
DOI：10.1016/j.bbrc.2021.09.081
影响因子 ：3.1
引用产品： 人牙髓干细胞 , 人牙髓干细胞完全培养基
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