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产品概述
| 名称 | SV40 MES 13 (小鼠肾小球系膜细胞) (种属鉴定正确) |
| 别称 | SV40-MES13; MES-13; MES 13; MES13 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | SV40 MES 13细胞的细胞骨架染色突出呈现肌动蛋白，在细胞质中有丰富的平行微丝。有报道称，在1uM血管紧张素Ⅱ存在下，SV40 MES 13细胞会收缩。SV40 MES 13细胞在软琼脂中形成克隆；SV40大T抗原阳性。 |
| 年龄（性别） | 7-10周龄 |
| 组织来源 | 肾小球系膜细胞 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-2 |
| 倍增时间 | ~26 hours |
| 保藏机构 | ATCC; CRL-1927 |
STR鉴定
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STR位点信息
18-3 16 6-7 12 5-5 14,17 X-1 28 1-2 13,19 7-1 25.2 8-1 16 1-1 17 19-2 13 15-3 22.3 12-1 17 6-4 15.1 4-2 20.3 3-2 14 2-1 9,16 13-1 16.2,17.1
11-2 16 17-2 15 -
STR鉴定图
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参考文献
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tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis (2024-01-29)
作者：Yun-Yang Qiao:1.Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China. ; 2.Department of Pediatrics, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, China. ; Jia-Ling Ji:1.Department of Pediatrics, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 210031, China. ; Wei-Ling Hou:1.Department of Science and Education, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, 211199, China. ; Gao-Ting Qu:1.Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China. ; Shan-Wen Li:1.Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China. ; Xing-Yue Li:1.Department of Pediatric Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China. ; Ran Jin:1.Department of Pediatric Nephrology, the Sec
期刊：tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis
DOI：10.1038/s41401-024-01228-5
影响因子 ：8.2
引用产品： SV40 MES 13 细胞
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ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway (2023-10-23)
作者：Wen Zhong:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Chen Hong:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Yuyu Zhang:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Yuhui Li:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Chenxi Xiao:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Xinhua Liu:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. Electronic address: liuxinhua@fudan.edu.cn. ;
期刊：ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway
DOI：10.1016/j.trsl.2023.10.002
影响因子 ：7.8
引用产品： SV40 MES 13 细胞
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Seven new triterpenoid saponins from Astragalus membranaceus var. mongholicus and the inhibition of high-glucose induced SV40 MES 13 cells (2023-04-07)
作者：Hai-dan Zou: 1.Key Laboratory of Basic and Application Research of Beiyao, College of Pharmacy (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 He** Road, Harbin 150040, **angfang District, P. R. China E-mail: ybywater@163.com, hxkuang@yahoo.com; Yan Liu: 1.Key Laboratory of Basic and Application Research of Beiyao, College of Pharmacy (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 He** Road, Harbin 150040, **angfang District, P. R. China E-mail: ybywater@163.com, hxkuang@yahoo.com; Zhen-Peng Zhang: 1.Key Laboratory of Basic and Application Research of Beiyao, College of Pharmacy (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 He** Road, Har
期刊：Seven new triterpenoid saponins from Astragalus membranaceus var. mongholicus and the inhibition of high-glucose induced SV40 MES 13 cells
影响因子 ：3.3
引用产品： SV40 MES 13 细胞
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ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells (2022-11-29)
作者：Wen Zhong:1.School of pharmacy, Fudan University, Shanghai 201203, China. ; 2.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Chen Hong:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Yejun Dong:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Yuhui Li:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Chenxi Xiao:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ; Xinhua Liu:1.Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China. ;
期刊：ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells
影响因子 ：4.1
引用产品： SV40 MES 13 细胞
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LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2 (2001-02-20)
作者：Yan-Xia Chen:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ; Shu-Ying Zhu:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ; Chong Huang:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ; Cheng-Yun Xu:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ; Xiang-Dong Fang:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ; Wei-Ping Tu:1.Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. ;
期刊：LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2
影响因子 ：2.8
引用产品： SV40 MES 13 细胞
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METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy (2003-02-20)
作者：Weiming Tang:1.Department of Clinical Laboratory, Liyang People's Hospital, No. 70, Jianshe West Road, Licheng Town, Liyang, 213300, Jiangsu, P. R. China. ; Yilin Zhao:1.Department of Clinical Laboratory, Liyang People's Hospital, No. 70, Jianshe West Road, Licheng Town, Liyang, 213300, Jiangsu, P. R. China. ; Hui Zhang:1.Department of Clinical Laboratory, Liyang People's Hospital, No. 70, Jianshe West Road, Licheng Town, Liyang, 213300, Jiangsu, P. R. China. ; Ying Peng:1.Department of Clinical Laboratory, Liyang People's Hospital, No. 70, Jianshe West Road, Licheng Town, Liyang, 213300, Jiangsu, P. R. China. ; Zhilian Rui:1.Department of Clinical Laboratory, Liyang People's Hospital, No. 70, Jianshe West Road, Licheng Town, Liyang, 213300, Jiangsu, P. R. China. Rzhilian4201@126.com. ;
期刊：METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy
DOI：10.1186/s12882-022-02753-3
影响因子 ：2.3
引用产品： SV40 MES 13 细胞
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Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway. (2011-01-20)
作者：Yuanyuan Fu:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; Pengzhi Wan:1.Department of Nephrology, First Affiliated Hospital of China Medical University, Shenyang, China. ; Jie Zhang:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; Xue Li:1.Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China. ; Jia Xing:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; Yu Zou:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; Kaiyue Wang:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; Hui Peng:1.Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China. ; 2.Department of Nephrology, Shengjing Hospital of China Me
期刊：Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway.
影响因子 ：5.5
引用产品： SV40 MES 13 细胞
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CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition (2011-01-20)
作者：Rina Wu:1.Department of Endocrinology, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China. ; Zheli Niu:1.Department of Nephrology, The First Hospital of Hebei Medical University, 9 Donggang Road, Shijiazhuang City, 050030, Hebei Province, China. ; Guangwei Ren:1.Department of Nephrology, The First Hospital of Hebei Medical University, 9 Donggang Road, Shijiazhuang City, 050030, Hebei Province, China. ; Lin Ruan:1.Department of Nephrology, The First Hospital of Hebei Medical University, 9 Donggang Road, Shijiazhuang City, 050030, Hebei Province, China. ; Lijun Sun:1.Department of Nephrology, The First Hospital of Hebei Medical University, 9 Donggang Road, Shijiazhuang City, 050030, Hebei Province, China. docsunlj89@163.com. ;
期刊：CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition
DOI：10.1186/s13098-021-00753-1
影响因子 ：4.8
引用产品： SV40 MES 13 细胞
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Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway (2003-01-20)
作者：Dongbo Zhao:1.Department of Endocrinology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China. ; Junli Guo:1.Department of Nephrology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China. ; Lingping Liu:1.Department of Endocrinology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China. ; Ying Huang:1.Department of Endocrinology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China. ;
期刊：Rosiglitazone attenuates high glucose-induced proliferation, inflammation, oxidative stress and extracellular matrix accumulation in mouse mesangial cells through the Gm26917/miR-185-5p pathway
影响因子 ：2.9
引用产品： SV40 MES 13 细胞 , DMEM高糖 培养基 , Ham's F-12 培养基 , 特级胎牛血清
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miR-1968-5p is involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1 (2007-01-20)
作者：Shipeng Li:1.Department of Rheumatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Nan Li Shi Road No. 56, Beijing, 100045, China. ; Xia Wang:1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, 100069, China. ; Xinxin Zhu:1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing, 100069, China. ; Yuan Xue:1.Department of Rheumatology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Nan Li Shi Road No. 56, Beijing, 100045, China. ; Junmei
期刊：miR-1968-5p is involved in the pathogenesis of lupus nephritis of NZBWF1 mice by targeting csf1
DOI：10.1007/s10157-021-02091-y
影响因子 ：2.3
引用产品： SV40 MES 13 细胞
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