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产品概述
人子宫内膜基质细胞
Cat NO.: CP-H208
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产品名称：人子宫内膜基质细胞
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英文简称：ESCs
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组织来源：子宫组织
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产品规格：5×10⁵Cells/T25培养瓶
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细胞简介：
人子宫内膜基质细胞分离自子宫组织；子宫是孕育胎儿的器官，位于盆腔中部，膀胱与直肠之间，其位置可随膀胱与直肠的充盈程度或体位而有变化。子宫的正常位置主要依靠子宫诸韧带、盆膈、尿生殖膈及会阴中心腱等结构维持，这些结构受损或松弛时，可以引起子宫脱垂。子宫内膜即黏膜，由上皮(属单层柱状上皮，有分泌细胞和纤毛细胞二种)和固有膜(由结缔组织构成，其内有大量的星形细胞，称为基质细胞)组成，子宫内膜可分为浅表的功能膜和深部的基底层，功能层较厚，约占内膜厚度的4/5；基底层较薄较致密，约占1/5，功能层可剥脱，而基底层不可剥脱。子宫内膜构成雌性哺乳动物子宫壁的最内层，位于子宫腔面，在动物生殖生理活动中占有重要地位。子宫和子宫内膜是维持雌性动物生理功能和生育能力的重要器官，子宫内膜的再生修复是子宫的重要生理功能。体外培养的子宫内膜基质细胞对于研究其生理功能、药物作用以及各种致病因素作用下的病理生理改变具重要意义。
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方法简介：
普诺赛实验室分离的人子宫内膜基质细胞采用混合胶原酶消化法结合差速贴壁法制备而来，细胞总量约为5×10⁵cells/瓶。
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质量检测：
普诺赛实验室分离的人子宫内膜基质细胞经Vimentin免疫荧光鉴定，纯度可达90%以上，且不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌等。
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培养信息：
包被条件 培养基 含FBS、生长添加剂、Penicillin、Streptomycin等 产品货号 CM-H208 换液频率 每2-3天换液一次 生长特性 贴壁 细胞形态 成纤维细胞样 传代特性 可传3-5代左右 消化液 0.25%胰蛋白酶 人子宫内膜基质细胞体外培养周期有限；建议使用普诺赛配套的专用生长培养基及正确的操作方法来培养，以此保证该细胞的最佳培养状态。
参考文献
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Integrative analysis links autophagy to intrauterine adhesion and establishes autophagy-related circRNA-miRNA-mRNA regulatory network (2023-08-23)
作者：Xiaotong Peng:1.Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China. ; 2.Department of Gynaecology and Obstetrics, Xiangya Hospital, Central South University, Changsha 410008, China. ; Yiping Zhu:1.Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China. ; Tao Wang:1.Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China. ; Shuo Wang:1.Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicin
期刊：Integrative analysis links autophagy to intrauterine adhesion and establishes autophagy-related circRNA-miRNA-mRNA regulatory network
影响因子 ：5.2
引用产品： 人子宫内膜基质细胞
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Oxycodone alleviates mifepristone-stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO-1 signaling pathway (2023-09-20)
作者：Aibing Zhu:1.Department of Anesthesiology, Wuxi Maternity and Child Health Care Hospital, Wuxi, China. ; Fei Yao:1.Department of Anesthesiology, Wuxi Maternity and Child Health Care Hospital, Wuxi, China. ; Mingkun Shen:1.Department of Anesthesiology, Wuxi Maternity and Child Health Care Hospital, Wuxi, China. ;
期刊：Oxycodone alleviates mifepristone-stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO-1 signaling pathway
影响因子 ：3.2
引用产品： 人子宫内膜基质细胞
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Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway (2023-10-13)
作者：Rong Zheng:1.Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei, China. ; Yulan Liu:1.Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei, China. ; Yan Lei:1.Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei, China. ; Yan Yue:1.Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, No. 745 Wu Luo Road, Hongshan District, Wuhan 430070, Hubei, China. ;
期刊：Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway
影响因子 ：2.1
引用产品： 人子宫内膜基质细胞
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Oxidized LDL promotes EMS-induced angiogenesis by increasing VEGF-A expression and secretion by endometrial cells (2022-12-12)
作者：Caiqi Ma:1.Department of Oncology, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, No. 621, Gangwan Road, Huangpu District, Guangzhou, 510530, China. ; Wei Huang:1.Department of Oncology, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, No. 621, Gangwan Road, Huangpu District, Guangzhou, 510530, China. ; Hui Wang:1.Reproductive Medical Center, Affiliated Guangzhou Women and Children's Medical Center of Guangzhou Medical University, No. 9, Jinsui Road, Guangzhou, 510530, China. ; Wenxia Yao:1.Department of Oncology, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, No. 621, Gangwan Road, Huan
期刊：Oxidized LDL promotes EMS-induced angiogenesis by increasing VEGF-A expression and secretion by endometrial cells
DOI：10.1186/s10020-022-00582-6
影响因子 ：6.4
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Lidocaine inhibits the proliferation and migration of endometrial cancer cells, and promotes apoptosis by inducing autophagy (2022-08-17)
作者：Dingde Long:1.Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China. ; Yayu Chen:1.Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China. ; Liangchao Qu:1.Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China. ; Yang Dong:1.Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China. ;
期刊：Lidocaine inhibits the proliferation and migration of endometrial cancer cells, and promotes apoptosis by inducing autophagy
影响因子 ：3.1
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Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway (2022-08-12)
作者：Jia Li:1.The Third Central Clinical College of Tianjin Medical University, Tianjin China. ; 2.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases. ; 3.Artificial Cell Engineering Technology Research Center. ; 4.Tianjin Institute of Hepatobiliary Disease, Tianjin, China. ; 5.Clinical School of Obstetrics and Gynecology Center, Tianjin Medical University, Tianjin Central Hospital of Gynecology and Obstetrics. ; 6.The Third Central Hospital of Tianjin, Tianjin, China. ; Zhidong Zhang:1.The Third Central Clinical College of Tianjin Medical University, Tianjin China. ; 2.Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases. ; 3.Artificial Cell Engineering Technology Research Center. ; 4.Tianjin Institute of Hepatobiliary Disease, Tianjin, China. ; Yuanjing Hu:1.Clinical School of Obstetrics and Gynecology Center, Tianjin Medical University, Tianjin Central Hospital of Gynecology and Obstetrics. ; 2.The Third Central Hospital of Tianjin, Tianj
期刊：Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway
DOI：10.1097/CAD.0000000000001377
影响因子 ：2.4
引用产品： Ishikawa 细胞 , RL95-2 细胞 , 人子宫内膜基质细胞
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MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling (2011-01-20)
作者：Dongyan Sun:1.Department of Gynecology, Maternity and Child Health Care Hospital of Hubei Province, Wuhan, Hubei, China. ; Zhihe Jiang:1.Department of Obstetrics and Gynecology, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. ; Yanling Chen:1.Department of Obstetrics and Gynecology, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. ; Di Shang:1.Department of Obstetrics and Gynecology, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. ; Pan Miao:1.Yangtze University Health Science Center, Jingzhou, Hubei, China. ; Jian Gao:1.Department of Obstetrics and Gynecology, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. ;
期刊：MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling
DOI：10.1080/21655979.2021.2006976
影响因子 ：4.9
引用产品： 人子宫内膜基质细胞
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