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| 名称 | HEC-1-B (人子宫内膜腺癌细胞) (STR鉴定正确) |
| 别称 | Hec-1-B; HEC-1B; HEC1-B; HEC1B; Hec1B |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HEC-1-B细胞是由H·Kuramoto于1968年分离的HEC-1-A细胞亚株。不同于HEC-A-1的是：HEC-1-B细胞在培养第135天到190天之间表现出稳定的生长周期，且重现扁平，与亲本细胞系相比更具铺路石样。此外，HEC-1-B细胞的主要染色体组是亲本细胞的两倍。 |
| 年龄（性别） | 女性；71岁 |
| 组织来源 | 子宫内膜腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 子宫内膜腺癌 |
| 生物安全等级 | BSL-1 |
| 致瘤性 | Yes, in nude mice (The cells form moderately well differentiated adenocarcinomas consistent with endometrial carcinoma (grade II)).Yes, in the cheek pouch of cortisone treated hamsters (The cells form typical papillary adenomas). |
| 抗原表达情况 | Blood Type B; Rh+ |
| 保藏机构 | ATCC; HTB-113 JCRB; JCRB1193 JCRB; NIHS0480 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 18,19 D3S1358 15 D5S818 11,13 D7S820 9,11 D8S1179 13,14 D13S317 11,16 D16S539 11,12 D18S51 16,20 D19S433 13 D21S11 30,31 FGA 21 PentaD 9,13 PentaE 11 TH01 6,7 TPOX 8,11 vWA 18 D6S1043 12,18 D12S391 18,19 D2S441 11,13 -
STR鉴定图
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参考文献
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Inhibition of ATM with KU-55933 Sensitizes Endometrial Cancer Cell Lines to Olaparib (2023-12-31)
作者：Anqing Zhang:1.Gynaecology Department, Sunshine Union Hospital, Weifang, People's Republic of China. ; Liqin Zhang:1.Gynaecology Department, Affiliated Hospital of Weifang Medical University, Weifang, People's Republic of China. ; Xia Xie:1.Gynaecology Department, Sunshine Union Hospital, Weifang, People's Republic of China. ; Dan Liu:1.Gynaecology Department, Affiliated Hospital of Weifang Medical University, Weifang, People's Republic of China. ;
期刊：Inhibition of ATM with KU-55933 Sensitizes Endometrial Cancer Cell Lines to Olaparib
影响因子 ：4.0
引用产品： Ishikawa 细胞 , HEC-1-B 细胞 , AN3 CA 细胞 , KLE 细胞 , RL95-2 细胞
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Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer (2023-08-28)
作者：Chunying Zheng:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Zhen Ren:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Hongliang Chen:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Xiaorui Yuan:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Suye Suye:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Huan Yin:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Chun Fu:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, H
期刊：Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer
影响因子 ：3.9
引用产品： HEC-1-A 细胞 , HEC-1-B 细胞
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IGFBP‑rP1 affects the proliferation, apoptosis and macrophage polarization of endometrial cancer cells by regulating the PI3K/AKT pathway (2023-03-03)
作者：Juan Gao:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Shiqi Suo:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Jingxia Li:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Chunxia Wang:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Ranran Deng:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Yuxia Hu:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Chunzheng Zhang:1.Department of Functional Section I, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056000, P.R. China. ;
期刊：IGFBP‑rP1 affects the proliferation, apoptosis and macrophage polarization of endometrial cancer cells by regulating the PI3K/AKT pathway
影响因子 ：2.7
引用产品： Ishikawa 细胞 , HEC-1-A 细胞 , RL95-2 细胞 , HEC-1-B 细胞 , AN3 CA 细胞 , THP-1 细胞
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FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value (2022-10-15)
作者：Chunying Zheng:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Zhen Ren:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Hongliang Chen:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Xiaorui Yuan:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Suye Suye:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Huan Yin:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Zhixian Zhou:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changs
期刊：FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value
DOI：10.1016/j.yexcr.2022.113388
影响因子 ：4.1
引用产品： HEC-1-B 细胞 , Ishikawa 细胞
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Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer (2008-01-20)
作者：Xiaobin Gu:1.Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Zhengzhou, 450000, Henan, People's Republic of China. fahzzugu@126.com. ; Yonggang Shi:1.Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Zhengzhou, 450000, Henan, People's Republic of China. ; Meilian Dong:1.Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Zhengzhou, 450000, Henan, People's Republic of China. ; Li Jiang:1.Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Zhengzhou, 450000, Henan, People's Republic of China. ; Jing Yang:1.Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Zhengzhou, 450000, Henan, People's Republic of China. ; Zheyan Liu:1.Department of Radiation Oncology, The First Affiliated Hos
期刊：Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer
DOI：10.1038/s41419-021-04087-8
影响因子 ：9.0
引用产品： THP-1 细胞 , Ishikawa 细胞 , HEC-1-B 细胞
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N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma (2003-01-20)
作者：Jie Shen:1.Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. ; Xiao-Ping Feng:1.Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. ; 2.Department of Gynecology, Yiwu Central Hospital, Yiwu, Zhejiang, China. ; Ru-Bing Hu:1.Department of Gynecology, Yiwu Central Hospital, Yiwu, Zhejiang, China. ; Hao Wang:1.Department of Gynecology, Yiwu Central Hospital, Yiwu, Zhejiang, China. ; Yan-Li Wang:1.Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. ; Jian-Hua Qian:1.Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. ; Yun-Xiao Zhou:1.Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Zhouyx2017@zju.edu.cn. ;
期刊：N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma
DOI：10.1038/s41374-021-00543-3
影响因子 ：5.5
引用产品： Ishikawa 细胞 , HEC-1-B 细胞
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The Circadian Gene NPAS2 Act as a Putative Tumor Stimulative Factor for Uterine Corpus Endometrial Carcinoma (2012-01-20)
作者：Xiaojiao Zheng:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035, People's Republic of China. ; 2.Department of Biochemistry & Genetics, The National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang Province, People's Republic of China. ; Xiuyi Lv:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035, People's Republic of China. ; Linyan Zhu:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035, People's Republic of China. ; Kejun Xu:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035, People's Republic of China. ; Cong Shi:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035, People's Republic of China. ; Lining Cui:1.Department of Obstetrics and Gynecology, Ningbo First Hospital, Ningbo, Zhejiang, 315035
期刊：The Circadian Gene NPAS2 Act as a Putative Tumor Stimulative Factor for Uterine Corpus Endometrial Carcinoma
影响因子 ：3.6
引用产品： HEC-1-B 细胞
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hsa_circ_0001610 knockdown modulates miR-646-STAT3 axis to suppress endometrial carcinoma progression (2004-01-20)
作者：Bo Wang:1.Department of Gynaecology, Nanyang First People's Hospital, Nanyang, China. ; Ye Lu:1.Department of Radiation Oncology, The Fifth People's Hospital of Huai'an, Huai'an, China. ; Eryan Feng:1.Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, The Second People's Hospital of Huai'an, Huai'an, China. ;
期刊：hsa_circ_0001610 knockdown modulates miR-646-STAT3 axis to suppress endometrial carcinoma progression
DOI：10.1002/jgm.3337
影响因子 ：3.5
引用产品： HEC-1-B 细胞 , KLE 细胞 , Ishikawa 细胞
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Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment (2012-01-20)
作者：Chengyu Wang:1.Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, China. ; 2.Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, China. ; Tong Zhu:1.Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, China. ; Zhangxiang Zhao:1.The Sino-Russian Medical Research Center of Jinan University, The Institute of Chronic Disease of Jinan University, The First Affiliated Hospital of Jinan University, Guangzhou, China. ; Bo Chen:1.Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, China. ; Tingting Chen:1.Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, China. ; Qi Dong:1.Dep
期刊：Pan-cancer multi-omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment
影响因子 ：3.5
引用产品： HEC-1-B 细胞 , RL95-2 细胞
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