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产品概述
| 名称 | JEG-3 (人绒毛膜癌细胞) (STR鉴定正确) |
| 别称 | Jeg-3; JEG3; Jeg3; jeg3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | JEG-3细胞是一株超三倍体人类细胞株。JEG-3细胞的典型染色体数为71，发生率为34%，多倍体率为2.6%。t(4;11)(p15;q13)，i(13q)，t(10p15q)，del(18)(q21)和6个其他标记在大多数细胞中常见，另有两个标记在一些细胞中可见，在一个N14和两个N22中可见大卫星。N2、N5和N9有4个拷贝，而N7、N13、N18、N21和X为单拷贝，Q-带检测法可以检测到单个Y染色体。 |
| 年龄（性别） | 男性；胎儿 |
| 组织来源 | 胎盘病变；绒毛膜癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 其它肿瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24-36 hours |
| 致瘤性 | Yes, in nude mice; forms malignant tumor consistent with choriocarcinoma. |
| 基因表达情况 | human chorionic gonadotropin (hCG), human chorionic somatomammotropin (placental lactogen); progesterone |
| 保藏机构 | ATCC; HTB-36 BCRC; 60428 BCRJ; 0123 DSMZ; ACC-463 ECACC; 92120308 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11,12 D2S1338 24 D3S1358 15,16 D5S818 10,11 D7S820 10,12 D8S1179 12 D13S317 9,11 D16S539 13,14 D18S51 14 D19S433 13,15 D21S11 30 FGA 23,24 PentaD 9,12 PentaE 8,12 TH01 9,9.3 TPOX 8 vWA 16 D6S1043 11 D12S391 17,24 D2S441 14,15 -
STR鉴定图
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参考文献
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Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway (2024-01-04)
作者：Jing Yang:1.Reproductive Medical Center, Renmin Hospital of Wuhan University & Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, 430060, Hubei, People's Republic of China. ; 2.Department of Gynecology, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, People's Republic of China. ; Longfei Li:1.Shenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Guangdong Engineering Technology Research Center of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Obstetrics & Gynecology Hospital (Formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, 518045, Guangdong, People's Republic of China. lilongfei2005@163.com. ; Linlin Wang:1.Shenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Guangdong Engineering Technology Rese
期刊：Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway
DOI：10.1186/s12967-023-04831-y
影响因子 ：7.4
引用产品： HTR-8-Svneo 细胞 , JEG-3 细胞 , THP-1 细胞 , RAW 264.7 细胞
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Profilin1 regulates trophoblast invasion and macrophage differentiation (2023-05-08)
作者：Xin Chen:1.Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China. ; Qian Lin Song:1.Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. ; Jia Yu Wang:1.Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China. ; Rui Ji:1.Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China. ; Ze Hong Li:1.Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, China. ; Ming Liang Cao:1.Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China. ; Xue Feng Mu:1.Department of Obst
期刊：Profilin1 regulates trophoblast invasion and macrophage differentiation
DOI：10.1016/j.ajpath.2023.04.008
影响因子 ：6.0
引用产品： JEG-3 细胞
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Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p/TGFB2 axis (2023-01-20)
作者：Meiyu Song:1.Department of Obstetrics, Yantai Yantaishan Hospital, Yantai, Shandong, China. ; Peng Xu:1.Department of Nursing, Yantai Yuhuangding Hospital, Yantai, Shandong, China. ; Li Wang:1.Department of Pediatrics, Yantai Yuhuangding Hospital, Yantai, Shandong, China. ; Jie Liu:1.Department of Obstetrics, Yantai Yuhuangding Hospital, Yantai, Shandong, China. ; Xiaofei Hou:1.Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong, China. ;
期刊：Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p/TGFB2 axis
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞 , JAR 细胞 , JEG-3 细胞
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Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia (2023-06-05)
作者：Ruijing Chang:1.Department of Obstetrics, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, 050000, Hebei, People's Republic of China. ; Yuan Su:1.Department of Obstetrics, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, 050000, Hebei, People's Republic of China. ; Hongfang Kong:1.Department of Obstetrics, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, 050000, Hebei, People's Republic of China. ; Fang Wang:1.Department of Obstetrics, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, 050000, Hebei, People's Republic of China. ; Ying Xing:1.Department of Obstetrics, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Shijiazhuang, 050000, Hebei, People's Republic of China. ; Lei Jiang:1.Department of Obstetrics, Shijiazhuang Maternity & Child Healthcare Hospital, Shijiazhuang, Hebei, People's Repu
期刊：Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
DOI：10.1007/s12033-023-00774-3
影响因子 ：2.6
引用产品： JEG-3 细胞
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IL‑1β‑induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL‑1β antagonists (2002-02-20)
作者：Xiaoxi Wang:1.Department of Obstetrics and Gynecology, Maternity Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China. ; Jing Zhang:1.Department of Obstetrics and Gynecology, Maternity Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China. ; Jing Ji:1.Obstetric Ward II, The Affiliated Northwest Women's and Children's Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China. ;
期刊：IL‑1β‑induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL‑1β antagonists
影响因子 ：3.4
引用产品： JEG-3 细胞 , HTR-8-Svneo 细胞
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Talin1 regulates endometrial adhesive capacity through the Ras signaling pathway (2003-01-20)
作者：Saiqiong Chen:1.Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China; Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China. ; Bo Liu:1.Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. ; Jingjing Li:1.Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China. ; Shengbin Liao:1.Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. ; Yin Bi:1.Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. ; Weiyu Huang:1.Center of Reproductive Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. ; Lifang Yuan:1.Center of
期刊：Talin1 regulates endometrial adhesive capacity through the Ras signaling pathway
影响因子 ：6.8
引用产品： 小鼠子宫内膜上皮细胞完全培养基 , Ishikawa 细胞 , JEG-3 细胞 , MEM (含NEAA) 培养基
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miR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway (2002-00-20)
作者：Fengyan Gong:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. ; Wei Chai:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. ; Junwei Wang:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. ; Huiyan Cheng:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. ; Yuee Shi:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. ; Lifeng Cui:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun 130021, People's Republic of China. Electronic address: Run1019@163.com. ; Guifeng Jia:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun
期刊：miR-214-5p suppresses the proliferation, migration and invasion of trophoblast cells in pre-eclampsia by targeting jagged 1 to inhibit notch signaling pathway
DOI：10.1016/j.acthis.2020.151527
影响因子 ：2.5
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The Possible Involvement of miR-371a-5p Regulating XIAP in the Pathogenesis of Recurrent Pregnancy Loss: (2002-09-20)
作者：Erqiu Du:1.Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China. ; 2.Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. ; 3.Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China. ; Yuming Cao:1.Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China. ; 2.Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. ; Chun Feng:1.Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China. ; 2.Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. ; Jing Lu:1.Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, China. ; 2.Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University, Wuhan, China. ; Hanxiao Yang:1.Department of Obstetrics and Gynecology, Zhongn
期刊：The Possible Involvement of miR-371a-5p Regulating XIAP in the Pathogenesis of Recurrent Pregnancy Loss:
影响因子 ：2.9
引用产品： JEG-3 细胞
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