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产品概述
| 名称 | HTR-8-Svneo (人绒毛膜滋养层细胞) (STR鉴定正确) |
| 别称 | HTR-8/SV neo; HTR-8/SV-neo; HTR8/SVneo; HTR8svn |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | The HTR-8-Svneo cell line was derived by transfecting the cells that grew out of chorinic villi explants of human first-trimester placenta with the gene encoding for simian virus 40 large T antigen. |
| 年龄（性别） | 女性；6-12周龄胚胎 |
| 组织来源 | 胎盘 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-1 |
| 致瘤性 | No (tested in soft agar and nude mice). |
| 抗原表达情况 | cytokeratin-7+; insulin-like growth factor (IGF)-II+; NDOG-5 (placental alkaline phosphatase (PLAP) antibody) +; proliferating cell nuclear antigen (PCNA)+; human leukocyte antigen framework antigen (W6/32)+; integrin subunits alpha 1, alpha 3, alpha |
| 保藏机构 | ATCC; CRL-3271 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 23,24 D3S1358 16 D5S818 12 D7S820 12 D8S1179 12,15 D13S317 9,12 D16S539 11,13 D18S51 13 D19S433 14,15 D21S11 29,30 FGA 21,23 PentaD 9,12 PentaE 7,17 TH01 6,9.3 TPOX 8 vWA 13,18 D6S1043 14,19 D12S391 19 D2S441 11 -
STR鉴定图
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参考文献
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Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway (2024-01-04)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04831-y
影响因子 ：7.4
引用产品： HTR-8-Svneo 细胞 , JEG-3 细胞 , THP-1 细胞 , RAW 264.7 细胞
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Inhibition of the endoplasmic reticulum stress-associated IRE-1 pathway alleviates preterm birth (2024-03-26)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞
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Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss (2024-03-25)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-024-03096-8
影响因子 ：3.1
引用产品： HTR-8-Svneo 细胞 , JAR 细胞
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MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells (2024-03-21)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-024-03088-8
影响因子 ：3.1
引用产品： HTR-8-Svneo 细胞 , 293T [HEK-293T] 细胞 , 青霉素-链霉素溶液 (双抗)，100×
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Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway (2024-01-02)
期刊：Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
DOI：10.1007/s43450-023-00505-4
影响因子 ：1.6
引用产品： HTR-8-Svneo 细胞
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Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses (2023-06-29)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-023-00669-8
影响因子 ：5.7
引用产品： HTR-8-Svneo 细胞
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USP17 regulates preeclampsia by modulating the NF-κB signaling pathway via deubiquitinating HDAC2 (2023-11-21)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.11.010
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞 , 293T [HEK-293T] 细胞 , RPMI-1640 培养基 , DMEM高糖 培养基
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Aspirin protects human trophoblast HTR-8/SVneo cells from H2O2-Induced oxidative stress via NADPH/ROS pathway (2023-11-18)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.11.008
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞
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DNMT1 mediates proliferation, migration and invasion of extravillous trophoblasts by regulating the methylation level of APLNR (2023-05-03)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.05.001
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞
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Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p/TGFB2 axis (2023-01-20)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞 , JAR 细胞 , JEG-3 细胞
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AQP9 causes recurrent spontaneous abortion by inhibiting trophoblast cell EMT and invasion through the PI3K/AKT pathway (2023-08-21)
期刊：BIOLOGY OF REPRODUCTION
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞 , JAR 细胞
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HNRNPC mediated m6A methylation of 5-Methyltetrahydrofolate-homocysteine methyltransferase and involved in the occurrence of recurrent spontaneous abortion (2023-10-04)
期刊：JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影响因子 ：3.4
引用产品： HTR-8-Svneo 细胞
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FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway (2023-03-01)
期刊：BMC Pregnancy and Childbirth
DOI：10.1186/s12884-023-05448-1
影响因子 ：3.1
引用产品： HTR-8-Svneo 细胞
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Maternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss (2023-02-06)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-023-02733-y
影响因子 ：3.1
引用产品： HTR-8-Svneo 细胞
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Reversal of H2O2-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis (2023-05-15)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01070-8
影响因子 ：2.9
引用产品： HTR-8-Svneo 细胞
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Downregulation of BRD4 attenuates high glucose-induced damage of trophoblast cells by inhibiting activation of AKT/mTOR pathway (2023-03-03)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2023.100751
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞
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circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia (2023-03-01)
期刊：Open Medicine
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞
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Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts (2023-12-19)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2023.100841
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞
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COLEC12 expression participates in trophoblast insulin resistance, and reverses celecoxib-mediated inhibition of COX2-PGE2 axis in gestational diabetes (2023-06-05)
期刊：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
影响因子 ：0.6
引用产品： HTR-8-Svneo 细胞
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Forkhead-box C1 attenuates high glucose-induced trophoblast cell injury during gestational diabetes mellitus via activating adenosine monophosphate-activated protein kinase through regulating fibroblast growth factor 19 (2001-02-20)
期刊：Bioengineered
DOI：10.1080/21655979.2021.2018094
影响因子 ：4.9
引用产品： HTR-8-Svneo 细胞
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Circ_0111277 suppresses trophoblast cell proliferation, angiogenesis, migration, invasion and EMT via regulating miR-188-3p/GRHL2 axis (2022-11-21)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞 , HTR-8-Svneo细胞专用培养基 , 人脐静脉内皮细胞
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Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis (2003-02-20)
期刊：Biology Of Reproduction
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞 , PUMC-HUVEC-T1
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IL‑1β‑induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL‑1β antagonists (2002-02-20)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： JEG-3 细胞 , HTR-8-Svneo 细胞
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miR-2115-3p inhibits ferroptosis by downregulating the expression of glutamic-oxaloacetic transaminase in preeclampsia (2022-10-10)
期刊：PLACENTA
DOI：10.1016/j.placenta.2022.09.014
影响因子 ：3.3
引用产品： HTR-8-Svneo 细胞
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Silencing of LncRNA SNHG6 protects trophoblast cells through regulating miR-101-3p/OTUD3 axis in unexplained recurrent spontaneous abortion (2022-09-29)
期刊：JOURNAL OF MOLECULAR HISTOLOGY
DOI：10.1007/s10735-022-10102-9
影响因子 ：3.2
引用产品： HTR-8-Svneo 细胞
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Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis (2001-02-20)
期刊：Reproductive Sciences
DOI：10.1007/s43032-021-00827-5
影响因子 ：2.9
引用产品： HTR-8-Svneo 细胞
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LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathway (2022-10-31)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100696
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞 , 293 [HEK-293] 细胞
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Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells (2006-01-20)
期刊：Frontiers in Endocrinology
影响因子 ：5.2
引用产品： HTR-8-Svneo 细胞
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MiR-296-3p promotes the development and progression of preeclampsia via targeting the CEMIP (2006-01-20)
期刊：European Review for Medical and Pharmacological Sciences
DOI：10.26355/eurrev_202106_26034
影响因子 ：3.8
引用产品： JAR 细胞 , HTR-8-Svneo 细胞
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Puerarin attenuates preeclampsia-induced trophoblast mobility loss and inflammation by modulating miR-181b-5p/RBAK axis (2012-01-20)
期刊：American Journal Of Reproductive Immunology
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞
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LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell via miR-497-5p/FOXO1 axis (2006-01-20)
期刊：Cardiovascular Diagnosis and Therapy
影响因子 ：2.4
引用产品： HTR-8-Svneo 细胞
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LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells (2011-01-20)
期刊：Gynecologic And Obstetric Investigation
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞
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Circular RNA circ_0032962 promotes trophoblast cell progression as ceRNA to target PBX3 via sponging miR-326 in preeclampsia (2011-01-20)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2021.100571
影响因子 ：2.1
引用产品： HTR-8-Svneo 细胞 , HTR-8-Svneo细胞专用培养基
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Rhynchophylline improves trophocyte mobility potential by upregulating ZEB1 level via the inhibition of miR-141-3p level (2001-01-20)
期刊：Bioscience Biotechnology and Biochemistry
影响因子 ：1.6
引用产品： HTR-8-Svneo 细胞
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Integrin β1 regulates proliferation, apoptosis, and migration of trophoblasts through activation of phosphoinositide 3 kinase/protein kinase B signaling (2004-01-20)
期刊：Journal Of Obstetrics And Gynaecology Research
影响因子 ：1.6
引用产品： IMDM完全培养基 (含10%FBS) , HTR-8-Svneo 细胞
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The regulatory network of lncRNA DLX6-AS1/miR-149–5p/ERP44 is possibly related to the progression of preeclampsia (2002-00-20)
期刊：Placenta
DOI：10.1016/j.placenta.2020.02.001
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞
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CircLRRK1 targets miR-223-3p to inhibit the proliferation, migration and invasion of trophoblast cells by regulating the PI3K/AKT signaling pathway (2012-00-20)
期刊：Placenta
DOI：10.1016/j.placenta.2020.12.003
影响因子 ：3.8
引用产品： HTR-8-Svneo 细胞
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The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8‐Svneo cells (2010-00-20)
期刊：Cell Biochemistry and Function
DOI：10.1002/cbf.3594
影响因子 ：3.6
引用产品： HTR-8-Svneo 细胞
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