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产品概述
名称 | ARPE-19 (人视网膜上皮细胞) (STR鉴定正确) |
别称 | ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:5 |
推荐换液频率 | 2-3次/周 |
年龄(性别) | 男性;19岁 |
组织来源 | 眼睛,视网膜 |
细胞类型 | 自发永生化细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~55-65 hours |
基因表达情况 | RPE-specific markers CRALBP and RPE-65 |
保藏机构 | ATCC; CRL-2302 BCRC; 60383 BCRJ; 0041 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11 D2S1338 19 D3S1358 14,15 D5S818 13 D7S820 9,11 D8S1179 13 D13S317 11,12 D16S539 9,11 D18S51 12,16 D19S433 12,13 D21S11 28,29 FGA 23 PentaD 11,13 PentaE 7,11 TH01 6,9.3 TPOX 9,11 vWA 16,19 D6S1043 17,19 D12S391 21,22 D2S441 10,15 -
STR鉴定图
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参考文献
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Hirudo extract ameliorates proliferative vitreoretinopathy by promoting autophagy and attenuating the THBS2/PI3K/Akt pathway (2025-01-08)
期刊:Scientific Reports
DOI:10.1038/s41598-025-85882-7
影响因子 :3.8
引用产品: ARPE-19 细胞
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Asperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis (2025-01-07)
期刊:Frontiers in Medicine
影响因子 :3.1
引用产品: ARPE-19 细胞
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Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway (2025-01-06)
期刊:EXPERIMENTAL EYE RESEARCH
DOI:10.1016/j.exer.2025.110232
影响因子 :3.0
引用产品: ARPE-19 细胞
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Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization (2024-11-13)
期刊:JOURNAL OF NANOBIOTECHNOLOGY
DOI:10.1186/s12951-024-02943-1
影响因子 :10.6
引用产品: ARPE-19 细胞 , 特级胎牛血清 , 人脐静脉内皮细胞 , 青霉素-链霉素溶液(双抗),100× , 293T [HEK-293T] 细胞 , DMEM高糖 培养基 , 人脐静脉内皮细胞完全培养基
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Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis (2024-06-28)
期刊:JOURNAL OF CONTROLLED RELEASE
DOI:10.1016/j.jconrel.2024.06.047
影响因子 :10.5
引用产品: ARPE-19 细胞 , HMC3细胞专用培养基 , HMC3 细胞
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Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies (2024-07-11)
期刊:Cell Communication and Signaling
DOI:10.1186/s12964-024-01710-x
影响因子 :8.2
引用产品: ARPE-19 细胞
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AI-driven determination of active compounds and investigation of multi-pharmacological effects of Chrysanthemi Flos (2024-08-13)
期刊:COMPUTERS IN BIOLOGY AND MEDICINE
DOI:10.1016/j.compbiomed.2024.108985
影响因子 :7.0
引用产品: RAW 264.7 细胞 , ARPE-19 细胞 , Hep G2 细胞
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Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration (2024-03-25)
期刊:Molecular Therapy-Nucleic Acids
DOI:10.1016/j.omtn.2024.102176
影响因子 :6.5
引用产品: 293T [HEK-293T] 细胞 , ARPE-19 细胞
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Overexpressed Poldip2 incurs retinal fibrosis via the TGFβ1/SMAD3 signaling pathway in diabetic retinopathy (2024-07-05)
期刊:DIABETES
影响因子 :6.2
引用产品: DMEM/F12 培养基 , ARPE-19 细胞
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Triptonide protects retinal cells from oxidative damage via activation of Nrf2 signaling (2024-07-08)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
影响因子 :5.7
引用产品: ARPE-19 细胞
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Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells (2024-10-01)
期刊:INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子 :5.0
引用产品: DMEM高糖 培养基 , 小鼠视网膜Muller细胞 , DMEM/F12 培养基 , ARPE-19 细胞 , BV2 (DMEM) 细胞
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Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection (2024-06-21)
期刊:ANTIVIRAL RESEARCH
DOI:10.1016/j.antiviral.2024.105936
影响因子 :4.5
引用产品: ARPE-19 细胞 , Hacat 细胞 , VERO C1008 [Vero E6] 细胞
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The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis (2024-07-02)
期刊:CELLULAR SIGNALLING
DOI:10.1016/j.cellsig.2024.111283
影响因子 :4.4
引用产品: ARPE-19 细胞 , D-葡萄糖溶液(200 g/L) , 293T [HEK-293T] 细胞
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells (2024-05-14)
期刊:Human Cell
DOI:10.1007/s13577-024-01075-w
影响因子 :4.3
引用产品: ARPE-19 细胞
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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina (2024-03-15)
期刊:World Journal of Diabetes
影响因子 :4.2
引用产品: ARPE-19 细胞 , DMEM高糖 培养基
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YTHDF1-regulated ALOX5 in retinal pigment epithelial cells under hypoxia enhances VEGF expression and promotes viability, migration, and angiogenesis of vascular endothelial cells (2024-10-05)
期刊:Scientific Reports
DOI:10.1038/s41598-024-72388-x
影响因子 :3.8
引用产品: ARPE-19 细胞 , DMEM/F12 培养基
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Tropisetron attenuates high glucose-induced oxidative stress and inflammation in ARPE-19 cells in vitro via regulating SIRT1/ROCK1 signaling (2024-10-09)
期刊:DRUG DEVELOPMENT RESEARCH
影响因子 :3.5
引用产品: ARPE-19 细胞
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Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: implications for proliferative vitreoretinopathy (2024-10-11)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e39333
影响因子 :3.4
引用产品: ARPE-19 细胞
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GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis (2024-04-16)
期刊:MICROVASCULAR RESEARCH
影响因子 :3.1
引用产品: ARPE-19 细胞
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Identification of biomarkers associated with ferroptosis in diabetic retinopathy based on WGCNA and machine learning (2024-05-28)
期刊:Frontiers in Genetics
DOI:10.3389/fgene.2024.1376771
影响因子 :2.8
引用产品: ARPE-19 细胞
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PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress (2024-10-15)
期刊:Diagnostic Pathology
DOI:10.1186/s13000-024-01556-4
影响因子 :2.4
引用产品: ARPE-19细胞专用培养基 , 293T [HEK-293T] 细胞 , ARPE-19 细胞
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Silencing the long noncoding RNA MALAT1 inhibits vitreous-induced epithelial–mesenchymal transition in RPE cells by regulating the PDGFRs/AKT axis (2024-09-04)
期刊:INTERNATIONAL OPHTHALMOLOGY
DOI:10.1007/s10792-024-03295-3
影响因子 :1.4
引用产品: ARPE-19 细胞
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Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism (2023-12-27)
期刊:Journal of Extracellular Vesicles
影响因子 :16.0
引用产品: ARPE-19 细胞
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Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma (2023-05-04)
期刊:JOURNAL OF NANOBIOTECHNOLOGY
DOI:10.1186/s12951-023-01891-6
影响因子 :10.2
引用产品: C918 细胞 , ARPE-19 细胞
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PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation (2023-01-23)
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05590-w
影响因子 :9.0
引用产品: ARPE-19 细胞
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A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection (2023-09-12)
期刊:Cell and Bioscience
DOI:10.1186/s13578-023-01108-1
影响因子 :7.5
引用产品: ARPE-19 细胞 , Hacat 细胞
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Development of Uveal Melanoma-Specific Aptamer for Potential Biomarker Discovery and Targeted Drug Delivery (2023-02-22)
期刊:ANALYTICAL CHEMISTRY
DOI:10.1021/acs.analchem.3c00005
影响因子 :7.4
引用产品: C918 细胞 , ARPE-19 细胞
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Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data (2023-01-30)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1099071
影响因子 :7.3
引用产品: ARPE-19 细胞 , C918 细胞
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Efficiency co-delivery of ellagic acid and oxygen by a non-invasive liposome for ameliorating diabetic retinopathy (2023-05-18)
期刊:INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI:10.1016/j.ijpharm.2023.122987
影响因子 :5.8
引用产品: ARPE-19 细胞 , 人脐静脉内皮细胞 , 293T [HEK-293T] 细胞
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ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization (2023-10-24)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.6
引用产品: ARPE-19 细胞 , THP-1 细胞
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Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid (2023-09-01)
期刊:INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子 :4.4
引用产品: ARPE-19 细胞
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Integrated network pharmacology and experimental validation to explore the potential pharmacological mechanism of Qihuang Granule and its main ingredients in regulating ferroptosis in AMD (2023-11-21)
期刊:BMC Complementary Medicine and Therapies
DOI:10.1186/s12906-023-04205-3
影响因子 :3.9
引用产品: ARPE-19 细胞
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Exome sequencing reveals PPEF2 variant associated with high myopia (2023-12-16)
期刊:GENE
DOI:10.1016/j.gene.2023.148091
影响因子 :3.5
引用产品: 293T [HEK-293T] 细胞 , ARPE-19 细胞
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Acteoside inhibits high glucose-induced oxidative stress injury in RPE cells and the outer retina through the Keap1/Nrf2/ARE pathway (2023-05-31)
期刊:EXPERIMENTAL EYE RESEARCH
DOI:10.1016/j.exer.2023.109496
影响因子 :3.4
引用产品: ARPE-19 细胞
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Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway (2023-10-26)
期刊:CURRENT EYE RESEARCH
DOI:10.1080/02713683.2023.2276683
影响因子 :2.0
引用产品: ARPE-19 细胞 , BV2 细胞 , DMEM高糖 培养基
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All-trans retinoic acid regulates the expression of MMP-2 and TGF-β2 via RDH5 in retinal pigment epithelium cells (2023-06-18)
期刊:International Journal of Ophthalmology
影响因子 :1.4
引用产品: ARPE-19 细胞
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Inhibition of chaetocin on retinoblastoma progression by modulating the miR-124/SBK1 axis (2023-12-01)
期刊:Materials Express
影响因子 :0.7
引用产品: WERI-Rb-1 细胞 , ARPE-19 细胞
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Fundus-Vascular Responses to Color Deviation Caused by Non-Oxidative Blue Filtering (2022-10-12)
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :7.3
引用产品: ARPE-19 细胞
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Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2 (2022-03-18)
期刊:Bioengineered
DOI:10.1080/21655979.2022.2049471
影响因子 :4.9
引用产品: ARPE-19 细胞
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Long non?coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment (2022-03-21)
期刊:Molecular Medicine Reports
影响因子 :3.4
引用产品: ARPE-19 细胞
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GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells (2022-03-29)
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :0.0
引用产品: WERI-Rb-1 细胞 , ARPE-19 细胞
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MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells (2021-07-15)
期刊:Cell Death & Disease
DOI:10.1038/s41419-021-03956-6
影响因子 :9.0
引用产品: ARPE-19 细胞 , 293T [HEK-293T] 细胞
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Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization (2021-05-06)
期刊:Life Sciences
影响因子 :6.8
引用产品: BV2 细胞 , ARPE-19 细胞 , DMEM/F12 培养基
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Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway (2021-11-25)
期刊:Current Eye Research
DOI:10.1080/02713683.2021.1925697
影响因子 :2.0
引用产品: ARPE-19 细胞
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Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells (2021-06-18)
期刊:International Journal of Ophthalmology
影响因子 :1.4
引用产品: ARPE-19 细胞
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Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo (2020-11-27)
期刊:Cell Stress & Chaperones
DOI:10.1007/s12192-020-01182-1
影响因子 :3.8
引用产品: DMEM/F12 培养基 , ARPE-19 细胞
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Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells (2019-04-18)
期刊:International Journal of Ophthalmology
影响因子 :1.4
引用产品: ARPE-19 细胞
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Aligned Nanofibers from Polypyrrole/Graphene as Electrodes for Regeneration of Optic Nerve via Electrical Stimulation (2016-03-09)
期刊:ACS Applied Materials & Interfaces
影响因子 :9.5
引用产品: ARPE-19 细胞
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