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产品概述
| 名称 | ARPE-19 (人视网膜上皮细胞) (STR鉴定正确) |
| 别称 | ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:5 |
| 推荐换液频率 | 2-3次/周 |
| 年龄（性别） | 男性；19岁 |
| 组织来源 | 眼睛，视网膜 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~55-65 hours |
| 基因表达情况 | RPE-specific markers CRALBP and RPE-65 |
| 保藏机构 | ATCC; CRL-2302 BCRC; 60383 BCRJ; 0041 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11 D2S1338 19 D3S1358 14,15 D5S818 13 D7S820 9,11 D8S1179 13 D13S317 11,12 D16S539 9,11 D18S51 12,16 D19S433 12,13 D21S11 28,29 FGA 23 PentaD 11,13 PentaE 7,11 TH01 6,9.3 TPOX 9,11 vWA 16,19 D6S1043 17,19 D12S391 21,22 D2S441 10,15 -
STR鉴定图
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参考文献
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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina (2024-03-15)
期刊：World Journal of Diabetes
影响因子 ：4.2
引用产品： ARPE-19 细胞 , DMEM高糖 培养基
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Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism (2023-12-27)
期刊：Journal of Extracellular Vesicles
影响因子 ：16.0
引用产品： ARPE-19 细胞
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Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma (2023-05-04)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01891-6
影响因子 ：10.2
引用产品： C918 细胞 , ARPE-19 细胞
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PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation (2023-01-23)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05590-w
影响因子 ：9.0
引用产品： ARPE-19 细胞
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Development of Uveal Melanoma-Specific Aptamer for Potential Biomarker Discovery and Targeted Drug Delivery (2023-02-22)
期刊：ANALYTICAL CHEMISTRY
DOI：10.1021/acs.analchem.3c00005
影响因子 ：7.4
引用产品： C918 细胞 , ARPE-19 细胞
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Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data (2023-01-30)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1099071
影响因子 ：7.3
引用产品： ARPE-19 细胞 , C918 细胞
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Efficiency co-delivery of ellagic acid and oxygen by a non-invasive liposome for ameliorating diabetic retinopathy (2023-05-18)
期刊：INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI：10.1016/j.ijpharm.2023.122987
影响因子 ：5.8
引用产品： ARPE-19 细胞 , 人脐静脉内皮细胞 , 293T [HEK-293T] 细胞
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ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization (2023-10-24)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： ARPE-19 细胞 , THP-1 细胞
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Acteoside inhibits high glucose-induced oxidative stress injury in RPE cells and the outer retina through the Keap1/Nrf2/ARE pathway (2023-05-31)
期刊：EXPERIMENTAL EYE RESEARCH
DOI：10.1016/j.exer.2023.109496
影响因子 ：3.4
引用产品： ARPE-19 细胞
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Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway (2023-10-26)
期刊：CURRENT EYE RESEARCH
DOI：10.1080/02713683.2023.2276683
影响因子 ：2.0
引用产品： ARPE-19 细胞 , BV2 细胞 , DMEM高糖 培养基
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All-trans retinoic acid regulates the expression of MMP-2 and TGF-β2 via RDH5 in retinal pigment epithelium cells (2023-06-18)
期刊：International Journal of Ophthalmology
影响因子 ：1.4
引用产品： ARPE-19 细胞
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Fundus-Vascular Responses to Color Deviation Caused by Non-Oxidative Blue Filtering (2022-10-12)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3
引用产品： ARPE-19 细胞
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Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2 (2003-02-20)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2049471
影响因子 ：4.9
引用产品： ARPE-19 细胞
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Long non‑coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment (2003-02-20)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： ARPE-19 细胞
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GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells (2003-02-20)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.0
引用产品： WERI-Rb-1 细胞 , ARPE-19 细胞
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MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells (2007-01-20)
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03956-6
影响因子 ：9.0
引用产品： ARPE-19 细胞 , 293T [HEK-293T] 细胞
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Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization (2005-01-20)
期刊：Life Sciences
影响因子 ：6.8
引用产品： BV2 细胞 , ARPE-19 细胞 , DMEM/F12 培养基
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Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway (2011-01-20)
期刊：Current Eye Research
DOI：10.1080/02713683.2021.1925697
影响因子 ：2.0
引用产品： ARPE-19 细胞
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Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells (2006-01-20)
期刊：International Journal of Ophthalmology
影响因子 ：1.4
引用产品： ARPE-19 细胞
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Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo (2011-00-20)
期刊：Cell Stress & Chaperones
DOI：10.1007/s12192-020-01182-1
影响因子 ：3.8
引用产品： DMEM/F12 培养基 , ARPE-19 细胞
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Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells (2004-09-20)
期刊：International Journal of Ophthalmology
影响因子 ：1.4
引用产品： ARPE-19 细胞
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Aligned Nanofibers from Polypyrrole/Graphene as Electrodes for Regeneration of Optic Nerve via Electrical Stimulation (2003-06-20)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： ARPE-19 细胞
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