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产品概述
名称 | HOS (人骨肉瘤细胞)(STR鉴定正确) |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 成纤维细胞、上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | HOS细胞是从一名13岁的白人女性的骨肉瘤组织中分离建立的;HOS细胞表现为扁平形态、低饱和密度、软琼脂中的低克隆形成率和对化合物及病毒感染的敏感性。 |
年龄(性别) | 女性;13岁 |
组织来源 | 骨;骨肉瘤 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肉瘤细胞 |
生物安全等级 | BSL-1 |
保藏机构 | ATCC; CRL-1543 ECACC; 87070202 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 24,25 D3S1358 15 D5S818 13 D7S820 11,12 D8S1179 14 D13S317 12 D16S539 10,13 D18S51 14 D19S433 13 D21S11 31.2,32.2 FGA 24 PentaD 9,10 PentaE 7,12 TH01 6 TPOX 8,11 vWA 18 D6S1043 18 D12S391 20 D2S441 10 -
STR鉴定图
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参考文献
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DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis (2025-01-01)
期刊:International Journal of Biological Sciences
影响因子 :8.2
引用产品: U-2 OS [U2OS] 细胞 , MG-63 细胞 , HOS 细胞
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A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma (2025-01-27)
期刊:Frontiers in Pharmacology
DOI:10.3389/fphar.2024.1532610
影响因子 :4.4
引用产品: HOS 细胞 , U-2 OS [U2OS] 细胞 , DMEM无糖 培养基 , MEM(含NEAA) 培养基 , McCoy's 5A 培养基
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Exosome-Delivered Hsa_Circ_0000116 Facilitates Osteosarcoma Cell Malignancy via PI3K/Akt/mTOR and p38/MAPK Pathways (2025-01-08)
期刊:DNA AND CELL BIOLOGY
影响因子 :2.6
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Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway (2024-02-01)
期刊:International Journal of Nanomedicine
影响因子 :8.0
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Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression (2024-02-15)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2024.155459
影响因子 :7.9
引用产品: HOS 细胞 , K7M2 wt [K7M2-WT] 细胞 , DMEM高糖 培养基
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Ziyuglycoside II, a triterpene glycoside compound in Sanguisorbae officinalis L. extract, suppresses metastasis in osteosarcoma via CBX4-mediated Wnt/β-catenin signal pathway (2024-05-09)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2024.155716
影响因子 :7.9
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Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma (2024-01-05)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1280945
影响因子 :7.3
引用产品: hFOB 1.19 细胞 , HOS 细胞 , Saos-2 细胞 , 143B 细胞
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Deubiquitinase USP10 promotes osteosarcoma autophagy and progression through regulating GSK3β-ULK1 axis (2024-09-02)
期刊:Cell and Bioscience
DOI:10.1186/s13578-024-01291-9
影响因子 :6.1
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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance (2024-01-13)
期刊:Cancer Cell International
DOI:10.1186/s12935-024-03216-5
影响因子 :5.8
引用产品: McCoy's 5A 培养基 , DMEM高糖 培养基 , U-2 OS [U2OS] 细胞 , HOS 细胞
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A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma (2024-11-06)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2024.1467052
影响因子 :5.7
引用产品: hFOB 1.19 细胞 , HOS 细胞 , 143B 细胞
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Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation (2024-04-24)
期刊:Frontiers in Pharmacology
DOI:10.3389/fphar.2024.1399625
影响因子 :5.6
引用产品: MG-63 细胞 , hFOB 1.19 细胞 , HOS 细胞 , U-2 OS [U2OS] 细胞
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Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416 (2024-04-20)
期刊:Marine Drugs
影响因子 :5.4
引用产品: K-562 [K562] 细胞 , TE-1 细胞 , HOS 细胞 , GBC-SD 细胞 , PaTu 8988t 细胞 , DU 145 细胞 , 293T [HEK-293T] 细胞 , SF126 细胞 , MCF7 [MCF-7] 细胞 , HCT 116 细胞 , Hela 细胞 , A549 [A-549] 细胞 , Hep G2 细胞 , A-375 细胞 , MKN-45 细胞 , 5637 细胞 , 786-O [786-0] 细胞 , CAL-62 细胞 , A-673 细胞 , HL-7702 [L-02; LO2] 细胞
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The expression and clinical significance of ARHGAP25 in osteosarcoma based on bioinformatics analysis (2024-08-12)
期刊:Scientific Reports
DOI:10.1038/s41598-024-68318-6
影响因子 :3.8
引用产品: MG-63 细胞 , HOS 细胞 , hFOB 1.19 细胞
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A GAD1 inhibitor suppresses osteosarcoma growth through the Wnt/β-catenin signaling pathway (2024-05-17)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e31444
影响因子 :3.4
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WTAP-mediated m6A modification of circ_0032463 promotes osteosarcoma progression by sponging miR-145-5p and regulating GFRA1 expression (2024-09-07)
期刊:JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 :3.2
引用产品: HOS 细胞 , hFOB 1.19 细胞 , U-2 OS [U2OS]细胞专用培养基 , 人脐静脉内皮细胞 , U-2 OS [U2OS] 细胞 , HOS细胞专用培养基
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Distinct Gene Expression and Immune Features Between Different Neutrophil Extracellular Trap-Related Osteosarcoma Subtypes (2024-08-03)
期刊:APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI:10.1007/s12010-024-05021-2
影响因子 :3.1
引用产品: MEM(含NEAA) 培养基 , 特级胎牛血清 , U-2 OS [U2OS] 细胞 , McCoy's 5A 培养基 , HOS 细胞
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Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma (2024-02-27)
期刊:Cancer Biomarkers
影响因子 :2.2
引用产品: hFOB 1.19 细胞 , HOS 细胞 , Saos-2 细胞 , 特级胎牛血清 , McCoy's 5A 培养基 , DMEM高糖 培养基 , Leibovitz's L-15 培养基
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MiR-150-5p inhibits cell proliferation and metastasis by targeting FTO in osteosarcoma (2024-10-16)
期刊:ONCOLOGY RESEARCH
影响因子 :2.0
引用产品: MG-63 细胞 , HOS 细胞 , Saos-2 细胞 , U-2 OS [U2OS] 细胞 , hFOB 1.19 细胞
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Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy (2024-02-07)
期刊:Natural Product Communications
影响因子 :1.8
引用产品: HOS 细胞 , 143B 细胞
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MFAP2 induces epithelial-mesenchymal transformation of osteosarcoma cells by activating the Notch1 pathway (2024-06-27)
期刊:Translational Cancer Research
影响因子 :1.5
引用产品: U-2 OS [U2OS] 细胞 , HOS 细胞 , hFOB 1.19 细胞 , MG-63 细胞
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Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction (2023-12-15)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1265098
影响因子 :7.3
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A novel molecular signature for predicting prognosis and immunotherapy response in osteosarcoma based on tumor-infiltrating cell marker genes (2023-04-06)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1150588
影响因子 :7.3
引用产品: 143B 细胞 , HOS 细胞
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function (2023-10-03)
期刊:EXPERT OPINION ON THERAPEUTIC TARGETS
DOI:10.1080/14728222.2023.2263908
影响因子 :5.8
引用产品: U-2 OS [U2OS] 细胞 , Saos-2 细胞 , MG-63 细胞 , HOS 细胞 , SJSA-1 细胞 , hFOB 1.19 细胞 , McCoy's 5A 培养基 , MEM 培养基 , RPMI-1640 培养基 , DMEM/F12 培养基
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Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma (2023-06-28)
期刊:AMERICAN JOURNAL OF CHINESE MEDICINE
影响因子 :5.7
引用产品: HOS 细胞 , U-2 OS [U2OS] 细胞
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Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma (2023-01-09)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2023.109684
影响因子 :5.6
引用产品: HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling (2023-08-15)
期刊:American Journal of Cancer Research
DOI:PMID:37693131
影响因子 :5.3
引用产品: HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞 , 293T [HEK-293T] 细胞 , MG-63 细胞
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling (2023-06-15)
期刊:American Journal of Cancer Research
DOI:PMID:37424831
影响因子 :5.3
引用产品: hFOB 1.19 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , Saos-2 细胞 , MG-63 细胞
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HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway (2023-07-30)
期刊:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
DOI:10.1016/j.bbamcr.2023.119553
影响因子 :5.1
引用产品: HOS 细胞 , Saos-2 细胞 , SW 1353 细胞 , McCoy's 5A 培养基
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Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment (2023-06-08)
期刊:Frontiers in Oncology
影响因子 :4.7
引用产品: MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , K7M2 wt [K7M2-WT] 细胞 , RAW 264.7 细胞
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WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner (2023-03-29)
期刊:ENVIRONMENTAL TOXICOLOGY
影响因子 :4.5
引用产品: DMEM/F12 培养基 , 特级胎牛血清 , MEM 培养基 , hFOB 1.19 细胞 , McCoy's 5A 培养基 , HOS 细胞 , U-2 OS [U2OS] 细胞 , 青霉素-链霉素溶液(双抗),100×
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hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression (2023-11-18)
期刊:CANCER BIOLOGY & THERAPY
DOI:10.1080/15384047.2023.2274120
影响因子 :3.6
引用产品: hFOB 1.19 细胞 , HOS 细胞 , Saos-2 细胞 , SW 1353 细胞 , Leibovitz's L-15 培养基 , McCoy's 5A完全培养基 (含10%FBS) , MEM 培养基 , DMEM/F12 培养基 , 青霉素-链霉素溶液 (双抗),100× , 特级胎牛血清
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Comprehensive landscape of TGFβ-related signature in osteosarcoma for predicting prognosis, immune characteristics, and therapeutic response (2023-05-12)
期刊:Journal of Bone Oncology
影响因子 :3.4
引用产品: HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression (2023-02-21)
期刊:CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 :2.9
引用产品: HOS 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , 青霉素-链霉素溶液 (双抗),100× , hFOB 1.19 细胞
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Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells (2023-02-28)
期刊:Oncology Letters
影响因子 :2.9
引用产品: Hela S3 细胞 , HOS 细胞 , MEM (含NEAA) 培养基
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy (2023-11-22)
期刊:Journal of Orthopaedic Surgery and Research
DOI:10.1186/s13018-023-04338-8
影响因子 :2.6
引用产品: MG-63 细胞 , HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞
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ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells (2023-11-29)
期刊:Journal of Orthopaedic Surgery and Research
DOI:10.1186/s13018-023-04406-z
影响因子 :2.6
引用产品: MG-63 细胞 , HOS 细胞 , hFOB 1.19 细胞 , MEM 培养基 , DMEM高糖 培养基 , G-418溶液 (50mg/mL)
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Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma (2022-12-23)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2022.1096009
影响因子 :8.8
引用产品: MG-63 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞 , HOS 细胞 , hFOB 1.19 细胞
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Dissecting the effect of sphingolipid metabolism gene in progression and microenvironment of osteosarcoma to develop a prognostic signature (2022-10-14)
期刊:Frontiers in Endocrinology
DOI:10.3389/fendo.2022.1030655
影响因子 :6.1
引用产品: HOS 细胞
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CKB affects human osteosarcoma progression by regulating the p53 pathway (2022-10-15)
期刊:American Journal of Cancer Research
DOI:PMID:36381321
影响因子 :5.9
引用产品: U-2 OS [U2OS] 细胞 , hFOB 1.19 细胞 , Saos-2 细胞 , HOS 细胞 , MG-63 细胞
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Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1 (2022-09-09)
期刊:Journal of Bone Oncology
影响因子 :4.5
引用产品: U-2 OS [U2OS] 细胞 , HOS 细胞 , U-2 OS [U2OS]细胞专用培养基 , HOS细胞专用培养基 , hFOB 1.19 细胞 , 青霉素-链霉素溶液 (双抗),100× , 人脐静脉内皮细胞
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Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway (2022-10-26)
期刊:DISEASE MARKERS
影响因子 :3.5
引用产品: HOS 细胞
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A New 7-Azaindole Structure Analog: Molecular Docking, Synthesis and Preliminary Biological Activity in Vitro for Anticancer (2022-09-09)
期刊:CHEMISTRY & BIODIVERSITY
影响因子 :2.8
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Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/β-catenin signaling pathway (2022-01-01)
期刊:Anti-Cancer Drugs
DOI:10.1097/CAD.0000000000001206
影响因子 :2.4
引用产品: U-2 OS [U2OS] 细胞 , HOS 细胞 , hFOB 1.19 细胞
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression (2021-08-26)
期刊:Molecular Therapy-Nucleic Acids
DOI:10.1016/j.omtn.2021.08.022
影响因子 :8.8
引用产品: Saos-2 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9 (2021-07-14)
期刊:Cancer Cell International
DOI:10.1186/s12935-021-02041-4
影响因子 :5.8
引用产品: HOS 细胞 , MG-63 细胞 , DMEM高糖完全培养基 (含10%FBS)
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circATP2A2 promotes osteosarcoma progression by upregulating MYH9 (2021-11-22)
期刊:Open Medicine
影响因子 :2.1
引用产品: U-2 OS [U2OS] 细胞 , HOS 细胞 , Saos-2 细胞 , 特级胎牛血清 , DMEM/F12 培养基 , hFOB 1.19 细胞
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells (2021-10-18)
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :0.0
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A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration (2020-06-01)
期刊:Materials Today
DOI:10.1016/j.mattod.2019.12.005
影响因子 :24.2
引用产品: MC3T3-E1 Subclone 14 细胞 , HOS 细胞
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ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p (2020-03-30)
期刊:Cancer Cell International
DOI:10.1186/s12935-020-01174-2
影响因子 :5.8
引用产品: Saos-2 细胞 , SW 1353 细胞 , HOS 细胞 , McCoy's 5A 培养基
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Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells (2020-02-21)
期刊:OncoTargets and Therapy
影响因子 :4.0
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COLEC12 regulates apoptosis of osteosarcoma through Toll-like receptor 4–activated inflammation (2020-08-21)
期刊:JOURNAL OF CLINICAL LABORATORY ANALYSIS
影响因子 :1.5
引用产品: hFOB 1.19 细胞 , MG-63 细胞 , Saos-2 细胞 , HOS 细胞
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy (2019-08-07)
期刊:Artificial Cells Nanomedicine and Biotechnology
DOI:10.1080/21691401.2019.1648280
影响因子 :5.8
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