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| 名称 | HOS (人骨肉瘤细胞)(STR鉴定正确） |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞、上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HOS细胞是从一名13岁的白人女性的骨肉瘤组织中分离建立的；HOS细胞表现为扁平形态、低饱和密度、软琼脂中的低克隆形成率和对化合物及病毒感染的敏感性。 |
| 年龄（性别） | 女性；13岁 |
| 组织来源 | 骨；骨肉瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | BSL-1 |
| 保藏机构 | ATCC; CRL-1543 ECACC; 87070202 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 24,25 D3S1358 15 D5S818 13 D7S820 11,12 D8S1179 14 D13S317 12 D16S539 10,13 D18S51 14 D19S433 13 D21S11 31.2,32.2 FGA 24 PentaD 9,10 PentaE 7,12 TH01 6 TPOX 8,11 vWA 18 D6S1043 18 D12S391 20 D2S441 10 -
STR鉴定图
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参考文献
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Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway (2024-02-01)
作者：Jiaxu Lu:1.Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; 2.Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Jiaxian Chen:1.Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Junhong Ye:1.Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Zhen Shi:1.Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Xiang Gao:1.Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Peicong Chen:1.Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People's Republic of China. ; Yanzhou Ch
期刊：Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway
影响因子 ：8.0
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Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression (2024-02-15)
作者：Zhuo Chen:1.The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China; Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, PR China. ; Feng-Feng Wu:1.Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, PR China; The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, PR China; The Affiliated Central Hospital, Huzhou University, Huzhou, Zhejiang, PR China; Huzhou Basic and Clinical Translation of Orthopaedics Key Laboratory, Huzhou, Zhejiang, PR China. ; Jing Li:1.School of Medicine, Huzhou University, Huzhou, Zhejiang, PR China. ; Jia-Bao Dong:1.The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China; Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, Zhejiang, PR China. ; Hong-Yi He:1.Schoo
期刊：Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression
DOI：10.1016/j.phymed.2024.155459
影响因子 ：7.9
引用产品： HOS 细胞 , K7M2 wt [K7M2-WT] 细胞 , DMEM高糖 培养基
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Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma (2024-01-05)
作者：Chenguang Jia:1.Department of Osteonecrosis and Hip Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. ; 2.Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, China. ; Mei Liu:1.Molecular Biology Laboratory, Hebei Chest Hospital, Shijiazhuang, China. ; Liming Yao:1.Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, China. ; Fangchao Zhao:1.Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China. ; Shuren Liu:1.Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, China. ; Zhuo Li:1.Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang, China. ; Yongtai Han:1.Department of Osteonecrosis and Hip Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. ;
期刊：Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma
DOI：10.3389/fimmu.2023.1280945
影响因子 ：7.3
引用产品： hFOB 1.19 细胞 , HOS 细胞 , Saos-2 细胞 , 143B 细胞
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What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance (2024-01-13)
作者：Jin Qi:1.Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, Anhui Province, China. ; Sihang Liu:1.Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, Anhui Province, China. ; Zhirui Zhang:1.Department of Pharmacy, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, 241001, Anhui Province, China. zhiruizhanghr@163.com. ;
期刊：What role does GPR65 play in the progression of osteosarcoma? Its mechanism and clinical significance
DOI：10.1186/s12935-024-03216-5
影响因子 ：5.8
引用产品： McCoy's 5A 培养基 , DMEM高糖 培养基 , U-2 OS [U2OS] 细胞 , HOS 细胞
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Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy (2024-02-07)
作者：Department of Orthopaedics, General Hospital of Ningxia Medical University, Yinchuan, China
期刊：Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy
影响因子 ：1.8
引用产品： HOS 细胞 , 143B 细胞
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Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction (2023-12-15)
作者：Junchao Zhu:1.Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ; Jinghong Yuan:1.Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ; Shahrzad Arya:1.Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. ; Zhi Du:1.Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ; Xijuan Liu:1.Department of Pediatrics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ; Jingyu Jia:1.Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ;
期刊：Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction
DOI：10.3389/fimmu.2023.1265098
影响因子 ：7.3
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A novel molecular signature for predicting prognosis and immunotherapy response in osteosarcoma based on tumor-infiltrating cell marker genes (2023-04-06)
作者：Haijun Tang:1.Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Shangyu Liu:1.Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Xiaoting Luo:1.Department of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Yu Sun:1.Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Xiangde Li:1.Department of Radiotherapy, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Kai Luo:1.Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Shijie Liao:1.Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. ; Feicui Li:1.Department of Sp
期刊：A novel molecular signature for predicting prognosis and immunotherapy response in osteosarcoma based on tumor-infiltrating cell marker genes
DOI：10.3389/fimmu.2023.1150588
影响因子 ：7.3
引用产品： 143B 细胞 , HOS 细胞
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function (2023-10-03)
作者：Xiuxin Han:1.Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin, China. ; Mengfan Yin:1.Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of Cancer, Tianjin, China. ; 2.Department of Orthopedic Surgery, Tianjin Fifth Central Hospital, Tianjin, China. ; Chen Gong:1.General Clinical Research Center, Anhui Wanbei Coal-Electricity Group General Hospital, Suzhou, Anhui, China. ; Chao Zhang:1.Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center of
期刊：A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function
DOI：10.1080/14728222.2023.2263908
影响因子 ：5.8
引用产品： U-2 OS [U2OS] 细胞 , Saos-2 细胞 , MG-63 细胞 , HOS 细胞 , SJSA-1 细胞 , hFOB 1.19 细胞 , McCoy's 5A 培养基 , MEM 培养基 , RPMI-1640 培养基 , DMEM/F12 培养基
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Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma (2023-06-28)
作者：Bangjun Wang:1.Department of Emergency, Xiangyang Central Hospital of Hubei University of Arts and Science, Hubei, Xiangyang 441021, P. R. China. ; Yi Zhou:1.Department of Emergency, Xiangyang Central Hospital of Hubei University of Arts and Science, Hubei, Xiangyang 441021, P. R. China. ; Peng Zhang:1.Department of Emergency, Xiangyang Central Hospital of Hubei University of Arts and Science, Hubei, Xiangyang 441021, P. R. China. ; Jun Li:1.Department of Emergency, Xiangyang Central Hospital of Hubei University of Arts and Science, Hubei, Xiangyang 441021, P. R. China. ; Xinyan Lu:1.Department of Emergency, Xiangyang Central Hospital of Hubei University of Arts and Science, Hubei, Xiangyang 441021, P. R. China. ;
期刊：Solasonine Inhibits Cancer Stemness and Metastasis by Modulating Glucose Metabolism via Wnt/β-Catenin/Snail Pathway in Osteosarcoma
影响因子 ：5.7
引用产品： HOS 细胞 , U-2 OS [U2OS] 细胞
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Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma (2023-01-09)
作者：Zhao Zhang:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Zhijie Zhu:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Jun Fu:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Xincheng Liu:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Zhenzhou Mi:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Huiren Tao:1.Department of Orthopaedics, Shenzhen University General Hospital, Shenzhen 518052, China. ; Hongbin Fan:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: fanhb@fmmu.edu.cn. ;
期刊：Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma
DOI：10.1016/j.intimp.2023.109684
影响因子 ：5.6
引用产品： HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling (2023-08-15)
作者：Xinrui Wang:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Zige Jin:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Shanshan Tang:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Xiyu Huang:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Shanshan Wang:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Xiaohe Ren:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ; Mafei Xu:1.Department of Cell Biology, School of Life Sciences, Anhui Medical University Hefei 230032, Anhui, China. ;
期刊：ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling
DOI：PMID:37693131
影响因子 ：5.3
引用产品： HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞 , 293T [HEK-293T] 细胞 , MG-63 细胞
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling (2023-06-15)
作者：Rujin Xu:1.Laboratory Department, Hangzhou Linping First People's Hospital Hangzhou 311400, Zhejiang, P. R. China. ; Xingyuan Ci:1.Laboratory Department, Hangzhou Linping First People's Hospital Hangzhou 311400, Zhejiang, P. R. China. ; Fang He:1.Laboratory Department, Hangzhou Linping First People's Hospital Hangzhou 311400, Zhejiang, P. R. China. ; Yueqin Chen:1.Laboratory Department, Hangzhou Linping First People's Hospital Hangzhou 311400, Zhejiang, P. R. China. ;
期刊：Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling
DOI：PMID:37424831
影响因子 ：5.3
引用产品： hFOB 1.19 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , Saos-2 细胞 , MG-63 细胞
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HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway (2023-07-30)
作者：Ziyuan Tong:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, People's Republic of China. ; Yuan Shen:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, People's Republic of China. ; Quan Yuan:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, People's Republic of China. ; Honghao Yu:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, People's Republic of China. Electronic address: yhhspine2022@163.com. ;
期刊：HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway
DOI：10.1016/j.bbamcr.2023.119553
影响因子 ：5.1
引用产品： HOS 细胞 , Saos-2 细胞 , SW 1353 细胞 , McCoy's 5A 培养基
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Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment (2023-06-08)
作者：Song Liao:1.Medical School of Chinese PLA, Beijing, China. ; 2.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Jianxiong Li:1.Medical School of Chinese PLA, Beijing, China. ; 2.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Song Gao:1.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Yuchen Han:1.Medical School of Chinese PLA, Beijing, China. ; 2.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Xinli Han:1.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Yanan Wu:1.Medical School of Chinese PLA, Beijing, China. ; 2.Senior Department of Orthopedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. ; Jingyou Bi:1.Medical School of Chinese PLA, Beijing, China. ;
期刊：Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment
影响因子 ：4.7
引用产品： MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , K7M2 wt [K7M2-WT] 细胞 , RAW 264.7 细胞
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hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression (2023-11-18)
作者：Liang Liu:1.Department of Spinal Surgery, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei, China. ; 2.Department of molecular therapy of cancer, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, Hubei, China. ; Wenze Huang:1.Department of Spinal Surgery, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei, China. ; 2.Department of molecular therapy of cancer, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, Hubei, China. ;
期刊：hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression
DOI：10.1080/15384047.2023.2274120
影响因子 ：3.6
引用产品： hFOB 1.19 细胞 , HOS 细胞 , Saos-2 细胞 , SW 1353 细胞 , Leibovitz's L-15 培养基 , McCoy's 5A完全培养基 (含10%FBS） , MEM 培养基 , DMEM/F12 培养基 , 青霉素-链霉素溶液 (双抗)，100× , 特级胎牛血清
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Comprehensive landscape of TGFβ-related signature in osteosarcoma for predicting prognosis, immune characteristics, and therapeutic response (2023-05-12)
作者：Dong Liu:1.Department of Orthopaedic Surgery, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Ye Peng:1.Department of Orthopaedics, Air Force Medical Center, PLA, Beijing 100142, China. ; Xian Li:1.Department of Orthopaedics, Shenzhen University General Hospital, Shenzhen, China. ; Zhijie Zhu:1.Department of Orthopaedic Surgery, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Zhenzhou Mi:1.Department of Orthopaedic Surgery, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Zhao Zhang:1.Department of Orthopaedic Surgery, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ; Hongbin Fan:1.Department of Orthopaedic Surgery, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China. ;
期刊：Comprehensive landscape of TGFβ-related signature in osteosarcoma for predicting prognosis, immune characteristics, and therapeutic response
影响因子 ：3.4
引用产品： HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression (2023-02-21)
作者：Dawei Wang:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ; Yang Wang:1.Sanya Central Hospital (Hainan Third People's Hospital), Sanya, China. ; Huadong Wang:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ; Yafeng Yang:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ; Li Li:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ; Yihao Liu:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ; Xin Yin:1.Department of Orthopedics, The Fourth Medical Center of PLA General Hospital, Beijing, China. ;
期刊：Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression
影响因子 ：2.9
引用产品： HOS 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , 青霉素-链霉素溶液 (双抗)，100× , hFOB 1.19 细胞
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Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells (2023-02-28)
作者：Lijuan Wang:1.Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China. ; Zhigang Chen:1.ABLife BioBigData Institute, Wuhan, Hubei 430075, P.R. China. ; Dong Chen:1.ABLife BioBigData Institute, Wuhan, Hubei 430075, P.R. China. ; Bo Kan:1.Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China. ; Yangfang He:1.Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China. ; Hanqing Cai:1.Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China. ;
期刊：Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells
影响因子 ：2.9
引用产品： Hela S3 细胞 , HOS 细胞 , MEM (含NEAA) 培养基
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy (2023-11-22)
作者：Chenyang Meng:1.Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. ; Yun Yang:1.Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. ; Wei Feng:1.Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. ; Penglei Ma:1.Department of Anesthesiology, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. 39818135@qq.com. ; Rui Bai:1.Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. bairuiandaiqing@126.com. ;
期刊：Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy
DOI：10.1186/s13018-023-04338-8
影响因子 ：2.6
引用产品： MG-63 细胞 , HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞
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ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells (2023-11-29)
作者：Shizhe Li:1.Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China. ; 2.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Jiancheng Xue:1.Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; He Zhang:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Guanning Shang:1.Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. cmushanggn@126.com. ;
期刊：ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells
DOI：10.1186/s13018-023-04406-z
影响因子 ：2.6
引用产品： MG-63 细胞 , HOS 细胞 , hFOB 1.19 细胞 , MEM 培养基 , DMEM高糖 培养基 , G-418溶液 (50mg/mL)
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Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1 (2022-09-09)
作者：Gang Xu:1.Department of Bone and Soft-Tissue Tumor, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China. ; Haijiao Zhang:1.The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. ; Yuxia Shi:1.Department of Bone and Soft-Tissue Tumor, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China. ; Fan Yang:1.Department of Bone and Soft-Tissue Tumor, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China. ;
期刊：Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1
影响因子 ：4.5
引用产品： U-2 OS [U2OS] 细胞 , HOS 细胞 , U-2 OS [U2OS]细胞专用培养基 , HOS细胞专用培养基 , hFOB 1.19 细胞 , 青霉素-链霉素溶液 (双抗)，100× , 人脐静脉内皮细胞
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Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway (2022-10-26)
作者：Peng Sun:1.Joint Surgery, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430081 Hubei, China. ; Xuan Yang:1.Joint Surgery, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, 430081 Hubei, China. ;
期刊：Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway
影响因子 ：3.5
引用产品： HOS 细胞
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A New 7-Azaindole Structure Analog: Molecular Docking, Synthesis and Preliminary Biological Activity in Vitro for Anticancer (2022-09-09)
作者：Yifeng Zhan:1.Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), 430068, Wuhan, China. ; 2.Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, 430068, Wuhan, China. ; Hang Tong:1.Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), 430068, Wuhan, China. ; 2.Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, 430068, Wuhan, China. ; Shibo He:1.Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), 430068, Wuhan, China. ; 2.Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, 430068, Wuhan, China. ; Hongda Zhu:1.Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), 430068, Wuhan, China. ; 2.National "111" Center for Cellular Regulation and Molecular Pharmaceutics, 430068, Wuhan, China. ; 3.Key Laboratory of Fermentation
期刊：A New 7-Azaindole Structure Analog: Molecular Docking, Synthesis and Preliminary Biological Activity in Vitro for Anticancer
影响因子 ：2.7
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Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/β-catenin signaling pathway (2001-02-20)
作者：Zheng Zhou:1.Department Of Orthopedics, The Second Xiangya Hospital Of Central South University, China. ; Tang Liu: Zhihong Li: Lu Wang:
期刊：Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/β-catenin signaling pathway
DOI：10.1097/CAD.0000000000001206
影响因子 ：2.4
引用产品： U-2 OS [U2OS] 细胞 , HOS 细胞 , hFOB 1.19 细胞
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression (2008-01-20)
作者：Lei Ding:1.Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Taiyuan Liu:1.Department of Breast Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; 2.Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning, China. ; Yuan Qu:1.Department of Spine Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Zhichen Kang:1.Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Lixin Guo:1.Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Haina Zhang:1.Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Junjie Jiang:1.Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin, China. ; Fuling Qu:1.Department of Rehabilitation,
期刊：lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：8.8
引用产品： Saos-2 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9 (2007-01-20)
作者：Weihang Li:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China. ; Ziyi Ding:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China. ; Dong Wang:1.Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China. ; Chengfei Li:1.School of Aerospace Medicine, Fourth Military Medical University, 169 Chang Le Xi Road, Xi'an, 710032, Shaanxi, China. ; Yikai Pan:1.School of Aerospace Medicine, Fourth Military Medical University, 169 Chang Le Xi Road, Xi'an, 710032, Shaanxi, China. ; Yingjing Zhao:1.Department of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, Jiangsu, China. ; Hongzhe Zhao:1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Re
期刊：Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9
DOI：10.1186/s12935-021-02041-4
影响因子 ：5.8
引用产品： HOS 细胞 , MG-63 细胞 , DMEM高糖完全培养基 (含10%FBS)
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circATP2A2 promotes osteosarcoma progression by upregulating MYH9 (2011-01-20)
作者：Xin Cao:1.Department of Trauma and Orthopaedics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ; Xianfeng Meng:1.Department of Trauma and Orthopaedics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ; Peng Fu:1.Department of Trauma and Orthopaedics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ; Lin Wu:1.Department of Trauma and Orthopaedics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ; Zhen Yang:1.Department of Trauma and Orthopaedics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ; Huijin Chen:1.Department of Clinical Laboratory, Shengli Oilfield Central Hospital, No. 31, Jinan Road, Dongying, 257000, Shandong, China. ;
期刊：circATP2A2 promotes osteosarcoma progression by upregulating MYH9
影响因子 ：2.1
引用产品： U-2 OS [U2OS] 细胞 , HOS 细胞 , Saos-2 细胞 , 特级胎牛血清 , DMEM/F12 培养基 , hFOB 1.19 细胞
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells (2010-01-20)
作者：Yi Luo:1.Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. ; 2.Department of Pain Medicine, Bishan Hospital of Chongqing, Chongqing 402760, China. ; Xu Gao:1.Department of Ophthalmology, Bishan Hospital of Chongqing, Chongqing 402760, China. ; Luetao Zou:1.Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. ; Miao Lei:1.Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. ; Junming Feng:1.Department of Pathology, Bishan Hospital of Chongqing, Chongqing 402760, China. ; Zhenming Hu:1.Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. ;
期刊：Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells
影响因子 ：0.0
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A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration (2006-00-20)
作者：Liang Ma: 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Xiaobo Feng: 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hang Liang: 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Kun Wang: 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Yu Song: 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Lei Tan: 1.Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China; Bingjin Wang: 1.
期刊：A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration
DOI：10.1016/j.mattod.2019.12.005
影响因子 ：24.2
引用产品： MC3T3-E1 Subclone 14 细胞 , HOS 细胞
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ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p (2003-00-20)
作者：Quan Yuan:1.1Department of Orthopedics, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004 People's Republic of China. ; Honghao Yu:1.1Department of Orthopedics, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004 People's Republic of China. ; Jianhua Chen:1.1Department of Orthopedics, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004 People's Republic of China. ; Xiaoyu Song:1.2Institute of Translational Medicine, China Medical University, Shenyang, 110122 People's Republic of China. ; Li Sun:1.3Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001 People's Republic of China. ;
期刊：ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p
DOI：10.1186/s12935-020-01174-2
影响因子 ：5.8
引用产品： Saos-2 细胞 , SW 1353 细胞 , HOS 细胞 , McCoy's 5A 培养基
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Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells (2002-00-20)
作者：Quan Yuan:1.Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. ; Honghao Yu:1.Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. ; Jianhua Chen:1.Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. ; Xiaoyu Song:1.Institute of Translational Medicine, China Medical University, Shenyang 110122, People's Republic of China. ; Li Sun:1.Department of Nephrology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China. ;
期刊：Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells
影响因子 ：4.0
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy (2008-09-20)
作者：Hongliang Ying:1.a Department of Orthopaedics, China-Japan Union Hospital of Jilin University , Changchun , China. ; Boda Ying:1.b Department of Joint Surgery of Orthopaedic Center, The Second Hospital of Jilin University , Changchun , China. ; Jinrui Zhang:1.a Department of Orthopaedics, China-Japan Union Hospital of Jilin University , Changchun , China. ; Daliang Kong:1.a Department of Orthopaedics, China-Japan Union Hospital of Jilin University , Changchun , China. ;
期刊：Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy
DOI：10.1080/21691401.2019.1648280
影响因子 ：5.8
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