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产品概述
名称 | SK-N-SH (人神经母细胞瘤细胞) (STR鉴定正确) |
别称 | SK N SH; SKN-SH; SK-NSH; SKNSH; NSH |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | SK-N-SH细胞是由J·L·Bieder建系,它与SK-N-MC细胞所不同的是倍增时间较长,且多巴胺-β-羟基酶水平较高。SK-N-SH细胞在细胞介导的细胞毒性试验中用作靶细胞系。 |
年龄(性别) | 女性;4岁 |
组织来源 | 脑神经母细胞瘤,转移部位骨髓 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 神经母细胞瘤细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~44 hours |
抗原表达情况 | Blood Type A; Rh+ |
基因表达情况 | plasminogen activator, shows increased expression of M-CSF after treatment with amyloid-beta peptide. |
保藏机构 | ATCC; HTB-11 ECACC; 86012802 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11 D2S1338 17,19 D3S1358 15,16 D5S818 12 D7S820 7,10 D8S1179 15 D13S317 11 D16S539 8,13 D18S51 13,16 D19S433 13,14 D21S11 31,31.2 FGA 23.2,24 PentaD 10,12 PentaE 7,11 TH01 7,10 TPOX 8,11 vWA 14,18 D6S1043 12,18 D12S391 18,22 D2S441 11,11.3 -
STR鉴定图
参考文献
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Resveratrol alleviates amyloid β-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer's disease (2023-08-24)
作者:Yanchun Zhang:1.Department of Rehabilitation, Cangzhou Central Hospital, Cangzhou, China. ; Deqiang Chen:1.Department of CT Room, Cangzhou Central Hospital, Cangzhou, China. ; Rui Tian:1.Department of Rehabilitation, Cangzhou Central Hospital, Cangzhou, China. ; Xinyue Yan:1.Department of Rehabilitation, Cangzhou Central Hospital, Cangzhou, China. ; Yingwen Zhou:1.Department of Magnetic Resonance Imaging Room, Cangzhou Central Hospital, Cangzhou, China. ;
期刊:Resveratrol alleviates amyloid β-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer's disease
影响因子 :3.0
引用产品: SK-N-SH 细胞 , DMEM高糖 培养基 , 特级胎牛血清
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Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis (2002-02-20)
作者:Jinsheng Liu:1.Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ; Li Li:1.Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ; Ping Xie:1.Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing, China. ; Xiaoyan Zhao:1.Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ; Dongjing Shi:1.Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ; Yan Zhang:1.College of Life Science, Peking University, Beijing, China. ; Chuxiong Pan:1.Department of Anesthesiology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China. Electronic address: pandedao@126.com. ; Tianzuo Li:1.Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. Electronic address: t
期刊:Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis
DOI:10.1016/j.freeradbiomed.2022.01.031
影响因子 :7.4
引用产品: SK-N-SH 细胞 , 293T [HEK-293T] 细胞
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C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone (2022-08-09)
作者:Cai Zhang:1.Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, 430071, Wuhan, China. ; 2.Graduate University of Chinese Academy of Science, 100049, Beijing, China. ; Yunshan Pei:1.Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, 430071, Wuhan, China. ; 2.Graduate University of Chinese Academy of Science, 100049, Beijing, China. ; Zeting Zhang:1.Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Re
期刊:C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
DOI:10.1038/s42003-022-03768-0
影响因子 :6.5
引用产品: SK-N-SH 细胞
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Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model (2001-02-20)
作者:Yuanqiang Dai:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. ; Ying Sheng:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. ; Yu Deng:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. ; Heng Wang:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. ; Zhenzhen Zhao:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. ; Xiya Yu:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, China. Electronic address: yuxiyash@163.com. ; Tao Xu:1.Department of Faculty of Anesthesiology, Changhai Hospital Affiliated to Naval Medical University, Shanghai 200433, Chin
期刊:Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model
DOI:10.1016/j.intimp.2021.108464
影响因子 :5.6
引用产品: SK-N-SH 细胞 , SK-N-SH细胞专用培养基
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Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis (2002-02-20)
作者:Jian Zhang:1.Department of Geriatrics, Qingdao Chengyang District People's Hospital, Qingdao, Shandong, P.R. China. ; Wei Liu:1.Department of Health Management, Qingdao Eighth People's Hospital, Qingdao, Shandong, P.R. China. ; Ping Ji:1.Department of Ophthalmology, Qingdao Eighth People's Hospital, Qingdao, Shandong, P.R. China. ; Yan Zhang:1.The Third Department of Internal Medicine, Qingdao Women and Children's Hospital, Qingdao University, Qingdao, Shandong, P.R. China. ;
期刊:Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis
DOI:10.1080/21655979.2022.2042999
影响因子 :4.9
引用产品: 人脐静脉内皮细胞 , SH-SY5Y [SHSY-5Y] 细胞 , SK-N-SH 细胞 , SK-N-AS 细胞 , SK-N-BE (2) 细胞
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CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma (2002-02-20)
作者:Lin Qiu:1.Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. ; Rui Zhou:1.Department of General Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China. ; 2.Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. ; Ziyan Luo:1.Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. ; Jiangxue Wu:1.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. ; Hua Jiang:1.Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. ;
期刊:CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma
影响因子 :4.7
引用产品: SK-N-SH 细胞 , SH-SY5Y [SHSY-5Y] 细胞
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CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer’s Disease via Repressing PDE4A by Releasing miR-1306-5p (2003-02-20)
作者:Shengxi Meng:1.Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yi Shan Road, Xuhui District, Shanghai, 200233, China. mengsx163@163.com. ; Bing Wang:1.Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yi Shan Road, Xuhui District, Shanghai, 200233, China. ; Wentao Li:1.Department of Encephalopathy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai City, China. ;
期刊:CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer’s Disease via Repressing PDE4A by Releasing miR-1306-5p
DOI:10.1007/s11064-022-03563-7
影响因子 :4.4
引用产品: SK-N-SH 细胞
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Long non-coding RNA UCA1 regulates MPP+-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells (2022-12-14)
作者:Zhengheng Hao:1.Department of Neurosurgery, Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, 030001, China. ; Wen Dang:1.Department of Pharmacy, Second Hospital of Shanxi Medical University, 030001, Taiyuan, Shanxi, China. ; Qingfeng Zhu:1.Department of Neurosurgery, Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, 030001, China. zhuqingfengvip@163.com. ; Jianxing Xu:1.Department of Neurosurgery, Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, 030001, China. ;
期刊:Long non-coding RNA UCA1 regulates MPP+-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells
DOI:10.1007/s11011-022-01118-x
影响因子 :3.7
引用产品: SK-N-SH 细胞 , SK-N-SH细胞专用培养基
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HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2 (2012-01-20)
作者:Xiaodan Zhong:1.Department of Pediatric Oncology, The First Hospital of Jilin University, Changchun, China. ; Songling Zhang:1.Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun, China. ; Yutong Zhang:1.Department of Pediatric Oncology, The First Hospital of Jilin University, Changchun, China. ; Zongmiao Jiang:1.Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China. ; Yanan Li:1.Department of Pediatrics, The First Hospital of Jilin University, Changchun, China. ; Jian Chang:1.Department of Pediatric Oncology, The First Hospital of Jilin University, Changchun, China. ; Junqi Niu:1.Department of Hepatology, The First Hospital of Jilin University, Changchun, China. ; Ying Shi:1.Department of Hepatology, The First Hospital of Jilin University, Changchun, China. ;
期刊:HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2
影响因子 :5.5
引用产品: SK-N-SH 细胞 , SH-SY5Y [SHSY-5Y] 细胞 , SK-N-BE (2) 细胞
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LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis (2006-01-20)
作者:Lixia Yang:1.Department of Neurology, The First People's Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen, 434000, People's Republic of China. ; Liangyan Pei:1.Department of Neurology, The First People's Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen, 434000, People's Republic of China. ; Jilong Yi:1.Department of Neurology, The First People's Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen, 434000, People's Republic of China. ;
期刊:LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis
影响因子 :3.2
引用产品: IMR-32 细胞 , SK-N-SH 细胞 , 293 [HEK-293] 细胞 , DMEM高糖 培养基
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Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis (2004-01-20)
作者:Xiao Xiao:1.Department of Encephalopathy, Hubei Provincial Hospital of Traditional Chinese Medicine (Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Hubei Institute of Traditional Chinese Medicine), Wuhan City, Hubei Province, People's Republic of China. ; Zhiwen Tan:1.Department of Encephalopathy, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi City, Hubei Province, People's Republic of China. ; Min Jia:1.Department of Neurology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi City, Hubei Province, People's Republic of China. ; Xiaoli Zhou:1.Department of Encephalopathy, Hubei Provincial Hospital of Traditional Chinese Medicine (Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Hubei Institute of Traditional Chinese Medicine), Wuhan City, Hubei Province, People's Republic of China. ; Kemei Wu:1.Department of Neurology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefectu
期刊:Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis
影响因子 :3.2
引用产品: SK-N-SH 细胞 , 小鼠多巴胺神经元细胞
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miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2 (2001-01-20)
作者:Haibin Yuan:1.Department of Neonatal Surgery, Xuzhou Children's Hospital, No.18 Sudi North Road, Quanshan District, 221001, Xuzhou, China. ; Fengli Liu:1.Department of Neonatal Surgery, Xuzhou Children's Hospital, No.18 Sudi North Road, Quanshan District, 221001, Xuzhou, China. ; Tongsheng Ma:1.Department of Neonatal Surgery, Xuzhou Children's Hospital, No.18 Sudi North Road, Quanshan District, 221001, Xuzhou, China. ; Zhandong Zeng:1.Department of Neonatal Surgery, Xuzhou Children's Hospital, No.18 Sudi North Road, Quanshan District, 221001, Xuzhou, China. ; Ning Zhang:1.Department of Neonatal Surgery, Xuzhou Children's Hospital, No.18 Sudi North Road, Quanshan District, 221001, Xuzhou, China. ;
期刊:miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2
影响因子 :2.2
引用产品: SK-N-SH 细胞
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Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis (2010-00-20)
作者:Peisheng Jia:1.Department of Pediatric Intensive Care Unit (PICU), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Erhu Wei:1.Department of Pediatric Intensive Care Unit (PICU), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Huiqiong Liu:1.Department of Pediatric Intensive Care Unit (PICU), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Tingting Wu:1.Department of Pediatric Intensive Care Unit (PICU), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Huaili Wang:1.Department of Pediatric Intensive Care Unit (PICU), The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ;
期刊:Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis
DOI:10.1002/iub.2392
影响因子 :4.6
引用产品: SK-N-SH 细胞 , SK-N-AS 细胞
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LncRNA NEAT1 Regulates the Development of Parkinson’s Disease by Targeting AXIN1 Via Sponging miR-212-3p (2011-00-20)
作者:Tao Liu:1.Department of Neurology, Tianjin Hospital of ITCWM Nankai Hospital, No. 6 Changjiang Road, Nankai District, Tianjin, 300100, China. dr_mateo@163.com. ; Yang Zhang:1.Department of Acupuncture & Physiotherapy, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin, 300100, China. ; Weihong Liu:1.Department of Traditional Chinese Medicine, Tianjin Fourth Central Hospital, Tianjin, 300140, China. ; Jinsheng Zhao:1.Department of Acupuncture & Physiotherapy, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin, 300100, China. ;
期刊:LncRNA NEAT1 Regulates the Development of Parkinson’s Disease by Targeting AXIN1 Via Sponging miR-212-3p
DOI:10.1007/s11064-020-03157-1
影响因子 :4.4
引用产品: SK-N-SH 细胞 , 293T [HEK-293T] 细胞 , 青霉素-链霉素溶液 (双抗),100×
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