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产品概述
名称 | C-33 A (人子宫颈癌细胞) (STR鉴定正确) |
别称 | C33A; C33a; C33-A; C-33-A; C-33A; C33 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | C-33 A细胞是由N·Auersperg从宫颈癌切片中建立的一系列细胞株中的一株。C-33 A细胞一开始就表现出亚二倍体核型及上皮细胞形态,C-33 A细胞经连续传代可以观察到核型不稳定。C-33 A细胞存在成视网膜细胞瘤蛋白(pRB),但大小不正常;C-33 A细胞p53表达上调,且有一个273位密码子的点突变导致Arg→Cys的替换。 |
年龄(性别) | 女性;66岁 |
组织来源 | 宫颈癌 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 宫颈癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~32-48 hours |
保藏机构 | ATCC; HTB-31 ATCC; CRM-HTB-31 BCRC; 60554 BCRJ; 0348 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 23,25 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 10,14 D13S317 13 D16S539 13,14 D18S51 15,18 D19S433 11,13,14 D21S11 29,30,31 FGA 21,26 PentaD 10 PentaE 6,8 TH01 7,8 TPOX 9 vWA 18,20 D6S1043 9,11,12 D12S391 18,27 D2S441 10,14 -
STR鉴定图
参考文献
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Design of Selective PARP-1 Inhibitors and Antitumor Studies(2024/05/22)
作者:Yiting Zhang, Xiangqian Li, Fang Liu
期刊:JOURNAL OF MEDICINAL CHEMISTRY
DOI:10.1021/acs.jmedchem.3c02460
影响因子 :7.300
引用产品:CL-0045
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Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB(2021/01/19)
作者:Wanyue Wang, Xin Li, Ye Xu
期刊:Cellular Oncology
DOI:10.1007/s13402-020-00582-w
影响因子 :6.600
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3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway(2023/03/11)
作者:Xiaojiao Chen, Zhibo Liu, Xue Li
期刊:Journal of Functional Foods
影响因子 :5.600
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Marine Sulfated Polysaccharide PMGS Synergizes with Paclitaxel in Inhibiting Cervical Cancer In Vitro(2023/04/23)
作者:Xuan Xia, Yanhong Wang, Yingchun Shao
期刊:Marine Drugs
影响因子 :5.400
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Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9(2022/04/07)
作者:Caimei Wang, Yiyuan Wang, Congrong Liu
期刊:Bioengineered
DOI:10.1080/21655979.2022.2061144
影响因子 :4.900
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Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo(2022/08/30)
作者:Ziruizhuo Zhang, Songcheng Zhang, Bingjie Lin
期刊:Frontiers in Oncology
影响因子 :4.700
引用产品:CL-0045
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USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer(2021/11/25)
作者:Zhengliang Li , Xiaojing Liu , Haizhou Yu
期刊:Human Cell
DOI:10.1007/s13577-021-00650-9
影响因子 :4.300
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OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway(2022/09/29)
作者:Limin Zhou, Hongying Li, Dunlan Zhang
期刊:ONCOLOGY REPORTS
影响因子 :4.200
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HPV16+-miRNAs in cervical cancer and the anti-tumor role played by miR-5701(2019/10/25)
作者:Nuerbieke Pulati, Zegao Zhang, Aireti Gulimilamu
期刊:Journal Of Gene Medicine
DOI:10.1002/jgm.3126
影响因子 :4.152
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HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression(2024/01/11)
作者:Jianing Zhang, Xiaohui Yu, Yi Guo
期刊:Cancer Medicine
影响因子 :4.000
引用产品:CL-0045
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APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway(2024/03/30)
作者:Qi Wang, Bingyu Wang, Wenjing Zhang
期刊:ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影响因子 :3.900
引用产品:CL-0045
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Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells(2023/09/11)
作者:Fang Wang, Shuyan Song, Bingxuan Guo
期刊:BMC CANCER
DOI:10.1186/s12885-023-11129-1
影响因子 :3.800
引用产品:CL-0045
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Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance(2023/02/03)
作者:Wujiang Lai, Jinrong Liao, Xiaoxuan Li
期刊:Frontiers in Genetics
DOI:10.3389/fgene.2023.1067666
影响因子 :3.700
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Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer.(2022/09/20)
作者:Xinyu Liu, Lei Zhou, Minghui Gao
期刊:Frontiers in Genetics
影响因子 :3.700
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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells(2021/12/24)
作者:Yinghui Wang, Yihang Xie, Boxuan Sun
期刊:Infectious Agents and Cancer
DOI:10.1186/s13027-021-00409-9
影响因子 :3.700
引用产品:CL-0045
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Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein(2023/11/07)
作者:Junying Zhou, Ningjing Lei, Wanjia Tian
期刊:Radiation Oncology
DOI:10.1186/s13014-023-02369-3
影响因子 :3.600
引用产品:CL-0045
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Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells(2019/11/30)
作者:Rui Tong, Jingru Zhang, Chunyan Wang
期刊:Naunyn-Schmiedebergs Archives of Pharmacology
DOI:10.1007/s00210-019-01772-6
影响因子 :3.600
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Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress(2024/03/07)
作者:Zhongbao Zhang, Beibei Sun, Jinqiu Lu
期刊:Molecular Medicine Reports
影响因子 :3.400
引用产品:CL-0045
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hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2(2022/03/11)
作者:Yumei Lv, Mingyi Wang, Mingli Chen
期刊:Journal Of Clinical Laboratory Analysis
影响因子 :3.124
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Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer(2023/09/16)
作者:Mei Wu, Mingji Ye
期刊:FUNCTIONAL & INTEGRATIVE GENOMICS
DOI:10.1007/s10142-023-01218-6
影响因子 :2.900
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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p(2019/10/06)
作者:Rui Tong, Jingru Zhang, Chunyan Wang
期刊:Clinical And Experimental Pharmacology And Physiology
影响因子 :2.900
引用产品:CL-0045
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SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A(2023/04/21)
作者:Boya Deng, Ailin Li, Ying Zhu
期刊:Oncology Letters
影响因子 :2.900
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N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma(2024/04/28)
作者:Qingqing Tian, Juqing Huang, Qin Zhang
期刊:CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 :2.900
引用产品:CL-0045
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Expression of GMFB in High-Grade Cervical Intraepithelial Neoplasia and Its Role in Cervical Cancer(2022/09/22)
作者:Jun Tian, Jianqing Wang, Yinxiu Chi
期刊:Computational and Mathematical Methods in Medicine
影响因子 :2.809
引用产品:CL-0045
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FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma(2022/08/28)
作者:Yanru Yang, Yun Zhao, Guorui Sun
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.800
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TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma(2023/07/23)
作者:Yanru Yang, Saijie Zuo, Wenqing Li
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.800
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CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways(2022/10/25)
作者:Wenhu Xin, Jian Zhang, Haibin Zhang
期刊:BMC Molecular and Cell Biology
DOI:10.1186/s12860-022-00440-7
影响因子 :2.800
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ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma(2022/12/05)
作者:Qingge Jia, Junyang Song, Tianqi Xu
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.800
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Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer(2023/11/24)
作者:Jiaxin Liu, Lu Tang, Wenzhu Chu
期刊:BIOCHEMICAL GENETICS
DOI:10.1007/s10528-023-10568-6
影响因子 :2.400
引用产品:CL-0045
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PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway(2023/01/05)
作者:Boya Deng, Siyang Zhang, Yingying Zhou
期刊:HISTOCHEMISTRY AND CELL BIOLOGY
DOI:10.1007/s00418-022-02175-0
影响因子 :2.300
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MiR-1299 is regulated by KCNQ1OT1 and inhibits cervical cancer progression(2023/10/31)
作者:Qian Yang, Jing Fu, Min Wang
期刊:CELLULAR AND MOLECULAR BIOLOGY
DOI:10.14715/cmb/2023.69.10.24
影响因子 :1.600
引用产品:CL-0045
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