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产品概述
| 名称 | C-33 A (人子宫颈癌细胞) (STR鉴定正确) |
| 别称 | C33A; C33a; C33-A; C-33-A; C-33A; C33 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | C-33 A细胞是由N·Auersperg从宫颈癌切片中建立的一系列细胞株中的一株。C-33 A细胞一开始就表现出亚二倍体核型及上皮细胞形态，C-33 A细胞经连续传代可以观察到核型不稳定。C-33 A细胞存在成视网膜细胞瘤蛋白(pRB)，但大小不正常；C-33 A细胞p53表达上调，且有一个273位密码子的点突变导致Arg→Cys的替换。 |
| 年龄（性别） | 女性；66岁 |
| 组织来源 | 宫颈癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 宫颈癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~32-48 hours |
| 保藏机构 | ATCC; HTB-31 ATCC; CRM-HTB-31 BCRC; 60554 BCRJ; 0348 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 23,25 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 10,14 D13S317 13 D16S539 13,14 D18S51 15,18 D19S433 11,13 D21S11 29,30,31 FGA 21,26 PentaD 10 PentaE 6,8 TH01 7,8 TPOX 9 vWA 18,20 D6S1043 9,11,12 D12S391 18,27 D2S441 10,14 -
STR鉴定图
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参考文献
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SOX2 promotes the glycolysis process to accelerate cervical cancer progression by regulating the expression of HK2 (2025-01-16)
期刊：ACTA HISTOCHEMICA
DOI：10.1016/j.acthis.2025.152230
影响因子 ：2.3
引用产品： Hela 细胞 , Ca Ski 细胞 , C-33 A 细胞 , SiHa 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液（双抗），100×
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Design of Selective PARP-1 Inhibitors and Antitumor Studies (2024-05-22)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c02460
影响因子 ：7.3
引用产品： SiHa 细胞 , Hela 细胞 , C-33 A 细胞 , SK-OV-3 细胞
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Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1-mediated fatty acid synthesis (2024-10-18)
期刊：Molecular Oncology
影响因子 ：5.0
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Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer (2024-08-24)
期刊：Translational Oncology
DOI：10.1016/j.tranon.2024.102103
影响因子 ：4.5
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HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression (2024-01-11)
期刊：Cancer Medicine
影响因子 ：4.0
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APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway (2024-03-30)
期刊：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影响因子 ：3.9
引用产品： C-33 A 细胞 , Hela 细胞 , SiHa 细胞 , Ca Ski 细胞 , ECT1/E6E7 细胞 , 人子宫颈上皮细胞完全培养基
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Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress (2024-03-07)
期刊：Molecular Medicine Reports
影响因子 ：3.4
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Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway (2024-10-17)
期刊：Cancer Medicine
影响因子 ：2.9
引用产品： SiHa 细胞 , Ca Ski 细胞 , C-33 A 细胞 , 青霉素-链霉素溶液（双抗），100× , MEM 培养基
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N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma (2024-04-28)
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.9
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Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development (2024-12-31)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2024.102713
影响因子 ：2.7
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Design, Synthesis, and In vitro Anti-cervical Cancer Activity of a Novel MDM2-p53 Inhibitor Based on a Chalcone Scaffold (2024-04-01)
期刊：Anti-Cancer Agents in Medicinal Chemistry
DOI：10.2174/0118715206274066231220071557
影响因子 ：2.6
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METTL14-mediated m6A modification upregulates HOXB13 expression to activate NF-κB and exacerbate cervical cancer progression (2024-11-11)
期刊：Molecular & Cellular Oncology
DOI：10.1080/23723556.2024.2423986
影响因子 ：2.6
引用产品： MEM（含NEAA） 培养基 , C-33 A 细胞 , 青霉素-链霉素溶液（双抗），100× , 特级胎牛血清 , Hela 细胞
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3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway (2023-03-11)
期刊：Journal of Functional Foods
影响因子 ：5.6
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Marine Sulfated Polysaccharide PMGS Synergizes with Paclitaxel in Inhibiting Cervical Cancer In Vitro (2023-04-23)
期刊：Marine Drugs
影响因子 ：5.4
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HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition (2023-05-16)
期刊：CELL BIOLOGY INTERNATIONAL
影响因子 ：3.9
引用产品： C-33 A 细胞 , Ca Ski 细胞 , SiHa 细胞 , Hela 细胞 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , RPMI-1640 培养基 , DMEM高糖 培养基 , McCoy's 5A 培养基 , DMEM/F12 培养基
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Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells (2023-09-11)
期刊：BMC CANCER
DOI：10.1186/s12885-023-11129-1
影响因子 ：3.8
引用产品： C-33 A 细胞 , Hacat 细胞
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Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance (2023-02-03)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1067666
影响因子 ：3.7
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Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein (2023-11-07)
期刊：Radiation Oncology
DOI：10.1186/s13014-023-02369-3
影响因子 ：3.6
引用产品： SiHa 细胞 , C-33 A 细胞 , Hela 细胞 , 青霉素-链霉素溶液 (双抗)，100×
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SHCBP1 contributes to the proliferation and self?renewal of cervical cancer cells and activation of the NF?κB signaling pathway through EIF5A (2023-04-21)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： SiHa 细胞 , C-33 A 细胞 , Ca Ski 细胞 , DMEM/F12 培养基
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Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer (2023-09-16)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01218-6
影响因子 ：2.9
引用产品： C-33 A 细胞 , Ca Ski 细胞 , Hela S3 细胞 , SiHa 细胞 , 人子宫颈上皮细胞
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BTG2 suppresses the growth and metastasis of cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
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TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma (2023-07-23)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
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UCHL1 acts as a prognostic factor and promotes cancer stemness in cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
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Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk (2023-03-23)
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00721-2
影响因子 ：2.6
引用产品： SiHa 细胞 , C-33 A 细胞 , 人脐静脉内皮细胞 , SiHa细胞专用培养基 , C-33 A细胞专用培养基 , 人脐静脉内皮细胞完全培养基
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Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer (2023-11-24)
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-023-10568-6
影响因子 ：2.4
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PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway (2023-01-05)
期刊：HISTOCHEMISTRY AND CELL BIOLOGY
DOI：10.1007/s00418-022-02175-0
影响因子 ：2.3
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MiR-1299 is regulated by KCNQ1OT1 and inhibits cervical cancer progression (2023-10-31)
期刊：CELLULAR AND MOLECULAR BIOLOGY
DOI：10.14715/cmb/2023.69.10.24
影响因子 ：1.6
引用产品： C-33 A 细胞
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CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway (2023-01-01)
期刊：ANNALS OF CLINICAL AND LABORATORY SCIENCE
DOI：PMID:36889763
影响因子 ：0.8
引用产品： MS751 细胞 , Ca Ski 细胞 , SiHa 细胞 , C-33 A 细胞 , Hela 细胞 , MEM 培养基 , RPMI-1640 培养基
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Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo. (2022-08-30)
期刊：Frontiers in Oncology
影响因子 ：5.7
引用产品： C-33 A 细胞
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Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9 (2022-04-07)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2061144
影响因子 ：4.9
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Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer (2022-09-20)
期刊：Frontiers in Genetics
影响因子 ：4.8
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OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway (2022-09-29)
期刊：ONCOLOGY REPORTS
影响因子 ：4.1
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ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma (2022-12-05)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：3.3
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FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma (2022-08-28)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：3.3
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tRNA?derived fragment tRF?Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 (2022-08-09)
期刊：Oncology Letters
影响因子 ：3.1
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hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2 (2022-03-11)
期刊：Journal Of Clinical Laboratory Analysis
影响因子 ：3.1
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Expression of GMFB in High-Grade Cervical Intraepithelial Neoplasia and Its Role in Cervical Cancer (2022-09-22)
期刊：Computational and Mathematical Methods in Medicine
影响因子 ：2.8
引用产品： C-33 A 细胞 , 293T [HEK-293T] 细胞
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CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways (2022-10-25)
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00440-7
影响因子 ：2.8
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Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB (2021-01-19)
期刊：Cellular Oncology
DOI：10.1007/s13402-020-00582-w
影响因子 ：6.6
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USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer (2021-11-25)
期刊：Human Cell
DOI：10.1007/s13577-021-00650-9
影响因子 ：4.3
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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells (2021-12-24)
期刊：Infectious Agents and Cancer
DOI：10.1186/s13027-021-00409-9
影响因子 ：3.7
引用产品： C-33 A 细胞
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Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p (2020-08-01)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-020-03853-0
影响因子 ：4.3
引用产品： SiHa 细胞 , C-33 A 细胞 , Hela 细胞 , MEM (含NEAA) 培养基
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Long non?coding RNA AK001903 regulates tumor progression in cervical cancer (2020-11-30)
期刊：Oncology Letters
影响因子 ：2.9
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HPV16+-miRNAs in cervical cancer and the anti-tumor role played by miR-5701 (2019-10-25)
期刊：Journal Of Gene Medicine
DOI：10.1002/jgm.3126
影响因子 ：4.2
引用产品： C-33 A 细胞 , Hela S3 细胞
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Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells (2019-11-30)
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-019-01772-6
影响因子 ：3.6
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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p (2019-10-06)
期刊：Clinical And Experimental Pharmacology And Physiology
影响因子 ：2.9
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