产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
| 名称 | SiHa (人子宫颈鳞癌细胞) (STR鉴定正确) |
| 别称 | Siha; SIHA |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | SiHa细胞是建自一个日本病人的外科手术的原位组织样品。电镜观察表明，在SiHa细胞连接处有典型的桥粒，在SiHa细胞胞质中有丰富的张力丝。在裸鼠中，SiHa细胞能形成低分化的表皮样癌(Ⅲ级)；SiHa细胞中，癌基因PRB和p53阳性。 |
| 年龄（性别） | 女性；55岁 |
| 组织来源 | 子宫颈鳞癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 宫颈癌细胞 |
| 生物安全等级 | BSL-2 [Cells contain human papilloma virus] |
| 倍增时间 | ~50-60 hours |
| 致瘤性 | Yes, in nude mice; forms poorly differentiated epidermoid carcinoma (grade III). |
| 基因表达情况 | Oncogenes: p53+; pRB+ |
| 保藏机构 | ATCC; HTB-35 |
STR鉴定
-
STR位点信息
Amelogenin X CSF1PO 12 D2S1338 24 D3S1358 16,17 D5S818 9 D7S820 10 D8S1179 13,16 D13S317 11 D16S539 12 D18S51 15 D19S433 14.2 D21S11 31 FGA 21 PentaD 9 PentaE 10,12 TH01 6,9 TPOX 8 vWA 14,17 D6S1043 18 D12S391 19,22 D2S441 10 -
STR鉴定图
-
参考文献
-
The CXCLs-CXCR2 axis modulates the cross-communication between tumor-associated neutrophils and tumor cells in cervical cancer (2024-01-15)
期刊：Expert Review of Clinical Immunology
DOI：10.1080/1744666X.2024.2305808
影响因子 ：4.4
-
HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression (2024-01-11)
期刊：Cancer Medicine
影响因子 ：4.0
-
APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway (2024-03-30)
期刊：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影响因子 ：3.9
引用产品： C-33 A 细胞 , Hela 细胞 , SiHa 细胞 , Ca Ski 细胞 , ECT1/E6E7 细胞 , 人子宫颈上皮细胞完全培养基
-
Prognosis, immune microenvironment, and personalized treatment prediction in Rho GTPase-activating protein 4-mutant cervical cancer: Computer strategies for precision oncology (2023-01-03)
期刊：LIFE SCIENCES
影响因子 ：6.1
-
Silencing DTX3L Inhibits the Progression of Cervical Carcinoma by Regulating PI3K/AKT/mTOR Signaling Pathway (2023-01-03)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
-
Methionine enkephalin inhibited cervical cancer migration as well as invasion and activated CD11b+ NCR1+ NKs of tumor microenvironment (2023-09-21)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110967
影响因子 ：5.6
-
3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway (2023-03-11)
期刊：Journal of Functional Foods
影响因子 ：5.6
-
USF1 regulated circPRDM4 modulates tumorigenesis and immune escape in chemoresistant cervical cancer (2023-09-04)
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.3
-
Lymph node metastasis-related gene signature shows good performance in predicting prognosis and immune infiltration in cervical cancer (2023-06-22)
期刊：Frontiers in Oncology
影响因子 ：4.7
引用产品： SiHa 细胞
-
Significance of Immunogenic Cell Death-Related Prognostic Gene Signature in Cervical Cancer Prognosis and Anti-Tumor Immunity (2023-05-21)
期刊：Journal of Inflammation Research
影响因子 ：4.5
-
Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway. (2023-05-25)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e16683
影响因子 ：4.0
引用产品： SiHa 细胞 , Hela 细胞 , MEM (含NEAA) 培养基
-
HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition (2023-05-16)
期刊：CELL BIOLOGY INTERNATIONAL
影响因子 ：3.9
引用产品： C-33 A 细胞 , Ca Ski 细胞 , SiHa 细胞 , Hela 细胞 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , RPMI-1640 培养基 , DMEM高糖 培养基 , McCoy's 5A 培养基 , DMEM/F12 培养基
-
Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance (2023-02-03)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1067666
影响因子 ：3.7
-
Circ_0005615 promotes cervical cancer cell growth and metastasis by modulating the miR-138-5p/KDM2A axis (2023-07-02)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.6
引用产品： SiHa 细胞 , Ca Ski 细胞 , 293T [HEK-293T] 细胞 , MEM 培养基 , RPMI-1640 培养基
-
Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein (2023-11-07)
期刊：Radiation Oncology
DOI：10.1186/s13014-023-02369-3
影响因子 ：3.6
引用产品： SiHa 细胞 , C-33 A 细胞 , Hela 细胞 , 青霉素-链霉素溶液 (双抗)，100×
-
LINC00460 knockdown sensitizes cervical cancer to cisplatin by downregulating TGFBI (2023-12-28)
期刊：Chemical Biology & Drug Design
影响因子 ：3.0
-
SHCBP1 contributes to the proliferation and self‑renewal of cervical cancer cells and activation of the NF‑κB signaling pathway through EIF5A (2023-04-21)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： SiHa 细胞 , C-33 A 细胞 , Ca Ski 细胞 , DMEM/F12 培养基
-
Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer (2023-09-16)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01218-6
影响因子 ：2.9
引用产品： C-33 A 细胞 , Ca Ski 细胞 , Hela S3 细胞 , SiHa 细胞 , 人子宫颈上皮细胞
-
BTG2 suppresses the growth and metastasis of cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
-
Design, Synthesis, and Anti-tumor Activity of Novel 2-Aryl Benzimidazole Compounds (2023-08-01)
期刊：Anti-Cancer Agents in Medicinal Chemistry
DOI：10.2174/1871520623666230411152115
影响因子 ：2.8
引用产品： MCF7 [MCF-7] 细胞 , A549 [A-549] 细胞 , Caco-2 细胞 , SiHa 细胞
-
TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma (2023-07-23)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
-
UCHL1 acts as a prognostic factor and promotes cancer stemness in cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
-
Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk (2023-03-23)
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00721-2
影响因子 ：2.6
引用产品： SiHa 细胞 , C-33 A 细胞 , 人脐静脉内皮细胞 , SiHa细胞专用培养基 , C-33 A细胞专用培养基 , 人脐静脉内皮细胞完全培养基
-
Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis (2023-08-04)
期刊：JOURNAL OF APPLIED GENETICS
DOI：10.1007/s13353-023-00772-w
影响因子 ：2.4
-
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer (2023-11-24)
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-023-10568-6
影响因子 ：2.4
-
PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway (2023-01-05)
期刊：HISTOCHEMISTRY AND CELL BIOLOGY
DOI：10.1007/s00418-022-02175-0
影响因子 ：2.3
-
HIV gp120/Tat protein-induced epithelial–mesenchymal transition promotes the progression of cervical lesions (2023-11-19)
期刊：AIDS Research and Therapy
DOI：10.1186/s12981-023-00577-1
影响因子 ：2.2
引用产品： SiHa 细胞 , 人子宫颈上皮细胞 , SiHa细胞专用培养基
-
Gene signatures, immune infiltration, and drug sensitivity based on a comprehensive analysis of m6a RNA methylation regulators in cervical cancer (2022-09-04)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03600-7
影响因子 ：8.4
-
Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor (2006-02-20)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.108933
影响因子 ：5.7
-
CDK6 increases glycolysis and suppresses autophagy by mTORC1-HK2 pathway activation in cervical cancer cells (2002-02-20)
期刊：Cell Cycle
DOI：10.1080/15384101.2022.2039981
影响因子 ：5.2
-
Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9 (2004-02-20)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2061144
影响因子 ：4.9
-
OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway (2022-09-29)
期刊：ONCOLOGY REPORTS
影响因子 ：4.1
-
ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma (2022-12-05)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：3.3
-
FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma (2022-08-28)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：3.3
-
hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2 (2003-02-20)
期刊：Journal Of Clinical Laboratory Analysis
影响因子 ：3.1
-
tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 (2022-08-09)
期刊：Oncology Letters
影响因子 ：3.1
-
CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways (2022-10-25)
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00440-7
影响因子 ：2.8
-
Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3 (2022-08-10)
期刊：ANTI-CANCER DRUGS
DOI：10.1097/CAD.0000000000001335
影响因子 ：2.4
引用产品： Ca Ski 细胞 , SiHa 细胞 , SiHa细胞专用培养基
-
LncRNA Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) promotes the migration, invasion and epithelial-mesenchymal transition (EMT) through targeting miR-147a/insulin-like growth factor 1 receptor (IGF1R) pathway in cervical cancer tissues and c (2003-02-20)
期刊：Journal Of Obstetrics And Gynaecology Research
影响因子 ：1.6
-
Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB (2001-01-20)
期刊：Cellular Oncology
DOI：10.1007/s13402-020-00582-w
影响因子 ：6.6
-
The anticancer effect of extract of medicinal mushroom Sanghuangprous vaninii against human cervical cancer cell via endoplasmic reticulum stress-mitochondrial apoptotic pathway (2006-01-20)
期刊：Journal Of Ethnopharmacology
影响因子 ：5.4
引用产品： SGC-7901 细胞 , SiHa 细胞 , SK-OV-3 细胞
-
Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer (2012-01-20)
期刊：Bioengineered
DOI：10.1080/21655979.2021.2001218
影响因子 ：4.9
引用产品： Hela 细胞 , SiHa 细胞 , DMEM高糖 培养基
-
T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways (2002-01-20)
期刊：Bioengineered
DOI：10.1080/21655979.2021.1880732
影响因子 ：4.9
引用产品： Ca Ski 细胞 , RPMI-1640 培养基 , SiHa 细胞 , MEM (含NEAA) 培养基
-
USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer (2011-01-20)
期刊：Human Cell
DOI：10.1007/s13577-021-00650-9
影响因子 ：4.3
-
KMT2A regulates cervical cancer cell growth through targeting VDAC1. (2005-00-20)
期刊：Aging-US
影响因子 ：5.2
-
Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p (2008-00-20)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-020-03853-0
影响因子 ：4.3
引用产品： SiHa 细胞 , C-33 A 细胞 , Hela 细胞 , MEM (含NEAA) 培养基
-
Long non‑coding RNA AK001903 regulates tumor progression in cervical cancer (2011-00-20)
期刊：Oncology Letters
影响因子 ：2.9
-
Relevance research between the expression of p16INK4a, Notch1, and hTERC genes: The development of HPV16‐positive cervical cancer (2001-00-20)
期刊：Journal Of Clinical Laboratory Analysis
影响因子 ：2.7
引用产品： SiHa 细胞
-
Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells (2011-09-20)
期刊：Am J Pathol
DOI：10.1016/j.ajpath.2019.07.012
影响因子 ：6.0
-
Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1 (2005-09-20)
期刊：Cancer Cell International
影响因子 ：5.8
引用产品： SiHa 细胞
-
Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells (2011-09-20)
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-019-01772-6
影响因子 ：3.6
FAQs
Q：{{item.question}}
A：
产品资料
识别码示意图
