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产品概述
名称 | ES-2 (人卵巢透明细胞癌细胞) (STR鉴定正确) |
别称 | ES2 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 成纤维细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | ES-2细胞是建自45岁女性黑人的外科肿瘤标本,该肿瘤为低分化卵巢透明细胞癌。ES-2细胞最初生长在软琼脂中;ES-2细胞在裸鼠中成瘤。ES-2细胞对多种化疗药物包括阿霉素、顺铂、卡氯芥、依托泊甙等表现出低到中等的耐受性;ES-2细胞表达低水平的P糖蛋白。 |
年龄(性别) | 女性;47岁 |
组织来源 | 透明细胞癌,卵巢 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 卵巢癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~28-36 hours |
致瘤性 | Yes, tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
基因表达情况 | P glycoprotein |
保藏机构 | ATCC; CRL-1978 BCRC; 60067 BCRJ; 0080 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,15 D2S1338 17,23 D3S1358 15,18 D5S818 11,13 D7S820 11 D8S1179 14 D13S317 11 D16S539 11,13 D18S51 13,15 D19S433 15,15.2 D21S11 32.2,33.2 FGA 21 PentaD 8,13 PentaE 13,16 TH01 9.3 TPOX 8,12 vWA 16,17 D6S1043 11,12 D12S391 20,21 D2S441 11 -
STR鉴定图
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参考文献
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GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer (2024-04-25)
期刊:ONCOGENE
DOI:10.1038/s41388-024-03040-1
影响因子 :8.0
引用产品: RPMI-1640 培养基 , DMEM高糖 培养基 , 293T [HEK-293T] 细胞 , A2780 细胞 , McCoy's 5A 培养基 , Hey 细胞 , SW626 细胞 , OVCAR-8 细胞 , SK-OV-3 细胞 , ES-2 细胞 , Caov-3 细胞
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ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis (2024-02-21)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-024-04980-8
影响因子 :7.4
引用产品: OVCAR-8 细胞 , SK-OV-3 细胞 , ES-2 细胞
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USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2 (2024-09-10)
期刊:ONCOGENE
DOI:10.1038/s41388-024-03151-9
影响因子 :6.9
引用产品: 293T [HEK-293T] 细胞 , SK-OV-3 细胞 , Caov-3 细胞 , A2780 细胞 , Hey 细胞 , SW626 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Enterolactone combined with m6A Reader IGF2BP3 inhibits malignant angiogenesis and disease progression in ovarian cancer (2024-12-21)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2024.156343
影响因子 :6.7
引用产品: ES-2 细胞 , SK-OV-3 细胞
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Cannabidiol Inhibits Epithelial Ovarian Cancer: Role of Gut Microbiome (2024-04-11)
期刊:JOURNAL OF NATURAL PRODUCTS
DOI:10.1021/acs.jnatprod.3c00782
影响因子 :5.1
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CYP24A1 affected macrophage polarization through degradation of vitamin D as a candidate biomarker for ovarian cancer prognosis (2024-07-03)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.112575
影响因子 :4.8
引用产品: ES-2 细胞
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The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk (2024-03-18)
期刊:Scientific Reports
DOI:10.1038/s41598-024-57196-7
影响因子 :4.6
引用产品: IOSE80 细胞 , SK-OV-3 细胞 , ES-2 细胞 , A2780 细胞
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SUGT1 regulates the progression of ovarian cancer through the AKT/PI3K/mTOR signaling pathway (2024-08-20)
期刊:Translational Oncology
DOI:10.1016/j.tranon.2024.102088
影响因子 :4.5
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞
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CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells (2024-03-27)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-024-01393-5
影响因子 :4.0
引用产品: Annexin V Binding Buffer (1×) , SK-OV-3 细胞 , Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , ES-2 细胞 , HO-8910 细胞 , IOSE-80 细胞
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Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis (2024-09-30)
期刊:Scientific Reports
DOI:10.1038/s41598-024-72506-9
影响因子 :3.8
引用产品: SK-OV-3 细胞 , IOSE-80 细胞 , A2780 细胞 , Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , HO-8910 细胞
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METTL2B m3C RNA transferase: oncogenic role in ovarian cancer progression via regulation of the mTOR/AKT pathway and its link to the tumor immune microenvironment (2024-11-27)
期刊:BMC CANCER
DOI:10.1186/s12885-024-13225-2
影响因子 :3.4
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Identification and Validation of Prognostic Markers for Endometriosis-Associated Ovarian Cancer (2024-07-22)
期刊:International Journal of Medical Sciences
影响因子 :3.2
引用产品: ES-2 细胞
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Placental extracellular vesicles induce ovarian tumour cell death in an ex vivo explant model: Possible therapeutic potential (2024-12-31)
期刊:PLACENTA
DOI:10.1016/j.placenta.2024.12.028
影响因子 :3.0
引用产品: SK-OV-3 细胞 , ES-2 细胞 , 特级胎牛血清
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Suppression of KLF5 targets RREB1 to restrain the proliferation of ovarian cancer cells through ERK/MAPK signaling pathway (2024-12-11)
期刊:3 Biotech
DOI:10.1007/s13205-024-04171-8
影响因子 :2.6
引用产品: A2780 细胞 , HO-8910 细胞 , SK-OV-3 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , CoC1 细胞
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Enterolactone and trabectedin suppress epithelial ovarian cancer synergistically via upregulating THBS1 (2023-07-13)
期刊:PHYTOTHERAPY RESEARCH
DOI:10.1002/ptr.7942
影响因子 :7.2
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Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM) (2023-04-22)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-023-01156-8
影响因子 :4.0
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , A2780 细胞
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BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency (2022-10-05)
期刊:Nature Communications
DOI:10.1038/s41467-022-33323-8
影响因子 :17.7
引用产品: ES-2 细胞
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PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib (2022-09-05)
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :7.3
引用产品: A2780 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , McCoy's 5A 培养基 , 增强型细胞活力检测试剂盒 (CCK-8) , 碘化丙啶 (PI)染色液 (50μg/mL)
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Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota (2022-08-19)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2022.154401
影响因子 :6.7
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CCNB1, Negatively Regulated by miR-559, Promotes the Proliferation, Migration, and Invasion of Ovarian Carcinoma Cells (2022-03-09)
期刊:Molecular Biotechnology
DOI:10.1007/s12033-022-00463-7
影响因子 :2.6
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Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells (2022-12-05)
期刊:Reproductive Biology
DOI:10.1016/j.repbio.2022.100704
影响因子 :2.1
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , ES-2 细胞 , 293T [HEK-293T] 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100×
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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer (2021-04-17)
期刊:Gynecologic Oncology
DOI:10.1016/j.ygyno.2021.04.013
影响因子 :4.7
引用产品: A2780 细胞 , 人卵巢上皮细胞 , SK-OV-3 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis (2021-11-13)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-021-00917-7
影响因子 :4.0
引用产品: CoC1 细胞 , SW626 细胞 , ES-2 细胞 , SK-OV-3 细胞
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miR?638 suppresses proliferation by negatively regulating high mobility group?A1 in ovarian cancer cells (2021-09-20)
期刊:Experimental and Therapeutic Medicine
影响因子 :2.7
引用产品: A2780 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , Caov-3 细胞
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Suppressive activities of mangiferin on human epithelial ovarian cancer (2020-06-15)
期刊:Phytomedicine
DOI:10.1016/j.phymed.2020.153267
影响因子 :7.9
引用产品: ES-2 细胞
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Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma (2020-01-30)
期刊:Front Oncol
影响因子 :5.7
引用产品: ES-2 细胞
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Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p (2020-02-24)
期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI:10.1007/s11010-020-03704-y
影响因子 :4.3
引用产品: ES-2 细胞 , McCoy's 5A 培养基 , NIH:OVCAR-3 [OVCAR3] 细胞
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MiR-337–3p suppresses proliferation of epithelial ovarian cancer bytargeting PIK3CA and PIK3CB (2019-10-17)
期刊:Cancer Letters
DOI:10.1016/j.canlet.2019.10.021
影响因子 :9.7
引用产品: A2780 细胞 , 293T [HEK-293T] 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞
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Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization (2017-05-08)
期刊:Oncogene
影响因子 :8.0
引用产品: A2780 细胞 , SK-OV-3 细胞 , ES-2 细胞 , MCF7 [MCF-7] 细胞
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Enterolactone has stronger effects than enterodiol on ovarian cancer (2017-07-24)
期刊:Journal of Ovarian Research
影响因子 :4.0
引用产品: ES-2 细胞
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Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9 (2017-11-27)
期刊:Cancer Biology & Therapy
DOI:10.1080/15384047.2017.1394542
影响因子 :3.6
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