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产品概述
名称 | NIH:OVCAR-3 [OVCAR3] (人卵巢癌细胞) (STR鉴定正确) |
别称 | Ovcar-3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR.3; OVCAR3; Ovcar3 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | NIH:OVCAR-3 [OVCAR3]细胞是由T·C·Hamilton在1982年建系,NIH:OVCAR-3 [OVCAR3]细胞取材于患进行性卵巢腺癌病人的恶性腹水。在裸鼠皮下接种 1×10^7细胞,21天后全部成瘤。NIH:OVCAR-3 [OVCAR3]细胞是研究卵巢癌药物抗性的一个合适的模型系统且由于存在激素受体,这对于激素治疗的评估或许是有用的。 |
年龄(性别) | 女性;60岁 |
组织来源 | 卵巢腺癌 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 卵巢癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~35-64 hours |
致瘤性 | Yes, Forms colonies in soft agar.Yes, in nude mice inoculated subcutaneously with 1×10^7 cells (Tumors developed within 21 days at 100% frequency (5/5)). |
受体表达情况 | Androgen receptor, positive;estrogen receptor, positive;progesterone receptor, positive |
保藏机构 | ATCC; HTB-161 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 17,21 D3S1358 17,18 D5S818 11,12 D7S820 10 D8S1179 10,15 D13S317 12 D16S539 12 D18S51 13 D19S433 14,16.2 D21S11 29,31.2 FGA 21 PentaD 12,13 PentaE 7,13 TH01 9 TPOX 8 vWA 17 D6S1043 10,11 D12S391 19,22 D2S441 11,14 -
STR鉴定图
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参考文献
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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies (2025-01-17)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2024.1500153
影响因子 :5.7
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞
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Iodinated Copper–Cysteamine Nanoparticles as Radiosensitizers for Tumor Radiotherapy (2025-01-22)
期刊:Pharmaceutics
DOI:10.3390/pharmaceutics17020149
影响因子 :4.9
引用产品: ID8 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞
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Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer (2024-02-26)
期刊:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI:10.1186/s13046-024-02981-5
影响因子 :11.3
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞 , McCoy's 5A 培养基
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MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy (2024-10-09)
期刊:Cell Death & Disease
DOI:10.1038/s41419-024-07120-8
影响因子 :8.1
引用产品: A2780 细胞 , TOV21G 细胞 , SK-OV-3 细胞 , 293T [HEK-293T] 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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m6A methylation-mediated regulation of LncRNA MEG3 suppresses ovarian cancer progression through miR-885-5p and the VASH1 pathway (2024-01-29)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-024-04929-x
影响因子 :7.4
引用产品: A2780 细胞 , Caov-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞 , IOSE80 细胞
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USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2 (2024-09-10)
期刊:ONCOGENE
DOI:10.1038/s41388-024-03151-9
影响因子 :6.9
引用产品: 293T [HEK-293T] 细胞 , SK-OV-3 细胞 , Caov-3 细胞 , A2780 细胞 , Hey 细胞 , SW626 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Dietary flavonoid tectochrysin synergistically enhances cisplatin sensitivity on ovarian cancer cells through targeting the CDK1/cyclin B1 pathway (2024-05-21)
期刊:Journal of Functional Foods
影响因子 :5.6
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , SK-OV-3 细胞
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Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53 (2024-02-04)
期刊:MOLECULES
影响因子 :4.6
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞
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SUGT1 regulates the progression of ovarian cancer through the AKT/PI3K/mTOR signaling pathway (2024-08-20)
期刊:Translational Oncology
DOI:10.1016/j.tranon.2024.102088
影响因子 :4.5
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞
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Micellar curcumol for maintenance therapy of ovarian cancer by activating the FOXO3a (2024-10-01)
期刊:Nanomedicine-Nanotechnology Biology and Medicine
DOI:10.1016/j.nano.2024.102789
影响因子 :4.2
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞
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Ubiquitin ligase TRIM22 inhibits ovarian cancer malignancy via TCF4 degradation (2024-06-06)
期刊:MOLECULAR CANCER RESEARCH
DOI:10.1158/1541-7786.MCR-23-0962
影响因子 :4.1
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells (2024-03-27)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-024-01393-5
影响因子 :4.0
引用产品: Annexin V Binding Buffer (1×) , SK-OV-3 细胞 , Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , ES-2 细胞 , HO-8910 细胞 , IOSE-80 细胞
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Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis (2024-09-30)
期刊:Scientific Reports
DOI:10.1038/s41598-024-72506-9
影响因子 :3.8
引用产品: SK-OV-3 细胞 , IOSE-80 细胞 , A2780 细胞 , Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , HO-8910 细胞
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Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway (2024-12-19)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-024-01570-6
影响因子 :3.8
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1 (2024-04-08)
期刊:EXPERIMENTAL CELL RESEARCH
DOI:10.1016/j.yexcr.2024.114006
影响因子 :3.7
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞 , Hey 细胞
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MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer proliferation in vitro and in vivo (2024-01-08)
期刊:EXPERIMENTAL CELL RESEARCH
DOI:10.1016/j.yexcr.2024.113913
影响因子 :3.7
引用产品: Anglne 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Comprehensive analysis of ferroptosis-related genes indicates that TRIM46 is a novel biomarker and promotes the progression of ovarian cancer via modulating ferroptosis and Wnt signaling pathway (2024-10-15)
期刊:American Journal of Cancer Research
影响因子 :3.6
引用产品: Caov-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , SNU-8 细胞 , IOSE80 细胞
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RNA-binding protein THUMPD2 inhibits proliferation and promotes metastasis in epithelial ovarian cancer (2024-06-24)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e33201
影响因子 :3.4
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞
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hsa_circ_0000129 targets miR-383-5p/tropomyosin 3 axis to facilitate ovarian cancer progression (2024-09-01)
期刊:BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
DOI:10.1002/bab.2643
影响因子 :3.2
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , McCoy's 5A 培养基 , DMEM高糖 培养基 , RPMI-1640 培养基 , Caov-3 细胞 , 青霉素-链霉素溶液(双抗),100× , SK-OV-3 细胞
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A disulfidptosis-related lncRNAs cluster to forecast the prognosis and immune landscapes of ovarian cancer (2024-07-09)
期刊:Frontiers in Genetics
DOI:10.3389/fgene.2024.1397011
影响因子 :2.8
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , 青霉素-链霉素溶液(双抗),100× , 重组人胰岛素溶液(10 mg/mL)
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Suppression of KLF5 targets RREB1 to restrain the proliferation of ovarian cancer cells through ERK/MAPK signaling pathway (2024-12-11)
期刊:3 Biotech
DOI:10.1007/s13205-024-04171-8
影响因子 :2.6
引用产品: A2780 细胞 , HO-8910 细胞 , SK-OV-3 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , CoC1 细胞
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KDM1A-mediated ZFP64 demethylation activates CENPL to promote epithelial ovarian cancer progression (2024-12-01)
期刊:CYTOTECHNOLOGY
DOI:10.1007/s10616-024-00671-w
影响因子 :2.0
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞 , RPMI-1640 培养基 , SK-OV-3 细胞 , McCoy's 5A 培养基
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CST2 promotes cell proliferation and regulates cell cycle by activating Wnt-β-catenin signalling pathway in serous ovarian cancer (2024-06-12)
期刊:JOURNAL OF OBSTETRICS AND GYNAECOLOGY
DOI:10.1080/01443615.2024.2363515
影响因子 :0.9
引用产品: Caov-3 细胞 , Anglne 细胞 , 人卵巢上皮细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Loss of SMURF2 expression enhances RACK1 stability and promotes ovarian cancer progression (2023-10-12)
期刊:CELL DEATH AND DIFFERENTIATION
DOI:10.1038/s41418-023-01226-w
影响因子 :12.4
引用产品: 293T [HEK-293T] 细胞 , SK-OV-3 细胞 , Caov-3 细胞 , A2780 细胞 , Hey 细胞 , SW626 细胞 , Anglne 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM) (2023-04-22)
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-023-01156-8
影响因子 :4.0
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , A2780 细胞
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Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives (2023-11-27)
期刊:CANCER BIOLOGY & THERAPY
DOI:10.1080/15384047.2023.2285817
影响因子 :3.6
引用产品: A2780 细胞 , Caov-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞 , IOSE80 细胞
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ARID5B promoted the histone demethylation of SORBS2 and hampered the metastasis of ovarian cancer (2023-11-03)
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.8
引用产品: A2780 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3 (2023-02-01)
期刊:Recent Patents on Anti-Cancer Drug Discovery
DOI:10.2174/1574892817666220316152201
影响因子 :2.8
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , HO-8910 细胞 , 人卵巢上皮细胞
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Superior Anticancer Potential of Nano-Paclitaxel Combined Bevacizumab Treatment in Ovarian Cancer (2023-07-01)
期刊:CURRENT PHARMACEUTICAL BIOTECHNOLOGY
DOI:10.2174/1389201023666221011115301
影响因子 :2.8
引用产品: A2780 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 增强型细胞活力检测试剂盒(CCK-8) , Annexin V-FITC/PI荧光双染细胞凋亡检测试剂盒
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MOB kinase activator 1A acts as an oncogene by targeting PI3K/AKT/mTOR in ovarian cancer (2023-06-14)
期刊:Discover Oncology
DOI:10.1007/s12672-023-00705-3
影响因子 :2.2
引用产品: IOSE80 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , SK-OV-3 细胞
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Down-regulation of DPP4 by TGFβ1/miR29a-3p inhibited proliferation and promoted migration of ovarian cancer cells (2023-10-31)
期刊:Discover Oncology
DOI:10.1007/s12672-023-00815-y
影响因子 :2.2
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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circ_0025033 promotes ovarian cancer development via regulating the hsa_miR-370-3p/SLC1A5 axis (2022-10-22)
期刊:CELLULAR & MOLECULAR BIOLOGY LETTERS
DOI:10.1186/s11658-022-00364-2
影响因子 :8.7
引用产品: Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , 人脐静脉内皮细胞 , 人脐静脉内皮细胞完全培养基
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PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib (2022-09-05)
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :7.3
引用产品: A2780 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , McCoy's 5A 培养基 , 增强型细胞活力检测试剂盒 (CCK-8) , 碘化丙啶 (PI)染色液 (50μg/mL)
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Norcantharidin induces ferroptosis via the suppression of NRF2/HO?1 signaling in ovarian cancer cells (2022-08-25)
期刊:Oncology Letters
影响因子 :3.1
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells (2022-12-05)
期刊:Reproductive Biology
DOI:10.1016/j.repbio.2022.100704
影响因子 :2.1
引用产品: SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , A2780 细胞 , ES-2 细胞 , 293T [HEK-293T] 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100×
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Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression (2021-06-17)
期刊:Biomedicine & Pharmacotherapy
DOI:10.1016/j.biopha.2021.111533
影响因子 :7.5
引用产品: CoC1 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , RPMI-1640 培养基 , McCoy's 5A 培养基
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P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway (2021-08-12)
期刊:Cell Cycle
DOI:10.1080/15384101.2021.1963910
影响因子 :5.2
引用产品: OV-90 细胞 , A2780 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , 人卵巢上皮细胞 , NIH:OVCAR-3 [OVCAR3]细胞专用培养基 , 人卵巢上皮细胞完全培养基 , OV-90细胞专用培养基
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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer (2021-04-17)
期刊:Gynecologic Oncology
DOI:10.1016/j.ygyno.2021.04.013
影响因子 :4.7
引用产品: A2780 细胞 , 人卵巢上皮细胞 , SK-OV-3 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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CircLNPEP promotes the progression of ovarian cancer through regulating miR-876-3p/ WNT5A axis (2021-08-31)
期刊:Cell Cycle
DOI:10.1080/15384101.2021.1965723
影响因子 :4.3
引用产品: A2780 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , SK-BR-3 [SKBR3] 细胞
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Long non-coding RNA SNHG25 promotes epithelial ovarian cancer progression by up-regulating COMP (2021-01-16)
期刊:Journal of Cancer
影响因子 :3.9
引用产品: A2780 细胞 , SK-OV-3 细胞 , Hey 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞
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miR?638 suppresses proliferation by negatively regulating high mobility group?A1 in ovarian cancer cells (2021-09-20)
期刊:Experimental and Therapeutic Medicine
影响因子 :2.7
引用产品: A2780 细胞 , ES-2 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , Caov-3 细胞
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Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p (2020-02-24)
期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI:10.1007/s11010-020-03704-y
影响因子 :4.3
引用产品: ES-2 细胞 , McCoy's 5A 培养基 , NIH:OVCAR-3 [OVCAR3] 细胞
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MiR-337–3p suppresses proliferation of epithelial ovarian cancer bytargeting PIK3CA and PIK3CB (2019-10-17)
期刊:Cancer Letters
DOI:10.1016/j.canlet.2019.10.021
影响因子 :9.7
引用产品: A2780 细胞 , 293T [HEK-293T] 细胞 , SK-OV-3 细胞 , NIH:OVCAR-3 [OVCAR3] 细胞 , ES-2 细胞
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A 19F NMR probe for the detection of β-galactosidase: simple structure with low molecular weight of 274.2, “turn-on” signal without the background, and good performance applicable in cancer cell line (2017-06-28)
期刊:J Mater Chem B
影响因子 :7.6
引用产品: NIH:OVCAR-3 [OVCAR3] 细胞
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