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产品概述
| 名称 | HEC-1-A (人子宫内膜腺癌细胞) (STR鉴定正确) |
| 别称 | Hec-1-A; HEC-1A; HEC1-A; HEC1A; Hec1A |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HEC-1-A细胞及其亚株HEC-1-B细胞是H·Kuramoto及其同事于1968年从一位ⅠA期子宫内膜癌患者身上分离得到的。PAF可以诱导，HEC-1-A细胞c-fos的表达。 |
| 年龄（性别） | 女性；71岁 |
| 组织来源 | 腺癌；子宫；子宫内膜炎 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 子宫内膜腺癌 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~27-36 hours |
| 致瘤性 | Yes, in nude mice (The cells form moderately well differentiated adenocarcinomas consistent with endometrial carcinoma (grade II)).Yes, in the cheek pouch of cortisone treated hamsters (The cells form typical papillary adenomas). |
| 受体表达情况 | platelet activating factor (PAF) |
| 抗原表达情况 | Blood Type B; Rh+ |
| 基因表达情况 | c-fos+ |
| 保藏机构 | ATCC; HTB-112 BCRC; 60552 JCRB; JCRB1117 JCRB; NIHS0388 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 18,19 D3S1358 15 D5S818 11,15 D7S820 9,11 D8S1179 13,14 D13S317 11 D16S539 12 D18S51 16,21 D19S433 13 D21S11 30,31 FGA 21,22 PentaD 9,12,13 PentaE 11 TH01 6,7 TPOX 8,11 vWA 18,19 D6S1043 12,18 D12S391 19 D2S441 11,13 -
STR鉴定图
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参考文献
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SIM2: Its Prognostic Significance and Oncogenic Role in Endometrial Carcinoma (2024-01-26)
作者：Yunfang Wei:1.Department of Obstetrics & Gynecology, Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China. ; Xianlei Zhao:1.Department of Obstetrics & Gynecology, Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China. ; Hong Tang:1.Department of Obstetrics & Gynecology, Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China. ; Jin Ma:1.Department of Obstetrics & Gynecology, Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China. ; Yongfeng Wang:1.Department of Obstetrics & Gynecology, Shanghai Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republ
期刊：SIM2: Its Prognostic Significance and Oncogenic Role in Endometrial Carcinoma
影响因子 ：4.0
引用产品： Ishikawa 细胞 , HEC-1-A 细胞
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Construction of the novel immune risk scoring system related to CD8+ T cells in uterine corpus endometrial carcinoma (2023-06-22)
作者：Ganghua Zhang:1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China. ; Zhijing Yin:1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China. ; Jianing Fang:1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China. ; Anshan Wu:1.Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, China. ; Guanjun Chen:1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China. ; Ke Cao:1.Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, China. csucaoke@163.com. ;
期刊：Construction of the novel immune risk scoring system related to CD8+ T cells in uterine corpus endometrial carcinoma
DOI：10.1186/s12935-023-02966-y
影响因子 ：5.8
引用产品： HEC-1-A 细胞 , Ishikawa 细胞
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Comprehensive analysis and experimental validation reveal elevated CLCN4 is a promising biomarker in endometrial cancer (2023-09-05)
作者：Chenyang Wang:1.Department of Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. ; 2.Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China. ; Jing Li:1.Department of Gynecology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong 266000, China. ; Weina Liu:1.Department of Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. ; 2.Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China. ; Shiya Li:1.Department of Gynecology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. ; 2.Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450000, China. ; Yi Zhang:1.Department of Gynecology, The University of Auckland, Grafton, Auckland 1023, New Zealand. ; Yanbin Jin:1.Department of Gynecology, Hainan Affiliated Hospital of Hainan Medical University (Hainan General Hospit
期刊：Comprehensive analysis and experimental validation reveal elevated CLCN4 is a promising biomarker in endometrial cancer
影响因子 ：5.2
引用产品： HEC-1-A 细胞
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Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation (2023-07-19)
作者：Yan-Bin Jin:1.Department of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, China. ; 2.Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China. ; 3.Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, Hainan, China. ; 4.Medical Laboratory Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, China. ; Xiao-Chen Liang:1.Department of Gynecology and Obstetrics, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, China. ; 2.Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education, Haikou, Hainan, China. ; 3.Hainan Provincial Key Laborato
期刊：Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation
影响因子 ：4.7
引用产品： HEC-1-A 细胞
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Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma (2023-03-11)
作者：Min Wang:1.Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. ; Song Yue:1.Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. ; Zhu Yang:1.Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. yangzhu@hospital.cqmu.edu.cn. ;
期刊：Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma
DOI：10.1038/s41598-023-31325-0
影响因子 ：4.6
引用产品： HEC-1-A 细胞
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Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer (2023-08-28)
作者：Chunying Zheng:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Zhen Ren:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Hongliang Chen:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Xiaorui Yuan:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Suye Suye:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Huan Yin:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. ; Chun Fu:1.Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, H
期刊：Reduced FANCE Confers Genomic Instability and Malignant Behavior by Regulating Cell Cycle Progression in Endometrial Cancer
影响因子 ：3.9
引用产品： HEC-1-A 细胞 , HEC-1-B 细胞
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Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer (2023-02-10)
作者：Aijun Qin:1.Shanghai Huaota Biopharmaceutical Co., Ltd., Shanghai, China. ; Qiaoxia Qian:1.Shanghai Huaota Biopharmaceutical Co., Ltd., Shanghai, China. ; 2.School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China. ; 3.Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China. ; Xiaopei Cui:1.Shanghai Huaota Biopharmaceutical Co., Ltd., Shanghai, China. ; Wenling Bai:1.Shanghai Huaota Biopharmaceutical Co., Ltd., Shanghai, China. ;
期刊：Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer
影响因子 ：3.6
引用产品： HEC-1-A 细胞 , Ishikawa 细胞 , 特级胎牛血清 , 增强型细胞活力检测试剂盒 (CCK-8)
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ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer (2023-04-06)
作者：Yuming Zhang:1.Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China. ; Hai'ou Lu:1.Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China. ; Yuexin Yu:1.Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China. ;
期刊：ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer
影响因子 ：2.9
引用产品： HEC-1-A 细胞 , Ishikawa 细胞 , 特级胎牛血清
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IGFBP‑rP1 affects the proliferation, apoptosis and macrophage polarization of endometrial cancer cells by regulating the PI3K/AKT pathway (2023-03-03)
作者：Juan Gao:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Shiqi Suo:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Jingxia Li:1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056001, P.R. China. ; Chunxia Wang:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Ranran Deng:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Yuxia Hu:1.Department of Obstetrics, Handan First Hospital, Handan, Hebei 056002, P.R. China. ; Chunzheng Zhang:1.Department of Functional Section I, Affiliated Hospital of Hebei Engineering University, Handan, Hebei 056000, P.R. China. ;
期刊：IGFBP‑rP1 affects the proliferation, apoptosis and macrophage polarization of endometrial cancer cells by regulating the PI3K/AKT pathway
影响因子 ：2.7
引用产品： Ishikawa 细胞 , HEC-1-A 细胞 , RL95-2 细胞 , HEC-1-B 细胞 , AN3 CA 细胞 , THP-1 细胞
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Friend leukemia integration 1 overexpression decreases endometrial receptivity and induces embryo implantation failure by promoting PART1 transcription in the endometrial epithelial cells (2023-09-26)
作者：Yile Zhang:1.Reproductive Medical Center, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People's hospital, Taiyuan, China. ; 2.Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Beining Yin:1.Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Sichen Li:1.Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Yueyue Cui:1.Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ; Jianrong Liu:1.Reproductive Medical Center, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People's hospital, Taiyuan, China. ;
期刊：Friend leukemia integration 1 overexpression decreases endometrial receptivity and induces embryo implantation failure by promoting PART1 transcription in the endometrial epithelial cells
影响因子 ：2.7
引用产品： HEC-1-A 细胞 , Ishikawa 细胞 , RL95-2 细胞 , BeWo 细胞
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Effects of RFRP‑3 on an ovariectomized estrogen‑primed rat model and HEC‑1A human endometrial carcinoma cells (2022-12-23)
作者：Xueying Zhao:1.Department of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Lina Si:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Lin Niu:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Meng Wei:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Fengxia Wang:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Xiaochao Liu:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Zhihong Chen:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Yuebing Qiao:1.Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Luyang Cheng:1.Department of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China. ; Songhe Yang:1.Department of Hu
期刊：Effects of RFRP‑3 on an ovariectomized estrogen‑primed rat model and HEC‑1A human endometrial carcinoma cells
影响因子 ：2.8
引用产品： HEC-1-A 细胞
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CMBs carrying PTX and CRISPR/Cas9 targeting C‑erbB‑2 plasmids interfere with endometrial cancer cells (2009-01-20)
作者：Siyuan Peng:1.Department of Gynaecology and Obstetrics, Hainan Hospital Affiliated to University of South China, Haikou, Hainan 570311, P.R. China. ; Junhong Cai:1.Key Laboratory of Cell and Molecular Genetic Translational Medicine in Hainan Province, Hainan General Hospital, Haikou, Hainan 570311, P.R. China. ; Shan Bao:1.Department of Gynaecology and Obstetrics, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China. ;
期刊：CMBs carrying PTX and CRISPR/Cas9 targeting C‑erbB‑2 plasmids interfere with endometrial cancer cells
影响因子 ：3.4
引用产品： HEC-1-A 细胞
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Exosomal-lncRNA DLEU1 Accelerates the Proliferation, Migration, and Invasion of Endometrial Carcinoma Cells by Regulating microRNA-E2F3 (2008-00-20)
作者：Jianjun Jia:1.Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou City, Guangdong Province 510632, People's Republic of China. ; Suiqun Guo:1.Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Southern Medical University, Guangzhou City, Guangdong Province, People's Republic of China. ; Dong Zhang:1.Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou City, Guangdong Province 510632, People's Republic of China. ; Xiaohui Tian:1.Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen City, Guangdong Province, People's Republic of China. ; Xingmei Xie:1.Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou City, Guangdong Province 510632, People's Republic of China. ;
期刊：Exosomal-lncRNA DLEU1 Accelerates the Proliferation, Migration, and Invasion of Endometrial Carcinoma Cells by Regulating microRNA-E2F3
影响因子 ：4.0
引用产品： KLE 细胞 , Ishikawa 细胞 , HEC-1-A 细胞 , RL95-2 细胞
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Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis (2009-00-20)
作者：Xihuan Gao:1.Department of Gynecology, Qingdao Traditional Chinese Medicine Hospital, Qingdao City, Shandong Province 266000, People's Republic of China. ; Liming Yu:1.Department of Gynecology, Qingdao Traditional Chinese Medicine Hospital, Qingdao City, Shandong Province 266000, People's Republic of China. ; Jingjing Zhang:1.Department of Gynecology, Qingdao Traditional Chinese Medicine Hospital, Qingdao City, Shandong Province 266000, People's Republic of China. ; Ping Xue:1.Department of Gynecology, Qingdao Traditional Chinese Medicine Hospital, Qingdao City, Shandong Province 266000, People's Republic of China. ;
期刊：Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis
影响因子 ：4.0
引用产品： KLE 细胞 , Ishikawa 细胞 , HEC-1-A 细胞
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