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产品概述
| 名称 | A-431 (人表皮癌细胞) (STR鉴定正确) |
| 别称 | A431; A431/P |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.细胞成片生长，生长速度缓慢；2.细胞贴壁很牢、较难消化；如有必要，可分次消化。 |
| 背景描述 | 皮肤癌细胞株A-431源自一位85岁女性，是由D·J·Giard等人建立的一系列细胞株中的一株。A-431细胞在抗胸腺细胞球蛋白、血清处理的NIH瑞士小鼠中形成类似于恶性黑素瘤快速增长的皮下肿瘤，在普通成纤维细胞和琼脂上形成克隆。A-431细胞是一个超三倍体人细胞株。 |
| 年龄（性别） | 女性；85岁 |
| 组织来源 | 皮肤；上皮；皮肤癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 其它肿瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~80-100 hours |
| 致瘤性 | Yes, forms rapidly growing subcutaneous tumors in immunosuppressed mice and colonies in soft agar. |
| 保藏机构 | ATCC; CRL-1555 ATCC; CRL-7907BCRC; 60161 BCRJ; 0032 DSMZ; ACC-91 ECACC; 85090402 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 17,20 D3S1358 14 D5S818 12,13 D7S820 10 D8S1179 13 D13S317 9,13 D16S539 12,14 D18S51 13,17 D19S433 15,15.2 D21S11 28,30 FGA 20 PentaD 9,11 PentaE 12,13 TH01 9 TPOX 11 vWA 15,17 D6S1043 12,18 D12S391 18,23 D2S441 11.3,15 -
STR鉴定图
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参考文献
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Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy (2024-01-06)
作者：Haobing Wang:1.College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. ; Yidan Lai:1.College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. ; 2.School of Pharmaceutical Science, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China. ; Dan Li:1.College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. ; Johannes Karges:1.Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Bochum 44780, Germany. ; Pingyu Zhang:1.College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China. ; Huaiyi Huang:1.School of Pharmaceutical Science, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China. ;
期刊：Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy
DOI：10.1021/acs.jmedchem.3c01889
影响因子 ：7.3
引用产品： A549 [A-549] 细胞 , A549/DDP 细胞 , A549/Tax 细胞 , A-431 细胞 , MRC-5 细胞
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NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma (2024-02-15)
作者：Wang Ye:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; Cao Ya-Xuan:1.Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, China. ; Tang Shan-Shan:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; Long Qiu:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; Ma Ting:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; Chen Shao-Jie:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; 2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, China. ; Cao Yu:1.School of Clinical Medicine, Guizhou Medical University, Guiyang, China. ; 2.Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, China. ;
期刊：NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma
影响因子 ：3.2
引用产品： Hacat 细胞 , A-431 细胞 , Colo-16 细胞 , SCL-1 细胞 , SCL-2 细胞 , HSC-5 细胞
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UBE2C promotes malignancy of cutaneous squamous cell carcinoma (2023-11-16)
作者：Ruiting Luo:1.Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ; Ruimin Bai:1.Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ; Jiaqi Guo:1.Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ; Ningyi Xian:1.Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ; Yan Zheng:1.Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ;
期刊：UBE2C promotes malignancy of cutaneous squamous cell carcinoma
影响因子 ：2.2
引用产品： A-431 细胞
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Near-Infrared Light-Activated Oxygen Generator a Multidynamic Photo-Nanoplatform for Effective Anti-Cutaneous Squamous Cell Carcinoma Treatment (2022-11-28)
作者：Xin Zhang:1.Department of Dermatology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, People's Republic of China. ; 2.Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China. ; 3.Department of Dermatology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People's Republic of China. ; Xiangbo Bu:1.Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu, 221009, People's Republic of China. ; Wenyu Jia:1.Department of Dermatology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, People's Republic of China. ; 2.Department of Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People's Republic of China. ; Yu Ying:1.Department of Dermatology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, People's Republic of China. ; 2.Depart
期刊：Near-Infrared Light-Activated Oxygen Generator a Multidynamic Photo-Nanoplatform for Effective Anti-Cutaneous Squamous Cell Carcinoma Treatment
影响因子 ：7.0
引用产品： A-431 细胞
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The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy (2001-02-20)
作者：Mei Zeng:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; 2.Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, People's Republic of China. ; Qingxiang Li:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; Junzhao Chen:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; Wenfu Huang:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; Jinhua Liu:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; Cuiyan Wang:1.Department of Dermatology, Huizhou Municipal Central Hospital, Huizhou 516000, Guangdong, People's Republic of China. ; Manni Huang:1.Department of Dermatology, Huizhou Municipa
期刊：The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy
影响因子 ：3.6
引用产品： A-431 细胞
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Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN (2022-11-11)
作者：Zhong-Zhao Zhang:1.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China. ; Chang-Hui Wen:1.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China. ; Min Jia:1.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China. ; Hong-Qiang Zhang:1.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China. ; Shao-Qin Sun:1.Department of Dermatology, The First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China. ;
期刊：Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN
影响因子 ：3.0
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Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma (2002-02-20)
作者：Jing Xu:1.Department of Radiation Oncology, The Second Affiliated Hospital and Cancer Institute (National Ministry of Education Key Laboratory of Cancer Prevention and Intervention), Zhejiang University School of Medicine, Hangzhou, China. ; Dongping Wu:1.Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, China. ; Bicheng Zhang:1.Department of Radiation Oncology, The Second Affiliated Hospital and Cancer Institute (National Ministry of Education Key Laboratory of Cancer Prevention and Intervention), Zhejiang University School of Medicine, Hangzhou, China. ; Chi Pan:1.Department of Breast Surgey, The Second Affiliated Hospital, Zhejiang University, College of Medicine, Hangzhou, China. ; Yinglu Guo:1.Department of Radiation Oncology, The Second Affiliated Hospital and Cancer Institute (National Ministry of Education Key Laboratory of Cancer Prevention and Intervention), Zhejiang University School of Medicine, Hangzhou, C
期刊：Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma
影响因子 ：2.7
引用产品： A-431 细胞
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Artesunate restrains the malignant progression of human cutaneous squamous cell carcinoma cells via the suppression of the PI3K/AKT pathway (2003-02-20)
作者：Xinyan Huang:1.Dermatology Department, The Second Affiliated Hospital Zhejiang University School of Medicine, China. ; Songzhao Zhang:1.Laboratory Department, The Second Affiliated Hospital Zhejiang University School of Medicine, China. ; Wenxi Wang:1.College of Pharmacy, Zhejiang University of Technology, China. Electronic address: wenxiw_wwx@163.com. ;
期刊：Artesunate restrains the malignant progression of human cutaneous squamous cell carcinoma cells via the suppression of the PI3K/AKT pathway
DOI：10.1016/j.tice.2022.101789
影响因子 ：2.6
引用产品： A-431 细胞 , DMEM高糖完全培养基 (含10%FBS)
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Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma (2007-01-20)
作者：Xueli Bai:1.Department of Gynecology, The Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Huanggu District, Shenyang, Liaoning 110004, China. Electronic address: xlbai@cmu.edu.cn. ; Fengping Shan:1.Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang 110122, China. ; Na Qu:1.Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang 110122, China. ; Hai Huang:1.Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang 110122, China. ; Mike Handley:1.Cytocom Inc., 3001 Aloma Ave., Winter Park, FL 32792, USA. ; Noreen Griffin:1.Cytocom Inc., 3001 Aloma Ave., Winter Park, FL 32792, USA. ; Shuling Zhang:1.Department of Immunology, College of Basic Medical Science, China Medical University, Shenyang 110122, China; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: slzhang@cmu.ed
期刊：Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma
DOI：10.1016/j.intimp.2021.107996
影响因子 ：5.6
引用产品： A-431 细胞
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Novel 4-anilinoquinazoline derivatives featuring an 1-adamantylmoiety as potent EGFR inhibitors with enhanced activity againstNSCLC cell lines (2001-06-20)
作者：Haiqing Yu:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Yanxia Li:1.Respiratory Department, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China. ; Yang Ge:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Zhendong Song:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Changyuan Wang:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Shanshan Huang:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Yue Jin:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Xu Han:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Yuhong Zhen:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. ; Kexin Liu:1.College of Pharmacy, Dalian Medical University, Dalian 116044, PR China. Electronic address: kexinliu@dlmedu.edu.cn. ; Youwen Zhou:1.Department of De
期刊：Novel 4-anilinoquinazoline derivatives featuring an 1-adamantylmoiety as potent EGFR inhibitors with enhanced activity againstNSCLC cell lines
DOI：10.1016/j.ejmech.2016.01.045
影响因子 ：6.7
引用产品： A-431 细胞 , HCC827 细胞 , NCI-H1975 细胞 , A549 [A-549] 细胞 , MCF7 [MCF-7] 细胞
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