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产品概述
| 名称 | MOLT-4 (人急性淋巴母细胞白血病细胞) (STR鉴定正确) |
| 别称 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C |
| 种属 | 人 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 淋巴母细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 4×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | MOLT-4细胞是从一位复发病人的细胞中建立。这个病人接受过多种药物联合前期化疗，p53基因的248位密码子有一个G→A突变，p53不表达。MOLT-4细胞不生成免疫球蛋白或EB病毒；MOLT-4细胞与MOLT-3细胞均来源于同一位病人。 |
| 年龄（性别） | 男性；19岁 |
| 组织来源 | T淋巴母细胞；急性淋巴母细胞白血病 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 白血病细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24-48 hours |
| 致瘤性 | Yes, in untreated nude mice, anti lymphocyte serum treated mice and X-irradiated mice. |
| 抗原表达情况 | CD1 (49%), CD2 (35%), CD3 A (26%) B (33%) C (34%), CD4 (55%), CD5 (72%), CD6 (22%), CD7 (77%) |
| 基因表达情况 | high levels of terminal deoxynucleotidyl transferase (TdT) are produced. |
| 保藏机构 | ATCC; CRL-1582 DSMZ; ACC-362 ECACC; 85011413 ECACC; 94022544 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11,12,13 D2S1338 23,24 D3S1358 14,16 D5S818 12 D7S820 8,10,11 D8S1179 9,14 D13S317 12,13 D16S539 11,14 D18S51 13,17 D19S433 14,15 D21S11 28,29,30,31 FGA 22,23,24,25 PentaD 8,13 PentaE 14,16 TH01 6,8 TPOX 8 vWA 17,18 D6S1043 15 D12S391 16,17,18,19 D2S441 10,11 -
STR鉴定图
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参考文献
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IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein (2023-02-04)
作者：Yujing Wu:1.Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Provincial Institute of Translational Medicine, Hefei 230032, China. ; Aijun Zhang:1.Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Provincial Institute of Translational Medicine, Hefei 230032, China. ; Wensheng Chen:1.Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Provincial Institute of Translational Medicine, Hefei 230032, China. ; Qianling Xin:1.Institute of Clinical Pharmacology, Anhui M
期刊：IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein
DOI：10.1016/j.phrs.2023.106686
影响因子 ：9.3
引用产品： Jurkat, Clone E6-1 细胞 , MOLT-4 细胞 , EL4 细胞
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An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3 (2023-12-04)
作者：Xu Wang:1.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University Wuhan 430072, China. Electronic address: wangxu@whu.edu.cn. ; Lingyan Yan:1.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University Wuhan 430072, China. ; Jihua Guo:1.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University Wuhan 430072, China; Department of Endodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, China. Electronic address: jihuaguo@whu.edu.cn. ; Rong Jia:1.State Key Laboratory of Oral
期刊：An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3
DOI：10.1016/j.intimp.2023.111280
影响因子 ：5.6
引用产品： MOLT-4 细胞 , FaDu 细胞 , Ca Ski 细胞 , HCT 116 细胞
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The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV‐infected patients on suppressive antiretroviral therapy (2012-00-20)
作者：J H Li:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; J Ma:1.Department of Gastroenterology, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; W Kang:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; C F Wang:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; F Bai:1.Department of Infectious Diseases, 986 Hospital of Air Force affiliated to Xijing Hospital, The Air Force Military Medical University, Xi'an, China. ; K Zhao:1.Department of Infectious Diseases, 986 Hospital of Air Force affiliated to Xijing Hospital, The Air Force Military Medical University, Xi'an, China. ; N Yao:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; Q Liu:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Mili
期刊：The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV‐infected patients on suppressive antiretroviral therapy
影响因子 ：3.0
引用产品： CCRF-CEM [CCRF CEM] 细胞 , MOLT-4 细胞
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The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells (2008-08-20)
作者：Wei Wu:1.1Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060 People's Republic of China. ; Li Nie:1.2Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, 430060 People's Republic of China. ; Li Zhang:1.3Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, 430060 People's Republic of China. ; Yan Li:1.1Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060 People's Republic of China. ;
期刊：The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells
影响因子 ：8.3
引用产品： MOLT-4 细胞
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![SH-SY5Y [SHSY-5Y] (人神经母细胞瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0208-1.jpg)
