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产品概述
名称 | CCRF-CEM [CCRF CEM] (人急性淋巴细胞白血病T淋巴细胞) (STR鉴定正确) |
别称 | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671 |
种属 | 人 |
生长特性 | 悬浮细胞 |
细胞形态 | 淋巴母细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 3×10^5-5×10^5cells/mL |
推荐换液频率 | 2-3次/周 |
注意事项 | 该细胞为悬浮细胞,请注意离心收集细胞悬液;请勿直接倒掉细胞培养液。 |
背景描述 | CCRF-CEM [CCRF CEM]细胞是由G·E·Foley等人于1964年11月从一位四岁白人女性急性淋巴细胞白血病患者的外周血白血球衣中建立的类淋巴母细胞细胞株。 |
年龄(性别) | 女性;4岁 |
组织来源 | 白血病,急性淋巴细胞白血病,外周血,T淋巴母细胞 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 白血病细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~24-30 hours |
致瘤性 | Yes, in syrian hamsters. |
抗原表达情况 | CD3; Homo sapiens, expressedCD4; Homo sapiens, expressedCD5; Homo sapiens, expressedCD7; Homo sapiens, expressed |
基因表达情况 | CD3; Homo sapiens, expressed CD4; Homo sapiens, expressed CD5; Homo sapiens, expressed CD7; Homo sapiens, expressed |
保藏机构 | ATCC; CCL-119 ATCC; CRM-CCL-119 ATCC; CRL-7916ATCC; CRL-8436 BCRC; 60137 BCRJ; 0063 DSMZ; ACC-240 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11 D2S1338 24 D3S1358 15 D5S818 12,13,14 D7S820 9,13 D8S1179 13 D13S317 11 D16S539 10,13 D18S51 13,18 D19S433 14 D21S11 30,33.2 FGA 23,24 PentaD 11 PentaE 5,14 TH01 6,7 TPOX 8 vWA 17,19 D6S1043 11,13,14 D12S391 18,20,21 D2S441 11,14 -
STR鉴定图
参考文献
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A dual aptamer recognition-based fluorescent biosensor for extracellular vesicles assays with high sensitivity and specificity (2023-04-26)
作者:Fangfang Guo: 1.Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou 510632, PR China; Mengxu Sun: 1.NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China; Ya Zhang: 1.Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou 510632, PR China; Juan Xie: 1.Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou 510632, PR China; Qingxin Gao: 1.NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China; Wen-Jun Duan: 1.NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceut
期刊:A dual aptamer recognition-based fluorescent biosensor for extracellular vesicles assays with high sensitivity and specificity
影响因子 :8.4
引用产品: CCRF-CEM [CCRF CEM] 细胞
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Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication (2023-02-09)
作者:Mingyuan Bi:1.Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, China. ; Wen Kang:1.Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, China. ; Yongtao Sun:1.Department of Infectious Diseases, Tangdu Hospital, Air Force Medical University, Xi'an, China. ;
期刊:Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication
DOI:10.3389/fimmu.2023.1123600
影响因子 :7.3
引用产品: CCRF-CEM [CCRF CEM] 细胞 , Jurkat, Clone E6-1 细胞 , 293T [HEK-293T] 细胞
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Combination of specific proteins as markers for accurate detection of extracellular vesicles using proximity ligation-mediated bHCR amplification (2023-05-11)
作者:Jingru Zhu:1.School of Biological Sciences and Technology, University of Jinan, Jinan, 250022, PR China. ; Wenyu Sun:1.State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, PR China. ; Yuying Yao:1.School of Biological Sciences and Technology, University of Jinan, Jinan, 250022, PR China. ; Zhiqiang Guo:1.Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China. ; Qianru Li:1.School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, PR China. ; Zongqiang Li:1.School of Biological Sciences and Technology, University of Jinan, Jinan, 250022, PR China. ; Long Jiang:1.Qingdao Spring Water-treatment Co, Ltd, Qingdao, 266000, PR China. ; Shangci Zuo:1.School of Biological Sciences and Technology, University of Jinan, Jinan, 250022, PR China. ; Su Liu:1.School
期刊:Combination of specific proteins as markers for accurate detection of extracellular vesicles using proximity ligation-mediated bHCR amplification
影响因子 :6.2
引用产品: CCRF-CEM [CCRF CEM] 细胞
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Syringaldehyde ameliorates mouse arthritis by inhibiting dendritic cell maturation and proinflammatory cytokine secretion (2023-06-18)
作者:Teng Li:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China. ; Xiaoying Liu:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China. ; Peng Han:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China. ; Alimu Aimaier:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China. ; Yaosheng Zhang:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830017, China. ; Jinyao Li:1.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang Un
期刊:Syringaldehyde ameliorates mouse arthritis by inhibiting dendritic cell maturation and proinflammatory cytokine secretion
DOI:10.1016/j.intimp.2023.110490
影响因子 :5.6
引用产品: CCRF-CEM [CCRF CEM] 细胞
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Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126 (2023-04-10)
作者:You-Jia Hao:1.College of Marine Sciences, Shanghai Ocean University, 999 Hucheng Ring Road, Shanghai 201306, China. ; 2.Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. ; Zheng-Biao Zou:1.Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. ; Ming-Min Xie:1.Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. ; Yong Zhang:1.Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. ; Lin Xu:1.Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. ; Hao-Yu Yu:1.Key Laboratory of Marine Genetic Resources, Third Institute of Oceano
期刊:Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126
影响因子 :5.4
引用产品: CCRF-CEM [CCRF CEM] 细胞
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Development and evaluation of novel artemisinin-isatin hybrids with potential anti-leukemic cytotoxicity (2023-04-14)
作者:Peng Wang:1.Department of Critical Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ; Zhe Zhang:1.Department of Tumor Radiotherapy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ; Wei Cao:1.Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Provincial Qianfoshan Hospital, Shandong Institute of Nephrology, Jinan, Shandong, China. ; Xuan Zhang:1.Department of Geriatric Respiratory Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ;
期刊:Development and evaluation of novel artemisinin-isatin hybrids with potential anti-leukemic cytotoxicity
影响因子 :4.7
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Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation (2023-08-21)
作者:Peng Wang: 1.The First Clinical College, Shandong University of Traditional Chinese Medicine, **an, China;2.Department of Critical Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, **an, China; Weiwei Wang: 1.The First Clinical College, Shandong University of Traditional Chinese Medicine, **an, China; Lei Zhou: 1.The First Clinical College, Shandong University of Traditional Chinese Medicine, **an, China; Lin Wang: 1.The First Clinical College, Shandong University of Traditional Chinese Medicine, **an, China; Yang Zhao: 1.The First Clinical College, Shandong University of Traditional Chinese Medicine, **an, China; Jiarui Xu: 1.Department of Critical Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, **an, China; Dai Yuan: 1.Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, **an, China; Li Kong: 1.Department of Emergency Center, Shandong University of Tradit
期刊:Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation
DOI:10.1007/s00044-023-03122-x
影响因子 :2.6
引用产品: K-562 [K562] 细胞 , K562/ADR 细胞 , CCRF-CEM [CCRF CEM] 细胞 , 人外周血单核细胞
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Pentanoate-Tethered Artemisinin-Isatin Hybrids with Antileukemic Potential (2023-03-21)
作者:School of Pharmacy, Guizhou University of Traditional Chinese Medicine, 550025 Guiyang, Guizhou, PR China
期刊:Pentanoate-Tethered Artemisinin-Isatin Hybrids with Antileukemic Potential
影响因子 :2.1
引用产品: K-562 [K562] 细胞 , K562/ADR 细胞 , CCRF-CEM [CCRF CEM] 细胞
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Knockout KHDRBS3 inhibits cell proliferation and glucocorticoid resistance in acute lymphoblastic leukemia (2022-10-01)
作者:**ncui Lu: 1.Department of Pediatrics, The Affiliated Huaian No.1 People’s Hospital of Nan**g Medical University, No. 1, Huanghe West Road, Huaiyin District, Huaian City, 223300, Jiangsu Province, China; Li Ma: 1.Department of Pediatrics, The Affiliated Huaian No.1 People’s Hospital of Nan**g Medical University, No. 1, Huanghe West Road, Huaiyin District, Huaian City, 223300, Jiangsu Province, China; Yufang Yuan: 1.Department of Pediatrics, The Affiliated Huaian No.1 People’s Hospital of Nan**g Medical University, No. 1, Huanghe West Road, Huaiyin District, Huaian City, 223300, Jiangsu Province, China;
期刊:Knockout KHDRBS3 inhibits cell proliferation and glucocorticoid resistance in acute lymphoblastic leukemia
DOI:10.1007/s13273-022-00299-x
影响因子 :1.7
引用产品: Reh 细胞 , CEM/C1 细胞 , CCRF-CEM [CCRF CEM] 细胞 , BALL-1 细胞 , RPMI-1640 培养基 , 青霉素-链霉素溶液 (双抗),100×
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Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p (2011-01-20)
作者:Huanhuan Feng:1.Department of Neonatology, Xi'an Gaoxi Hospital, Xi'an, People's Republic of China. ; Fei Li:1.Department of Neonatology, Xi'an Gaoxi Hospital, Xi'an, People's Republic of China. ; Ping Tang:1.Department of Neonatology, Xi'an Gaoxi Hospital, Xi'an, People's Republic of China. ;
期刊:Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p
DOI:10.1080/16078454.2021.1997197
影响因子 :1.9
引用产品: 人外周血单个核细胞 , CCRF-CEM [CCRF CEM] 细胞 , Jurkat, Clone E6-1 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100× , IL-2 (重组人白细胞介素-2、白细胞介素-2) (250μL×4)
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The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV‐infected patients on suppressive antiretroviral therapy (2012-00-20)
作者:J H Li:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; J Ma:1.Department of Gastroenterology, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; W Kang:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; C F Wang:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; F Bai:1.Department of Infectious Diseases, 986 Hospital of Air Force affiliated to Xijing Hospital, The Air Force Military Medical University, Xi'an, China. ; K Zhao:1.Department of Infectious Diseases, 986 Hospital of Air Force affiliated to Xijing Hospital, The Air Force Military Medical University, Xi'an, China. ; N Yao:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Military Medical University, Xi'an, China. ; Q Liu:1.Department of Infectious Diseases, Tangdu Hospital, The Air Force Mili
期刊:The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV‐infected patients on suppressive antiretroviral therapy
影响因子 :3.0
引用产品: CCRF-CEM [CCRF CEM] 细胞 , MOLT-4 细胞
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