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产品概述
名称 | Jurkat, Clone E6-1 (人T淋巴细胞白血病细胞) (STR鉴定正确) |
别称 | JurkatE6-1; Jurkat E6-1; Jurkat, Clone E6-1; Jurkat Clone E6-1; Jurkat (clone E6-1); JURKAT E-6.1; JURKAT E-61; Jurkat-E6; Jurkat E6; J.E6-1; E6-1 |
种属 | 人 |
生长特性 | 悬浮细胞 |
细胞形态 | 淋巴细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 3×10^5-5×10^5cells/mL |
推荐换液频率 | 2-3次/周 |
注意事项 | 该细胞为悬浮细胞,请注意离心收集细胞悬液;请勿直接倒掉细胞培养液。 |
背景描述 | Jurkat, Clone E6-1细胞是Jurkat-FHCRC细胞株(Jurkat细胞株的衍生)的一个克隆。Jurkat, Clone E6-1细胞来源于一个14岁男孩的外周血,经佛波酯和外源凝集素或抗T3单克隆抗体(两种类型的诱导都需要)诱导后可产生大量IL-2。 |
年龄(性别) | 男性;14岁 |
组织来源 | T淋巴细胞;急性T细胞白血病 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 白血病细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~24-48 hours |
受体表达情况 | T cell antigen receptor, expressed |
抗原表达情况 | CD3; Homo sapiens, expressed |
基因表达情况 | interleukin-2 (interleukin 2, IL-2), CD3; Homo sapiens, expressed |
保藏机构 | ATCC; TIB-152 BCRC; 60424 BCRJ; 0125 ECACC; 88042803 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 11,12 D2S1338 19,23 D3S1358 15 D5S818 9 D7S820 8,12 D8S1179 13,14 D13S317 8,12 D16S539 11 D18S51 13,21 D19S433 14,15.2 D21S11 31.2,33.2 FGA 20,21 PentaD 11,13 PentaE 10,12 TH01 6,9.3 TPOX 8,10 vWA 18 D6S1043 11 D12S391 23 D2S441 14,15 -
STR鉴定图
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参考文献
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Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype (2023-03-31)
期刊:Nature Communications
DOI:10.1038/s41467-023-37527-4
影响因子 :16.6
引用产品: RAW 264.7 细胞 , THP-1 细胞 , Jurkat, Clone E6-1 细胞
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner (2023-02-03)
期刊:Cancer Immunology Research
DOI:10.1158/2326-6066.CIR-22-0439
影响因子 :10.1
引用产品: Jurkat, Clone E6-1 细胞 , RKO 细胞 , CT26.WT 细胞 , B16-F10 细胞 , MC38 细胞 , 4T1 细胞 , LLC [LL/2; LLC1] 细胞 , Hepa 1-6 细胞 , YAC-1 细胞 , 293T [HEK-293T] 细胞 , AAV-293 细胞 , STR鉴定
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IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein (2023-02-04)
期刊:PHARMACOLOGICAL RESEARCH
DOI:10.1016/j.phrs.2023.106686
影响因子 :9.3
引用产品: Jurkat, Clone E6-1 细胞 , MOLT-4 细胞 , EL4 细胞
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Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy (2023-08-22)
期刊:SENSORS AND ACTUATORS B-CHEMICAL
影响因子 :8.4
引用产品: K-562 [K562] 细胞 , U-937 细胞 , Raji 细胞 , Jurkat, Clone E6-1 细胞 , K-562 [K562]细胞专用培养基 , U-937细胞专用培养基 , Raji细胞专用培养基 , Jurkat, Clone E6-1细胞专用培养基
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BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation (2023-12-11)
期刊:JOURNAL OF CELL BIOLOGY
影响因子 :7.8
引用产品: U-87 MG 细胞 , Jurkat, Clone E6-1 细胞 , Raji 细胞 , A20 细胞
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IL-17A promotes tumorigenesis and upregulates PD-L1 expression in non-small cell lung cancer (2023-11-17)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-023-04365-3
影响因子 :7.4
引用产品: Jurkat, Clone E6-1 细胞
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Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication (2023-02-09)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1123600
影响因子 :7.3
引用产品: CCRF-CEM [CCRF CEM] 细胞 , Jurkat, Clone E6-1 细胞 , 293T [HEK-293T] 细胞
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ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus (2023-08-25)
期刊:BIOCHEMICAL PHARMACOLOGY
影响因子 :5.8
引用产品: Jurkat, Clone E6-1 细胞
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Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus (2023-09-09)
期刊:BIOCHEMICAL PHARMACOLOGY
影响因子 :5.8
引用产品: Jurkat, Clone E6-1 细胞
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ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus (2023-04-26)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2023.110216
影响因子 :5.6
引用产品: Jurkat, Clone E6-1 细胞
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Yi-Qi-Jian-Pi formula ameliorates immune function in acute-on-chronic liver failure by upregulating autophagy and mitochondrial biogenesis in CD8+ T lymphocytes (2023-02-17)
期刊:JOURNAL OF ETHNOPHARMACOLOGY
影响因子 :5.4
引用产品: RPMI-1640 培养基 , Jurkat, Clone E6-1 细胞
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CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren’s Syndrome by Activating GRK2 to Promote T Lymphocyte Migration (2023-02-18)
期刊:INFLAMMATION
DOI:10.1007/s10753-023-01791-9
影响因子 :5.1
引用产品: Jurkat, Clone E6-1 细胞
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Down-regulation of Musashi-2 exerts antileukemic effects on acute lymphoblastic leukemia cells and increases sensitivity to dexamethasone (2023-09-26)
期刊:ANNALS OF HEMATOLOGY
DOI:10.1007/s00277-023-05468-z
影响因子 :3.5
引用产品: Jurkat, Clone E6-1 细胞
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Glyoxalase 1 inhibitor BBGC suppresses the progression of chronic lymphocytic leukemia and promotes the efficacy of Palbociclib (2023-02-02)
期刊:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI:10.1016/j.bbrc.2023.01.034
影响因子 :3.1
引用产品: Jurkat, Clone E6-1 细胞
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Hyposterolactone A, a 3α-Hydroxy Steroidal Lactone from the Deep-Sea-Derived Fungus Hypocrea sp. ZEN14 (2023-06-02)
期刊:CHEMISTRY & BIODIVERSITY
影响因子 :2.9
引用产品: HuH-7 细胞 , Hep G2 细胞 , HL-60 细胞 , Jurkat, Clone E6-1 细胞
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration (2023-03-23)
期刊:Oncologie
DOI:10.1515/oncologie-2022-1002
影响因子 :0.9
引用产品: U-937 细胞 , Jurkat, Clone E6-1 细胞 , A549 [A-549] 细胞 , A-375 细胞 , Hep G2 细胞 , U-87 MG 细胞
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1,25(OH)2D3 Promotes Macrophage Efferocytosis Partly by Upregulating ASAP2 Transcription via the VDR-Bound Enhancer Region and ASAP2 May Affect Antiviral Immunity (2022-11-21)
期刊:Nutrients
影响因子 :6.7
引用产品: THP-1 细胞 , J774A.1 细胞 , Jurkat, Clone E6-1 细胞
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An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis (2004-01-20)
期刊:Acta Pharmacologica Sinica
DOI:10.1038/s41401-021-00665-w
影响因子 :8.2
引用产品: Jurkat, Clone E6-1 细胞
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Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses (2011-01-20)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-021-03138-0
影响因子 :7.4
引用产品: Jurkat, Clone E6-1 细胞
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Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment (2021-12-17)
期刊:iScience
DOI:10.1016/j.isci.2021.103639
影响因子 :5.8
引用产品: Jurkat, Clone E6-1 细胞
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Cosmc transfection decreases malignant behavior of Tn+ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure (2010-01-20)
期刊:Aging-US
影响因子 :5.2
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Acute lymphoblastic leukemia‑derived exosome inhibits cytotoxicity of natural killer cells by TGF‑β signaling pathway (2006-01-20)
期刊:3 BIOTECH
DOI:10.1007/s13205-021-02817-5
影响因子 :2.8
引用产品: Jurkat, Clone E6-1 细胞 , NK-92MI 细胞
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Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p (2011-01-20)
期刊:Hematology
DOI:10.1080/16078454.2021.1997197
影响因子 :1.9
引用产品: 人外周血单个核细胞 , CCRF-CEM [CCRF CEM] 细胞 , Jurkat, Clone E6-1 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100× , IL-2 (重组人白细胞介素-2、白细胞介素-2) (250μL×4)
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产品资料
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