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产品概述
名称 | MV-4-11 (人髓性单核细胞白血病细胞) (STR鉴定正确) |
种属 | 人 |
生长特性 | 悬浮细胞 |
细胞形态 | 淋巴母细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 5×10^5-1×10^6cells/mL |
推荐换液频率 | 2-3次/周 |
注意事项 | 该细胞为悬浮细胞,请注意离心收集细胞悬液;请勿直接倒掉细胞培养液。 |
年龄(性别) | 男性;10岁 |
组织来源 | 外周血 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 白血病细胞 |
生物安全等级 | BSL-1 |
保藏机构 | ATCC; CRL-9591 DSMZ; ACC-102 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 24,25 D3S1358 16,17 D5S818 11,12 D7S820 8,9 D8S1179 13 D13S317 13 D16S539 11,12 D18S51 11,17 D19S433 15 D21S11 32,32.2 FGA 19,21 PentaD 9,10 PentaE 7,18 TH01 8,9.3 TPOX 8,11 vWA 14,15 D6S1043 12,20 D12S391 21,23 D2S441 10,11 -
STR鉴定图
参考文献
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Discovery of D25, a Potent and Selective MNK Inhibitor for Sepsis-Associated Acute Spleen Injury (2024-02-05)
作者:Qiang Li:1.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China. ; 2.Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China. ; Linmao Ke:1.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China. ; 2.Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China. ; Dandan Yu:1.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China. ; 2.Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Zhanjiang 524023, China. ; Han Xu:1.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China. ; 2.School of
期刊:Discovery of D25, a Potent and Selective MNK Inhibitor for Sepsis-Associated Acute Spleen Injury
DOI:10.1021/acs.jmedchem.3c02441
影响因子 :7.3
引用产品: RAW 264.7 细胞 , MV-4-11 细胞
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Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway (2024-01-01)
作者:Jianming Wei:1.Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. ; Xiaojuan Zhong:1.Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. ; Huiting Peng:1.Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. ; Bingqing Cui:1.Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. ; Xianlin Yue:1.School of Pharmacy and Pharmaceutical Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. ; Zewei Sun:1.School of Pharmacy and Pharmaceutical Science, Shandong First Me
期刊:Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway
影响因子 :3.9
引用产品: 特级胎牛血清 , MV-4-11 细胞 , U-87 MG 细胞
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Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199 (2023-08-29)
作者:Wen-Xiang Ren:1.Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ; Hao Guo:1.Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ; 2.Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450000, China. ; Sheng-Yan Lin:1.Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ; Si-Yi Chen:1.Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ; Yao-Ying Long:1.Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. ; Liu-Yue Xu:1.Department of Hematology, Union Hospital, Tongji Medical College, Huazh
期刊:Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199
DOI:10.1038/s41401-023-01142-2
影响因子 :8.2
引用产品: MV-4-11 细胞
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Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer (2023-06-24)
作者:Wen-Shan Liu:1.Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, 261041, Shandong Province, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, 261041, Shandong Province, China. Electronic address: liuwenshan@wfmc.edu.cn. ; Ji-Feng Zhao:1.Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, 261041, Shandong Province, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, 261041, Shandong Province, China. ; Xiao-Jing Guo:1.Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, 261041, Shandong Province, China. ; Sheng-Ze Lu:1.School of Pharmacy, Weifang Medical University, Weifang, 261053, Shandong Province, China. ; Wei Li:1.School of Pharmacy, Weifang
期刊:Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer
DOI:10.1016/j.ejmech.2023.115585
影响因子 :6.7
引用产品: MV-4-11 细胞 , NCI-H358 细胞 , A549 [A-549] 细胞 , MDA-MB-468 细胞
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Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171 (2023-05-24)
作者:Ruiqing Xiang:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Mingzhu Lu:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Tianze Wu:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Chengbin Yang:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Yu Jia:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Xiaofeng Liu:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Mingli Deng:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. Electronic address: mldeng@fudan.edu.cn. ; Yu Ge:1.SD Chem, Inc., San Diego, CA, 92128, USA. ; Jun Xu:1.ABA Chemicals Co., Ltd., Taicang, Jiangsu, 215400, China. ; Tong Cai:1.ABA Chemicals Co., Ltd., Taicang, Jiangsu, 215400, China. ; Yun Ling:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. ; Yaming Zhou:1.Department of Chemistry, Fudan University, Shanghai, 200438, China. Electron
期刊:Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171
DOI:10.1016/j.ejmech.2023.115514
影响因子 :6.7
引用产品: MV-4-11 细胞
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Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia (2023-02-17)
作者:Zi-Yao Ou:1.School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; Anhui Laboratory of Inflammatory and Immune Disease, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China. ; Ke Wang:1.Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China. ; Wen-Wen Shen:1.School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, China; Anhui Laboratory of Inflammatory and Immune Disease, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China. ; Ge Deng:1.School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Anhui Province Key Laboratory of Maj
期刊:Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia
影响因子 :5.8
引用产品: MV-4-11 细胞 , THP-1 细胞
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Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors (2022-12-07)
作者:Jiangkun Yan:1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 26003, Shandong, PR China; Laboratory for Marine Drugs and Bioproducts, Center for Innovation Marine Drug Screening & Evaluation, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266200, PR China. ; Kairui Yue:1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 26003, Shandong, PR China; Laboratory for Marine Drugs and Bioproducts, Center for Innovation Marine Drug Screening & Evaluation, Pilot National Laboratory for Marine Science and Technology, Qingdao, 266200, PR China. ; Xuejing Fan:1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 26003, Shandong, PR China; Laboratory for Marine Drugs and Bioproducts, Center for Innovation Marine Drug Screening & Ev
期刊:Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors
DOI:10.1016/j.ejmech.2022.115004
影响因子 :7.1
引用产品: 22RV1 细胞 , MM.1S 细胞 , MV-4-11 细胞 , JeKo-1 细胞 , 4T1 细胞 , DMEM高糖 培养基
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The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy (2022-10-28)
作者:Ke Wang:1.School of Pharmacy, Anhui Medical University, Hefei 230032, China. ; 2.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Hefei 230000, China. ; 3.Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei 230032, China. ; 4.Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China. ; Ziyao Ou:1.School of Pharmacy, Anhui Medical University, Hefei 230032, China. ; 2.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Hefei 230000, China. ; 3.Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei 230032, China. ; Ge Deng:1.School of Pharmacy, Anhui Medical University, Hefei 230032, China. ; 2.Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Hefei 230000, China. ; 3.Anhui Province Key Labo
期刊:The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy
DOI:10.3390/pharmaceutics14112329
影响因子 :6.5
引用产品: MV-4-11 细胞
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Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622 (2004-02-20)
作者:Xiaoyan Hu:1.Department of Pediatric Hematology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou City, People's Republic of China. ; Jiaojiao Yin:1.Department of Clinical Laboratory, Gansu Provincial Maternity and Child-care Hospital, Lanzhou City, People's Republic of China. ; Rui He:1.Department of Clinical Laboratory, Gansu Provincial Maternity and Child-care Hospital, Lanzhou City, People's Republic of China. ; Rong Chao:1.Department of Pediatric Hematology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou City, People's Republic of China. ; Shengdong Zhu:1.Department of Pediatric Hematology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou City, People's Republic of China. ;
期刊:Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622
DOI:10.1080/16078454.2022.2056983
影响因子 :1.9
引用产品: Kasumi-1 细胞 , MV-4-11 细胞
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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation (2009-01-20)
作者:Tanjing Song:1.Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address: songt@hust.edu.cn. ; Qingli Zou:1.Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. ; Yingying Yan:1.Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. ; Suli Lv:1.Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. ; Neng Li:1.Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technol
期刊:DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
DOI:10.1016/j.celrep.2021.109739
影响因子 :8.8
引用产品: RPMI-1640 培养基 , IMDM 培养基 , MV-4-11 细胞 , THP-1 细胞
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