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| 名称 | HMEC-1 (人微血管内皮细胞) (STR鉴定正确) |
| 别称 | Hmec-1; HMEC1; CDC/EU.HMEC-1; Human Microvascular Endothelial Cell line-1 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 血管内皮类 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HMEC-1是一种从男性患者包皮内皮中分离出来的内皮样细胞。该细胞系可用于心血管疾病的研究。HMEC-1细胞是从一位男性患者包皮中分离出的微血管内皮细胞，后经pSVT载体转染后，显示出保留了很多内皮细胞的特性，且通过连续传代获得的永生化细胞株。作为永生化细胞株，HMEC-1细胞是人类内皮微血管细胞的持续可再生来源之一，也可用于构建人真皮微血管内皮细胞体外模型，用于许多研究。 细胞可应用于血管生成、白细胞运输、伤口愈合、炎症、循环、肿瘤生长和转移。癌症研究，内皮功能，细胞运输，表面分子相互作用，药物筛选，制药和化妆品行业的毒理学研究。 |
| 年龄（性别） | 男性；新生儿 |
| 组织来源 | 真皮；微血管内皮 |
| 细胞类型 | 转化细胞系 |
| 生物安全等级 | BSL-2 |
| 倍增时间 | ~48 hours |
| 保藏机构 | ATCC; CRL-3243 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 19,25 D3S1358 16,17 D5S818 12 D7S820 8,10 D8S1179 14 D13S317 11,12 D16S539 11,12 D18S51 17,21 D19S433 12,17.2 D21S11 29,30 FGA 21,22 PentaD 9,10 PentaE 8,13 TH01 7 TPOX 8,11 vWA 15,17 D6S1043 11,18 D12S391 17,18 D2S441 10,11 -
STR鉴定图
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参考文献
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Microfibril-AssociatedGlycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling (2023-03-17)
作者：Zhiguang Chen:1.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. ; Haibin Zhao:1.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. ; Lingshuai Meng:1.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. ; Shengwei Yu:1.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. ; Zhenning Liu:1.Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China. ; Jinqi Xue:1.Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: xuejq77cmu@163.com. ;
期刊：Microfibril-AssociatedGlycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling
DOI：10.1016/j.labinv.2023.100121
影响因子 ：5.0
引用产品： HMEC-1 细胞
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Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis (2023-05-23)
作者：Lin Li:1.Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China. ; 2.Department of Dermatology, Chengdu Second People's Hospital, Chengdu, China. ; Huidi Shucheng:1.Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China. ; 2.Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. ; Lixin Fu:1.Department of Dermatology, Chengdu Second People's Hospital, Chengdu, China. ; Baoqiang Pei:1.Department of Dermatology, Chengdu Second People's Hospital, Chengdu, China. ; Wen Xu:1.Department of Dermatology, Chengdu Second People's Hospital, Chengdu, China. ; Xian Jiang:1.Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China. ; 2.Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Scie
期刊：Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis
影响因子 ：3.6
引用产品： HMEC-1 细胞 , lipopolysaccharide A
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KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway (2023-05-10)
作者：Youchao Zeng:1.Department of Neurology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi 56300, Guizhou, China. Electronic address: Zengyouchao0808@163.com. ; Yongsu Xu:1.Nursing Department, Affiliated Hospital of Zunyi Medical University, Zunyi 56300, Guizhou, China. ; Yongjie Pan:1.Department of Neurology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi 56300, Guizhou, China. ; Hong Guo:1.Department of Neurology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi 56300, Guizhou, China. ;
期刊：KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway
DOI：10.1016/j.tice.2023.102106
影响因子 ：2.6
引用产品： HMEC-1 细胞
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Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing (2022-09-27)
作者：Shengqiang Chen:1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China. ; Yanxia Zhu:1.Department of Cell Biology and Medical Genetics, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China. ; Qingqing Xu:1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China. ; Qi Jiang:1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China. ; Danyang Chen:1.Shanghai Key Laboratory of Hydrogen Science & Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China. ; Ting Chen:1.Guangdong Key Laboratory for B
期刊：Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
DOI：10.1038/s41467-022-33475-7
影响因子 ：17.7
引用产品： Hacat 细胞 , 人真皮成纤维细胞 , HMEC-1 细胞 , HMEC-1细胞专用培养基
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Two-Dimensional Mg2Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin (2022-12-22)
作者：Yanxia Zhu:1.School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, 518060, P. R. China. ; 2.Department of Cell Biology and Medical Genetics, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, 518060, P. R. China. ; Qi Jiang:1.School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, 518060, P. R. China. ; Zhaokui Jin:1.School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, 518060, P. R. China. ; Danyang Chen:1.School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong, 518060, P. R. China. ; 2.Shanghai Key Laboratory of Hydrogen Science and Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China. ; 3.Shenzhen Research Institute, Shanghai Jiao Tong University, Shenzhen, 518057, P. R. China. ; Qingqing Xu:1.School of Biomedical Engineering, Health Sc
期刊：Two-Dimensional Mg2Si Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin
影响因子 ：11.1
引用产品： Hacat 细胞 , 人真皮成纤维细胞 , HMEC-1 细胞 , HMEC-1细胞专用培养基
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LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR‐25‐3p/SIRT6 pathway (2001-01-20)
作者：Wei Qian:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Ze-Qi Zheng:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Jun-Gang Nie:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Li-Juan Liu:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Xiang-Zhu Meng:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Hong Sun:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Feng-Ming Xiao:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ; Ting Kang:1.Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China. ;
期刊：LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR‐25‐3p/SIRT6 pathway
影响因子 ：5.5
引用产品： MCDB 131 (不含L-谷氨酰胺) 培养基 , HMEC-1 细胞
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An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing (2008-01-20)
作者：Yuheng Zhang:1.Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ; 2.Air Force Hospital of Western Theater Command, Chengdu, China. ; Tian Li:1.Air Force Hospital of Western Theater Command, Chengdu, China. ; 2.School of Basic Medicine, Fourth Military Medical University, Xi'an, China. ; Congying Zhao:1.Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ; Jinqing Li:1.Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ; Rong Huang:1.Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ; Qianru Zhang:1.School of Software Center for High Performance Computing, Northwestern Polytechnical University, Xi'an, China. ; Yongqian Li:1.Key Laboratory of Micro/Nano Systems for Aerospace, Ministry of Education, Northwestern Polytechnical University, Xi'an, China. ; Xueyon
期刊：An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing
影响因子 ：5.5
引用产品： HMEC-1 细胞
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Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis (2010-01-20)
作者：Yiqiong Yang:1.Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing 210009, Jiangsu, China. ; Jing Wang:1.Institute of Andrology, The Affiliated Drum Tower Hospital, Nanjing University, Nanjing 210008, Jiangsu, China. ; Yu Zhang:1.Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing 210009, Jiangsu, China. ; Xiuxiu Hu:1.Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing 210009, Jiangsu, China. ; Li Li:1.Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing 210009, Jiangsu, China. ; Pingsheng Chen:1.Institute of Nephrology, The Affiliated Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu, China. ;
期刊：Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis
影响因子 ：5.2
引用产品： HMEC-1 细胞
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Human umbilical cord mesenchymal stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis (2009-01-20)
作者：Gang Tian:1.Department of Orthopedics, Weihai Central Hospital, Affiliated to Qingdao University & Qingdao University, Weihai, China. ; Chuanjie Liu:1.Weihai Key Laboratory of Autoimmunity & Central Laboratory, Weihai Central Hospital, Affiliated to Qingdao University & Qingdao University, Weihai, China. ; Haitao Wang:1.Department of Trauma Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China. ; Zhiping Yu:1.Department of Sports Medicine, Weihai Central Hospital Affiliated to Qingdao University, Weihai, China. ; Jian Huang:1.Department of Sports Medicine, Limin Hospital, Weihai City Central Hospital, Weihai, China. ; Qi Gong:1.Weihai Key Laboratory of Autoimmunity & Central Laboratory, Weihai Central Hospital, Affiliated to Qingdao University & Qingdao University, Weihai, China. ; Daoqiang Zhang:1.Weihai Key Laboratory of Autoimmunity & Central Laboratory, Weihai Central Hospital, Affiliated to Qingdao University & Qingdao University, Weihai, China. ;
期刊：Human umbilical cord mesenchymal stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis
DOI：10.1080/2000656X.2021.1981352
影响因子 ：1.3
引用产品： HMEC-1 细胞
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The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model (2011-09-20)
作者：Shidi Wu:1.Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. ; Mengjie Zhao:1.Department of Dermatology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430022, Hubei, PR China. ; Yanhong Sun:1.Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. ; Meng Xie:1.Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. ; Kehao Le:1.Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. ; Ming Xu:1.Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, PR China. ; Changzheng Huang:1.Department of Dermatol
期刊：The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model
影响因子 ：6.1
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