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产品概述
| 名称 | VCaP (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | VCAP; Vcap; Vertebral Cancer of the Prostate |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞贴壁疏松，影响细胞生长，建议使用多聚-L-赖氨酸溶液包被培养瓶后进行培养，请提前准备多聚-L-赖氨酸溶液（货号 PB180523）。 |
| 背景描述 | VCaP细胞是于1997年从一位不受激素影响的前列腺癌患者脊椎转移灶中建立的细胞株。VCaP细胞先在小鼠中进行异种移植传代，随后进行体外培养；体内及体外VCaP细胞都对雄性激素敏感。最近发现，前列腺癌细胞Vcap细胞在异种移植到小鼠时可能需要小鼠亲异逆转录病毒Bxv-1。 |
| 年龄（性别） | 男性 |
| 组织来源 | 器官：前列腺；组织：脊椎转移；疾病：癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | BSL-2 |
| 倍增时间 | ~53-144 hours |
| 致瘤性 | Yes, in nude and SCID mice. |
| 抗原表达情况 | cytokeratin-18; Homo sapiens, expressedp53 antigen; Homo sapiens, expressedprostate specific antigen (PSA); Homo sapiens, expressedprostatic acid phosphatase (PAP); Homo sapiens, expressedRb protein; Homo sapiens, expressed |
| 基因表达情况 | cytokeratin-18; Homo sapiens, expressed, p53 antigen; Homo sapiens, expressed, prostate specific antigen (PSA); Homo sapiens, expressed, prostatic acid phosphatase (PAP); Homo sapiens, expressed, Rb protein; Homo sapiens, expressed |
| 保藏机构 | ATCC; CRL-2876 ECACC; 06020201 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17,25 D3S1358 14,15 D5S818 12 D7S820 9,12 D8S1179 12,13 D13S317 11,12 D16S539 9 D18S51 13 D19S433 13 D21S11 31 FGA 26 PentaD 9 PentaE 10,12 TH01 9.3 TPOX 8,11 vWA 18,19 D6S1043 11 D12S391 21,23 D2S441 11,14 -
STR鉴定图
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参考文献
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TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling (2023-10-16)
作者：Jianfeng Ye:1.Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Wangmin Liu:1.Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Xueyang Yu:1.Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Lina Wu:1.Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. ; Zhengjie Chen:1.Department of Urology, the First Hospital of China Medical University, Shenyang, Liaoning, China. ; Yufei Yu:1.Department of Urology, the First Hospital of China Medical University, Shenyang, Liaoning, China. ; Jianfeng Wang:1.Department of Urology, the First Hospital of China Medical University, Shenyang, Liaoning, China. ; Song Bai:1.Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. baisongcmu@163.com. ; Mo Zhang:1.Department of Urology, the First Hospital of
期刊：TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling
DOI：10.1038/s41420-023-01675-9
影响因子 ：7.0
引用产品： VCaP 细胞 , Ham's F-12K 培养基
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USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma (2023-07-26)
作者：Dewang Fu:1.Department of Urology Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China. ; Qingyue Si:1.Department of Urology Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China. ; Chenxi Yu:1.Department of Urology Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China. ; Zhifu Han:1.Department of Urology Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China. ; Li'e Zang:1.Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, P.R. China. ;
期刊：USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma
DOI：10.1002/mc.23609
影响因子 ：4.6
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Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer (2022-09-01)
作者：Shidong Lv:1.Department of Urology, Nanfang Hospital, Southern Medical University-Guangzhou, Guangzhou, China. ; 2.Department of Urology, University of Pittsburgh School of Medicine-Pittsburgh, Pittsburgh, PA, USA. ; Zeyu Wu:1.Department of Urology, University of Pittsburgh School of Medicine-Pittsburgh, Pittsburgh, PA, USA. ; 2.Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University-Changsha, Changsha, China. ; Mayao Luo:1.Department of Urology, Nanfang Hospital, Southern Medical University-Guangzhou, Guangzhou, China. ; Yifan Zhang:1.Department of Urology, Nanfang Hospital, Southern Medical University-Guangzhou, Guangzhou, China. ; Jianqiang Zhang:1.Department of Urology, Nanfang Hospital, Southern Medical University-Guangzhou, Guangzhou, China. ; 2.Department of urology surgery department ward III, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine-Nanning, Guangxi, China. ; Laura E Pascal:1.Department of Urology, University of
期刊：Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
DOI：10.1038/s41419-022-05182-0
影响因子 ：9.7
引用产品： LNCaP clone FGC 细胞 , VCaP 细胞 , 22RV1 细胞
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Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models (2012-00-20)
作者：Yuanyuan Wang:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ; Shanqi Guo:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ; Yingjie Jia:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ; Xiaoyu Yu:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ; Ruiyu Mou:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ; Xiaojiang Li:1.Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. ;
期刊：Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models
影响因子 ：1.6
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