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| 名称 | DU 145 (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | DU-145; Du-145; DU 145; DU_145; Duke University 145 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | DU 145细胞是从一位有3年淋巴细胞白血病史的前列腺癌患者的脑部转移病灶损害中建株的。DU 145细胞和从软琼脂中分离到的细胞不具有可检测的激素敏感性，酸性磷酸酶呈弱阳性。对DU 145细胞及原始肿瘤细胞的亚显微结构分析可见微绒毛，微丝及细胞桥粒，有许多线粒体，发育良好高尔基体和异质溶酶体。DU 145细胞不表达前列腺抗体。 |
| 年龄（性别） | 男性；69岁 |
| 组织来源 | 前列腺；转移灶；脑癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30-40 hours |
| 致瘤性 | Yes, in nude mice; forms adenocarcinoma (grade II) consistent with prostatic primary. |
| 抗原表达情况 | Blood Type O; Rh+ |
| 保藏机构 | ATCC; HTB-81 BCRC; 60348 BCRJ; 0078 DSMZ; ACC-261 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,11 D2S1338 16,17 D3S1358 16 D5S818 10,13 D7S820 7,10,11 D8S1179 13,14 D13S317 12,14 D16S539 11,13 D18S51 12 D19S433 13 D21S11 30,33 FGA 21,22 PentaD 9,13 PentaE 12,14 TH01 7 TPOX 11 vWA 17,18,19 D6S1043 11 D12S391 17,18,20,21 D2S441 9,14 -
STR鉴定图
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参考文献
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Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1 (2025-01-16)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-025-01073-0
影响因子 ：6.0
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
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Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer (2024-03-21)
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01282-w
影响因子 ：12.4
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METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy (2024-08-14)
期刊：CELLULAR & MOLECULAR BIOLOGY LETTERS
DOI：10.1186/s11658-024-00628-z
影响因子 ：9.2
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Environmental explanation of prostate cancer progression based on the comprehensive analysis of polychlorinated biphenyls (2024-07-18)
期刊：SCIENCE OF THE TOTAL ENVIRONMENT
DOI：10.1016/j.scitotenv.2024.174870
影响因子 ：8.2
引用产品： PC-3细胞专用培养基 , PC-3 细胞 , DU 145细胞专用培养基 , DU 145 细胞
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Metabolic characterization of sphere-derived prostate cancer stem cells reveals aberrant urea cycle in stemness maintenance (2024-04-22)
期刊：INTERNATIONAL JOURNAL OF CANCER
影响因子 ：6.4
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Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1–SNAI1 axis (2024-07-18)
期刊：JOURNAL OF PATHOLOGY
影响因子 ：5.6
引用产品： DU 145 细胞 , PC-3M-2B4 细胞
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Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416 (2024-04-20)
期刊：Marine Drugs
影响因子 ：5.4
引用产品： K-562 [K562] 细胞 , TE-1 细胞 , HOS 细胞 , GBC-SD 细胞 , PaTu 8988t 细胞 , DU 145 细胞 , 293T [HEK-293T] 细胞 , SF126 细胞 , MCF7 [MCF-7] 细胞 , HCT 116 细胞 , Hela 细胞 , A549 [A-549] 细胞 , Hep G2 细胞 , A-375 细胞 , MKN-45 细胞 , 5637 细胞 , 786-O [786-0] 细胞 , CAL-62 细胞 , A-673 细胞 , HL-7702 [L-02; LO2] 细胞
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Wound healing assay on a gravity-driven unidirectional perfusion microfluidic device (2024-11-27)
期刊：MICROCHEMICAL JOURNAL
DOI：10.1016/j.microc.2024.112289
影响因子 ：4.9
引用产品： DU 145 细胞
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YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation (2024-03-09)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.8
引用产品： PC-3 细胞 , DU 145 细胞 , 22RV1 细胞 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , RPMI-1640 培养基
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Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics (2024-04-19)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：4.8
引用产品： LNCaP clone FGC 细胞 , 22RV1 细胞 , PC-3 细胞 , DU 145 细胞
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Identification of neutrophil extracellular traps (NETs)-related molecular clusters in prostate cancer: Implications for predicting biochemical recurrence (2024-12-28)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113908
影响因子 ：4.8
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Characterizing adipocytokine-related signatures for prognosis prediction in prostate cancer (2024-10-25)
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2024.1475980
影响因子 ：4.6
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Comprehensiveness cuproptosis related genes study for prognosis and medication sensitiveness across cancers, and validation in prostate cancer (2024-04-26)
期刊：Scientific Reports
DOI：10.1038/s41598-024-57303-8
影响因子 ：4.6
引用产品： RWPE-1 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , PC-3 细胞
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Natural flavonoid glycoside-based self-assembled nanoparticles for synergistic antibacterial activity and improved antioxidant properties (2024-12-30)
期刊：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI：10.1016/j.jddst.2024.106583
影响因子 ：4.5
引用产品： DU 145 细胞
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Meta-biosensor with High Q-factor Based on Wet Etching for Terahertz Detection (2024-02-27)
期刊：IEEE SENSORS JOURNAL
影响因子 ：4.3
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The Mechanism by Which Hedgehog Interacting Protein (HHIP) in Cancer-Associated Fibroblasts Regulate the Secretion of Inflammatory Factors Through the JAK1/STAT3 Pathway Affecting Prostate Cancer Stemness (2024-11-11)
期刊：Journal of Inflammation Research
影响因子 ：4.2
引用产品： DU 145 细胞 , DMEM/F12 培养基 , PC-3 细胞
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A Pump-Free Microfluidic Co-Culture System for Investigating NK Cell-Tumor Spheroid Interactions in Flow Conditions (2024-11-15)
期刊：JOURNAL OF BIOTECHNOLOGY
DOI：10.1016/j.jbiotec.2024.11.008
影响因子 ：4.1
引用产品： NK-92 细胞 , PNT1A 细胞 , NK-92细胞专用培养基 , DU 145 细胞
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PLA inhibits TNF-α-induced PANoptosis of prostate cancer cells through metabolic reprogramming (2024-02-24)
期刊：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
DOI：10.1016/j.biocel.2024.106554
影响因子 ：4.0
引用产品： DU 145 细胞 , PC-3M 细胞 , LNCaP clone FGC 细胞
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Epigenetic-related Gene-based Prognostic Model Construction and Validation in Prostate Adenocarcinoma (2024-05-08)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e30941
影响因子 ：4.0
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Therapeutic targets of formononetin for treating prostate cancer at the single-cell level (2024-06-13)
期刊：Aging-US
影响因子 ：3.9
引用产品： DU 145 细胞
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The Impact of 3D Tumor Spheroid Maturity on Cell Migration and Invasion Dynamics (2024-11-08)
期刊：BIOCHEMICAL ENGINEERING JOURNAL
影响因子 ：3.7
引用产品： MCF7 [MCF-7] 细胞 , EMT6 [EMT-6] 细胞 , DU 145 细胞
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PEI, a new transfection method, augments the inhibitory effect of RBM5 on prostate cancer (2024-02-21)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2024.149703
影响因子 ：3.1
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Self-supply of hydrogen peroxide by a bimetal-based nanocatalytic platform to enhance chemodynamic therapy for tumor treatment (2024-11-08)
期刊：NANOTECHNOLOGY
影响因子 ：2.9
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Identification of RBM15 as a prognostic biomarker in prostate cancer involving the regulation of prognostic m6A-related lncRNAs (2024-08-08)
期刊：EUROPEAN JOURNAL OF MEDICAL RESEARCH
DOI：10.1186/s40001-024-02000-5
影响因子 ：2.8
引用产品： BPH-1 细胞 , C4-2 细胞 , PC-3 细胞 , RWPE-1 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
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CRABP2 promotes cell migration and invasion by activating PI3K/AKT and MAPK signaling pathways via up-regulating LAMB3 in prostate cancer (2024-07-22)
期刊：JOURNAL OF BIOCHEMISTRY
影响因子 ：2.1
引用产品： RPMI-1640 培养基 , PC-3 细胞 , 22RV1 细胞 , 青霉素-链霉素溶液（双抗），100× , LNCaP clone FGC 细胞 , DMEM高糖 培养基 , DU 145 细胞 , 特级胎牛血清 , MEM 培养基
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TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation (2024-12-20)
期刊：ONCOLOGY RESEARCH
影响因子 ：2.0
引用产品： DU 145 细胞
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Relationship between circulating miRNA-222-3p and miRNA-136-5p and the efficacy of docetaxel chemotherapy in metastatic castration-resistant prostate cancer patients (2024-12-21)
期刊：BMC Urology
DOI：10.1186/s12894-024-01666-7
影响因子 ：1.7
引用产品： PC-3 细胞 , DU 145 细胞 , Ham's F-12K 培养基 , MEM（含NEAA） 培养基
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Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis (2024-07-28)
期刊：CELLULAR AND MOLECULAR BIOLOGY
影响因子 ：1.5
引用产品： 22RV1 细胞 , RWPE-1 细胞 , DMEM高糖完全培养基（含10% FBS） , SILAC RPMI-1640 培养基 , DU 145 细胞 , VCaP 细胞 , PC-3 细胞 , Ham's F-12完全培养基（含10% FBS）
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Accurate Visualization of Metabolic Aberrations in Cancer Cells by Temperature Mapping with Quantum Coherence Modulation Microscopy (2023-04-27)
期刊：ACS Nano
影响因子 ：17.1
引用产品： A549 [A-549] 细胞 , Hela 细胞 , Hep G2 细胞 , BxPC-3 细胞 , DU 145 细胞 , 4T1 细胞 , BEAS-2B 细胞 , MET-5A 细胞 , 潮霉素B溶液 (50mg/mL)
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ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003 (2023-12-04)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04760-w
影响因子 ：7.4
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , RWPE-1 细胞 , 293T [HEK-293T] 细胞
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A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients (2023-03-14)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： RWPE-1 细胞 , 22RV1 细胞 , PC-3 细胞 , DU 145 细胞 , DU 145细胞专用培养基 , PC-3细胞专用培养基
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Novel gene signature for predicting biochemical recurrence-free survival of prostate cancer and PRAME modulates prostate cancer progression (2023-07-15)
期刊：American Journal of Cancer Research
DOI：PMID:37559989
影响因子 ：5.3
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PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway. (2023-10-27)
期刊：Aging-US
影响因子 ：5.2
引用产品： 青霉素-链霉素溶液（双抗），100× , DU 145 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , PC-3 细胞 , RWPE-1 细胞
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Identification and validation of a novel overall survival prediction model for immune-related genes in bone metastases of prostate cancer (2023-07-25)
期刊：Aging-US
影响因子 ：5.2
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞 , RPMI-1640 培养基
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Orthogonal Optimization, Characterization, and In Vitro Anticancer Activity Evaluation of a Hydrogen Peroxide-Responsive and Oxygen-Reserving Nanoemulsion for Hypoxic Tumor Photodynamic Therapy (2023-03-03)
期刊：Cancers
影响因子 ：5.2
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance (2023-04-08)
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影响因子 ：4.6
引用产品： HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , DMEM高糖 培养基 , RPMI-1640 培养基 , Ham's F-12K 培养基 , 人前列腺上皮细胞完全培养基
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USF1-mediated ALKBH5 stabilizes FLII mRNA in an m6A-YTHDF2-dependent manner to repress glycolytic activity in prostate adenocarcinoma (2023-07-26)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23609
影响因子 ：4.6
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YAP1 inhibits RSL3-induced castration-resistant prostate cancer cell ferroptosis by driving glutamine uptake and metabolism to GSH (2023-09-29)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-023-04847-4
影响因子 ：4.3
引用产品： PC-3 细胞 , Ham's F-12K 培养基 , 特级胎牛血清 , DU 145 细胞 , MEM (含NEAA) 培养基
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Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer (2023-06-10)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113686
影响因子 ：3.7
引用产品： PC-3 细胞 , LNCaP clone FGC 细胞 , DU 145 细胞 , WPMY-1 细胞
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A cuproptosis-related LncRNA signature: Integrated analysis associated with biochemical recurrence and immune landscape in prostate cancer (2023-02-24)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1096783
影响因子 ：3.7
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , RWPE-1 细胞
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Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing (2023-06-07)
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影响因子 ：3.6
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A Prognostic Model for Prostate Cancer Patients Based on Two DNA Damage Response Mutation-Related Immune Genes (2023-08-22)
期刊：CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
影响因子 ：3.4
引用产品： DU 145 细胞 , LNCaP clone FGC 细胞
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Sennoside A induces autophagic death of prostate cancer via inactivation of PI3K/AKT/mTOR axis (2023-09-23)
期刊：JOURNAL OF MOLECULAR HISTOLOGY
DOI：10.1007/s10735-023-10156-3
影响因子 ：3.2
引用产品： DU 145 细胞 , PC-3 细胞 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer (2023-04-12)
期刊：PeerJ
影响因子 ：2.7
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
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Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis (2023-03-13)
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-022-10328-y
影响因子 ：2.4
引用产品： LNCaP clone FGC 细胞 , DU 145 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , RWPE-1 细胞 , K-SFM 培养基 , EGF/Urogastrone/URG, Human, Recombinant
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TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α (2023-11-10)
期刊：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
影响因子 ：2.3
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Inhibitory function of CDK12i combined with WEE1i on castration-resistant prostate cancer cells in?vitro and in?vivo (2023-08-08)
期刊：Oncologie
DOI：10.1515/oncologie-2023-0233
影响因子 ：0.9
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FAM107A Inactivation Associated with Promoter Methylation Affects Prostate Cancer Progression through the FAK/PI3K/AKT Pathway (2022-08-13)
期刊：Cancers
影响因子 ：6.6
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Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis. (2022-09-21)
期刊：Frontiers in Pharmacology
影响因子 ：6.0
引用产品： SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , Ham's F-12K 培养基 , DMEM高糖 培养基 , 人前列腺上皮细胞完全培养基 , RPMI-1640 培养基
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Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway (2022-11-11)
期刊：Translational Oncology
DOI：10.1016/j.tranon.2022.101578
影响因子 ：4.8
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GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (2022-10-25)
期刊：PeerJ
影响因子 ：3.1
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
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Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer (2022-01-07)
期刊：Biochemical Genetics
DOI：10.1007/s10528-021-10160-w
影响因子 ：2.4
引用产品： DU 145 细胞 , LNCaP clone FGC 细胞 , DMEM高糖完全培养基 (含10%FBS) , RPMI-1640完全培养基 (含10%FBS) , RWPE-1 细胞
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LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway (2021-08-19)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
引用产品： C4-2 细胞 , PC-3 细胞 , 22RV1 细胞 , LNCaP clone FGC 细胞 , DU 145 细胞
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MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways (2021-11-10)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
引用产品： DU 145 细胞 , PC-3 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
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Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src (2021-10-28)
期刊：Endocrine
DOI：10.1007/s12020-021-02907-7
影响因子 ：3.9
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Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy (2021-11-19)
期刊：Andrologia
影响因子 ：2.4
引用产品： LNCaP clone FGC 细胞 , PC-3 细胞 , DU 145 细胞 , RPMI-1640 培养基 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , RWPE-1 细胞 , RWPE-1细胞专用培养基
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Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration?resistant prostate cancer (2020-11-19)
期刊：Oncology Letters
影响因子 ：2.9
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Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models (2020-12-15)
期刊：Bioscience Biotechnology and Biochemistry
影响因子 ：1.6
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Silencing of MALAT1 inhibits migration and invasion by sponging miR?1?3p in prostate cancer cells (2019-08-22)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： 293T [HEK-293T] 细胞 , DU 145 细胞 , DU 145细胞专用培养基 , PC-3 细胞 , PC-3细胞专用培养基
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Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells (2019-01-07)
期刊：Pathology Research And Practice
影响因子 ：2.8
引用产品： DU 145 细胞 , MEM (含NEAA) 培养基 , PC-3 细胞 , Ham's F-12K 培养基
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