产品中心Cell Resources
联系我们CONTACT US
400-999-210024小时服务热线
产品概述
| 名称 | PC-3 (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | PC3; PC.3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | PC-3细胞源于一位62岁白人男性Ⅳ级前列腺腺癌患者的骨头转移灶；PC-3细胞的酸性磷酸酶活性和5-α-睾丸激素还原酶活性都低。 |
| 年龄（性别） | 男性；62岁 |
| 组织来源 | 前列腺；骨腺癌转移灶 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~25-50 hours |
| 致瘤性 | Yes, in semi-solid medium.Yes, tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 抗原表达情况 | HLA A1, A9 |
| 基因表达情况 | HLA A1, A9 |
| 保藏机构 | ATCC; CRL-1435 ATCC; CRL-7934DSMZ; ACC-465 ECACC; 90112714 |
STR鉴定
-
STR位点信息
Amelogenin X CSF1PO 11 D2S1338 18,20 D3S1358 16 D5S818 13 D7S820 8,11 D8S1179 13 D13S317 11 D16S539 11 D18S51 14,15 D19S433 14 D21S11 29,31.2 FGA 24 PentaD 9 PentaE 10,17 TH01 6,7 TPOX 8,9 vWA 17 D6S1043 18 D12S391 21 D2S441 10,11 -
STR鉴定图
-
参考文献
-
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer (2024-03-21)
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01282-w
影响因子 ：12.4
-
Targeted Ultrasound Nanobubbles Therapy for Prostate Cancer via Immuno-Sonodynamic Effect (2024-03-18)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： PC-3 细胞
-
β-hydroxybutyrate inhibits malignant phenotypes of prostate cancer cells through β-hydroxybutyrylation of indoleacetamide-N-methyltransferase (2024-03-30)
期刊：Cancer Cell International
DOI：10.1186/s12935-024-03277-6
影响因子 ：5.8
引用产品： PC-3 细胞 , LNCaP clone FGC 细胞
-
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation (2024-03-09)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.8
引用产品： PC-3 细胞 , DU 145 细胞 , 22RV1 细胞 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , RPMI-1640 培养基
-
Epigenetic activation of METTL14 promotes docetaxel resistance in prostate cancer by promoting pri-microRNA-129 maturation (2024-03-28)
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.5
-
PEI, a new transfection method, augments the inhibitory effect of RBM5 on prostate cancer (2024-02-21)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2024.149703
影响因子 ：3.1
-
3D bioprinting of multi-cellular tumor microenvironment for prostate cancer metastasis (2023-06-09)
期刊：Biofabrication
影响因子 ：9.0
-
Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA transcription (2023-12-29)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.155328
影响因子 ：7.9
引用产品： SK-OV-3 细胞 , Caco-2 细胞 , PANC-1 细胞 , PC-3 细胞 , NCI-H1395 细胞 , MCF7 [MCF-7] 细胞
-
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003 (2023-12-04)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04760-w
影响因子 ：7.4
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , RWPE-1 细胞 , 293T [HEK-293T] 细胞
-
Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5 (2023-09-26)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c00864
影响因子 ：7.3
引用产品： A-375 细胞 , HCT 116 细胞 , Hep G2 细胞 , MDA-MB-231 细胞 , NCI-H1975 细胞 , PC-3 细胞 , THP-1 细胞
-
Bimetallic Nanoplatform Dedicated to Sonodynamic-Calcium Overload Synergistic Therapy via Self-supplied Hydrogen Peroxide and Relieved Hypoxia (2023-12-12)
期刊：Biomaterials Science
影响因子 ：6.6
引用产品： PC-3 细胞
-
A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients (2023-03-14)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： RWPE-1 细胞 , 22RV1 细胞 , PC-3 细胞 , DU 145 细胞 , DU 145细胞专用培养基 , PC-3细胞专用培养基
-
A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy (2023-07-24)
期刊：Pharmaceutics
DOI：10.3390/pharmaceutics15072012
影响因子 ：5.4
引用产品： HT-29 细胞 , Hep G2 细胞 , PC-3 细胞 , McCoy's 5A 培养基 , MEM (含NEAA) 培养基 , Ham's F-12K 培养基
-
Novel gene signature for predicting biochemical recurrence-free survival of prostate cancer and PRAME modulates prostate cancer progression (2023-07-15)
期刊：American Journal of Cancer Research
DOI：PMID:37559989
影响因子 ：5.3
-
Identification and validation of a novel overall survival prediction model for immune-related genes in bone metastases of prostate cancer (2023-07-25)
期刊：Aging-US
影响因子 ：5.2
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞 , RPMI-1640 培养基
-
Orthogonal Optimization, Characterization, and In Vitro Anticancer Activity Evaluation of a Hydrogen Peroxide-Responsive and Oxygen-Reserving Nanoemulsion for Hypoxic Tumor Photodynamic Therapy (2023-03-03)
期刊：Cancers
影响因子 ：5.2
-
177Lu-Labeled Bivalent Ligands of Prostate-Specific Membrane Antigen for Endoradiotherapy of Prostate Cancer (2023-12-28)
期刊：MOLECULAR PHARMACEUTICS
DOI：10.1021/acs.molpharmaceut.3c00987
影响因子 ：4.9
-
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer (2023-08-16)
期刊：FASEB JOURNAL
影响因子 ：4.8
引用产品： LNCaP clone FGC 细胞 , PC-3 细胞 , 22RV1 细胞
-
A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance (2023-04-08)
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影响因子 ：4.6
引用产品： HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , DMEM高糖 培养基 , RPMI-1640 培养基 , Ham's F-12K 培养基 , 人前列腺上皮细胞完全培养基
-
YAP1 inhibits RSL3-induced castration-resistant prostate cancer cell ferroptosis by driving glutamine uptake and metabolism to GSH (2023-09-29)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-023-04847-4
影响因子 ：4.3
引用产品： PC-3 细胞 , Ham's F-12K 培养基 , 特级胎牛血清 , DU 145 细胞 , MEM (含NEAA) 培养基
-
Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer (2023-06-10)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113686
影响因子 ：3.7
引用产品： PC-3 细胞 , LNCaP clone FGC 细胞 , DU 145 细胞 , WPMY-1 细胞
-
A cuproptosis-related LncRNA signature: Integrated analysis associated with biochemical recurrence and immune landscape in prostate cancer (2023-02-24)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1096783
影响因子 ：3.7
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , RWPE-1 细胞
-
Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing (2023-06-07)
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影响因子 ：3.6
-
Sennoside A induces autophagic death of prostate cancer via inactivation of PI3K/AKT/mTOR axis (2023-09-23)
期刊：JOURNAL OF MOLECULAR HISTOLOGY
DOI：10.1007/s10735-023-10156-3
影响因子 ：3.2
引用产品： DU 145 细胞 , PC-3 细胞 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
-
IU1 and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer (2023-08-07)
期刊：PROSTATE
影响因子 ：2.8
引用产品： LNCaP clone FGC 细胞 , C4-2 细胞 , 22RV1 细胞 , PC-3 细胞
-
Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer (2023-04-12)
期刊：PeerJ
影响因子 ：2.7
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
-
TRPM2-L Participates in the Interleukin-6 Pathway to Enhance Tumor Growth in Prostate Cancer by Hypoxia-Inducible Factor-1α (2023-11-10)
期刊：JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
影响因子 ：2.3
-
Inhibitory function of CDK12i combined with WEE1i on castration-resistant prostate cancer cells in vitro and in vivo (2023-08-08)
期刊：Oncologie
DOI：10.1515/oncologie-2023-0233
影响因子 ：0.9
-
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis. (2022-09-21)
期刊：Frontiers in Pharmacology
影响因子 ：6.0
引用产品： SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , Ham's F-12K 培养基 , DMEM高糖 培养基 , 人前列腺上皮细胞完全培养基 , RPMI-1640 培养基
-
Risk subtyping and prognostic assessment of prostate cancer based on consensus genes (2003-02-20)
期刊：Communications Biology
DOI：10.1038/s42003-022-03164-8
影响因子 ：5.9
引用产品： PC-3 细胞
-
GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer (2022-10-25)
期刊：PeerJ
影响因子 ：3.1
引用产品： PC-3 细胞 , DU 145 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
-
LOC100996425 acts as a promoter in prostate cancer by mediating hepatocyte nuclear factor 4A and the AMPK/mTOR pathway (2008-01-20)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
引用产品： C4-2 细胞 , PC-3 细胞 , 22RV1 细胞 , LNCaP clone FGC 细胞 , DU 145 细胞
-
MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways (2011-01-20)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
引用产品： DU 145 细胞 , PC-3 细胞 , LNCaP clone FGC 细胞 , 22RV1 细胞
-
Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src (2010-01-20)
期刊：Endocrine
DOI：10.1007/s12020-021-02907-7
影响因子 ：3.9
-
Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy (2011-01-20)
期刊：Andrologia
影响因子 ：2.4
引用产品： LNCaP clone FGC 细胞 , PC-3 细胞 , DU 145 细胞 , RPMI-1640 培养基 , Ham's F-12K 培养基 , MEM (含NEAA) 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , RWPE-1 细胞 , RWPE-1细胞专用培养基
-
NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway (2003-00-20)
期刊：Experimental Cell Research
DOI：10.1016/j.yexcr.2020.111981
影响因子 ：3.7
引用产品： PC-3 细胞
-
Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration‑resistant prostate cancer (2011-00-20)
期刊：Oncology Letters
影响因子 ：2.9
-
A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH (2003-09-20)
期刊：Dyes And Pigments
DOI：10.1016/j.dyepig.2019.03.060
影响因子 ：4.5
引用产品： Hep G2 细胞 , MCF7 [MCF-7] 细胞 , PC-3 细胞 , A549/DDP 细胞
-
Silencing of MALAT1 inhibits migration and invasion by sponging miR‑1‑3p in prostate cancer cells (2008-09-20)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： 293T [HEK-293T] 细胞 , DU 145 细胞 , DU 145细胞专用培养基 , PC-3 细胞 , PC-3细胞专用培养基
-
Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells (2001-09-20)
期刊：Pathology Research And Practice
影响因子 ：2.8
引用产品： DU 145 细胞 , MEM (含NEAA) 培养基 , PC-3 细胞 , Ham's F-12K 培养基
-
Novel gadopentetic acid-doped silica nanoparticles conjugated with YPSMA-1 targeting prostate cancer for MR imaging: an in vitro study (2003-08-20)
期刊：Biochemical And Biophysical Research Communications
DOI：10.1016/j.bbrc.2018.03.124
影响因子 ：3.1
引用产品： LNCaP clone FGC 细胞 , PC-3 细胞
FAQs
Q：{{item.question}}
A：
产品资料
识别码示意图
