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![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0130-1.jpg)
![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0130-2.jpg)
![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0130-3.jpg)
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![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0130-5.jpg)
![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0130-6.jpg)
![K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确)](/Public/upfile/pic/product/cell-line-new.jpg)
产品概述
| 名称 | K-562 [K562] (人慢性髓原白血病细胞) (STR鉴定正确) |
| 别称 | K562; K 562; GM05372 |
| 种属 | 人 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 淋巴细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 3×10^5-5×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | 连续细胞株K-562是由Lozzio从一位临终的53岁女性慢性骨髓性白血病患者的胸水中建立。K-562细胞被归入高度未分化的粒性白细胞类，Erson等对其表面膜性质的研究表明，K-562细胞是一株人类红白血病细胞。K-562细胞在自然杀伤分析中广泛作为高敏感的体外受体，See Pross等将K-562细胞用于NK细胞的体外详细检测，包括NK细胞活性的数学量化。K-562母细胞是多能性造血恶性细胞，它能自发分化成可识别的红血球祖细胞、粒性白细胞、单核细胞等。K-562细胞是EBNA阴性的。 |
| 年龄（性别） | 女性；53岁 |
| 组织来源 | 骨髓；慢性骨髓性白血病(CML) |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 白血病细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30-48 hours |
| 致瘤性 | Yes, in nude mice (Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells). |
| 保藏机构 | ATCC; CCL-243 BCRC; 60007 BCRJ; 0126 CCLV; CCLV-RIE 0439 DSMZ; ACC-10 ECACC; 89121407 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 9,10 D2S1338 17 D3S1358 16 D5S818 11,12 D7S820 9,11 D8S1179 12 D13S317 8 D16S539 11,12 D18S51 15,16 D19S433 14,14.2 D21S11 29,31 FGA 21,24 PentaD 9,13 PentaE 5,14 TH01 9.3 TPOX 8,9 vWA 16 D6S1043 11 D12S391 23 D2S441 10,14 -
STR鉴定图
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参考文献
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Lipid droplets as endogenous intracellular microlenses(2021/12/06)
作者：Xixi Chen, Tianli Wu, Zhiyong Gong
期刊：Light-Science & Applications
DOI：10.1038/s41377-021-00687-3
影响因子 ：19.400
引用产品：CL-0130
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A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self-assembly Multivalent Scaffold LS-SUMO(2024/02/10)
作者：Qianlin Li, Jinsong Zhang, Qiang Deng
期刊：Advanced Healthcare Materials
影响因子 ：10.000
引用产品：CL-0130
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Rational Engineering a Multichannel Upconversion Sensorfor Multiplex Detection of Matrix Metalloproteinases Activities(2018/07/17)
作者：Sunan Cao, Zhi Li, Jinyuan Zhao
期刊：ACS Sensors
DOI：10.1021/acssensors.8b00320
影响因子 ：8.900
-
Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy(2023/08/22)
作者：Luyue Jiang, Matthew Xinhu Ren, Gang Niu, Jingang Shi, Xinhao Cao, Yan Duan, Heping Wu, Zhen Xie, Yi Quan, Libo Zhao, Zhuangde Jiang, Yihong Gong, Wei Ren, Gang Zhao
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影响因子 ：8.400
-
All-optical targeted drug delivery and real-time detection of a single cancer cell(2020/03/01)
作者：Xiaole Liu, Jie Yuan, Dong Wu
期刊：Nanophotonics
影响因子 ：7.500
引用产品：CL-0130
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CXCR5 guides migration and tumor eradication of anti-EGFR chimeric antigen receptor T cells(2021/07/16)
作者：Guangchao Li, Jintao Guo, Yanfang Zheng
期刊：Molecular Therapy-Oncolytics
DOI：10.1016/j.omto.2021.07.003
影响因子 ：5.700
-
Cytotoxic and Antibacterial Meroterpenoids Isolated from the Marine-Derived Fungus Talaromyces sp. M27416(2024/04/20)
作者：Lingzhi Tang, Jinmei Xia, Zhongwei Chen
期刊：Marine Drugs
影响因子 ：5.400
引用产品：CL-0130
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Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells(2022/08/17)
作者：Haiqun Dong, Shijing Liang, Yuling Xu
期刊：International Journal of Oncology
影响因子 ：5.200
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Development and evaluation of novel artemisinin-isatin hybrids with potential anti-leukemic cytotoxicity(2023/04/14)
作者：Peng Wang, Zhe Zhang, Wei Cao
期刊：Frontiers in Oncology
影响因子 ：4.700
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Human m6A-mRNA and lncRNA epitranscriptomic microarray reveal function of RNA methylation in hemoglobin H-constant spring disease(2021/10/14)
作者：Heyun Ruan, Fang Yang, Lingjie Deng
期刊：Scientific Reports
DOI：10.1038/s41598-021-99867-9
影响因子 ：4.600
引用产品：CL-0130
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Asperuloside regulates the proliferation, apoptosis, and differentiation of chronic myeloid leukemia cell line K562 through the RAS/MEK/ERK pathway(2023/12/16)
作者：Bingjie Zhao, Hong Che, Linlin Li
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e23580
影响因子 ：4.000
引用产品：CL-0130
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A novel upregulated LncRNA-AC026150.8 promotes chemo-resistance and predicts poor prognosis in acute myeloid leukemia(2021/10/19)
作者：Henan Zhang, Yue Zhao, Xuan Liu
期刊：Cancer Medicine
影响因子 ：4.000
引用产品：CL-0130
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Selection of reference genes in liproxstatin-1-treated K562 Leukemia cells via RT-qPCR and RNA sequencing(2024/01/02)
作者：Haiqun Dong, Xueying Hu, Shijing Liang
期刊：MOLECULAR BIOLOGY REPORTS
DOI：10.1007/s11033-023-08912-5
影响因子 ：2.800
引用产品：CL-0130
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Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation(2023/08/21)
作者：Peng Wang, Dai Yuan, Weiwei Wang
期刊：MEDICINAL CHEMISTRY RESEARCH
DOI：10.1007/s00044-023-03122-x
影响因子 ：2.600
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Pentanoate-Tethered Artemisinin-Isatin Hybrids with Antileukemic Potential(2023/03/21)
作者：Zhi Xu, Linzhi Chen, Dan Xu
期刊：ChemistrySelect
影响因子 ：2.100
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TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro(2021/12/07)
作者：Shuhan Liu, Wei Wu, Qiaoqian Chen
期刊：Oxidative Medicine and Cellular Longevity
DOI： 10.1155/2021/7674565
影响因子 ：0.000
引用产品：CL-0130
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![U266 [U266B1] (人多发性骨髓瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0510-1-1.jpg)
