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![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-1.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-2.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-3.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-4.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-5.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0168-6.jpg)
![Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确)](/Public/upfile/pic/product/cell-line-new.jpg)
产品概述
| 名称 | Neuro-2a [N2a; Neuro-2a] (小鼠脑神经瘤细胞) (STR鉴定正确) |
| 别称 | NEURO-2A; Neuro 2a; Neuro2a; Neuro2A; N-2a; N2a; N2A; Nb2a; NB2a |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 神经细胞样、阿米巴样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Neuro-2a [N2a]细胞是由R·J·Klebe和F·H·Ruddle经A株白鼠的自生肿瘤建立；Neuro-2a [N2a]细胞产生大量微管蛋白，此蛋白在神经细胞中起应答轴浆流动的收缩系统作用。 |
| 组织来源 | 脑神经母细胞瘤，神经母细胞 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 神经母细胞瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~70 hours |
| 抗原表达情况 | H-2, a haploType; Mus musculus, expressed |
| 基因表达情况 | acetylcholinesterase, tubulin |
| 保藏机构 | ATCC; CCL-131 DSMZ; ACC-148 ECACC; 89121404 |
STR鉴定
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STR位点信息
18-3 22 6-7 12 5-5 15,17 X-1 26,27 1-2 17,18 7-1 25.2 8-1 16,17 1-1 11 19-2 12 15-3 21.3,22.3,23.3,24.3 12-1 16 6-4 18,20 4-2 21.3,22.3 3-2 13,14 2-1 16 13-1 16.2,17.2
11-2 15 17-2 16 -
STR鉴定图
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参考文献
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Precise modelling of mitochondrial diseases using optimized mitoBEs (2025-01-22)
期刊：NATURE
DOI：10.1038/s41586-024-08469-8
影响因子 ：50.5
-
The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1-Induced Synaptic Plasticity in the Medial Prefrontal Cortex (2025-01-21)
期刊：Advanced Science
影响因子 ：14.3
-
A novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline (2025-01-17)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2025.117845
影响因子 ：6.9
引用产品： PC-12 (Low differentiation) 细胞 , bEnd.3 [BEND3] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer’s Disease Model Mice (2025-01-02)
期刊：Neuroscience Bulletin
DOI：10.1007/s12264-024-01336-6
影响因子 ：5.9
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , HT22 细胞
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All-RNA-mediated targeted gene integration in mammalian cells with rationally engineered R2 retrotransposons (2024-07-08)
期刊：CELL
DOI：10.1016/j.cell.2024.06.020
影响因子 ：45.5
引用产品： HuH-7 细胞 , 293T [HEK-293T] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞 , 磷酸盐缓冲液（PBS） 1×
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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders (2024-01-22)
期刊：NATURE CELL BIOLOGY
DOI：10.1038/s41556-023-01339-x
影响因子 ：21.3
-
A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease (2024-01-24)
期刊：Nature Communications
DOI：10.1038/s41467-024-44737-x
影响因子 ：16.6
引用产品： PC-12 (Undifferentiated) 细胞 , BV2 细胞 , SH-SY5Y [SHSY-5Y] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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SSK1-Loaded Neurotransmitter-Derived Nanoparticles for Alzheimer's Disease Therapy via Clearance of Senescent Cells (2024-03-01)
期刊：Small
影响因子 ：13.3
-
Integrated multi-omics approaches reveal the neurotoxicity of triclocarban in mouse brain (2024-08-30)
期刊：ENVIRONMENT INTERNATIONAL
DOI：10.1016/j.envint.2024.108987
影响因子 ：10.3
-
Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke (2024-05-27)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-02560-y
影响因子 ：10.2
引用产品： 小鼠脂肪间充质干细胞成骨诱导分化培养基 , 小鼠脂肪间充质干细胞成脂诱导分化培养基 , Neuro-2a [N2a; Neuro-2a] 细胞 , NCTC clone 929 [L cell, L-929] 细胞 , BV2 (DMEM) 细胞
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Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation (2024-11-21)
期刊：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子 ：9.4
-
Cholestane-3β,5α,6β-triol Induces Multiple Cell Death in A549 Cells via ER Stress and Autophagy Activation (2024-04-13)
期刊：Marine Drugs
影响因子 ：5.4
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , 293T [HEK-293T] 细胞 , SH-SY5Y [SHSY-5Y] 细胞 , A549 [A-549] 细胞 , Hep G2 细胞 , BV2 (DMEM) 细胞 , DMEM高糖 培养基
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Extracellular cold-inducible RNA-binding protein mediated neuroinflammation and neuronal apoptosis after traumatic brain injury (2024-05-29)
期刊：Burns & Trauma
影响因子 ：5.3
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Enriched oxygen improves age-related cognitive impairment through enhancing autophagy (2024-02-14)
期刊：Frontiers in Aging Neuroscience
DOI：10.3389/fnagi.2024.1340117
影响因子 ：4.8
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Neobavaisoflavone Ameliorates Memory Deficits and Brain Damage in Aβ25-35-Induced Mice by Regulating SIRT1 (2024-10-11)
期刊：CNS Neuroscience & Therapeutics
影响因子 ：4.8
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Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease (2024-04-18)
期刊：Drug Design Development and Therapy
影响因子 ：4.8
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Dietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway (2024-04-04)
期刊：Scientific Reports
DOI：10.1038/s41598-024-57998-9
影响因子 ：4.6
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Neuronostatin regulates neuronal function and energetic metabolism in Alzheimer's disease in a GPR107-dependent manner (2024-07-22)
期刊：NEUROPHARMACOLOGY
DOI：10.1016/j.neuropharm.2024.110090
影响因子 ：4.6
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Unraveling Neurotoxicity Discrepancies: Comparative In vitro and In vivo Analysis of Colistin and Polymyxin B and the Underlying Mechanisms (2024-10-28)
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-024-04577-8
影响因子 ：4.6
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , MEM 培养基 , DMEM高糖 培养基 , 特级胎牛血清 , RSC96 细胞
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High salt diet induces cognitive impairment and is linked to the activation of IGF1R/mTOR/p70S6K signaling (2024-05-21)
期刊：METABOLIC BRAIN DISEASE
DOI：10.1007/s11011-024-01358-z
影响因子 ：3.6
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Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice (2024-07-11)
期刊：PEPTIDES
DOI：10.1016/j.peptides.2024.171271
影响因子 ：2.8
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Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice (2024-05-31)
期刊：Open Life Sciences
影响因子 ：1.7
引用产品： BV2 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Aerobic exercise attenuates autophagy-lysosomal flux deficits by ADRB2/β2-adrenergic receptor-mediated V-ATPase assembly factor VMA21 signaling in APP-PSEN1/PS1 mice (2023-11-15)
期刊：Autophagy
DOI：10.1080/15548627.2023.2281134
影响因子 ：13.3
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , BV2 细胞
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Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis (2023-03-27)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01862-x
影响因子 ：10.2
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Piceatannol-3′-O-β-D-glucopyranoside attenuates colistin-induced neurotoxicity by suppressing oxidative stress via the NRF2/HO-1 pathway (2023-02-21)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.114419
影响因子 ：7.5
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , MEM (含NEAA) 培养基 , 特级胎牛血清
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Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy (2023-01-21)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3
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Identification and analysis of short open reading frame-encoded peptides in different regions of mouse brain (2023-03-17)
期刊：iScience
DOI：10.1016/j.isci.2023.106427
影响因子 ：5.8
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YTHDF3 modulates the Cbln1 level by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring (2023-12-09)
期刊：iScience
DOI：10.1016/j.isci.2023.108703
影响因子 ：5.8
引用产品： 青霉素-链霉素溶液（双抗），100× , Neuro-2a [N2a; Neuro-2a] 细胞 , 特级胎牛血清 , MEM（含NEAA） 培养基
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Berberine Rescues D-Ribose-Induced Alzheimer‘s Pathology via Promoting Mitophagy (2023-03-20)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
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High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy (2023-10-26)
期刊：EXPERIMENTAL NEUROLOGY
DOI：10.1016/j.expneurol.2023.114591
影响因子 ：5.3
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Biological and Immunological Characterization of a Functional L-HN Derivative of Botulinum Neurotoxin Serotype F (2023-03-06)
期刊：Toxins
影响因子 ：4.2
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Biology activity and characterization of the functional L-HN fragment derivative of botulinum neurotoxin serotype E (2023-07-20)
期刊：ANAEROBE
DOI：10.1016/j.anaerobe.2023.102764
影响因子 ：2.3
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Effect of intrathecal injection of γ-Oryzanol on motor function in mice after spinal cord injury (2023-09-18)
期刊：Interdisciplinary Neurosurgery-Advanced Techniques and Case Management
DOI：10.1016/j.inat.2023.101845
影响因子 ：0.4
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CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease (2022-08-12)
期刊：Redox Biology
DOI：10.1016/j.redox.2022.102430
影响因子 ：10.8
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Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging (2022-10-01)
期刊：Aging and Disease
影响因子 ：10.0
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Olfactory bulb microglia activation mediated neuronal death in real-ambient particulate matter exposure mice with depression-like behaviors (2022-01-29)
期刊：Science Of The Total Environment
DOI：10.1016/j.scitotenv.2022.153456
影响因子 ：9.8
引用产品： BV2 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Activation of β2-adrenergic Receptor Ameliorates Amyloid-β-induced Mitophagy Defects and Tau Pathology in Mice (2022-10-05)
期刊：NEUROSCIENCE
DOI：10.1016/j.neuroscience.2022.09.020
影响因子 ：3.7
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Molecular mechanism of Acanthopanax senticosus in the treatment of Alzheimer’s disease based on network pharmacology and molecular docking (2022-12-28)
期刊：MOLECULAR DIVERSITY
DOI：10.1007/s11030-022-10586-3
影响因子 ：3.4
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Neuroprotective effects of miR-532-5p against ischemic stroke (2020-01-21)
期刊：Metabolic Brain Disease
DOI：10.1007/s11011-020-00544-z
影响因子 ：3.6
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LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression (2020-08-29)
期刊：Metabolic Brain Disease
DOI：10.1007/s11011-020-00607-1
影响因子 ：3.6
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miR?183?5p attenuates cerebral ischemia injury by negatively regulating PTEN (2020-09-07)
期刊：Molecular Medicine Reports
影响因子 ：3.4
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Downregulation of BACH1 Protects AGAINST Cerebral Ischemia/Reperfusion Injury through the Functions of HO-1 and NQO1 (2020-06-01)
期刊：Neuroscience
DOI：10.1016/j.neuroscience.2020.04.014
影响因子 ：3.3
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