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  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)

bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)

货号:CL-0598

规格:1×10⁶cells/T25培养瓶

价格: ¥1800

生长培养基:DMEM10% FBS1% P/S

数量: - +

  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
  • bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)

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产品概述
产品信息
名称 bEnd.3 [BEND3] (小鼠脑微血管内皮细胞) (STR鉴定正确)
别称 bEND.3; b.End3; Bend.3; bEnd3; brain-derived Endothelial cells.3
种属 小鼠
生长特性 贴壁细胞
细胞形态 上皮细胞样
冻存条件 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮
培养方案A(默认)
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
推荐传代比例 1:2-1:4
推荐换液频率 2-3次/周
注意事项 1.该细胞在低密度下形态不规则,细胞数量少,铺展面积大,高密度后形态会趋于一致,胞体密集;2.细胞增殖偏慢,初次传代建议1:2,细胞稳定后建议传代比例也不超过1:4;3.注意观察培养基颜色,颜色偏紫会导致细胞漂浮增加;4.消化时间会随着细胞生长时间和细胞密度而有所不同,需要结合消化时细胞状态来判断,消化到细胞可以滑落方可终止。
参考资料(来源文献)
背景描述 The cells were transformed by infection with the NTKmT retrovirus vector that expresses polyomavirus middle T antigen
年龄(性别) 6周龄
组织来源 大脑皮层
细胞类型 转化细胞系
生物安全等级 BSL-1
抗原表达情况 ICAM-1 +; VCAM-1 +; MAdCAM-1 +
基因表达情况 von Willebrand factor,ICAM-1 +; VCAM-1 +; MAdCAM-1 +,The endothelial nature of these cells was confirmed by the observed expression of von Willebrand factor and uptake of fluorescently labeled low density lipoprotein (LDL).,The expression of Peyer's Patch high endothelial receptor for lymphocytes, the mucosal vascular addressin (MAdCAM-1) and E-selectin can be induced on bEnd
保藏机构 ATCC; CRL-2299 BCRC; 60515 ECACC; 96091929
STR鉴定
  • STR位点信息
    18-3 18
    6-7 11,12
    5-5 14
    X-1 26
    1-2 13
    7-1 29
    8-1 16
    1-1 10
    19-2 13
    15-3 19.3,20.3
    12-1 17
    6-4 17
    4-2 18.3
    3-2 14
    2-1 9
    13-1

    16.2

    11-2 14
    17-2 12
  • STR鉴定图
参考文献
文献列表
  • Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair (2024-03-25)

    作者:Chengjun Li:1.Department of Sports Medicine, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, China. ; 2.Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Road 87, Changsha, 410008, China. ; 3.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, China. ; Tian Qin:1.Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Road 87, Changsha, 410008, China. ; 2.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, China. ; 3.Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, China. ; Jinyun Zhao:1.Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Xiangya Road 87, Changsha, 410008, China. ; 2.National Clinical Res

    期刊:Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair

    DOI:10.1038/s41413-024-00323-x

    影响因子 :12.7

    引用产品: bEnd.3 [BEND3] 细胞

  • Enhancing Neuroprotection in Mouse Model of Parkinson’s Disease through Protein Nanosystem Conjugation with ApoE Peptide for miR-124 Delivery (2024-02-12)

    作者:Juan Zhang:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Bozhou Cui:1.Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Ting He:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Ruoxuan Hei:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Lan Yang:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Chong Liu:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Xianan Wu:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Xi Wang:1.Department of Clinical Laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. ; Zhaowei

    期刊:Enhancing Neuroprotection in Mouse Model of Parkinson’s Disease through Protein Nanosystem Conjugation with ApoE Peptide for miR-124 Delivery

    DOI:10.1021/acsami.3c13849

    影响因子 :9.5

    引用产品: bEnd.3 [BEND3] 细胞

  • The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair (2024-03-15)

    作者:Tingting Chen:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; Zimei Wu:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; 2.Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People's Republic of China. ; Qiaodan Hou:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; Yixin Mei:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; Kunkun Yang:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; Jing Xu:1.Southern University of Science and Technology Hospital, Shenzhen, People's Republic of China. ; Lin Wang:1.School of Medicine, Southern University of Science and Technology, Shenzhen, People's Republic of China. ; 2.Southern University of Science an

    期刊:The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

    DOI:10.2147/IJN.S449290

    影响因子 :8.0

    引用产品: MC3T3-E1 Subclone 14 细胞 ,  bEnd.3 [BEND3] 细胞

  • Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor (2024-02-09)

    作者:Zhiyi Liu:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Wei Hua:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Sinan Jin:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Yueying Wang:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Yuxin Pang:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Benshuai Wang:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Nan Zhao:1.Department of Pathology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. ; Yuejia Song:1.Department of Endocrinology, Harbin Medical University, First Clinical Hospital, Harbin, 150001, China. Electronic address: songyuejia@hrbmu.edu.cn. ; Jiping Qi:1.Department o

    期刊:Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor

    DOI:10.1016/j.ejphar.2024.176381

    影响因子 :5.0

    引用产品: bEnd.3 [BEND3] 细胞

  • A novel study of brain microvascular endothelial cells induced by astrocyte conditioned medium for constructing blood brain barrier model in vitro: A promising tool for meningitis of teleost (2024-01-23)

    作者:Yanghui Chen:1.Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, 524088, China. ; Yuan Li:1.Henry Fok College of Biology and Agriculture, Shaoguan University, Shaoguan, 512005, China. ; Junliang Luo:1.Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, 524088, China. ; Zixin Li:1.Fisheries College of Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture & Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, 524088, China. ; Yu Huang:1.Fisheries College of Guangdong Ocean

    期刊:A novel study of brain microvascular endothelial cells induced by astrocyte conditioned medium for constructing blood brain barrier model in vitro: A promising tool for meningitis of teleost

    DOI:10.1016/j.fsi.2024.109401

    影响因子 :4.7

    引用产品: bEnd.3 [BEND3] 细胞

  • Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption (2024-02-22)

    作者:Fei Xu:1.Department of Vascular Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Department of Vascular Surgery, Jining NO.1 People's Hospital, Jining, 272000, China. ; Qing Xin:1.Department of Physiology, Jining Medical University, Jining, 272000, China. ; Mengyao Ren:1.Department of Physiology, Jining Medical University, Jining, 272000, China. ; Peixin Shi:1.Department of Physiology, Jining Medical University, Jining, 272000, China. ; Bing Wang:1.Department of Vascular Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address: hnxgwk@126.com. ;

    期刊:Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption

    DOI:10.1016/j.neuint.2024.105702

    影响因子 :4.2

    引用产品: bEnd.3 [BEND3] 细胞

  • Long noncoding RNA KCNQ1OT1 aggravates cerebral infarction by regulating PTBT1/SIRT1 via miR-16-5p (2024-02-07)

    作者:Yuanming Jiang:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Chi Ma:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Yuxiu Guan:1.Department of Neurology, The Fifth Affiliated Hospital of Harbin Medical University, Daqing, Heilongjiang, China. ; Wenqi Yang:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Jiaqi Yu:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Hanfei Shi:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Zihang Ding:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. ; Zhuobo Zhang:1.Department of Neurology, The Fourth Affiliated Hospital of Harbin Medi

    期刊:Long noncoding RNA KCNQ1OT1 aggravates cerebral infarction by regulating PTBT1/SIRT1 via miR-16-5p

    DOI:10.1093/jnen/nlae005

    影响因子 :3.2

    引用产品: bEnd.3 [BEND3] 细胞

  • Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after Spinal Cord Injury (2023-09-11)

    作者:Yong Xie:1.Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha 410005, China. ; 2.Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha 410005, China. ; 3.Hunan Engineering Research Center of Sports and Health, Changsha 410005, China. ; 4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410005, China. ; Yi Sun:1.Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha 410005, China. ; 2.Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha 410005, China. ; 3.Hunan Engineering Research Center of Sports and Health, Changsha 410005, China. ; 4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410005, China. ; Yudong Liu:1.Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South Uni

    期刊:Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after Spinal Cord Injury

    DOI:10.1021/acsnano.3c04423

    影响因子 :17.1

    引用产品: bEnd.3 [BEND3] 细胞

  • C3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer’s disease (2023-09-15)

    作者:Xiuhua Yin:1.Institute of Quantitative Biology, Shanghai Institute for Advanced Study, College of Life Sciences, Zhejiang University, Hangzhou, 310027, China. ; 2.Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China. ; Hong Zhou:1.Institute of Quantitative Biology, Shanghai Institute for Advanced Study, College of Life Sciences, Zhejiang University, Hangzhou, 310027, China. ; Mengling Zhang:1.Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China. ; 2.Macao Institute of Materials Science and Engineering (MIMSE), MUST-SUDA Joint Research Center for Advanced Functional Materials, Macau University of Science and Technology, Taipa, 999078, Macao, China. ; Juan Su:1.State Key Laboratory of Radiation Medicine and Protection, School for Radiological and

    期刊:C3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer’s disease

    DOI:10.1038/s41467-023-41489-y

    影响因子 :16.6

    引用产品: bEnd.3 [BEND3] 细胞 ,  BV2 细胞

  • Protection of a novel velvet antler polypeptide PNP1 against cerebral ischemia-reperfusion injury (2023-07-13)

    作者:Hongyan Pei:1.College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. ; Rui Du:1.College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. Electronic address: durui@jlau.edu.cn. ; Zhongmei He:1.College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. ; Yi Yang:1.Department of pharmacy, The Second Affiliated Hospital of Jiaxing University, China. ; Shasha Wu:1.Department of pharmacy, The Second Affiliated Hospital of Jiaxing University, China. ; Wenyan Li:1.Department of pharmacy, The Second Affiliated Hospital of Jiaxing University, China. ; Jian Sheng:1.The Second Affiliated Hospital of Jiaxing University, 314001, China. Electronic address: jiansheng@jxey.com. ; Yahui Lv:1.The Second Affiliated Hospital of Jiaxing University, 314001, China. Electronic address: 19883396412@163.com. ; Chenyang Han:1.The Second Affiliated Hospital of Jiaxing University, 314001, Chi

    期刊:Protection of a novel velvet antler polypeptide PNP1 against cerebral ischemia-reperfusion injury

    DOI:10.1016/j.ijbiomac.2023.125815

    影响因子 :8.2

    引用产品: bEnd.3 [BEND3] 细胞 ,  BV2 细胞

  • Active fraction of Polyrhachis vicina (Roger) alleviated cerebral ischemia/reperfusion injury by targeting SIRT3-mediated mitophagy and angiogenesis (2023-09-18)

    作者:Jie Wei:1.Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China. ; Jiaxiu Xie:1.Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China. ; Junhui He:1.Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China. ; Dongmei Li:1.Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, China. ; Dongmei Wei:1.Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China. ; Yi Li:1.Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China. ; Xiang Li:1.State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. ; Weirong Fang:1.State Key Laboratory of Natural Medicin

    期刊:Active fraction of Polyrhachis vicina (Roger) alleviated cerebral ischemia/reperfusion injury by targeting SIRT3-mediated mitophagy and angiogenesis

    DOI:10.1016/j.phymed.2023.155104

    影响因子 :7.9

    引用产品: bEnd.3 [BEND3] 细胞

  • Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury (2023-02-21)

    作者:Wenyu Li:1.Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. ; Pengfei Xu:1.Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. Electronic address: xupengfei1026@126.com. ; Lingqi Kong:1.Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. ; Shuo Feng:1.Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. ; Nan Shen:1.Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui,

    期刊:Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

    DOI:10.1016/j.trsl.2023.02.002

    影响因子 :7.8

    引用产品: bEnd.3 [BEND3] 细胞

  • A Novel Blood–Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis (2023-05-15)

    作者:Lu Lu:1.Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-Based Medicine, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ; Longkun Wang:1.Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-Based Medicine, Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ; Lin Zhao:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ; Jing Liao:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College

    期刊:A Novel Blood–Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis

    DOI:10.3390/ijms24108753

    影响因子 :5.6

    引用产品: bEnd.3 [BEND3] 细胞

  • MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy (2023-11-30)

    作者:Yongri Hong:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. ; Caichuan Wei:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. ; Miaoying Fu:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. ; Xinyang Li:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. ; Haiju Zhang:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. Electronic address: 634326251@qq.com. ; Baozhen Yao:1.Department of Pediatrics, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China. Electronic address: professoryao@aliyun.com. ;

    期刊:MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy

    DOI:10.1016/j.intimp.2023.111236

    影响因子 :5.6

    引用产品: BV2 细胞 ,  bEnd.3 [BEND3] 细胞

  • Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: By suppressing M1 polarization of microglial cells and promoting cerebral angiogenesis (2023-02-09)

    作者:Liping Zhai:1.Department of Neurology, The Second Affiliated Hospital of Jiaxing University, China. ; Hongyan Pei:1.College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China. Electronic address: phy19990505@163.com. ; Heping Shen:1.Department of Neurology, The Second Affiliated Hospital of Jiaxing University, China. Electronic address: shenhp_77@163.com. ; Qiaobing Guan:1.Department of Neurology, The Second Affiliated Hospital of Jiaxing University, China. Electronic address: guanqb@126.com. ; Jian Sheng:1.Department of Neurology, The Second Affiliated Hospital of Jiaxing University, China. Electronic address: zhailp_82@126.com. ;

    期刊:Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: By suppressing M1 polarization of microglial cells and promoting cerebral angiogenesis

    DOI:10.1016/j.intimp.2023.109815

    影响因子 :5.6

    引用产品: BV2 细胞 ,  bEnd.3 [BEND3] 细胞

  • USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice (2023-06-02)

    作者:Wenzhong Hou:1.Department of Cerebrovascular Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qianyuan, China. ; Jianping Yao:1.Department of Anatomy, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. ; Junjie Liu:1.Department of Anatomy, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. ; Xiaohong Lin:1.Department of Anatomy, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China. ; JueXian Wei:1.Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. ; Xiaofan Yin:1.Department of Emergency, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. ; Hongbiao Huang:1.Department of Pathophysiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China. ; Xiaohui Chen:1.Department of Emergency, The Second Affiliated Hospital of Guangzhou Medica

    期刊:USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice

    DOI:10.1111/cns.14292

    影响因子 :5.5

    引用产品: bEnd.3 [BEND3] 细胞

  • Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury (2023-08-29)

    作者:Chengjie Wu:1.Department of Traumatology and Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ; 2.Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nanjing University of Chinese Medicine, Nanjing, China. ; Yalan Pan:1.Laboratory of Chinese Medicine Nursing Intervention for Chronic Diseases, Nanjing University of Chinese Medicine, Nanjing, China. ; Lining Wang:1.School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. ; Mengmin Liu:1.School of Chinese Medicine, School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. ; Pengcheng Tu:1.Department of Traumatology and Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ; 2.Laboratory of New Techniques of Restoration & Reconstruction, Institute of Traumatology & Orthopedics, Nan

    期刊:Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury

    DOI:10.1111/cns.14439

    影响因子 :5.5

    引用产品: bEnd.3 [BEND3] 细胞 ,  RAW 264.7 细胞

  • Advanced Glycation End-Products (AGEs) Promote Endothelial Cell Pyroptosis Under Cerebral Ischemia and Hypoxia via HIF-1α-RAGE-NLRP3 (2023-01-18)

    作者:Chenyang Han:1.The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. ; Liping Zhai:1.The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. ; Heping Shen:1.The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. ; Jin Wang:1.The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. ; Qiaobing Guan:1.The Second Affiliated Hospital of Jiaxing University, Jiaxing, China. guanqb@126.com. ;

    期刊:Advanced Glycation End-Products (AGEs) Promote Endothelial Cell Pyroptosis Under Cerebral Ischemia and Hypoxia via HIF-1α-RAGE-NLRP3

    DOI:10.1007/s12035-023-03228-8

    影响因子 :5.1

    引用产品: 小鼠脑微血管内皮细胞 ,  bEnd.3 [BEND3] 细胞

  • Nuclear Factor Erythroid 2-Related Factor 2 is Essential for Low-Normobaric Oxygen Treatment-Mediated Blood-Brain Barrier Protection Following Ischemic Stroke (2023-11-11)

    作者:Xiao-Xiao Ma:1.Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ; Hai-Yi Xie:1.Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ; Pin-Pin Hou:1.Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ; Xiao-Jing Wang:1.Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ; Wei Zhou:1.Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. winter8709@163.com. ; Zhen-Hong Wang:1.Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18621625707@163.com. ;

    期刊:Nuclear Factor Erythroid 2-Related Factor 2 is Essential for Low-Normobaric Oxygen Treatment-Mediated Blood-Brain Barrier Protection Following Ischemic Stroke

    DOI:10.1007/s12035-023-03767-0

    影响因子 :5.1

    引用产品: bEnd.3 [BEND3] 细胞

  • GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury (2023-12-01)

    作者:Yiqian Xu:1.Department of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. ; Xingyue Fang:1.Department of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. ; Zhenqiang Zhao:1.Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou 571199, China. ; Haolin Wu:1.Department of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. ; Haofei Fan:1.Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou 57

    期刊:GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury

    DOI:10.1016/j.ejphar.2023.176228

    影响因子 :5.0

    引用产品: bEnd.3 [BEND3] 细胞

  • Overexpression of ACE2 ameliorates Aβ-induced blood–brain barrier damage and angiogenesis by inhibiting NF-κB/VEGF/VEGFR2 pathway (2023-05-14)

    作者:Xueling Zhang:1.Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China. ; Yu Zhang:1.Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China. ; 2.National Human Diseases Animal Model Resource Center, Beijing, China. ; 3.NHC Key Laboratory of Human Disease Comparative Medicine, Beijing, China. ; 4.Changping National Laboratory (CPNL), Beijing, China. ; Ling Zhang:1.Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China. ; 2.National Human Diseases Animal Model Resource Center, Beijing, China. ; 3.NHC Key Laboratory of Human Disease Comparative Medicine, Beijing, China. ; 4.Changping National Laboratory (CPNL), Beijing, China. ; Chuan Qin:1.Institute of Laboratory Animal Sciences, CAMS & PUMC, Beijing, China. ; 2.National Human Diseases Animal Model Resource Center, Beijing, China. ; 3.NHC Key Laboratory of Human Disease Comparative Medicine, Beijing, China. ; 4.Changping National Laboratory (CPNL), Beijing, China. ;

    期刊:Overexpression of ACE2 ameliorates Aβ-induced blood–brain barrier damage and angiogenesis by inhibiting NF-κB/VEGF/VEGFR2 pathway

    DOI:10.1002/ame2.12324

    影响因子 :3.7

    引用产品: bEnd.3 [BEND3] 细胞

  • Vascular endothelial cell-derived exosomal miR-1246 facilitates posterior capsule opacification development by targeting GSK-3β in diabetes mellitus (2023-04-10)

    作者:Chenjun Guo:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. ; Jie Zhang:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. ; Jue Wang:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. ; Liping Su:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. ; Xiaona Ning:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. ; Yong Guo:1.Bright Eye Hospital, Xi'an, 710068, China. ; Jing Han:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. Electronic address: hanjing.cn@163.com. ; Nan Ma:1.Department of Ophthalmology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. Electronic address: manan840808@163.com. ;

    期刊:Vascular endothelial cell-derived exosomal miR-1246 facilitates posterior capsule opacification development by targeting GSK-3β in diabetes mellitus

    DOI:10.1016/j.exer.2023.109463

    影响因子 :3.4

    引用产品: bEnd.3 [BEND3] 细胞

  • Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides (2022-08-06)

    作者:Zhanchi Zhu:1.School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, China. ; 2.CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano Bionics, Chinese Academy of Sciences, Suzhou, China. ; Yuanxin Zhai:1.School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, China. ; 2.CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano Bionics, Chinese Academy of Sciences, Suzhou, China. ; Ying Hao:1.School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, China. ; 2.CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano Bionics, Chinese Academy of Sciences, Suzhou, China. ; 3.Guangdong Institute of Semiconductor Micro-Nano Manufacturing Technology, Guangdong, China. ; Quanwei Wang:1.CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano Bionics, Chinese Academy of Sciences, Suzhou, Ch

    期刊:Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides

    DOI:10.1002/jev2.12255

    影响因子 :17.3

    引用产品: bEnd.3 [BEND3] 细胞 ,  U-87 MG 细胞 ,  293T [HEK-293T] 细胞 ,  A549 [A-549] 细胞 ,  SH-SY5Y [SHSY-5Y] 细胞 ,  Hep G2 细胞

  • Gold nanocluster & indocyanine green based triple-effective therapy for MRSA infected central nervous system (2004-02-20)

    作者:Yi Zhuo: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Yi Zhang: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Bing Wang: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Shiqi Cheng: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Raorao Yuan: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Shaowen Liu: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Mailin Zhao: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Bin Xu: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China; Yan Zhang: 1.The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330088, China;2.Institute of Integration and Application of Clinical Sample Resources, Nanchang University, Nanchang, Jian

    期刊:Gold nanocluster & indocyanine green based triple-effective therapy for MRSA infected central nervous system

    DOI:10.1016/j.apmt.2022.101453

    影响因子 :8.3

    引用产品: NCTC clone 929 [L 细胞, L-929] 细胞 ,  BV2 细胞 ,  bEnd.3 [BEND3] 细胞 ,  PUMC-HUVEC-T1

  • Endothelial deletion of TBK1 contributes to BRB dysfunction via CXCR4 phosphorylation suppression (2022-10-28)

    作者:Bowen Zhao:1.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. ; Yueqi Ni:1.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. ; Hong Zhang:1.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. ; Yin Zhao:1.Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. zhaoyin85@hust.edu.cn. ; Lu Li:1.Department of Ophthalmology, Affiliated Wuxi Clinical College of Nantong University, Wuxi, 214000, People's Republic of China. lilull1982@Sina.com. ; 2.Department of Ophthalmology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, 214000,

    期刊:Endothelial deletion of TBK1 contributes to BRB dysfunction via CXCR4 phosphorylation suppression

    DOI:10.1038/s41420-022-01222-y

    影响因子 :7.1

    引用产品: bEnd.3 [BEND3] 细胞 ,  人视网膜微血管内皮细胞 ,  bEnd.3 [BEND3]细胞专用培养基 ,  人视网膜微血管内皮细胞完全培养基

  • Biosynthetic Gas Vesicles Combined with Focused Ultrasound for Blood–Brain Barrier Opening (2022-12-28)

    作者:Jinghan Zhang:1.Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. ; Fei Yan:1.Center for Cell and Gene Circuit Design, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China. ; Wei Zhang:1.Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. ; Lei He:1.Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. ; Yi Li:1.Department of Radiology, Peking Union Medical College Hospital, Beijing, People's Republic of China. ; Shuai Zheng:1.Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China. ; Yuanyuan Wang:1.Department of Ultrasound, The Second Hospital of Hebei Medical University, Shij

    期刊:Biosynthetic Gas Vesicles Combined with Focused Ultrasound for Blood–Brain Barrier Opening

    DOI:10.2147/IJN.S374039

    影响因子 :7.0

    引用产品: bEnd.3 [BEND3] 细胞

  • A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis (2009-01-20)

    作者:Yongzhi Cui:1.Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. ; 2.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, PR China. ; Yuanyuan Guo:1.Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, 430077, PR China. ; Li Kong:1.Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. ; Jingyu Shi:1.Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, 430077, PR China. ; Ping Liu:1.Department of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430077, PR China. ; Rui Li:1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of S

    期刊:A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

    DOI:10.1016/j.bioactmat.2021.09.015

    影响因子 :18.9

    引用产品: MC3T3-E1 Subclone 14 细胞 ,  bEnd.3 [BEND3] 细胞 ,  RAW 264.7 细胞

  • Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma (2001-01-20)

    作者:Lin Zhao:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. ; Hongyuan Chen:1.Department of General Surgery, Shandong University Affiliated Shandong Provincial Hospital, Jinan 250021, China. ; Lu Lu:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. ; Chunqian Zhao:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. ; Christina V Malichewe:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. ; Lei Wang:1.Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmacology, School of Pharmaceutical Sciences, Sha

    期刊:Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma

    DOI:10.1016/j.lfs.2021.119113

    影响因子 :6.1

    引用产品: bEnd.3 [BEND3] 细胞

  • Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2O2‐induced damage via NAMPT and the NF‐κB p65 signalling pathway (2002-01-20)

    作者:Xiujun Deng:1.Department of Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Xinghuan Liang:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Haiyan Yang:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Zhenxing Huang:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Xuemei Huang:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Chunfeng Liang:1.Department of Blood transfusion, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Yaqi Kuang:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Yingfen Qin:1.Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. ; Faquan

    期刊:Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2O2‐induced damage via NAMPT and the NF‐κB p65 signalling pathway

    DOI:10.1002/2211-5463.13067

    影响因子 :2.6

    引用产品: bEnd.3 [BEND3] 细胞

  • The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals (2002-07-20)

    作者:Yahua Wang:1.Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People's Republic of China. ; Xue Ying:1.Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People's Republic of China. ; Haolun Xu:1.Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People's Republic of China. ; Helu Yan:1.Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People's Republic of China. ; Xia Li:1.Key Laboratory of Xinjiang Phytomedicine Resources and Modernization of TCM, School of Pharmaceutical Sciences, Shihezi University, Shihezi, Xinjiang, People's Republic of China. ; Hui Tang:1.Key Laboratory of Xinji

    期刊:The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

    DOI:10.2147/IJN.S124276

    影响因子 :8.0

    引用产品: bEnd.3 [BEND3] 细胞

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