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| 名称 | PC-12(Undifferentiated) (大鼠肾上腺嗜铬细胞瘤细胞(未分化)) (种属鉴定正确) |
| 种属 | 大鼠 |
| 生长特性 | 疏松贴壁 |
| 细胞形态 | 圆形 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.PC-12(Undifferentiated)细胞正常生长状态为悬浮聚团，若需要用NGF诱导时，需要使用多聚-L-赖氨酸溶液（货号 PB180523）包被培养瓶后促使细胞贴壁。2.Undifferentiated、Low differentiation和High differentiation的区别：Undifferentiated的PC-12从形态上看是圆形的，聚团生长的漂浮细胞；Low differentiation的成多角形，有较短的突起；High differentiation的细胞有多个突起，突起数目不等，突触较长，类似神经元轴突。3.Low differentiation和High differentiation是在Undifferentiated的PC-12基础上诱导产生的，Low differentiation和High differentiation指的与神经细胞表型的相似程度，High differentiation更接近神经细胞表型。 |
| 背景描述 | PC-12(Undifferentiated)细胞是来自能移植的雄性大鼠肾上腺嗜铬细胞瘤。PC-12(Undifferentiated)细胞表达神经生长因子(NGF)受体，NGF可诱导产生神经表型。PC-12(Undifferentiated)细胞不合成肾上腺素。 |
| 年龄（性别） | 雄性 |
| 组织来源 | 肾上腺嗜铬细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 嗜铬细胞瘤细胞 |
种属鉴定
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种属鉴定图
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参考文献
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Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery (2024-02-22)
期刊：Bioactive Materials
DOI：10.1016/j.bioactmat.2024.01.021
影响因子 ：18.9
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A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease (2024-01-24)
期刊：Nature Communications
DOI：10.1038/s41467-024-44737-x
影响因子 ：16.6
引用产品： PC-12 (Undifferentiated) 细胞 , BV2 细胞 , SH-SY5Y [SHSY-5Y] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Enzyme-immobilized nanoclay hydrogel simultaneously reduces inflammation and scar deposition to treat spinal cord injury (2024-02-13)
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：15.1
引用产品： RAW 264.7细胞专用培养基 , BV2细胞专用培养基 (DMEM) , PC-12 (Undifferentiated) 细胞 , RAW 264.7 细胞 , BV2 细胞
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Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@DNA probe (2024-03-30)
期刊：NUCLEIC ACIDS RESEARCH
影响因子 ：14.9
引用产品： MCF7 [MCF-7] 细胞 , PC-12 (Undifferentiated) 细胞 , PC-12 (High differentiation)细胞专用培养基
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Activation of STING signaling aggravates chronic alcohol exposure-induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis (2024-03-22)
期刊：CNS Neuroscience & Therapeutics
影响因子 ：5.5
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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Ultrasensitive detecting of dopamine in complex components by field effect transistor sensor based on the synergistic enhancement effect and overcoming debye length limitations (2024-02-17)
期刊：Results in Physics
DOI：10.1016/j.rinp.2024.107487
影响因子 ：5.3
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Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification (2024-02-16)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176430
影响因子 ：5.0
引用产品： PC-12 (Undifferentiated) 细胞 , PC-12 (Undifferentiated)细胞专用培养基
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Two new quinoline alkaloid with neuroprotective activities from Xylaria longipes (2024-03-28)
期刊：FITOTERAPIA
DOI：10.1016/j.fitote.2024.105930
影响因子 ：3.4
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Development of Cholinesterase-Activatable Fluorescent Probes for Pesticide Residue Detection (2024-02-28)
期刊：ACS Agricultural Science & Technology
DOI：10.1021/acsagscitech.3c00466
影响因子 ：2.5
引用产品： PC-12 (Undifferentiated) 细胞 , OLN93 细胞
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Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting (2023-05-27)
期刊：Nature Communications
DOI：10.1038/s41467-023-38838-2
影响因子 ：16.6
引用产品： PC-12 (Undifferentiated) 细胞 , Hep G2 细胞
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Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy (2023-02-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01807-4
影响因子 ：10.2
引用产品： PC-12 (Undifferentiated) 细胞 , MEM (含NEAA) 培养基 , 特级胎牛血清
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Plant Protein-Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing (2023-03-24)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
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The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis (2023-05-18)
期刊：SCIENCE OF THE TOTAL ENVIRONMENT
DOI：10.1016/j.scitotenv.2023.164078
影响因子 ：9.8
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An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation (2023-03-13)
期刊：Materials Chemistry Frontiers
影响因子 ：7.0
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Low beauvericin concentrations promote PC-12 cell survival under oxidative stress by regulating lipid metabolism and PI3K/AKT/mTOR signaling (2023-12-07)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115786
影响因子 ：6.8
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IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway (2023-12-30)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111367
影响因子 ：5.6
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Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids (2023-06-24)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
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Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation (2023-07-17)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
引用产品： PC-12 (Undifferentiated) 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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Dandelion (Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics (2023-09-03)
期刊：Foods
影响因子 ：5.2
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Two New Compounds from the Fungus Xylaria nigripes (2023-01-04)
期刊：MOLECULES
影响因子 ：4.6
引用产品： 特级胎牛血清 , PC-12 (Undifferentiated) 细胞
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Gastrodin Induces Ferroptosis of Glioma Cells via Upregulation of Homeobox D10 (2023-12-13)
期刊：MOLECULES
影响因子 ：4.6
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Characterization of Polysaccharides from the Pericarp of Zanthoxylum bungeanum Maxim by Saccharide Mapping and Their Neuroprotective Effects (2023-02-15)
期刊：MOLECULES
影响因子 ：4.6
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Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion (2023-10-21)
期刊：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
DOI：10.1016/j.ejps.2023.106620
影响因子 ：4.6
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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model (2023-05-06)
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-023-03946-4
影响因子 ：4.4
引用产品： PC-12 (Undifferentiated) 细胞 , RSC96 细胞
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Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia (2023-06-02)
期刊：BMC GENOMICS
DOI：10.1186/s12864-023-09408-z
影响因子 ：4.4
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Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways (2023-07-12)
期刊：NEUROCHEMISTRY INTERNATIONAL
DOI：10.1016/j.neuint.2023.105586
影响因子 ：4.2
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Neuroprotective methylsuccinic acid and enoic acid derivatives from the fungus Xylaria longipes (2023-03-24)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2023.113652
影响因子 ：3.8
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Integrated insight into the molecular mechanisms of selenium-modulated, MPP+-induced cytotoxicity in a Parkinson’s disease model (2023-05-24)
期刊：JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
DOI：10.1016/j.jtemb.2023.127208
影响因子 ：3.5
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Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects (2023-07-26)
期刊：NEW JOURNAL OF CHEMISTRY
影响因子 ：3.3
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METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the Intracerebral hemorrhage progression (2023-04-25)
期刊：BRAIN RESEARCH
DOI：10.1016/j.brainres.2023.148373
影响因子 ：2.9
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Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats (2023-07-20)
期刊：Biochemistry and Biophysics Reports
DOI：10.1016/j.bbrep.2023.101497
影响因子 ：2.7
引用产品： 人脐带间充质干细胞 , PC-12 (Undifferentiated) 细胞
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STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis (2023-08-12)
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00823-x
影响因子 ：2.6
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2 (2023-06-30)
期刊：Journal of Stroke & Cerebrovascular Diseases
DOI：10.1016/j.jstrokecerebrovasdis.2023.107235
影响因子 ：2.5
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Two pairs of new isobenzofuranone enantiomers from a soil-derived fungus Penicillium canescens DWS225 (2023-04-11)
期刊：NATURAL PRODUCT RESEARCH
DOI：10.1080/14786419.2023.2198712
影响因子 ：2.2
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Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis (2023-01-24)
期刊：Open Medicine
影响因子 ：2.1
引用产品： PC-12 (Undifferentiated) 细胞 , 马血清
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Combining a Density Gradient of Biomacromolecular Nanoparticles with Biological Effectors in an Electrospun Fiber-Based Nerve Guidance Conduit to Promote Peripheral Nerve Repair (2022-12-09)
期刊：Advanced Science
影响因子 ：17.5
引用产品： PC-12 (Undifferentiated) 细胞 , 多聚-L-赖氨酸溶液 (10×) , PC-12 (Undifferentiated)细胞专用培养基
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Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice (2002-02-20)
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-04592-4
影响因子 ：9.0
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks (2022-12-14)
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7702
影响因子 ：6.4
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Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury (2022-12-22)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109616
影响因子 ：5.7
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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The SWGEDWGEIW from Soybean Peptides Reduce Oxidative Damage-Mediated Apoptosis in PC-12 Cells by Activating SIRT3/FOXO3a Signaling Pathway (2022-11-06)
期刊：MOLECULES
影响因子 ：4.9
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Calycosin ameliorates spinal cord injury by targeting Hsp90 to inhibit oxidative stress and apoptosis of nerve cells (2022-11-17)
期刊：JOURNAL OF CHEMICAL NEUROANATOMY
DOI：10.1016/j.jchemneu.2022.102190
影响因子 ：3.1
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miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim (2022-10-31)
期刊：NEUROSCIENCE RESEARCH
DOI：10.1016/j.neures.2022.10.008
影响因子 ：2.9
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Fabrication and detection of a novel hybrid conductive scaffold based on alginate/gelatin/carboxylated carbon nanotubes (Alg/Gel/mMWCNTs) for neural tissue engineering (2022-12-07)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2022.101995
影响因子 ：2.6
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Atractylenolide III induces apoptosis by regulating the Bax/Bcl-2 signaling pathway in human colorectal cancer HCT-116 Cells in vitro and in vivo (2001-02-20)
期刊：Anti-Cancer Drugs
DOI：10.1097/CAD.0000000000001136
影响因子 ：2.3
引用产品： HCT 116 细胞 , A549 [A-549] 细胞 , Hep G2 细胞 , PC-12 (Undifferentiated) 细胞
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Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion (2006-01-20)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： MG-63 细胞 , PC-12 (Undifferentiated) 细胞 , 重组人胰岛素溶液 (10mg/mL) , MEM非必需氨基酸溶液 (NEAA)，100× , PUMC-HUVEC-T1 , CCC-SMC-1 细胞
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Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinsons disease model through DNMT1 nuclear translocation and SNCAs methylation (2006-01-20)
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111832
影响因子 ：7.5
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Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway (2006-01-20)
期刊：Food & Function
影响因子 ：6.1
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A novel nonapeptide SSDAFFPFR from Antarctic krill exerts a protective effect on PC12 cells through the BCL-XL/Bax/Caspase-3/p53 signaling pathway (2008-01-20)
期刊：Food Bioscience
DOI：10.1016/j.fbio.2021.101345
影响因子 ：5.2
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Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway (2010-01-20)
期刊：Stem Cells International
影响因子 ：4.3
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Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats (2001-01-20)
期刊：Journal of Molecular Neuroscience
DOI：10.1007/s12031-020-01770-x
影响因子 ：3.1
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Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes (2003-01-20)
期刊：Natural Product Research
DOI：10.1080/14786419.2021.1897591
影响因子 ：2.2
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microRNA-184 enhances the sensitivity of pheochromocytoma-12 cells to doxorubicin by targeting ADAM22 (2002-01-20)
期刊：Molecular & Cellular Toxicology
DOI：10.1007/s13273-021-00116-x
影响因子 ：1.7
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A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation (2012-00-20)
期刊：Journal of Advanced Research
DOI：10.1016/j.jare.2020.12.010
影响因子 ：10.7
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Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes (2010-00-20)
期刊：Clinical and Translational Medicine
DOI：10.1002/ctm2.205
影响因子 ：10.6
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Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure–Activity Relationship (2006-00-20)
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.1
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Optimal route of gold nanoclusters administration in mice targeting Parkinson’s disease (2002-00-20)
期刊：Nanomedicine
影响因子 ：5.5
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Evaluation and structure–activity relationship analysis of antioxidant shrimp peptides (2008-09-20)
期刊：Food & Function
影响因子 ：6.1
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Egg yolk phosphatidylcholine: Extraction, purification and its potential neuroprotective effect on PC12 cells (2003-09-20)
期刊：Journal of Functional Foods
影响因子 ：5.6
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Glutamine Improves Oxidative Stress through the Wnt3a/ β-Catenin Signaling Pathway in Alzheimers Disease In Vitro and In Vivo (2004-09-20)
期刊：Biomed Research International
影响因子 ：3.2
引用产品： PC-12 (Undifferentiated) 细胞 , RPMI-1640 (不含L-谷氨酰胺) 培养基
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Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells (2002-09-20)
期刊：Neuroreport
DOI：10.1097/WNR.0000000000001180
影响因子 ：1.7
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