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产品概述
| 名称 | RSC96 (大鼠雪旺细胞) (种属鉴定正确) |
| 别称 | RSC 96; RSC-96 |
| 种属 | 大鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 神经细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | RSC96细胞是原代培养的大鼠雪旺细胞经长时间培养后自发转化而成的。2002年12月提交到ATCC的RSC96细胞污染了支原体，RSC96细胞后代细胞通过BM细胞周期蛋白处理21天消除支原体。处理后6周，用Hoechst染色、PCR和标准培养测试进行支原体检测，结果都呈阴性。 |
| 组织来源 | 雪旺细胞 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 受体表达情况 | Nerve growth factor receptor (Ngfr); Protein and mRNA, negative;Platelet derived growth factor receptor, alpha; negative;Platelet derived growth factor receptor, beta; negative |
| 保藏机构 | ATCC; CRL-2765 |
种属鉴定
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种属鉴定图
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参考文献
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Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis (2025-03-27)
期刊：Cell Death & Disease
DOI：10.1038/s41419-025-07543-x
影响因子 ：8.1
引用产品： RSC96 细胞
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Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway (2025-03-26)
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.8469
影响因子 ：6.1
引用产品： RSC96 细胞
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Mung Bean-Derived Carbon Dots Suppress Ferroptosis of Schwann Cells via Nrf2/HO-1/GPX4 Pathway to Promote Peripheral Nerve Repair (2025-01-15)
期刊：Biomaterials Science
影响因子 ：5.8
引用产品： RSC96 细胞
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Efficacy and mechanisms of concentrated growth factor on facial nerve rehabilitation in a rabbit model (2025-01-20)
期刊：Biomaterials Science
影响因子 ：5.8
引用产品： RSC96 细胞 , 青霉素-链霉素溶液（双抗），100× , 0.25%胰蛋白酶溶液（含EDTA，溶于PBS）
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Conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes (2024-11-07)
期刊：Bioactive Materials
DOI：10.1016/j.bioactmat.2024.11.001
影响因子 ：18.0
引用产品： RSC96 细胞
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Pathophysiology-Directed Engineering of a Combination Nanoanalgesic for Neuropathic Pain (2024-12-24)
期刊：Advanced Science
影响因子 ：14.3
引用产品： RAW 264.7 细胞 , RSC96 细胞 , PC-12 (High differentiation) 细胞
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Pleiotropic effects of nitric oxide sustained-release system for peripheral nerve repair (2024-05-16)
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2024.05.012
影响因子 ：9.7
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Digital light processing bioprinting neural systems with porous hydrogel in structure and function for disease models (2024-12-10)
期刊：Cell Reports Physical Science
DOI：10.1016/j.xcrp.2024.102311
影响因子 ：7.9
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Enhancing cellular behavior in repaired tissue via silk fibroin-integrated triboelectric nanogenerators (2024-05-24)
期刊：Microsystems & Nanoengineering
DOI：10.1038/s41378-024-00694-5
影响因子 ：7.9
引用产品： EA.hy926 细胞 , RSC96 细胞 , NIH/3T3 细胞
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Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction (2024-01-26)
期刊：Cell Death Discovery
DOI：10.1038/s41420-024-01824-8
影响因子 ：7.0
引用产品： RSC96 细胞 , DMEM高糖 培养基
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Xiaoke Bitong capsule alleviates inflammatory impairment via inhibition of the TNF signaling pathway to against diabetic peripheral neuropathy (2024-07-09)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155867
影响因子 ：6.7
引用产品： RSC96 细胞
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Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats (2024-03-02)
期刊：CNS Neuroscience & Therapeutics
影响因子 ：5.5
引用产品： RAW 264.7 细胞 , RSC96 细胞
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Unraveling Neurotoxicity Discrepancies: Comparative In vitro and In vivo Analysis of Colistin and Polymyxin B and the Underlying Mechanisms (2024-10-28)
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-024-04577-8
影响因子 ：4.6
引用产品： Neuro-2a [N2a; Neuro-2a] 细胞 , MEM 培养基 , DMEM高糖 培养基 , 特级胎牛血清 , RSC96 细胞
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Peripheral nervous system lymphatic vessels: A simple delivery route to promote nerve regeneration (2024-04-28)
期刊：EXPERIMENTAL NEUROLOGY
DOI：10.1016/j.expneurol.2024.114783
影响因子 ：4.6
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Identification of key genes and immune infiltration of diabetic peripheral neuropathy in mice and humans based on bioinformatics analysis (2024-11-18)
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2024.1437979
影响因子 ：3.9
引用产品： RSC96 细胞 , DMEM高糖完全培养基（含10% FBS）
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Sevoflurane impedes neuropathic pain by maintaining endoplasmic reticulum stress and oxidative stress homeostasis through inhibiting the activation of the PLCγ/CaMKII/IP3R signaling pathway (2024-07-05)
期刊：Aging-US
影响因子 ：3.9
引用产品： RSC96 细胞
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Melittin promotes the proliferation of Schwann cells in hyperglycemic environment by up?regulating the Crabp2/Wnt/β?catenin signaling pathway (2024-10-18)
期刊：Molecular Medicine Reports
影响因子 ：3.4
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Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration (2023-01-09)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01767-9
影响因子 ：10.2
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Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats (2023-11-24)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02222-5
影响因子 ：10.2
引用产品： RSC96 细胞 , 293T [HEK-293T] 细胞
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Endogenous Electric Field-Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway (2023-01-18)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
引用产品： RSC96 细胞
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Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells (2023-08-14)
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7984
影响因子 ：7.2
引用产品： RSC96 细胞
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Compound Qiying Granules alleviates diabetic peripheral neuropathy by inhibiting endoplasmic reticulum stress and apoptosis (2023-07-18)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-023-00698-3
影响因子 ：5.7
引用产品： RSC96 细胞
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Cisplatin causes erectile dysfunction by decreasing endothelial and smooth muscle content and inducing cavernosal nerve senescence in rats (2023-01-25)
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2023.1096723
影响因子 ：5.2
引用产品： RSC96 细胞
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The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and sciatic nerve demyelination in rats (2023-07-27)
期刊：CLINICAL AND EXPERIMENTAL IMMUNOLOGY
影响因子 ：4.6
引用产品： RSC96 细胞
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Evodiamine attenuates oxidative stress and ferroptosis by inhibiting the MAPK signaling to improve bortezomib-induced peripheral neurotoxicity (2023-11-27)
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.5
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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model (2023-05-06)
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-023-03946-4
影响因子 ：4.4
引用产品： PC-12 (Undifferentiated) 细胞 , RSC96 细胞
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Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3 (2023-11-07)
期刊：FOOD AND CHEMICAL TOXICOLOGY
影响因子 ：4.3
引用产品： RSC96 细胞
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Aptamer engineering exosomes loaded on biomimetic periosteum to promote angiogenesis and bone regeneration by targeting injured nerves via JNK3 MAPK pathway (2022-09-20)
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100434
影响因子 ：10.8
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