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产品概述
| 名称 | PC-12(Low differentiation) (大鼠肾上腺嗜铬细胞瘤细胞(低分化)) (种属鉴定正确) |
| 种属 | 大鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 多角形 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.Undifferentiated、Low differentiation和High differentiation的区别：Undifferentiated的PC-12从形态上看是圆形的，聚团生长的漂浮细胞；Low differentiation的成多角形，有较短的突起；High differentiation的细胞有多个突起，突起数目不等，突触较长，类似神经元轴突。2.Low differentiation和High differentiation是在Undifferentiated的PC-12基础上诱导产生的，Low differentiation和High differentiation指的与神经细胞表型的相似程度，High differentiation更接近神经细胞表型。 |
| 背景描述 | PC-12(Low differentiation)细胞是来自能移植的雄性大鼠肾上腺嗜铬细胞瘤。PC-12(Low differentiation)细胞表达神经生长因子(NGF)受体，NGF可诱导产生神经表型。PC-12(Low differentiation)细胞不合成肾上腺素。 |
| 年龄（性别） | 雄性 |
| 组织来源 | 肾上腺嗜铬细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 嗜铬细胞瘤细胞 |
种属鉴定
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种属鉴定图
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参考文献
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A novel supramolecular nanodrugs for improving the cognitive function of schizophrenia by protecting active lactone of arecoline (2025-01-17)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2025.117845
影响因子 ：6.9
引用产品： PC-12 (Low differentiation) 细胞 , bEnd.3 [BEND3] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Dual-layer microneedles with NO/O2 releasing for diabetic wound healing via neurogenesis, angiogenesis, and immune modulation (2024-12-16)
期刊：Bioactive Materials
DOI：10.1016/j.bioactmat.2024.12.012
影响因子 ：18.0
引用产品： NCTC clone 929 [L cell, L-929] 细胞 , PC-12 (Low differentiation) 细胞 , 人脐静脉内皮细胞
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A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease (2024-01-24)
期刊：Nature Communications
DOI：10.1038/s41467-024-44737-x
影响因子 ：16.6
引用产品： PC-12 (Undifferentiated) 细胞 , BV2 细胞 , SH-SY5Y [SHSY-5Y] 细胞 , Neuro-2a [N2a; Neuro-2a] 细胞
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Enzyme-immobilized nanoclay hydrogel simultaneously reduces inflammation and scar deposition to treat spinal cord injury (2024-02-13)
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：15.1
引用产品： RAW 264.7细胞专用培养基 , BV2细胞专用培养基 (DMEM) , PC-12 (Undifferentiated) 细胞 , RAW 264.7 细胞 , BV2 细胞
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Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@DNA probe (2024-03-30)
期刊：NUCLEIC ACIDS RESEARCH
影响因子 ：14.9
引用产品： MCF7 [MCF-7] 细胞 , PC-12 (Undifferentiated) 细胞 , PC-12 (High differentiation)细胞专用培养基
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pH-responsive coacervate with adrenergic nerve blockade function inhibits triple-negative breast cancer metastasis by blocking nerve-tumor-immune loop (2024-06-10)
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：13.3
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Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer (2024-10-10)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-024-03202-9
影响因子 ：11.4
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Engineered Basic Fibroblast Growth Factor Specifically Bonded with Injectable Extracellular Matrix Hydrogel for the Functional Restoration of Cerebral Ischemia in Rats (2024-05-02)
期刊：Biomaterials Research
影响因子 ：8.1
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Molecular insights into vasicine and butyrylcholinesterase interactions: A complimentary biophysical, multi-spectroscopic, and computational study (2024-12-27)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.139253
影响因子 ：7.7
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A novel NIR fluorescent probe for copper(II) imaging in Parkinson's disease mouse brain (2024-07-22)
期刊：Chemical Science
影响因子 ：7.6
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CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury (2024-12-19)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.12.041
影响因子 ：7.1
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Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide O-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease (2024-08-07)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.4c01132
影响因子 ：6.8
引用产品： PC-12 (High differentiation) 细胞 , 特级胎牛血清 , SH-SY5Y [SHSY-5Y] 细胞
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Gastrodin: Modulating the xCT/GPX4 and ACSL4/LPCAT3 pathways to inhibit ferroptosis after ischemic stroke (2024-12-27)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.156331
影响因子 ：6.7
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Natural Product Virtual-Interact-Phenotypic Target Characterization: A Novel Approach Demonstrated with Salvia Miltiorrhiza Extract (2024-09-16)
期刊：Journal of Pharmaceutical Analysis
DOI：10.1016/j.jpha.2024.101101
影响因子 ：6.1
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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury (2024-04-03)
期刊：Neural Regeneration Research
DOI：10.4103/NRR.NRR-D-23-01322
影响因子 ：6.1
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Low-density lipoprotein receptor-related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease (2024-07-29)
期刊：Neural Regeneration Research
DOI：10.4103/NRR.NRR-D-23-01965
影响因子 ：5.9
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Cerium Oxide-Modified Pd Nanosheets Encapsulated by Red Blood Cell Membranes with High-Efficiency RONS Scavenging for Depression Treatment (2024-10-14)
期刊：Nanoscale
影响因子 ：5.8
引用产品： PC-12 (High differentiation) 细胞 , NCTC clone 929 [L cell, L-929] 细胞 , bEnd.3 [BEND3] 细胞
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Activation of STING signaling aggravates chronic alcohol exposure-induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis (2024-03-22)
期刊：CNS Neuroscience & Therapeutics
影响因子 ：5.5
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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Nasal administration of Xingnaojing biomimetic nanoparticles for the treatment of ischemic stroke (2024-10-12)
期刊：INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI：10.1016/j.ijpharm.2024.124830
影响因子 ：5.3
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Ultrasensitive detecting of dopamine in complex components by field effect transistor sensor based on the synergistic enhancement effect and overcoming debye length limitations (2024-02-17)
期刊：Results in Physics
DOI：10.1016/j.rinp.2024.107487
影响因子 ：5.3
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Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production (2024-08-05)
期刊：Journal of Neuroimmune Pharmacology
DOI：10.1007/s11481-024-10136-8
影响因子 ：5.2
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Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy (2024-12-12)
期刊：NEUROBIOLOGY OF DISEASE
影响因子 ：5.1
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Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification (2024-02-16)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176430
影响因子 ：5.0
引用产品： PC-12 (Undifferentiated) 细胞 , PC-12 (Undifferentiated)细胞专用培养基
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Insulin-Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In?Vivo and In?Vitro Studies (2024-10-16)
期刊：CNS Neuroscience & Therapeutics
影响因子 ：4.8
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Guilu Erxian Jiao remodels dendritic spine morphology through activation of the hippocampal TRPC6-CaMKIV-CREB signaling pathway and suppresses fear memory generalization in rats with post-traumatic stress disorder (2024-12-14)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：4.8
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Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy (2024-11-21)
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-024-04635-1
影响因子 ：4.6
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Irisflorentin improves functional recovery after spinal cord injury by protecting the blood–spinal cord barrier and promoting axonal growth (2024-07-10)
期刊：EXPERIMENTAL NEUROLOGY
DOI：10.1016/j.expneurol.2024.114886
影响因子 ：4.6
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Sports training improves motor function after spinal cord injury by regulating microtubule dynamics (2024-11-23)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2024.167587
影响因子 ：4.2
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Neuroprotective effects of trigonelline in eggplant on oxidative damage of PC12 cells and cognitive impairment in aging mice (2024-09-11)
期刊：Journal of Functional Foods
影响因子 ：3.8
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Chlorogenic Acid Mitigates Ferroptosis by Activating the Nrf2/GPX4 Pathway through Keap1 Blockade in Vascular Dementia Rats (2024-10-07)
期刊：JOURNAL OF FOOD BIOCHEMISTRY
影响因子 ：3.5
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Two new quinoline alkaloid with neuroprotective activities from Xylaria longipes (2024-03-28)
期刊：FITOTERAPIA
DOI：10.1016/j.fitote.2024.105930
影响因子 ：3.4
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Five brasilane-type sesquiterpenoids with neuroprotective activities from Xylaria nigripes (2024-12-09)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2024.114357
影响因子 ：3.2
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Sodium para-aminosalicylic acid attenuates combined manganese/iron-induced cortical synaptic damage in rats (2024-05-23)
期刊：BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
影响因子 ：3.1
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IGFBP5 Promotes Neuronal Apoptosis in a 6-OHDA-Toxicant Model of Parkinson’s Disease by Inhibiting the Sonic Hedgehog Signaling Pathway (2024-04-02)
期刊：MEDICAL PRINCIPLES AND PRACTICE
影响因子 ：2.9
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MiR-335 Improves Functional Recovery in Rats After Spinal Cord Injury and Protects PC12 Cells Against Injury Via the SPI-Bax/Caspase-3 Axis (2024-01-03)
期刊：SPINE
DOI：10.1097/BRS.0000000000004862
影响因子 ：2.6
引用产品： PC-12 (Low differentiation) 细胞 , 特级胎牛血清
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Lepidium meyenii (Maca) polysaccharides mitigate liver toxicity of aflatoxin B1 through activation of NRF-2/GPX and AhR/STAT3 signaling pathways (2024-10-03)
期刊：TOXICON
DOI：10.1016/j.toxicon.2024.108117
影响因子 ：2.6
引用产品： THP-1 细胞 , Hank's平衡盐溶液（HBSS），含钙、镁，不含酚红 , PC-12 (High differentiation) 细胞 , 0.25%胰蛋白酶溶液（含EDTA，溶于PBS） , L-谷氨酰胺溶液（200 mM），100× , 特级胎牛血清 , DMEM高糖 培养基
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Development of Cholinesterase-Activatable Fluorescent Probes for Pesticide Residue Detection (2024-02-28)
期刊：ACS Agricultural Science & Technology
DOI：10.1021/acsagscitech.3c00466
影响因子 ：2.5
引用产品： PC-12 (Undifferentiated) 细胞 , OLN93 细胞
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Luteolin Mitigates Dopaminergic Neuron Degeneration and Restrains Microglial M1 Polarization by Inhibiting Toll Like Receptor 4 (2024-09-30)
期刊：Journal of Integrative Neuroscience
影响因子 ：2.5
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Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging (2023-06-02)
期刊：Nature Communications
DOI：10.1038/s41467-023-38842-6
影响因子 ：16.6
引用产品： C3H/10T1/2, Clone 8 细胞 , PC-12 (Low differentiation) 细胞
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Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting (2023-05-27)
期刊：Nature Communications
DOI：10.1038/s41467-023-38838-2
影响因子 ：16.6
引用产品： PC-12 (Undifferentiated) 细胞 , Hep G2 细胞
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Negatively charged bladder acellular matrix loaded with positively charged adipose-derived mesenchymal stem cell-derived small extracellular vesicles for bladder tissue engineering (2023-11-18)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2023.10.048
影响因子 ：10.8
引用产品： 大鼠膀胱平滑肌细胞 , 人脐静脉内皮细胞 , PC-12 (Low differentiation) 细胞 , 人骨髓间充质干细胞成骨诱导分化培养基 , 人骨髓间充质干细胞成脂诱导分化培养基 , 人骨髓间充质干细胞成软骨诱导分化培养基
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Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy (2023-02-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01807-4
影响因子 ：10.2
引用产品： PC-12 (Undifferentiated) 细胞 , MEM (含NEAA) 培养基 , 特级胎牛血清
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Micro electrical fields induced MSC-sEVs attenuate neuronal cell apoptosis by activating autophagy via lncRNA MALAT1/miR-22-3p/SIRT1/AMPK axis in spinal cord injury (2023-11-27)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02217-2
影响因子 ：10.2
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Plant Protein-Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing (2023-03-24)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
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The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis (2023-05-18)
期刊：SCIENCE OF THE TOTAL ENVIRONMENT
DOI：10.1016/j.scitotenv.2023.164078
影响因子 ：9.8
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Low beauvericin concentrations promote PC-12 cell survival under oxidative stress by regulating lipid metabolism and PI3K/AKT/mTOR signaling (2023-12-07)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115786
影响因子 ：6.8
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IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway (2023-12-30)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111367
影响因子 ：5.6
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ROS-responsive exogenous functional mitochondria can rescue neural cells post-ischemic stroke (2023-07-03)
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2023.1207748
影响因子 ：5.5
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Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids (2023-06-24)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
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Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation (2023-07-17)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
引用产品： PC-12 (Undifferentiated) 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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Indole Diterpenes from Mangrove Sediment-Derived Fungus Penicillium sp. UJNMF0740 Protect PC12 Cells against 6-OHDA-Induced Neurotoxicity via Regulating the PI3K/Akt Pathway (2023-11-14)
期刊：Marine Drugs
影响因子 ：5.4
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Dandelion (Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics (2023-09-03)
期刊：Foods
影响因子 ：5.2
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Two New Compounds from the Fungus Xylaria nigripes (2023-01-04)
期刊：MOLECULES
影响因子 ：4.6
引用产品： 特级胎牛血清 , PC-12 (Undifferentiated) 细胞
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Gastrodin Induces Ferroptosis of Glioma Cells via Upregulation of Homeobox D10 (2023-12-13)
期刊：MOLECULES
影响因子 ：4.6
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Characterization of Polysaccharides from the Pericarp of Zanthoxylum bungeanum Maxim by Saccharide Mapping and Their Neuroprotective Effects (2023-02-15)
期刊：MOLECULES
影响因子 ：4.6
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Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion (2023-10-21)
期刊：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
DOI：10.1016/j.ejps.2023.106620
影响因子 ：4.6
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Effects of Curcumin on Axon Growth and Myelin Sheath Formation in an In Vitro Model (2023-05-06)
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-023-03946-4
影响因子 ：4.4
引用产品： PC-12 (Undifferentiated) 细胞 , RSC96 细胞
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Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways (2023-07-12)
期刊：NEUROCHEMISTRY INTERNATIONAL
DOI：10.1016/j.neuint.2023.105586
影响因子 ：4.2
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Exosomes from magnetic particles-primed mesenchymal stem cells enhance neural differentiation of PC12 cells. (2023-10-16)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e21075
影响因子 ：4.0
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Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation (2023-07-21)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e18449
影响因子 ：4.0
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Neuroprotective methylsuccinic acid and enoic acid derivatives from the fungus Xylaria longipes (2023-03-24)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2023.113652
影响因子 ：3.8
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Integrated insight into the molecular mechanisms of selenium-modulated, MPP+-induced cytotoxicity in a Parkinson’s disease model (2023-05-24)
期刊：JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
DOI：10.1016/j.jtemb.2023.127208
影响因子 ：3.5
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Doping Ag2S quantum dots with Pb yields significantly enhanced in vivo fluorescence imaging in the NIR-II window and comparable toxic effects (2023-07-26)
期刊：NEW JOURNAL OF CHEMISTRY
影响因子 ：3.3
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Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis (2023-11-25)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2023.149324
影响因子 ：3.1
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METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the Intracerebral hemorrhage progression (2023-04-25)
期刊：BRAIN RESEARCH
DOI：10.1016/j.brainres.2023.148373
影响因子 ：2.9
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Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats (2023-07-20)
期刊：Biochemistry and Biophysics Reports
DOI：10.1016/j.bbrep.2023.101497
影响因子 ：2.7
引用产品： 人脐带间充质干细胞 , PC-12 (Undifferentiated) 细胞
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STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis (2023-08-12)
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00823-x
影响因子 ：2.6
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2 (2023-06-30)
期刊：Journal of Stroke & Cerebrovascular Diseases
DOI：10.1016/j.jstrokecerebrovasdis.2023.107235
影响因子 ：2.5
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Two pairs of new isobenzofuranone enantiomers from a soil-derived fungus Penicillium canescens DWS225 (2023-04-11)
期刊：NATURAL PRODUCT RESEARCH
DOI：10.1080/14786419.2023.2198712
影响因子 ：2.2
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Combining a Density Gradient of Biomacromolecular Nanoparticles with Biological Effectors in an Electrospun Fiber-Based Nerve Guidance Conduit to Promote Peripheral Nerve Repair (2022-12-09)
期刊：Advanced Science
影响因子 ：17.5
引用产品： PC-12 (Undifferentiated) 细胞 , 多聚-L-赖氨酸溶液 (10×) , PC-12 (Undifferentiated)细胞专用培养基
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Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks (2022-12-14)
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7702
影响因子 ：6.4
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Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway (2022-08-25)
期刊：Frontiers in Pharmacology
影响因子 ：6.0
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Taxifolin attenuates neuroinflammation and microglial pyroptosis via the PI3K/Akt signaling pathway after spinal cord injury (2022-12-22)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109616
影响因子 ：5.7
引用产品： BV2 细胞 , PC-12 (Undifferentiated) 细胞
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MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury (2022-02-08)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2031386
影响因子 ：4.9
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A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer’s Disease (2022-07-12)
期刊：MOLECULES
影响因子 ：4.9
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The SWGEDWGEIW from Soybean Peptides Reduce Oxidative Damage-Mediated Apoptosis in PC-12 Cells by Activating SIRT3/FOXO3a Signaling Pathway (2022-11-06)
期刊：MOLECULES
影响因子 ：4.9
-
Biogenic Selenium Nanoparticles Attenuate Aβ25–35-Induced Toxicity in PC12 Cells via Akt/CREB/BDNF Signaling Pathway (2022-11-26)
期刊：NEUROTOXICITY RESEARCH
DOI：10.1007/s12640-022-00590-8
影响因子 ：4.0
-
Protective effects of Dendrobium huoshanense polysaccharide on D-gal induced PC12 cells and aging mice, in vitro and in vivo studies (2022-11-09)
期刊：JOURNAL OF FOOD BIOCHEMISTRY
影响因子 ：3.7
-
Purification, Identification and Neuroprotective Effects of Proteins from Bombyx batryticatus in Glu-Stimulated PC12 Cells (2022-09-01)
期刊：Separations
DOI：10.3390/separations9090236
影响因子 ：3.3
-
Calycosin ameliorates spinal cord injury by targeting Hsp90 to inhibit oxidative stress and apoptosis of nerve cells (2022-11-17)
期刊：JOURNAL OF CHEMICAL NEUROANATOMY
DOI：10.1016/j.jchemneu.2022.102190
影响因子 ：3.1
-
Fabrication and detection of a novel hybrid conductive scaffold based on alginate/gelatin/carboxylated carbon nanotubes (Alg/Gel/mMWCNTs) for neural tissue engineering (2022-12-07)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2022.101995
影响因子 ：2.6
-
Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H2O2-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways (2021-07-20)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：6.5
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Preparation, structural characterization and neuroprotective effects of polysaccharides from the pericarp of Zanthoxylum bungeanum Maxim against H2O2-induced oxidative damage in PC12 cells (2021-07-08)
期刊：SOUTH AFRICAN JOURNAL OF BOTANY
DOI：10.1016/j.sajb.2021.06.026
影响因子 ：2.3
-
Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway (2020-07-09)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：5.1
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The Effect of Protein-Rich Extract from Bombyx Batryticatus against Glutamate-Damaged PC12 Cells Via Regulating γ-Aminobutyric Acid Signaling Pathway (2020-01-28)
期刊：MOLECULES
影响因子 ：3.3
-
Antiepileptic Effects of Protein-Rich Extract from Bombyx batryticatus on Mice and Its Protective Effects against H2O2-Induced Oxidative Damage in PC12 Cells via Regulating PI3K/Akt Signaling Pathways (2019-05-06)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：4.9
FAQs
Q：为什么我看的文献里的细胞培养条件和你们官网的培养条件不一样呢？
A：部分细胞是会出现多种培养条件的，我们公司优先选择引种来源的培养条件以及建系者所用培养条件，出现差异的原因是不同实验室在保藏过程中更改了细胞的培养条件，为了避免细胞突然更换培养条件后不适应，建议您优先使用厂家推荐的培养条件培养。
Q：冻存细胞运输与常温细胞运输相比有什么区别？
A：发货有两种形式，常温或者冻存都可以的，常温就是货期一周左右（具体以购买当时销售报的货期为准），我们培养好一个T25瓶发货；冻存细胞如果有库存下单第二天能发货，细胞系冻存细胞担心客户复苏不成功所以赠送了一管，实际发货2管；冻存细胞发货是10公斤干冰及顺丰运输，所以冻存细胞需额外支付干冰及运输费。
Q：培养细胞的培养瓶可以重复利用吗？
A：一般不建议重复利用，特别是贴壁不牢固细胞，重复利用会导致吸附性变差，漂浮增多；一个T25瓶建议使用最多不超过3次，其次需要注意无菌操作，避免污染。
Q：冻存的细胞出现颜色不一致，有的红有的粉，对复苏会有影响吗？
A：这种情况容易在不同冻存批次间出现，与冻存细胞的密度、冻存液配方、温度导致pH变化等有关，偶尔有遇到这种情况，不是绝对性对细胞状态有影响，可以复苏看下。
Q：不同引种单位的同一株细胞，RRID都是一样的吗？
A：是的，同一个细胞系只有一个RRID。
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