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产品概述
名称 | Hep 3B2.1-7 (人肝癌细胞) (STR鉴定正确) |
别称 | Hep 3B2_1-7; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:3 |
推荐换液频率 | 2-3次/周 |
背景描述 | Hep 3B2.1-7细胞是来自8岁男性黑人的组织。Hep 3B2.1-7细胞的染色体模式数目为60,在裸鼠中能致瘤。Hep 3B2.1-7细胞整合了完整的乙型肝炎病毒基因组,需在2级生物安全防护下操作。 |
年龄(性别) | 男性;8岁 |
组织来源 | 肝细胞癌,肝 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肝癌细胞 |
生物安全等级 | BSL-2 |
倍增时间 | ~40-50 hours |
致瘤性 | Yes, in nude mice. |
基因表达情况 | alpha-fetoprotein (AFP, alpha fetoprotein); hepatitis B surface antigen (HBsAg); albumin; alpha2 macroglobulin (alpha-2-macroglobulin); alpha1 antitrypsin (alpha-1-antitrypsin); transferrin; ,alpha1 antichymotrypsin (alpha-1-antichymotrypsin); haptoglobin; ceruloplasmin; plasminogen complement (C3, C4), C3 activator; fibrinogen; alpha1 acid glycoprotein (alpha-1 acid glycoprotein); ,alpha2 HS glycoprotein (alpha-2-HS-glycoprotein); beta lipoprotein (beta-lipoprotein); retinol binding protein (retinol-binding protein) |
保藏机构 | ATCC; HB-8064 BCRC; 60434 BCRJ; 0357 DSMZ; ACC-93 ECACC; 86062703 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 8 D2S1338 21,25 D3S1358 15 D5S818 13 D7S820 8,10 D8S1179 12 D13S317 12,14 D16S539 10 D18S51 20 D19S433 12.2,14 D21S11 30,31 FGA 18 PentaD 12,14 PentaE 5,16 TH01 6,7 TPOX 9 vWA 17 D6S1043 12,17 D12S391 17 D2S441 10,12 -
STR鉴定图
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参考文献
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How CLSPN could demystify its prognostic value and potential molecular mechanism for hepatocellular carcinoma: A crosstalk study (2024-03-11)
期刊:COMPUTERS IN BIOLOGY AND MEDICINE
DOI:10.1016/j.compbiomed.2024.108260
影响因子 :7.7
引用产品: HL-7702 [L-02; LO2] 细胞 , Hep G2 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling (2024-02-18)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-024-04964-8
影响因子 :7.4
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞 , PLC/PRF/5 细胞 , Li-7 细胞 , THLE-2 细胞
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CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway (2024-01-09)
期刊:iScience
DOI:10.1016/j.isci.2024.108843
影响因子 :5.8
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway (2024-03-12)
期刊:CANCER SCIENCE
影响因子 :5.7
引用产品: HuH-7 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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BMP9-ID1 Pathway Attenuates N6-Methyladenosine Levels of CyclinD1 to Promote Cell Proliferation in Hepatocellular Carcinoma (2024-01-12)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.6
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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Circ_0027791 contributes to the growth and immune evasion of hepatocellular carcinoma via the miR-496/programmed cell death ligand 1 axis in an m6A-dependent manner (2024-03-28)
期刊:ENVIRONMENTAL TOXICOLOGY
影响因子 :4.5
引用产品: MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞 , MHCC97-L细胞专用培养基 , Hep 3B2.1-7细胞专用培养基 , HuH-7细胞专用培养基
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miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2 (2024-02-23)
期刊:CANCER BIOLOGY & THERAPY
DOI:10.1080/15384047.2024.2315651
影响因子 :3.6
引用产品: HL-7702 [L-02; LO2] 细胞 , HuH-7 细胞 , Hep G2 细胞 , Hep 3B2.1-7 细胞 , SMMC-7721 细胞 , SK-Hep-1 细胞
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Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition (2024-03-14)
期刊:GENE
DOI:10.1016/j.gene.2024.148374
影响因子 :3.5
引用产品: HL-7702 [L-02; LO2] 细胞 , Hep 3B2.1-7 细胞
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Matrine inhibits cell proliferation, invasion, and stem cell formation in hepatocellular carcinoma by regulating the ELAVL1/RBM3-mediated Wnt/β-catenin signaling pathway (2024-01-23)
期刊:Chemical Biology & Drug Design
影响因子 :3.0
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞 , MEM 培养基 , DMEM高糖 培养基
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LINC00665 target let-7i/HMGA1 promotes the proliferation and invasion of hepatoma cells (2024-02-07)
期刊:MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
DOI:10.1016/j.mrfmmm.2024.111852
影响因子 :2.3
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞
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The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP (2023-10-12)
期刊:CANCER LETTERS
DOI:10.1016/j.canlet.2023.216439
影响因子 :9.7
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞
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Downregulated liver-elevated long intergenic noncoding RNA (LINC02428) is a tumor suppressor that blocks KDM5B/IGF2BP1 positive feedback loop in hepatocellular carcinoma (2023-05-03)
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05831-y
影响因子 :9.0
引用产品: Hep 3B2.1-7 细胞
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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I (2023-03-28)
期刊:Frontiers of Medicine
影响因子 :8.1
引用产品: HuH-7 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , Li-7 细胞
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JMJD6–BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells (2023-10-25)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-023-04394-y
影响因子 :7.4
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞 , 293T [HEK-293T] 细胞
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Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma (2023-04-28)
期刊:Cell Death Discovery
DOI:10.1038/s41420-023-01405-1
影响因子 :7.0
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2 (2023-05-19)
期刊:iScience
DOI:10.1016/j.isci.2023.106914
影响因子 :5.8
引用产品: Hep 3B2.1-7 细胞 , Hep G2 细胞 , HuH-7 细胞
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Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis (2023-09-20)
期刊:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 :5.3
引用产品: HL-7702 [L-02; LO2] 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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Chaetocochin J exhibits anti-hepatocellular carcinoma effect independent of hypoxia (2023-06-25)
期刊:BIOORGANIC CHEMISTRY
DOI:10.1016/j.bioorg.2023.106701
影响因子 :5.1
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞
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Asymmetric total synthesis and anti-hepatocellular carcinoma profile of enantiopure euphopilolide and jolkinolide E (2023-06-22)
期刊:BIOORGANIC CHEMISTRY
DOI:10.1016/j.bioorg.2023.106688
影响因子 :5.1
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC (2023-03-15)
期刊:MOLECULAR CARCINOGENESIS
DOI:10.1002/mc.23526
影响因子 :4.6
引用产品: HuH-7 细胞 , Hep G2 细胞 , HCCLM3 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , MHCC97-L 细胞
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Hepatoprotective effects of aspirin on diethylnitrosamine-induced hepatocellular carcinoma in rats by reducing inflammation levels and PD-L1 expression (2023-12-04)
期刊:Scientific Reports
DOI:10.1038/s41598-023-48812-z
影响因子 :4.6
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞 , DMEM高糖 培养基
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LINC00886 Facilitates Hepatocellular Carcinoma Tumorigenesis by Sequestering microRNA-409-3p and microRNA-214-5p (2023-06-07)
期刊:Journal of Hepatocellular Carcinoma
影响因子 :4.1
引用产品: LX-2 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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Circular RNA circBNC2 facilitates glycolysis and stemness of hepatocellular carcinoma through the miR-217/high mobility group AT-hook 2 (HMGA2) axis. (2023-06-09)
期刊:Heliyon
DOI:10.1016/j.heliyon.2023.e17120
影响因子 :4.0
引用产品: HL-7702 [L-02; LO2] 细胞 , HuH-7 细胞 , HCCLM3 细胞 , Hep 3B2.1-7 细胞
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The abrogation of GRP78 sensitizes liver cancer cells to lysionotin by enhancing ER stress-mediated pro-apoptotic pathway (2023-06-16)
期刊:CELL STRESS & CHAPERONES
DOI:10.1007/s12192-023-01358-5
影响因子 :3.8
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞
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HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p (2023-10-25)
期刊:NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI:10.1007/s00210-023-02793-y
影响因子 :3.6
引用产品: MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞 , MHCC97-L细胞专用培养基 , Hep 3B2.1-7细胞专用培养基 , HuH-7细胞专用培养基
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Active compounds and potential targets of Shuganning injection in the treatment of hepatocellular carcinoma by network pharmacology and in vitro validation (2023-03-04)
期刊:NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI:10.1007/s00210-023-02432-6
影响因子 :3.6
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞
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LncRNA FAM13A-AS1, transcriptionally regulated by PHOX2B, modulates hepatocellular carcinoma chemoresistance via stabilizing PPARγ (2023-06-16)
期刊:GENE
DOI:10.1016/j.gene.2023.147570
影响因子 :3.5
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma (2023-06-08)
期刊:Cancer Biomarkers
影响因子 :3.1
引用产品: Hep G2 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , HL-7702 [L-02; LO2] 细胞
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NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma (2023-01-21)
期刊:MEDICAL SCIENCE MONITOR
影响因子 :3.1
引用产品: SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Transcriptome-Wide Dynamics of m7G-Related LncRNAs during the Progression from HBV Infection to Hepatocellular Carcinoma (2023-12-19)
期刊:Frontiers in Bioscience-Landmark
影响因子 :3.1
引用产品: Hep 3B2.1-7 细胞
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Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer (2023-08-30)
期刊:Oncology Letters
影响因子 :2.9
引用产品: HuH-7 细胞 , PLC/PRF/5 细胞 , Hep 3B2.1-7 细胞 , Hep G2 细胞 , Li-7 细胞 , RPMI-1640 培养基 , DMEM高糖 培养基 , 青霉素-链霉素溶液 (双抗),100×
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Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3 (2023-06-16)
期刊:MOLECULAR BIOLOGY REPORTS
DOI:10.1007/s11033-023-08492-4
影响因子 :2.8
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma (2023-02-01)
期刊:BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子 :2.0
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞
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Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway (2023-09-01)
期刊:BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子 :2.0
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞 , 人骨髓树突状细胞 (成熟DC细胞)
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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression (2022-08-01)
期刊:International Journal of Biological Sciences
影响因子 :10.8
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , Hep G2 细胞 , H22 细胞 , THP-1 细胞
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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway (2022-08-16)
期刊:Cell Reports
DOI:10.1016/j.celrep.2022.111194
影响因子 :10.0
引用产品: SK-Hep-1 细胞 , Hep G2 细胞 , 293T [HEK-293T] 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma (2022-11-15)
期刊:Biomarker Research
DOI:10.1186/s40364-022-00422-z
影响因子 :8.6
引用产品: SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression (2001-02-20)
期刊:CELLULAR AND MOLECULAR LIFE SCIENCES
DOI:10.1007/s00018-021-04118-9
影响因子 :8.0
引用产品: MHCC97-L 细胞 , Hep 3B2.1-7 细胞
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VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4 (2022-10-14)
期刊:CANCER GENE THERAPY
DOI:10.1038/s41417-022-00540-8
影响因子 :5.9
引用产品: SK-Hep-1 细胞 , PLC/PRF/5 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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Identification and Characterization of Cell Lines HepG2, Hep3B217 and SNU387 as Models for Porcine Epidemic Diarrhea Coronavirus Infection (2022-12-10)
期刊:Viruses-Basel
影响因子 :5.8
引用产品: HuH-7 细胞 , Hep G2 细胞 , Hep 3B2.1-7 细胞 , BHK-21 [C-13] 细胞 , Li-7 细胞
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Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients (2006-02-20)
期刊:Frontiers in Oncology
影响因子 :5.7
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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Proteoglycan-4 predicts good prognosis in patients with hepatocellular carcinoma receiving transcatheter arterial chemoembolization and inhibits cancer cell migration in vitro (2022-11-11)
期刊:Frontiers in Oncology
影响因子 :5.7
引用产品: Hep 3B2.1-7 细胞 , HuH-1 细胞 , 293T [HEK-293T] 细胞
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Exosomes Derived from microRNA-27a-3p Overexpressing Mesenchymal Stem Cells Inhibit the Progression of Liver Cancer through Suppression of Golgi Membrane Protein 1 (2022-12-07)
期刊:Stem Cells International
影响因子 :5.1
引用产品: Hep G2 细胞 , MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞 , HL-7702 [L-02; LO2] 细胞
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Long noncoding RNA HULC regulates the NF-κB pathway and represents a promising prognostic biomarker in liver cancer (2022-10-10)
期刊:Cancer Medicine
影响因子 :4.7
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞 , LX-2 细胞
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Role of SLC39A6 in the development and progression of liver cancer (2001-02-20)
期刊:Oncology Letters
影响因子 :2.9
引用产品: Hep G2 细胞 , Hep 3B2.1-7 细胞
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Activation of YAP1 by STK25 contributes to the progression of hepatocellular carcinoma (2004-02-20)
期刊:TISSUE & CELL
DOI:10.1016/j.tice.2022.101797
影响因子 :2.6
引用产品: MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , SNU-182 细胞
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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway (2011-01-20)
期刊:Cellular & Molecular Biology Letters
DOI:10.1186/s11658-021-00295-4
影响因子 :8.3
引用产品: HCCLM3 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α (2009-01-20)
期刊:Frontiers in Cell and Developmental Biology
影响因子 :5.5
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis (2008-01-20)
期刊:Journal Of Ethnopharmacology
影响因子 :5.4
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞
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Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways (2002-01-20)
期刊:Plos Computational Biology
DOI:10.1371/journal.pcbi.1008696
影响因子 :4.3
引用产品: HCC 94 [HCC941122] 细胞 , Hep G2 细胞 , Hep 3B2.1-7 细胞
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ZSCAN16-AS1 expedites hepatocellular carcinoma progression via modulating the miR-181c-5p/SPAG9 axis to activate the JNK pathway (2006-01-20)
期刊:Cell Cycle
DOI:10.1080/15384101.2021.1919828
影响因子 :4.3
引用产品: HCCLM3 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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Targeting Hedgehog signalling in CD133-positive hepatocellular carcinoma: improving Lenvatinib therapeutic efficiency (2003-01-20)
期刊:MEDICAL ONCOLOGY
DOI:10.1007/s12032-021-01487-w
影响因子 :3.4
引用产品: Hep G2 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis (2001-01-20)
期刊:Digestive Diseases And Sciences
DOI:10.1007/s10620-020-06787-1
影响因子 :3.1
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞
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CKS1B promotes the progression of hepatocellular carcinoma by activating JAK/STAT3 signal pathway (2007-01-20)
期刊:Animal Cells and Systems
DOI:10.1080/19768354.2021.1953142
影响因子 :2.9
引用产品: Hep 3B2.1-7 细胞 , HuH-7 细胞
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Propofol enhances the lethality of cisplatin on liver cancer cells by up-regulating miR-195-5p (2011-01-20)
期刊:Tissue & Cell
DOI:10.1016/j.tice.2021.101680
影响因子 :2.6
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞 , HuH-7细胞专用培养基 , Hep 3B2.1-7细胞专用培养基
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An NAD+ -Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39 (2007-00-20)
期刊:iScience
DOI:10.1016/j.isci.2020.101351
影响因子 :5.8
引用产品: Hep 3B2.1-7 细胞
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LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis (2009-00-20)
期刊:Cell Cycle
DOI:10.1080/15384101.2020.1809259
影响因子 :4.3
引用产品: HuH-6 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , SNU-182 细胞
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Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein (2003-00-20)
期刊:Cancer Medicine
影响因子 :4.0
引用产品: Hep G2 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis (2003-08-20)
期刊:Oncogene
影响因子 :8.0
引用产品: Hep 3B2.1-7 细胞
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识别码示意图